DDR2

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Description

discoidin domain receptor tyrosine kinase 2

Protein family

CD markers, Enzymes, Kinases, Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

1:q23.3 (162601163 - 162750237)

Ensembl ID

ENSG00000162733  (ver. 69.37)

Orthologs

Mouse Ddr2: ENSMUSG00000026674

Human splice variants
Mouse splice variants