CTSD

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]

Description

cathepsin D

Protein family

Enzymes, Peptidases, Secreted proteins predicted by MDSP

Chromosome

11:p15.5 (1773982 - 1785222)

Ensembl ID

ENSG00000117984  (ver. 69.37)

Orthologs

-

Human splice variants