MRPL24

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

Description

mitochondrial ribosomal protein L24

Protein family

Mapped to UniProt SWISS-PROT, Potentially secreted proteins, Ribosomal proteins

Chromosome

1:q23.1 (156707095 - 156711382)

Ensembl ID

ENSG00000143314  (ver. 71.37)

Orthologs

Mouse Mrpl24: ENSMUSG00000019710

Human splice variants
Mouse splice variants