ATF6B

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Description

activating transcription factor 6 beta

Protein family

Membrane proteins predicted by MDM, Transcription factors

Chromosome

6:p21.33 (32065953 - 32096030)

Ensembl ID

ENSG00000213676  (ver. 69.37)

Orthologs

Mouse Atf6b: ENSMUSG00000015461

Human splice variants
Mouse splice variants