ABCB8

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq, Jul 2008]

Description

ATP-binding cassette, sub-family B (MDR/TAP), member 8

Protein family

Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

7:q36.1 (150725510 - 150744869)

Ensembl ID

ENSG00000197150  (ver. 69.37)

Orthologs

Mouse Abcb8: ENSMUSG00000028973

Human splice variants
Mouse splice variants