CFC1

This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. These proteins play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in this gene can cause autosomal visceral heterotaxy. This protein is involved in left-right asymmetric morphogenesis during organ development. [provided by RefSeq, Jul 2008]

Description

cripto, FRL-1, cryptic family 1

Protein family

Secreted proteins predicted by MDSP

Chromosome

2:q21.1 (131350339 - 131357123)

Ensembl ID

ENSG00000136698  (ver. 69.37)

Orthologs

-

Human splice variants