MAP3K1

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

Description

mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

Protein family

Enzymes, Kinases, Membrane proteins predicted by MDM

Chromosome

5:q11.2 (56111401 - 56191979)

Ensembl ID

ENSG00000095015  (ver. 69.37)

Orthologs

Mouse Map3k1: ENSMUSG00000021754

Human splice variants
Mouse splice variants