PRKACA

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Description

protein kinase, cAMP-dependent, catalytic, alpha

Protein family

Enzymes, Kinases, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins

Chromosome

19:p13.12 (14202500 - 14228896)

Ensembl ID

ENSG00000072062  (ver. 71.37)

Orthologs

Mouse Prkaca: ENSMUSG00000005469

Human splice variants
Mouse splice variants