CDK8

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]

Description

cyclin-dependent kinase 8

Protein family

Enzymes, Kinases

Chromosome

13:q12.13 (26828276 - 26979375)

Ensembl ID

ENSG00000132964  (ver. 69.37)

Orthologs

Mouse Cdk8: ENSMUSG00000029635

Human splice variants
Mouse splice variants