BEX2

This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Description

brain expressed X-linked 2

Protein family

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Chromosome

X:q22.1 (102564274 - 102565974)

Ensembl ID

ENSG00000133134  (ver. 69.37)

Orthologs

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Human splice variants