CA9

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jul 2008]

Description

carbonic anhydrase IX

Protein family

Enzymes, Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

9:p13.3 (35673853 - 35681156)

Ensembl ID

ENSG00000107159  (ver. 69.37)

Orthologs

Mouse Car9: ENSMUSG00000028463

Human splice variants
Mouse splice variants