AAK1

Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Description

AP2 associated kinase 1

Protein family

Enzymes, Kinases

Chromosome

2:p13.3 (69688532 - 69901481)

Ensembl ID

ENSG00000115977  (ver. 69.37)

Orthologs

Mouse Aak1: ENSMUSG00000057230

Human splice variants
Mouse splice variants