MAP3K2

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

Description

mitogen-activated protein kinase kinase kinase 2

Protein family

Enzymes, Kinases, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins

Chromosome

2:q14.3 (128056306 - 128146041)

Ensembl ID

ENSG00000169967  (ver. 71.37)

Orthologs

Mouse Map3k2: ENSMUSG00000024383

Human splice variants
Mouse splice variants