DLG3

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Description

discs, large homolog 3 (Drosophila)

Protein family

SH3-domain containing proteins

Chromosome

X:q13.1 (69664711 - 69725337)

Ensembl ID

ENSG00000082458  (ver. 69.37)

Orthologs

Mouse Dlg3: ENSMUSG00000000881

Human splice variants
Mouse splice variants