IGF1R

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008]

Description

insulin-like growth factor 1 receptor

Protein family

Candidate cancer biomarkers, CD markers, Enzymes, Kinases, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

15:q26.3 (99192200 - 99507759)

Ensembl ID

ENSG00000140443  (ver. 71.37)

Orthologs

Mouse Igf1r: ENSMUSG00000005533

Human splice variants
Mouse splice variants