Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [2003]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10176-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10176-2-AP, RRID:AB_2224574
- Product name
- AKT antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated AKT antibody (Cat. #10176-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Classic Protocadherin PCDH10 Functions as a Tumor Suppressive Scaffold Protein Antagonizing Oncogenic WNT/β-catenin Signaling in Breast Carcinogenesis.
Evaluation of the mechanism underlying melatonin action in cholestatic liver disease treatment via network pharmacology, molecular docking, and in vivo experiments.
Identification of Anti-Inflammatory and Analgesic Mechanisms of Naru-3 Wei Pill Using Animal Models, UHPLC-QE-MS, and Integrated Network Pharmacology.
FGF7-FGFR2 Signaling Enhances Contractile Activation of CAFs in Ovarian Cancer: Integrative Single-Cell and Spatial Transcriptomics.
Mechanisms of Yiqi Huoxue Granule in Atherosclerosis Treatment: Insights from UPLC-Q-Exactive Orbitrap-MS Analysis, Network Pharmacology, Molecular Docking, and Experimental Verification.
AK3 as a Hypoxia-Angiogenesis-Related Prognostic Biomarker and Therapeutic Target in Clear Cell Renal Cell Carcinoma.
Potential Anti-Cancer Drug 6RK73 Suppresses Ovarian Cancer Growth by Inactivating the AKT1/Sp1 Induced c-Myc Signaling Pathway.
Multi-omics analysis reveals the mechanism of verbenalin in treating gout via modulating purine metabolism, gut microbiota, and inflammatory pathways.
A berberine-loaded hydrogel for the treatment of atopic dermatitis through antibacterial activity, inhibition of inflammation and modulation of oxidative stress.
Crocin protects against smoke-induced chronic obstructive pulmonary disease by regulating AKT1.
Novel prognostic signature unveils PSEN1 contributes to depression-induced lung adenocarcinoma progression.
Microbiota-driven therapeutic efficacy of Hyperoside in ulcerative colitis and associated anxiety.
Gastrodia elata fermentation alleviates methamphetamine-induced neuroinflammation and anxiety- and depression-like behaviors by regulating the PI3K-AKT signaling pathway.
Synergistic mitochondrial homeostasis regulation and cholinergic circuits reconstruction via a one-step synthesized multifunctional hydrogel facilitates spinal cord injury repair.
Cinnamaldehyde inhibits the progression of gastric cancer by regulating glycolysis through PTP1B/PI3K/AKT/mTOR signaling pathway.
Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3-Mediated Mitophagy.
Peroxiredoxin 4 suppresses ferroptosis in esophageal squamous cell carcinoma by activating the phosphoinositide 3-kinase signaling pathway.
Luteolin prevents hyperoxaluria-induced renal injury by inhibiting crystal deposition and renal inflammation.
MFAP2 promotes metastasis and drug resistance by regulating epithelial-to-mesenchymal transition through EGFR signaling pathway in colorectal cancer cells.
Eupalinolide B ameliorates liver fibrosis by targeting PKCα to suppress the AKT/mTOR axis in hepatic stellate cells.
Lithocarpus litseifolius leaf extract alleviate hyperuricemia-induced renal injury by regulating uric acid metabolism and inhibiting the AKT/S6K pathway.
Analysis of Reactive Oxygen Species-Induced Cellular Damage in Cervical Cancer.
Homoharringtonine inhibits growth and migration in non-small cell lung cancer via PDIA4-mediated modulation of autophagy and EMT.
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.
Galangin 3-methyl ether alleviates mouse hypertrophic cardiomyopathy via targeting HDAC2 and subsequently inactivating the PI3K-AKT signaling pathway.
Unraveling the Therapeutic Mechanisms of Shanzhen Mingmu Pill in Diabetic Retinopathy: An Integration of Serum Pharmacochemistry, Network Pharmacology, and Experimental Validation.
Isolation, structural characterization and immunoregulatory activity of a novel acidic polysaccharide from Ganoderma sinense.
Insulin-like growth factor 2 alleviates metabolic inflammation and associated cognitive impairment in diet-induced obesity mice.
Multiscale analysis of resolvin D1 biosynthesis and its neuroprotective role in intracerebral hemorrhage.
Novel Ce/Cu-modified black ceramics disrupted mitochondrial dysfunction and tricarboxylic acid cycle to induce cuproptosis in osteosarcoma cells.
A novel proteolysis-targeting chimera strategy targeting multiple immune checkpoints containing ITIMs enhances antitumor immunity.
Transdermal Delivery of Icariin via Microneedle Patches Attenuates Phthalate-Induced Testicular Injury.
AURKA Activates FOXO3a to Form a Positive Feedback Loop in the Proliferation and Migration of Keloid Fibroblasts.
Gut-Metabolome-Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses.
An integrated network pharmacology and proteomics approach reveals the anti-fibrotic effect of Fushen Granule on peritoneal fibrosis.
A novel triaptosis-related prognostic signature to assess the clinical value in HER2-low breast cancer: evidence from clinical cohorts and experimental validation.
Unraveling the Molecular Mechanisms Linking Cigarette Smoke Exposure to Skin Damage.
Stigmasterol upregulates Akt/mTOR/p70S6K signaling through SYVN1 to alleviate osteoporosis in ovariectomized rats.
CBX2 phase-separation contributes to homologous recombination repair and drug resistance in ovarian cancer.
TRIM21-Mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma.
Ephrin-A4 ligand promotes gastric cancer cell epithelial-mesenchymal transition via the PI3K/AKT signaling pathway.
ITGA5 as a Dual Regulator of Epithelial-Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction.
Mycobacterial metallophosphatase MmpE acts as a nucleomodulin to regulate host gene expression and promote intracellular survival.
AG1295 Attenuates High-Glucose-Induced Proliferation, Migration, Phenotype Transition, and Interleukin-6 Expression in Human Corneal Stromal Fibroblasts.
Tanshinone IIA-pretreated mesenchymal stem cells alleviate neuroinflammation in 3×Tg-AD mice via the TREM2/PI3K/Akt pathway.
The Mechanism of Combined Exposure of Polystyrene Microplastics and Cadmium Inducing Hepatic Injury through the Modulation of PI3K/AKT/mTOR-Mediated Autophagy.
tLyP-1 peptide-modified MnO₂ co-delivering si-SLC16A1 and temozolomide synergistically suppresses glioblastoma via hypoxia modulation and metabolic stress.
Integrating neurotrophic and anti-inflammatory pathways: press-needle acupuncture as a multi-target therapy for adolescent depression.
The E3 ubiquitin ligase RNF180 modulates the EGFR/PI3K/AKT pathway to reduce cisplatin resistance in non-small cell lung cancer.
Acrylamide exposure induces neurotoxicity via the PI3K/Akt/NF-κB pathway: Evidence from network toxicology and experimental validation.
Androsin alleviates colorectal cancer by inhibiting the PI3K/Akt-centered signaling pathway.
The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson's disease.
Butyrate protects against Klebsiella pneumoniae-induced oxidative stress in alveolar macrophages via p62-Keap1-Nrf2 pathway.
