TRPC4

This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Description

transient receptor potential cation channel, subfamily C, member 4

Protein family

Membrane proteins predicted by MDM, Voltage-gated ion channels

Chromosome

13:q13.3 (38210773 - 38444562)

Ensembl ID

ENSG00000133107  (ver. 69.37)

Orthologs

Mouse Trpc4: ENSMUSG00000027748

Human splice variants
Mouse splice variants