ADAMTS8

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 8

Protein family

Peptidases, Secreted proteins predicted by MDSP

Chromosome

11:q24.3 (130274820 - 130298888)

Ensembl ID

ENSG00000134917  (ver. 69.37)

Orthologs

Mouse Adamts8: ENSMUSG00000031994

Human splice variants
Mouse splice variants