ATP1A1

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Description

ATPase, Na+/K+ transporting, alpha 1 polypeptide

Protein family

Enzymes, Membrane proteins predicted by MDM, Transporters

Chromosome

1:p13.1 (116915290 - 116952883)

Ensembl ID

ENSG00000163399  (ver. 69.37)

Orthologs

Mouse Atp1a1: ENSMUSG00000033161

Human splice variants
Mouse splice variants