RRP9 suppresses hepatocellular carcinoma progression by inhibiting the PI3K/AKT/mTOR pathway.
Integrated fabrication of a shape-adaptable, antioxidative composite stent for effective closure and biological repair of enteroatmospheric fistula.
Ophiopogonin B inhibits triple-negative breast cancer progression via suppressing PTP1B and regulating the PI3K/Akt pathway.
ACE2 impairs epidermal regeneration by inhibiting TNC expression and PI3K/AKT/mTOR signaling.
Resveratrol triggers autophagy-dependent apoptosis via suppressing the PI3K/AKT/mTOR pathway in Chlamydia psittaci-infected cells.
Impatiens shenglanii exerts antithrombotic effects by inhibiting the PI3K/Akt/GSK3B signaling pathway and reprogramming arachidonic acid metabolism.
Exploring the potential of heterocyclic-containing tail approach in the development of novel covalent inhibitors dual-targeting EGFR and HER-2: design, synthesis and biological evaluation.
Therapeutic mechanism of Polygonum multiflorum Thunb. in premature ovarian insufficiency: an integration of network pharmacology, molecular docking, and experimental validation.
Therapeutic mechanism of Changyong Decoction in suppressing colorectal cancer progression and inducing ferroptosis via the PIEZO1-PI3K/AKT signaling axis.
Aconitum septentrionale Koelle extract alleviates cigarette smoke and lipopolysaccharide-induced chronic obstructive pulmonary disease in mice by modulating the MAPK pathway.
Investigating the mechanism of Rehmannia glutinosa-Ephedra sinica in heart failure with preserved ejection fraction by network pharmacology, metabolomics and experimental validation.
ACOT8-mediated palmitate accumulation promotes M1 macrophage polarization in renal ischemia-reperfusion injury via activation of the cGAS-STING pathway.
Downregulation of TDP43 by atovaquone inhibits oxidative phosphorylation and enhances sensitivity of triple-negative breast cancer to EGFR-TKIs.
Design, synthesis, and biological evaluation of selective cytotoxicity-derived Miliusol derivatives inducing profound TNBC regression in vivo.
Discovery of 1H-pyrazolo[3,4-d]pyrimidin-4-ylamine derivatives as potent PI3Kδ/BTK dual-target inhibitors for the treatment of B-cell lymphoma.
Characterization of a polysaccharide from Rhodobryum giganteum and its activation effects on TLR4/PI3K-Akt/IκBα pathway.
Basement membrane-associated gene P3H2 regulates osteosarcoma progression and epithelial-mesenchymal transition through AKT/mTOR signaling axis.
HOMER3 drives oral squamous cell carcinoma progression through TRPV6 calcium influx and TUBB3 microtubule stabilization.
m6A-Modified BASP1 Regulates IL6 Expression to Induce TAM Infiltration to Promote Gastric Cancer Progression.
Oroxin A suppresses non-small cell lung cancer via the HSP90AA1/AKT signaling pathway.
Resveratrol can inhibit porcine reproductive and respiratory syndrome virus infection in vitro and in vivo by inhibiting PI3K/Akt signaling pathway.
IMPDH2 facilitates CD4+ T cell activation through AKT/mTOR pathway by upregulating SRPK1 in myasthenia gravis.
Ecdysteroid-enriched fraction of Cyathula officinalis suppresses synovial proliferation and inflammation to ameliorate RA by inhibiting the AKT/PI3K/mTOR signaling pathway.
Selaginella Tamariscina extract reduces UVA-induced skin photodamage via regulating apoptosis and autophagy by AKT phosphorylation.
Downregulation of BST2 Rescues Cochlear Nerve Demyelination in Age-Related Hearing Loss via Enhancing Schwann Cell Migration.
Effects of repetitive transcranial magnetic stimulation on apoptosis and MAPK/PI3K-AKT signaling pathways in rats with spinal cord injury.
Salidroside ameliorates experimental autoimmune neuritis by dually modulating neuroinflammation and immune homeostasis via PI3K/AKT signaling.
CDX2 Promotes Hepatic Specification of hiPSC-derived Endoderm Through the PI3K-Akt-GSK3β Pathway for Improved Therapeutic Efficacy.
Verticinone inhibits cell growth and induces pyroptosis via regulating AKT pathway in papillary thyroid cancer.
Isoimperatorin inhibits cell proliferation and induces apoptosis via regulating PI3K/AKT pathway in acute lymphoblastic leukemia.
The Tetradium ruticarpum-Zingiber officinale Roscoe herb pair inhibits atherogenic events: A study of the synergistic effects and active ingredient combination of a two-herb formula.
Toonasonoids A-K, limonoids from Toona ciliata M. Roem, attenuate inflammatory response through mediating the PI3K/AKT/NF-κB pathway.
Adipose-derived stem cells (ADSCs)-derived DKK1 promotes cutaneous wound healing by inducing M2 macrophage polarization via PI3K/AKT and JNK activation.
A pH-Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury.
NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex.
Circ_0005372 targets the miR-153-3p/ITGB3 axis to stimulate the PI3K/AKT signaling pathway to facilitate the occurrence and development of congenital heart disease and pulmonary arterial hypertension in children.
CCT3 Facilitates the Malignant Progression of NSCLC and SCLC via PI3 K/AKT-EMT Axis and Emerges as a Novel Serum Diagnostic Biomarker.
HSP90AA1 restrains clear cell renal cell carcinoma progression by promoting CADM1 expression and suppressing the PI3K-AKT pathway through interaction with FBXO7.
EIF4A3/circPTGR1/miR-4725-5p positive- feedback loop promotes colorectal cancer progression via FAK/AKT signaling pathway.
Mechanistic insights into myricetin-regulated autophagy via the PI3K/Akt and PINK1/Parkin pathway in diabetic kidney disease treatment.
PDK4-driven metabolic reprogramming enhances mesothelial cell invasion in colorectal cancer peritoneal metastasis.
Quercetin alleviates LPS-induced inflammatory response in dairy cow lamellar keratinocytes through PI3K/Akt/NF-κB signaling pathway.
SULT1E1 exerts a protective role in COPD by inhibiting the AKT pathway: an in vivo and in vitro study.
Danthron Attenuates Intestinal Inflammation by Modulating Oxidative Stress via the EGFR-PI3K-AKT and Nrf2-HO-1 Pathways.
TRPS1 confers paclitaxel resistance in TNBC through dual activation of the PDE4D-cAMP-AKT pathway and microtubule destabilization.
A Molecular and Functional Investigation of the Anabolic Effect of an Essential Amino Acids' Blend Which Is Active In Vitro in Supporting Muscle Function.
Inhibition of GALNT7 suppresses cell proliferation and invasiveness while elevating cell apoptosis via the inactivation of the AKT pathway in non-small cell lung cancer.
Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis.
ACAT1 inhibitor Avasimibe suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via CKB/PI3K-AKT signaling.
Enhancing the Osseointegration of Titanium Implants by Modulating M1/M2 Macrophage Polarization through PI3K-Akt Signal Pathway on a "Cortex-like" Microarc Oxidation Coating.
