ABCA2

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

ATP-binding cassette, sub-family A (ABC1), member 2

Protein family

Membrane proteins predicted by MDM, Transporters

Chromosome

9:q34.3 (139901686 - 139923367)

Ensembl ID

ENSG00000107331  (ver. 69.37)

Orthologs

Mouse Abca2: ENSMUSG00000026944

Human splice variants
Mouse splice variants