EPHB4

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]

Description

EPH receptor B4

Protein family

Candidate cancer biomarkers, Enzymes, Kinases, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

7:q22.1 (100400187 - 100425121)

Ensembl ID

ENSG00000196411  (ver. 71.37)

Orthologs

Mouse Ephb4: ENSMUSG00000029710

Human splice variants
Mouse splice variants