ATP1A4

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Description

ATPase, Na+/K+ transporting, alpha 4 polypeptide

Protein family

Enzymes, Membrane proteins predicted by MDM

Chromosome

1:q23.2 (160121360 - 160156767)

Ensembl ID

ENSG00000132681  (ver. 69.37)

Orthologs

Mouse Atp1a4: ENSMUSG00000007107

Human splice variants
Mouse splice variants