ADAMTS1

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 1

Protein family

Membrane proteins predicted by MDM, Peptidases, Secreted proteins predicted by MDSP

Chromosome

21:q21.3 (28208606 - 28217728)

Ensembl ID

ENSG00000154734  (ver. 69.37)

Orthologs

Mouse Adamts1: ENSMUSG00000022893

Human splice variants
Mouse splice variants