Microenvironment-targeted strontium delivery system reshapes redox homeostasis to halt degenerative cascades in intervertebral discs.
Fici hirtae radix alleviates influenza A virus-induced acute lung injury via TLR4-PI3K-AKT/p38 MAPK-NF-κB signaling pathway.
Coptisine mitigates acute lung injury by alleviating ferroptosis through the PI3K/AKT/Nrf2 pathway.
Ginsenoside Rb1 mitigates diabetes-induced erectile dysfunction in rats by reducing oxidative stress and modulating the PI3K/AKT/eNOS pathway.
Construction and clinical validation of a machine-learning-based consensus prognostic signature (MLPS) for osteosarcoma via multi-cohort data integration.
Adiponectin attenuates atherosclerosis via macrophage polarization-mediated T Cell exhaustion by modulating the NF-κB p65/PI3K/Akt signaling pathway.
Nitazoxanide reverses pulmonary vascular remodeling in pulmonary hypertension by targeting the IMPA1-RAGE signaling axis.
Identification of a Potential Biomarker PDGFRA for Endometriosis Based on Comprehensive Analysis of Multiple Omics Data.
The role of DNAJC3 in enhancing glioma progression and regulating the tumor immune microenvironment.
Exocarpium Citri Grandis-Derived Extracellular Vesicle-Like Particles for Accelerating Wound Healing via Regulating the Protein Expression on the VEGF/AKT Signaling Pathway.
DOT1L promotes phenotypic transition of vascular smooth muscle cells following vascular injury in diabetes through activation of the FGFR4/PI3K/AKT/Jag/Notch signaling pathway.
A Unique Chimeric RNA: ERCC1-iASPP Drives Benzo[a]pyrene-Induced Lung Carcinogenesis via Dual Coding and Non-Coding Mechanisms.
Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance.
Ursodeoxycholic acid alleviates α-Casein-induced cow's milk protein allergy via the TGR5/NF-κB signaling pathway.
Liver-muscle metabolic crosstalk: xanthosine as a key effector of broiler myogenesis.
Neuron-Derived Sema3B Facilitates Microglial Hematoma Clearance After Intracerebral Hemorrhage.
Single-Nucleus RNA Sequencing Reveals SPP1(+) Macrophages Induce Cardiomyocyte Apoptosis to Promote Atrial Fibrillation Susceptibility.
C5aR1(+) microglia exacerbate neuroinflammation and cerebral edema in acute brain injury.
Deciphering the molecular mechanisms underlying of Xin Xue Granule on LPS-induced pyrexia rats: A multi-omics analysis.
Cardiospermum halicacabum Extract Attenuates UVB-Induced Photoaging in Human Skin Fibroblasts via Inhibition of the PI3K/Akt/mTOR Signaling Pathway.
IGFBP-5/TGF-β1 mediated crosstalk between endothelial and tubular epithelial cells promotes interstitial fibrosis.
Uncovering the Potential Mechanisms of Ergothioneine in Neuroinflammation Through Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Validation.
Analysis of the proliferative role and prognostic value of GPR173 in gastric cancer.
Exosomes derived from bone marrow mesenchymal stem cells facilitate repair of radiation-Induced skin injury by attenuating inflammation and apoptosis.
Growth differentiation factor 15 promotes the malignant progression of multiple myeloma via activation of PI3K/Akt/NF-κB signaling pathway.
Neonatal inflammation induces ventral hippocampal microglial priming via epigenetic regulation of BAG3 to enhance adult depression susceptibility in mice.
Elucidating the PTK2-Targeted Anti-Hepatocellular Carcinoma Effects of Euphorbia helioscopia L. via Integrated Network Pharmacology, Mendelian Randomization, and Experimental Validation.
Association and Toxic Mechanism Between Foodborne OTA Exposure and Embryonic Development.
Investigating the Mechanisms of Prunella vulgaris against Acute Lymphoblastic Leukemia through Network Pharmacology and Experimental Validation.
Mechanistic insights into PI3K/Akt-MMP9 signaling in Crotonis Fructus-induced reproductive toxicity via integrated network toxicology and multi-model validation.
Peripheral regional anesthesia alleviates skeletal muscle injury and inflammation caused by acute compartment syndrome by inhibiting PI3K/AKT/NF-kB pathway and regulating macrophage polarization.
Anmei decoction alleviates myocardial injury in sleep-deprived rats by PI3K/Akt/mTOR/HIF-1 pathway.
OSBPL3 promotes LUAD metastasis and glycolysis through transcriptional upregulation of PLAU via NFE2L2.
Piperlongumine Inhibits Malignant Progression of Esophageal Squamous Cells Through the PI3K/AKT Signaling Pathway.
Transcription factor HOXA4 promotes HBV replication and hepatocellular carcinoma proliferation by activating KIF11 transcription.
Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells.
Ginkgetin inhibits non-small cell lung cancer via the HSP90-AKT signaling pathway.
Alendronic acid modified PLGA drug delivery system loaded with 17β-Estradiol and vitamin D3 has anti-osteoporotic effect.
The Dual Role of Gastrodin in Spinal Cord Injury: Microglial Phenotype Switching and Neuronal Survival via PI3K/AKT Activation.
HIF-1α/Netrin-4 Axis Mediates RIPC-Induced Angiogenesis and Neurogenesis After Ischemic Stroke.
Senescence-Driven Remodeling Defines an Aggressive and Immunomodulatory Subtype of Endometriosis.
Caffeine Sodium Benzoate-Induced Macrophage M1 Polarization Promotes Endothelial Progenitor Cell Dysfunction by Inducing Mitochondrial Dysfunction Via Targeting let-7a-5p/OPA1 Axis.
From computational prediction to in vitro experimental validation: Identifying active compounds in longan leaves and their anti-colorectal cancer mechanisms.
High-throughput screening of EGFR/Ca(2+) signaling modulators in cardiac hypertrophy using a tetrahedral DNA nanostructure-based hESC platform.
Ascites circRNA ASCOR Drives Platinum Resistance of High-Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation.
Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression.
MiR-93-5p Loaded Lipid Nanoparticles Break the Dry Eye Vicious Cycle via Targeting MAP3K8.
Tongnao Decoction Exerts a Treatment Effect on Ischemic Stroke by IL-6/PI3K/Akt/GSK-3β Pathway: Based on the Network Pharmacology and Molecular Docking.
KAT2B inhibits cholangiocarcinoma proliferation by binding with histone demethylase KDM6B.
Multiomics Analysis Reveals the Potential Sleep-Enhancing Peptide from Milk Casein Hydrolysate and Its Synergic Mechanism via Regulating the Key Hub CaMKII Pathway in Chronic Stressed Mice.
Neudesin modulates IGF1 and insulin signaling pathways by regulating the surface expression of IGF1R through a conserved WPE motif.
Discovery of FLC-8 as the First Covalent FLT3 Inhibitor Targeting Cys807 for FLT3 Mutant Acute Myeloid Leukemia.
Choline kinase beta promotes psoriasis pathogenesis by regulating sphingolipid metabolism and activating the PI3K/Akt/GSK3β signaling pathway.
Nerves Stimulate Cross-talk Between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression.
