BACE1

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

Description

beta-site APP-cleaving enzyme 1

Protein family

Enzymes, Membrane proteins predicted by MDM, Peptidases, Secreted proteins predicted by MDSP, Transporters

Chromosome

11:q23.3 (117156402 - 117186975)

Ensembl ID

ENSG00000186318  (ver. 69.37)

Orthologs

-

Human splice variants