PSRC1

This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as a microtubule destabilizing protein that controls spindle dynamics and mitotic progression by recruiting and regulating microtubule depolymerases. At least one genetic variation in this gene has been associated with decreased serum levels of low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2009]

Description

proline/serine-rich coiled-coil 1

Protein family

-

Chromosome

1:p13.3 (109822178 - 109825808)

Ensembl ID

ENSG00000134222  (ver. 69.37)

Orthologs

Mouse Psrc1: ENSMUSG00000068744

Human splice variants
Mouse splice variants