A Pathological Microenvironment-Responsive Catalytic Carbon Nanodots Release Platform Intercepting the ROS-Inflammation Cascade to Alleviate Intervertebral Disc Degeneration.
The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib.
Wenweishu Granule Plays a Protective Role against Stress-Induced Gastric Ulcers by Inhibiting the PI3K/AKT Signaling Pathway.
FR429 from Polygonum capitatum Demonstrates Potential as an Anti-hepatic Injury Agent by Modulating PI3K/Akt Signaling Pathway.
OTUB2 promotes proliferation and metastasis of triple-negative breast cancer by deubiquitinating TRAF6.
Ubiquitin C-terminal hydrolase L5 promotes the development of renal cell carcinoma through the glycolysis mediated by the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway.
BRD7 Inhibited Immune Escape in Nasopharyngeal Carcinoma via Inhibiting PD-L1 Expression.
Astragaloside IV Alleviates H(2)O(2)-Induced Mitochondrial Dysfunction and Inhibits Mitophagy Via PI3K/AKT/mTOR Pathway.
Methionine Promoted the Growth of Golden Pompano by Activating Intestinal Transport and TOR Signaling Pathway.
TRIM6 affects the prognosis of acute myeloid leukemia through the PI3K/AKT signaling pathway and is associated with immune infiltration.
High SRD5A3 expression is correlated with promotion of proliferation and inhibition of apoptosis in B-cell non-Hodgkin lymphoma and suggests a poor prognosis.
Exploring the level of metabolic reprogramming and the role of prognostic factor SF3A3 in hepatocellular carcinoma through integrated single-cell landscape analysis.
Nitroxyl protects H9C2 cells from H/R-induced damage and inhibits autophagy via PI3K/Akt/mTOR pathway.
ADH5 inhibits proliferation but promotes EMT in non-small cell lung cancer cell through activating Smad2/Smad3.
Lymph Node Exosomes Delivery Attenuates Myocardial Ischemia-Reperfusion Injury via Regulating PTEN-PI3K/Akt Pathway Mediated Myocardiocyte Apoptosis.
Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases.
Hepatic Stellate Cell TM4SF1 Accelerates Hepatic Fibrosis Progression via Interacting With the Tyrosine Kinase c-Src.
RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells.
Inhibition of Colorectal Cancer by Perillaldehyde Through Targeting SRD5A1 to Induce Autophagy via the PI3K/AKT Pathway.
Network Pharmacology, Molecular Docking, and in vitro Experiments Reveal the Role and Mechanism of Tanshinone IIA in Colorectal Cancer Treatment Through the PI3K/AKT Pathway.
Mechanism of the Traditional Chinese Medicine Simiao Biejia Decoction Improves the Diabetes Mellitus-Induced Erectile Dysfunction in Rats.
Thyroid Stimulating Hormone May Facilitates Adipose Tissue Insulin Resistance by Inducing M1 Macrophage Polarization.
Ethyl Acetate Extract of Elsholtzia bodinieri Vaniot Attenuates Oxidative Stress in ALI Mice.
IGFBP1 is One of 10 Metabolic Factors Predicting Recurrence Free Survival in Gastric Cancer and Promotes Cancer Progression via ZFX-IGFBP1 Axis.
MAP17 is a Novel NASH Progression Biomarker Associated with Macrophage Infiltration, Immunotherapy Response, and Oxidative Stress.
Network Pharmacology, Experimental Validation Explored Kakkalide to Ameliorate Endothelial Cell Dysfunction and Inflammatory Response.
Erianin inhibits endometrial cancer cell proliferation and migration by modulating glutamine metabolism through the ERK signaling pathway.
Network Pharmacology and Experimental Validation of the Therapeutic Effect of Baji Capsule on LPS-Induced Osteoporosis.
Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway.
Xingxiao Pill Suppressed the Progression of Non-Small Cell Lung Cancer by Targeting SREBP1/FASN-Induced Fatty Acid Biosynthesis via PI3K/AKT/mTOR Signaling Pathway.
LncRNA HOXB-AS4 Promotes Tumor Malignant Phenotype in Head and Neck Squamous Cell Carcinoma and Serves as a Prognosis Marker.
Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways.
Longikaurin A, a natural ent-kaurane, suppresses proliferation, invasion and tumorigenicity in oral squamous cell carcinoma cell by via inhibiting PI3K/Akt pathway in vitro and in vivo.
Lentinan inhibits melanoma development by regulating the AKT/Nur77/Bcl-2 signaling axis.
NCAPG promotes the malignant progression of endometrioid cancer through LEF1/SEMA7A/PI3K-AKT.
γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway.
RARS1 inhibits ENO1 ubiquitination and degradation to protect against ferroptosis in hepatocellular carcinoma.
Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis.
Unveiling the novel value of TREM1 in the proneural-mesenchymal transition of glioma via tumor-associated macrophages.
Targeted ferroptosis of myofibroblasts by tubeimoside I attenuates hypertrophic scar formation.
Identify GDPD3 as a key regulator of epithelial-mesenchymal transition and prostate adenocarcinoma progression via the LPA/LPAR1/AKT axis: transcriptomic and experimental study.
MK2-mediated AKT/MYC signaling activation promotes epithelial-mesenchymal transition in lung adenocarcinoma.
Jianpi-Huayu-Jiedu formula improves metabolic dysfunction-associated steatohepatitis through ameliorateing hepatic oxidative stress and lipid accumulation in vivo and in vitro.
Shikonin as a therapeutic agent in renal cell carcinoma: insights from TEK-related causal association with glaucoma.
Bletilla striata polysaccharide induces autophagy through PI3K/AKT signaling pathway to promote the survival of cross-boundary flap in rats.
Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer.
Yiqi Qingre Gao alleviates renal fibrosis in UUO mice via PI3K/AKT pathway.
Therapeutic potential of isochlorogenic acid A from Taraxacum officinale in improving immune response and enhancing the efficacy of PD-1/PD-L1 blockade in triple-negative breast cancer.
Harmine derivative B-9-3 inhibits non-small cell lung cancer via the VEGFA/PI3K/AKT pathway.
Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning.
An anti-FAP-scFv-functionalized exosome-carrying hydrogel delivers SKI mRNA to fibrotic nucleus pulposus cells to alleviate intervertebral disc degeneration by regulating FOXO3.
Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons.
Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma.
DDX49 as a novel prognostic biomarker regulates colorectal cancer cell proliferation through the TIMM44-PI3K-AKT pathway.
EMP1 regulates cell proliferation, migration and invasion in triple negative breast cancer through PI3K-AKT signaling.
The genetic landscape of primary malignant melanoma of the cervix using integrated bioinformatics analysis and whole-exome sequencing.
Qing-Re-Hua-Shi Decoction ameliorates DSS-induced colitis by modulating multiple signaling pathways and remodeling the gut microbiota and metabolite profile.
Acetylated Dendrobium huoshanense polysaccharide: a novel inducer of apoptosis in colon cancer cells via Fas-FasL pathway activation and metabolic reprogramming.
Isowighteone attenuates vascular calcification by targeting HSP90AA1-mediated PI3K-Akt pathway and suppressing osteogenic gene expression.
