MRPL18

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L18P ribosomal protein family. Three polymorphic sites exist in this gene, one of which is three nt in length which causes an extra aa near the N-terminus. [provided by RefSeq, Jul 2008]

Description

mitochondrial ribosomal protein L18

Protein family

Mapped to UniProt SWISS-PROT, Potentially secreted proteins, Ribosomal proteins

Chromosome

6:q25.3 (160210844 - 160219468)

Ensembl ID

ENSG00000112110  (ver. 71.37)

Orthologs

Mouse Mrpl18: ENSMUSG00000057388

Human splice variants
Mouse splice variants