BMX

This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]

Description

BMX non-receptor tyrosine kinase

Protein family

Enzymes, Kinases, SH2-domain containing proteins

Chromosome

X:p22.2 (15482369 - 15574652)

Ensembl ID

ENSG00000102010  (ver. 69.37)

Orthologs

Mouse Bmx: ENSMUSG00000031377

Human splice variants
Mouse splice variants