IL-6 signaling is required for the development and regeneration of ear cartilage in microtia.
Identification of a key environment-responsive gene mediating environmental impact on postmenopausal osteoporosis.
Matrix stiffness boosts PDAC chemoresistance via SCD1-dependent lipid metabolic reprogramming.
Exploration of the Mechanism of Action of Dendrobium officinale in the Treatment of Liver Cancer Based on Network Pharmacology, Molecular Docking and in vitro Validation.
Vitamin K protects against lipopolysaccharide-induced intestinal inflammation in piglets by inhibiting the MAPK and PI3K-AKT pathways.
Dihydromyricetin preserves β-cell function in type 1 diabetes via PI3K/AKT-mediated metabolic reprogramming.
Zingiber striolatum phytochemicals ameliorated hyperglycemia symptoms by modulating gut microbial communities in mice with type 2 diabetes mellitus.
TUFT1 Modulates Cell Proliferation, Migration, Invasion, Stemness and EGFR Signaling in Cervical Cancer through Interacting with and Targeting ATF1.
Berberine triggers apoptosis through the PI3K/Akt pathways and Nrf2 by inducing ROS in papillary thyroid cancer.
EIF3B‑METTL3 complex promotes cell proliferation, invasion and EGFR/AKT signaling in cervical cancer.
Ginsenoside Rg5 enhances Abemaciclib sensitivity in ER+ breast cancer by modulating cell cycle proteins via transcriptional and post-translational levels.
Insights Into the Mechanism of Action for Qingzhi Decoction for the Treatment of Non-Alcoholic Fatty Liver Disease via Regulation of the IRS/PI3K/Akt Signaling Pathway and the NRLP3 Inflammasome.
Upregulation of has_circ_0008389 promotes esophageal squamous cell carcinoma progression via miR-761 sponging and P2RY2 mRNA stabilization.
Resveratrol alleviates lipopolysaccharide-induced acute lung injury through blocking the excessive autophagy/mitophagy via SIRT1/PGC-1α and TNF/NF-κB/JNK pathways.
Glyphosate targets FYN to regulate glycolysis and promote glioblastoma proliferation: A network toxicology study.
Ovotransferrin ameliorated intestinal barrier dysfunction in DSS-induced ulcerative colitis mice via inhibition of PI3K-Akt/MAPK signaling pathways and modulation of tissue metabolism.
20-Acetylsinularolide B (ASB) From Lobophytum crassum Exhibits Anticancer Activity In Vitro Through IGF1R/PI3K/AKT/mTOR Pathway.
Indole-3-propionic acid enhances glycolytic myofiber formation in piglets through PI3K-mTOR activation and gut microbiota-driven tryptophan metabolic alteration.
IAV NS1 carried by exosomes promotes IL-10 production by the PI3K-AKT-GSK3β-CREB pathway.
MSC-EVs alleviate sepsis-induced acute lung injury through inhibiting NET-triggered damage to adherens junctions of endothelial cells.
Optimized synthesis of 5N-D and the exploration of its role as a promising anti-aging agent via AKR1B1 inhibition and PI3K/Akt/Nrf2 regulation.
Regulatory role of ATF2 in trophoblast ferroptosis via the PI3K/Akt/Nrf2 pathway in gestational diabetes mellitus.
Irisin/FNDC5 Regulates Endothelial Function to Improve Post-Stroke-Induced Cognitive Dysfunction by Stimulating AMPK-eNOS Signaling.
Ginger-processed Magnoliae Officinalis Cortex ameliorates ovalbumin-induced asthma by alleviating inflammation via the gut-lung axis.
Integrated metabolomics and network pharmacology reveal the PI3K/Akt-mediated therapeutic mechanism of Abrus cantoniensis in lipid metabolism disorders.
Lactate induces oxidative phosphorylation in osteoblasts via Gpr81-Stat3 signaling.
Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.
Rictor Ameliorates Acute Antibody-Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65-NLRP3 Axis.
Exploring the mechanism of action of trastuzumab-induced cardiomyocyte atrophy based on the FN1/PI3K/AKT-mediated mTOR-independent signaling pathway.
Investigation of the anti-inflammatory mechanisms of fermented Chinese herbal residue solution in an APEC-Infected HD11 cell model through the PI3K/AKT and NF-κB pathways.
Investigating the role of 1,8-Cineole in mitigating ferroptosis in a HFSD/STZ diabetes mellitus type 2-induced model: A GEO data analysis approach.
Peripheral blood mesenchymal stem cells repair oxidative damage and apoptosis in an H(2)O(2)-induced vitiligo oxidative stress in vitro model via the IL-10-mediated PI3K/AKT pathway.
Eucommia ulmoides (Duzhong) extract alleviates cerebral stroke by inhibiting ferroptosis-related gene DNA Damage-Inducible Transcript 4 (DDIT4) expression.
Yolk extract-derived vitellogenin 2 ameliorates muscle atrophy in mice via the PI3K/AKT/mTOR pathway.
Mechanisms of Saposhnikovia divaricata in attenuating NaAsO(2)-induced neural injury via the PI3K/AKT pathway.
Cyclic Heptapeptide FZ1 Acts as an Integrin αvβ3 Agonist to Facilitate Diabetic Skin Wound Healing by Enhancing Angiogenesis.
Design, Synthesis and Biological Evaluation of 7-(1-Methyl-1H-indole-3-yl)-5H-pyrrolo[2,3-b]pyrazine Derivatives as Novel Covalent pan-FGFR Inhibitors to Overcome Clinical Resistance.
Protective effects of Dachengqi Decoction in sepsis-associated liver injury based on network pharmacology analysis and experimental validation.
Integration of network pharmacology and transcriptomics to reveal the mechanism of Paeoniae Radix Alba Polysaccharide in alleviating hepatic fibrosis.
Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism.
CCDC137 knockdown suppresses bladder cancer progression by downregulating SCD.
Geniposide Inhibits Oral Squamous Cell Carcinoma by Regulating PI3K-Akt Signaling-Mediated Apoptosis: A Multi-Method Validation Study.
Orthosteric-allosteric dual inhibitors of PI5P4Kγ with potent antitumor activity in non-small cell lung cancer.
Nanopuerarin Improves Doxorubicin Therapeutic Efficacy by Inhibiting Angiogenesis via Regulating NSUN2 in Hepatocellular Carcinoma.
Study on Antitumor Secondary Metabolites from Euphorbia ebracteolata Hayata: Structural Characterization, Network Pharmacology, Molecular Docking and In Vitro.
Dibutyl phthalate promotes COAD cells growth and migration via the TIMP1/PI3K/AKT signaling axis.
Ginsenoside F4 inhibits colorectal cancer progression by boosting dendritic cell maturation and remodeling the tumor microenvironment.
CCP1 Inhibits Pulmonary Fibrosis by Suppressing Fibrotic Progression Through the EIF4B/PI3K/AKT Pathways.
IRGM Inhibits the AKT/mTOR Signaling Pathway by Interacting with TRIM21 to Alleviate Sepsis-Induced Acute Lung Injury.
