CCR9

The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Description

chemokine (C-C motif) receptor 9

Protein family

CD markers, GPCRs excl olfactory receptors, Membrane proteins predicted by MDM

Chromosome

3:p21.31 (45927996 - 45944667)

Ensembl ID

ENSG00000173585  (ver. 69.37)

Orthologs

Mouse Ccr9: ENSMUSG00000029530

Human splice variants
Mouse splice variants