ADAMTS10

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 10

Protein family

Peptidases, Secreted proteins predicted by MDSP

Chromosome

19:p13.2 (8645126 - 8673183)

Ensembl ID

ENSG00000142303  (ver. 69.37)

Orthologs

Mouse Adamts10: ENSMUSG00000024299

Human splice variants
Mouse splice variants