GDI1

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq, Jul 2008]

Description

GDP dissociation inhibitor 1

Protein family

Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

X:q28 (153665266 - 153671814)

Ensembl ID

ENSG00000203879  (ver. 71.37)

Orthologs

Mouse Gdi1: ENSMUSG00000015291

Human splice variants
Mouse splice variants