MiRNA-634 promotes apoptosis in HEI-OC1 cells by regulating AK4 and AKT/mTOR signaling pathways.
ESE-1 Regulates CREB-Mediated PTEN Expression to Activate the PI3K/Akt Pathway and Promote High-Glucose-Induced Endothelial Cell Injury.
Endothelial LRP1 activation mitigates microthrombosis after traumatic brain injury in mice.
Synergistic exacerbation of periprosthetic osteolysis by inflammatory bowel disease and titanium ions: Impaired osteogenesis of BMSCs via PI3K/AKT signaling.
ER‑α36 knockdown is associated with lysosomal dysfunction and proliferation inhibition in liver cancer cells.
Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice.
Research on the Pharmacodynamic Substances and Mechanism of Action of Tibetan Medicine Liuwei Muxiang Powder in the Treatment of Ethanol-Induced Gastric Ulcer Model of GES1 Cell.
CDDO-Me triggers ROS-dependent ferroptosis and apoptosis in cervical cancer via targeting PI3K/Nrf2 pathway.
Linarin alleviates high-fat diet-induced NAFLD via modulating the PI3K/Akt/mTOR pathway, autophagy, and gut microbiota.
Anti-inflammatory lathyrane diterpenoids from the aerial parts of Euphorbia wallichii.
The Acetic Acid Produced by Lactobacillus Species Regulates Immune Function to Alleviate PEDV Infection in Piglets.
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway.
Exploring the mechanism of Levistolide A in the treatment of lung cancer cells based on network analysis, molecular docking and experimental validation.
High-Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice.
Targeting the Phosphoinositide 3-Kinase/Protein Kinase B Pathway Suppresses Y-Box Binding Protein 1 Expression and Inhibits Colorectal Cancer Progression.
Artificial intelligence combined with affinity chromatography discover that 7-Epitaxol promotes autophagy in NSCLC cells by interacting with EGFR: Discovery of novel EGFR antagonist based on DL and CMC.
NSUN2-mediated m5C hypermethylation of hsa_circ_0004516 promotes breast cancer brain metastasis by activating AKT signaling.
Angiotensin (1-7) decreases the fibrotic process by modulating the TGF-β1/AKT pathway in rat corpus cavernosum smooth muscle cells.
Critical role of the β isoform of protein kinase C (PKCβ) in angiotensin II-induced oxidative stress in vascular smooth muscle cells.
USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF.
Long Non-Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R-AKT-mTOR Axis and Hepatocellular Carcinoma.
Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long-Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells.
Nanovesicles Synergistically Regulate Ferroptosis Characteristic Macrophage-Induced Angiogenesis via Ferritin Heavy Chain 1/Glutathione Peroxidase 4 Pathway to Promote Peripheral Nerve Regeneration.
Non canonical BRCA1 promotes cell survival via modulating PARP13-mediated SEC61G mRNA decay.
SIRT3 mediates Tubeimoside I's inhibition on pulmonary artery smooth muscle cell proliferation and oxidative stress in pulmonary arterial hypertension.
Myeloperoxidase inhibits prostate cancer progression, suppresses the PI3K/AKT signaling pathway and reshapes the immune microenvironment.
SIRT7 drives energy metabolic shifts in endometriosis via interaction with TUFM and Rhoa/Rock/Akt pathway activation.
Natsudaidain alleviates acute lung injury through the PI3K/Akt and P53 signaling pathways by inhibiting MLE-12 apoptosis: a network pharmacology study and experimental validation.
Neuronal pentraxin 1 accelerates post-stroke atherosclerosis by inducing endothelial cell senescence.
Poliumoside Alleviates Neuroinflammation and Oxidative Stress After Spinal Cord Injury by Activating the PI3K/AKT/mTOR Signaling Pathway.
Dietary quercetin supplementation alleviates claw lesions in dairy cows by modulating the PI3K/Akt and NF-κB signaling pathways.
Novel magnolol-sulforaphane hybrids as potent antitumor agents: synthesis and biological characterization.
Paeoniflorin inhibits glioblastoma proliferation and promotes autophagy through the AKT/mTOR pathway.
Eleutheroside E Ameliorates D-Gal-Induced Senescence in Human Skin Fibroblasts Through PI3K/AKT Signaling.
The SP1-SuperEnhancer-SPHK1 Axis Mediates Niraparib Resistance in TNBC.
Endoplasmic reticulum-resident protein DNAJC10 inhibits glioblastoma metastasis by suppressing XBP-1s-driven EGFR transcription.
[Pinostrobin targets the PI3K/AKT/CCL(2) axis in intestinal epithelial cells to inhibit intestinal macrophage infiltration and alleviate dextran sulfate sodium-induced colitis in mice].
Novel E-F ring derivatives of aconitine scaffold as potent Hsp90 inhibitors for the treatment of colorectal cancer.
Pregnane X receptor (PXR) as a prognostic marker and therapeutic target in kidney renal clear cell carcinoma (KIRC) via AMPK pathway regulation.
Silibinin accelerates diabetic wound healing through PI3K/Akt-mediated immunomodulation-angiogenesis crosstalk.
Salvigenin inhibits gastric cancer progression by suppressing the EGFR/PI3K/AKT pathway.
Mechanism of silica nanoparticles induced pulmonary epithelial-mesenchymal transition mediated by exosomal HNRNPAB.
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
Metformin carbon dots-based osteogenic and protein delivery system to promote bone regeneration in periodontitis.
Prolactin impairs erectile function via eNOS suppression independently of testosterone.
NPB-1575 attenuates neuroinflammation and resists ferroptosis in rat ischemic stroke via IRS2 signaling pathway.
Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2/STAT3 and PI3K/AKT Pathways.
Study on the anticancer mechanism of hydroxygenkwanin in esophageal cancer via the ESRRA signaling pathway.
Reynoutrin targets EphB4 to ameliorate hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus.
Olaparib synergy screen reveals Exemestane induces replication stress in triple-negative breast cancer.
Age-Dependent Amino Acid Metabolism.
Dendrobin A inhibits gastric cancer: Mechanistic insights supported by integrated evidence.
N-glycosylation stabilized TNFAIP6 promotes ovarian cancer metastasis by activating the PI3K-AKT signaling pathway.
PDCD4 exacerbates myocardial ischemia-reperfusion injury via AKT-mediated apoptosis.
GCN2 promotes fatty acid metabolism through the activation of PI3K/AKT signaling in gastric cancer.
EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy.
DHCR7 Promotes Liver Metastasis of Pancreatic Cancer Through PI3K-Akt Signaling Pathway.
7,8-dihydroxyflavone attenuates NIH IIIA subtype chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) via TrkB/AKT/SIRT3 signaling activation.
Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway.
Panax notoginseng saponins suppress the PI3K/AKT pathway to enhance autophagy and apoptosis in pulmonary fibrosis.
KAL suppresses cholangiocarcinoma growth via downregulating miR-21 and modulating the PTEN/AKT signaling pathway.
Exploring the effect and mechanism of baicalin on sepsis-induced acute lung injury based on network pharmacology and experimental verification.
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Silencing Clusterin Could Attenuate the Cell Properties of HCV Core Protein-Expressing HCC Cell Line.
