IKZF3

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

Description

IKAROS family zinc finger 3 (Aiolos)

Protein family

Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Transcription factors

Chromosome

17:q12 (37921198 - 38020441)

Ensembl ID

ENSG00000161405  (ver. 71.37)

Orthologs

Mouse Ikzf3: ENSMUSG00000018168

Human splice variants
Mouse splice variants