AGT

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

Description

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Protein family

Candidate cardiovascular disease genes, Mapped to UniProt SWISS-PROT, Plasma proteins, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

1:q42.2 (230838269 - 230850043)

Ensembl ID

ENSG00000135744  (ver. 71.37)

Orthologs

Mouse Agt: ENSMUSG00000031980

Human splice variants
Mouse splice variants