UMPS

This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Description

uridine monophosphate synthetase

Protein family

Enzymes

Chromosome

3:q21.2 (124449213 - 124464040)

Ensembl ID

ENSG00000114491  (ver. 69.37)

Orthologs

Mouse Umps: ENSMUSG00000022814

Human splice variants
Mouse splice variants