ATP6V1F

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]

Description

ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F

Protein family

Transporters

Chromosome

7:q32.1 (128502880 - 128505898)

Ensembl ID

ENSG00000128524  (ver. 69.37)

Orthologs

Mouse Atp6v1f: ENSMUSG00000004285

Human splice variants
Mouse splice variants