The TRPV4-YAP axis mediates cytoskeletal and extracellular matrix remodeling in trabecular meshwork cells as a novel glaucoma mechanism.
Diosgenin activates ERα-dependent PI3K/AKT/GSK3β signaling to enhance brain-derived serotonin and alleviate postmenopausal bone loss.
LRP12 promotes gastric cancer progression through AKT/mTOR signaling and M2 macrophage-mediated immunosuppression.
Dual Mechanisms of Cognitive Function and Pathological Improvements by the Selective S1PR1/5 Modulator Siponimod in 3xTg-AD Mice.
Network pharmacology, molecular docking, and experimental validation-based approach to explore the mechanism of action of ginsenoside Rh4 on acute myeloid leukemia cells.
Integrative Transcriptomic and Metabolomic Analysis Reveals That Acanthopanax senticosus Fruit Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing the NF-κB/PI3K-AKT Pathway via UGT1A1 Regulation.
IRF1 regulates apoptosis and osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates osteoporosis by activating the PI3K/AKT signaling pathway.
Structure-guided expansion strategy unveils potent allosteric SHP2 inhibitors with synergistic efficacy against AML through MCL-1 co-targeting.
TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice.
Mongolian medicine Qiqirigan-8 inhibition of PI3K/AKT/mTOR signaling pathway activation to ameliorate non-alcoholic Steatohepatitis.
RNF180 suppressed aggressiveness by degrading NOTCH1, TRIM24 and FOXC1, and chemoresistance by degrading ACC1 and ACLY in colorectal cancer.
GABA treatment promoting cell apoptosis in meningioma correlates with EGFR/BCL-2/BAX axis.
Folate Attenuates Ulcerative Colitis via PI3K/AKT/NF-κB/MLCK Axis Inhibition to Restore Intestinal Barrier Integrity.
A kinase-independent Bcr-Abl function mediating an Hsp70-Bim protein-protein interaction in chronic myeloid leukemia.
Investigating the molecular mechanism of purslane‑based vitiligo treatment using network pharmacology, molecular docking and in vitro analyses.
Lactoferrin ameliorates cognitive impairment in D-galactose-induced aging mice by regulating the PI3K/Akt/mTOR signaling pathway and the microbiome-gut-brain axis.
The important role of TLR2/MyD88/JNK in regulating the pathogenesis and inflammation induced by pseudorabies virus in mice.
Claudin-9 (CLDN9) promotes gastric cancer progression by enhancing the glycolysis pathway and facilitating PD-L1 lactylation to suppress CD8(+) T cell anti-tumor immunity.
The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism.
Neuroprotective effects of bone marrow mesenchymal stem cells combined with mannitol on radiation-induced brain injury by regulating autophagy via the PI3K/AKT/mTOR signaling pathway.
PTPRG-AS1 regulates the KITLG/KIT pathway through the ceRNA axis to promote the malignant progression of gastric cancer and the intervention effect of Compound Kushen injection on it.
Autophagy induction by piplartine ameliorates axonal degeneration caused by mutant HSPB1 and HSPB8 in Charcot-Marie-Tooth type 2 neuropathies.
Hypoglycemic effect of dietary fibers from Moringa oleifera leaves: In vitro and in vivo studies.
Grafting of syringic acid onto fucoidan: Enhanced functional properties and therapeutic potential in histamine-induced liver injury.
Melanocortin 5 receptor signaling protects against podocyte injury in proteinuric glomerulopathies.
Design, Synthesis and Biological Evaluation of POLRMT Inhibitors for the Treatment of Acute Myeloid Leukemia.
Novel Phenoxyacetic Acid (4-Aminophenoacetic Acid) Shikonin Ester Kills KRAS Mutant Colon Cancer Cells via Targeting the Akt Allosteric Site.
ESPN activates ZEB1-mediated EMT through the PI3K/AKT/mTOR axis to promote osteosarcoma metastasis.
INSL3 promotes macrophage polarization to an immunosuppressive phenotype via the cAMP downstream signaling pathway and Akt/mTOR pathway.
Metabolites from the Dendrobium Endophyte Pseudomonas protegens CM-YJ44 Alleviate Insulin Resistance in HepG2 Cells via the IRS1/PI3K/Akt/GSK3β/GLUT4 Pathway.
Aryl Hydrocarbon Receptor-Dependent miRNA-382-5p Mediates the Classical Pyroptosis Induced by Foodborne Benzo(a)pyrene through Targeting IκB in Liver.
Pyrotinib promotes the antitumor effect of T-DM1 by increasing drug endocytosis in HER2-positive breast cancer.
Single cell RNA sequencing reveals the role of local renin-angiotensin system in regulating ovarian physiological cycle and promoting PCOS.
LncRNA SNHG15 promotes angiogenesis and improves cardiac repair after myocardial infarction through MiR-665-mediated KDR expression.
MiR-485-3p/MELK cascade mediates tumor progression in pancreatic cancer.
Epigenetic activation of PTEN by valproic acid inhibits PI3K/AKT signaling and Burkitt lymphoma cell growth.
Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-induced β-cell dedifferentiation.
Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma.
Novel application of CHUANG BI FU biologic protein sponge in promoting peripheral nerve injury repair by regulating vascular regeneration.
Suppression of FOXO3 by BMP signaling contribute to the different primordial germ cell proliferation between layers and broilers†.
Lan-Qin oral liquid alleviates influenza A virus-induced acute lung injury by regulating monocyte-derived macrophages and TLR4-PI3K-AKT-NF-κB signal pathways.
Integrating metabolomics and network pharmacology to investigate Mu Jin Powder prevents ethanol-induced gastric ulcer in rats.
Dendrobium nobile lindl extract modulates integrin αIIbβ3-mediated signaling pathways to inhibit platelet activation and thrombosis.
Combining network pharmacology and transcriptomics to validate and explore the efficacy and mechanism of Huayu Wan in treating non-small cell lung cancer.
Penta-1,4-dien-3-one and quinoxaline conjugates as potential anticancer agents via inhibiting EphB3/SRC/AKT axis.
Prognostic role and tumor-suppressive effects of CADM family members and the potential molecular mechanisms of CADM1 in neuroblastoma.
Interplay and cooperation between GLI2 and master transcription factors promote progression of esophageal squamous cell carcinoma.
Exercise-induced Activation of SIRT1/BDNF/mTORC1 Signaling Pathway: A Novel Mechanism to Reduce Neuroinflammation and Improve Post-stroke Depression.
Melatonin Alleviates Behavioral and Neurodevelopmental Abnormalities in Offspring Caused by Prenatal Stress.
Integrating network pharmacology to investigate the mechanism of quercetin's action through AKT inhibition in co-expressed genes associated with polycystic ovary syndrome and endometrial cancer.
The MCM6-c-Myc positive feedback loop mediates bladder cancer progression and cisplatin resistance.
Single-cell RNA sequencing and cell-cell communication analysis reveal tumor microenvironment associated with chemotherapy responsiveness in ovarian cancer.
Oral exposure to nanoplastics altered lipid profiles in mouse intestine.
