MRPL35

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008]

Description

mitochondrial ribosomal protein L35

Protein family

Ribosomal proteins, Secreted proteins predicted by MDSP

Chromosome

2:p11.2 (86426580 - 86440917)

Ensembl ID

ENSG00000132313  (ver. 69.37)

Orthologs

Mouse Mrpl35: ENSMUSG00000052962

Human splice variants
Mouse splice variants