ITSN1

The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]

Description

intersectin 1 (SH3 domain protein)

Protein family

Membrane proteins predicted by MDM, SH3-domain containing proteins

Chromosome

21:q22.11 (35014706 - 35272165)

Ensembl ID

ENSG00000205726  (ver. 69.37)

Orthologs

Mouse Itsn1: ENSMUSG00000022957

Human splice variants
Mouse splice variants