ADM

Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]

Description

adrenomedullin

Protein family

Secreted proteins predicted by MDSP

Chromosome

11:p15.4 (10326227 - 10328944)

Ensembl ID

ENSG00000148926  (ver. 69.37)

Orthologs

Mouse Adm: ENSMUSG00000030790

Human splice variants
Mouse splice variants