PRKAA2

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]

Description

protein kinase, AMP-activated, alpha 2 catalytic subunit

Protein family

Enzymes, Kinases, Membrane proteins predicted by MDM

Chromosome

1:p32.2 (57110995 - 57181008)

Ensembl ID

ENSG00000162409  (ver. 69.37)

Orthologs

Mouse Prkaa2: ENSMUSG00000028518

Human splice variants
Mouse splice variants