ABL2

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Description

v-abl Abelson murine leukemia viral oncogene homolog 2

Protein family

Enzymes, Kinases, SH2-domain containing proteins, SH3-domain containing proteins

Chromosome

1:q25.2 (179068462 - 179198819)

Ensembl ID

ENSG00000143322  (ver. 69.37)

Orthologs

Mouse Abl2: ENSMUSG00000026596

Human splice variants
Mouse splice variants