ABCB4

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]

Description

ATP-binding cassette, sub-family B (MDR/TAP), member 4

Protein family

Enzymes, Membrane proteins predicted by MDM, Transporters

Chromosome

7:q21.12 (87031013 - 87109751)

Ensembl ID

ENSG00000005471  (ver. 69.37)

Orthologs

Mouse Abcb4: ENSMUSG00000042476

Human splice variants
Mouse splice variants