GRB14

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date. [provided by RefSeq, Jul 2008]

Description

growth factor receptor-bound protein 14

Protein family

SH2-domain containing proteins

Chromosome

2:q24.3 (165349322 - 165478358)

Ensembl ID

ENSG00000115290  (ver. 69.37)

Orthologs

Mouse Grb14: ENSMUSG00000026888

Human splice variants
Mouse splice variants