CACNA1E

Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

Description

calcium channel, voltage-dependent, R type, alpha 1E subunit

Protein family

Membrane proteins predicted by MDM, Voltage-gated ion channels

Chromosome

1:q25.3 (181382238 - 181777219)

Ensembl ID

ENSG00000198216  (ver. 69.37)

Orthologs

Mouse Cacna1e: ENSMUSG00000004110

Human splice variants
Mouse splice variants