APCS

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]

Description

amyloid P component, serum

Protein family

Mapped to UniProt SWISS-PROT, Plasma proteins, Potential transmembrane proteins, Potentially secreted proteins, Transporters

Chromosome

1:q23.2 (159557615 - 159558655)

Ensembl ID

ENSG00000132703  (ver. 71.37)

Orthologs

Mouse Apcs: ENSMUSG00000026542

Human splice variants
Mouse splice variants