The Role of Chemokine (C-C Motif) Ligand 7 (CCL7) in Hepatocellular Carcinoma: Expression, Function, and Mechanisms.
Quercetagetin alleviates inflammatory osteoclastogenesis and collagen antibody-induced arthritis via Nrf2 signaling and Pten/AKT/Nfatc1 axis.
Comparative effects of different sugar substitutes: Mogroside V, stevioside, sucralose, and erythritol on intestinal health in a type 2 diabetes mellitus mouse.
FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD(+) acute myeloid leukemia.
Cyanidin-3-glucoside upregulated NDRG2 through the PI3K/AKT pathway to alleviate EMT and ECM in renal fibrosis.
Wedelolactone activates the PI3K/AKT/NRF2 and SLC7A11/GPX4 signalling pathways to alleviate oxidative stress and ferroptosis and improve sepsis-induced liver injury.
Umbelliferone attenuates calcium oxalate crystal-induced renal injury and inflammation by attenuating autophagy through the PI3K/AKT pathway.
MiR-101-3p targets the PI3K-AKT signaling pathway via Birc5 to inhibit invasion, proliferation, and epithelial-mesenchymal transition in hepatocellular carcinoma.
MYBL2 promotes cell proliferation and inhibits cell apoptosis via PI3K/AKT and BCL2/BAX/Cleaved-caspase-3 signaling pathway in gastric cancer cells.
5-Aminolaevulinic Acid-Mediated Photodynamic Therapy Combined with Tirapazamine Enhances Efficacy in Ovarian Cancer.
Network pharmacology and experimental analysis reveal Ethyl caffeate delays osimertinib resistance in lung cancer by suppression of MET.
Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway.
Lactobacillus plantarum SMUM211204 Exopolysaccharides Have Tumor-Suppressive Effects on Colorectal Cancer by Regulating Autophagy via the mTOR Pathway.
Blueberry Anthocyanin Extracts (BAEs) Protect Retinal and Retinal Pigment Epithelium Function from High-Glucose-Induced Apoptosis by Activating GLP-1R/Akt Signaling.
Gengnianchun formula ameliorates insulin resistance-induced diminished ovarian reserve via the estrogen signaling pathway: evidence from network pharmacology and experimental validation.
Bisphenol A exposure enhances proliferation and tumorigenesis of papillary thyroid carcinoma through ROS generation and activation of NOX4 signaling pathways.
Topical transdermal administration of lenalidomide nanosuspensions-based hydrogels against melanoma: In vitro and in vivo studies.
Sirt4 Overexpression Modulates the JAK2/STAT3 and PI3K/AKT/mTOR Axes to Alleviate Sepsis-Induced Acute Lung Injury.
Administration with Yangxinshi ameliorates the progression of atrial fibrillation by affecting atrial remodeling and oxidative stress via the activation of the PI3K/AKT signaling.
Inhibition of serotonin-Htr2b signaling in skeletal muscle mitigates obesity-induced insulin resistance.
Melatonin attenuates brain edema via the PI3K/Akt/Nrf2 pathway in rats with cerebral ischemia-reperfusion injury.
A pectic polysaccharide from wax gourd peel improves ethanol-induced gastric ulcer injury in mice via the PI3K/AKT signaling pathway.
MicroRNA-9-3p inhibits endothelial pyroptosis in atherosclerosis by targeting the PTEN/AKT axis.
Tributyltin affects the growth of ovarian granulosa cells in polycystic ovary syndrome by upregulating YY1-mediated CDKN1C via the PI3K/AKT pathway.
The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy.
Macrophages-derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression.
S-phase kinase-associated protein 1 inhibits orbital fibroblasts adipogenesis to improve thyroid-associated ophthalmopathy (TAO).
Aloe Vera flowers extracts inhibit melanogenesis via activating PI3K/Akt signaling pathway: Network pharmacology and experimental validation.
ROS-Responsive Hydrogel Delivering METRNL Enhances Bone Regeneration via Dual Stem Cell Homing and Vasculogenesis Activation.
LRP1 regulates asthmatic airway smooth muscle proliferation through FGF2/ERK signaling.
S100 A16 promotes the progression of osteosarcoma by activating the PI3 K/AKT signaling pathway through ANXA2.
Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics.
TCN1 as an inflammatory regulator in psoriasis: Activation of the NF-κB pathway and potential therapeutic target.
Astragaloside's Role in Microglial Neuroinflammation: A Multi-Method Study Combining Experimental and Computational Analyses.
IGFBP2 Modulates Trophoblast Function and Epithelial-Mesenchymal Transition in Preeclampsia via the PI3K/AKT Signaling Pathway.
MiR-124-3p/EIF3B Regulates Host Cell Apoptosis Induced by Chlamydia psittaci Through PI3K/AKT Signaling Pathway.
Mechanism study on the regulation of autophagy and oxidative stress through SIRT1/PI3K/AKT pathway by Liuwei Dihuang pill to improve ovarian function.
Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer.
Generation of a spontaneous murine HPV + oral cancer model with site-specific oncogene insertion using CRISPR-SONIC.
NR4A3 suppresses bladder cancer progression by modulating autophagy via the PI3K/AKT/mTOR pathway.
RRP9 promotes prostate cancer metastasis and epithelial-mesenchymal transition through activation of the AKT/GSK3β/β-Catenin signaling pathway.
A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer.
Aspirin Suppresses Aromatase-Mediated Estrogen Biosynthesis to Alleviate Polycystic Ovary Syndrome by the Inhibition of Adenylate Cyclase.
The crosstalk between lung adenocarcinoma cells and M2 macrophages promotes cancer cell development via the SFRS1/miR-708-5p/PD-L1 axis.
A novel Quinazoline derivative exerts anti-tumor effects in non-small cell lung cancer through Wnt/β-catenin pathway inhibition.
Novel ALK inhibitors containing DAAP fragments: Rational drug design and anti-tumor activity research.
Adipose-derived stem cells extracellular vesicles enhance diabetic wound healing via CCN2/PI3K/AKT pathway: therapeutic potential and mechanistic insights.
Limosilactobacillus reuteri SXDT-32-derived shikimic acid protects against colonic inflammation in piglets by inhibiting the PI3K-Akt pathway.
Di (2-ethylhexyl) Phthalate decrease pregnancy rate via disrupting the microbe-gut-hypothalamic-pituitary-ovarian axis in mice.
Nobiletin from Citrus reticulata Blanco alleviates pulmonary fibrosis through inhibiting the PI3K/AKT pathway and epithelial-mesenchymal transition.
Time Does Matter: The Cellular Response to Resveratrol Varies Depending on the Exposure Duration.
Regulation of perinatal estrogen levels on primordial follicle formation and activation in mouse.
Lysosomal EGFR acts as a Rheb-GEF independent of its kinase activity to activate mTORC1.
Quercetin protects against neuronal toxicity by activating the PI3K/Akt/GSK-3β pathway in vivo models of MPTP-induced Parkinson's disease.
Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy.
Indolepropionic acid modulates the immune response in allergic rhinitis through the AKT/CEBPB/IL‑10 signaling pathway.
miR166u -enriched Polygonatum sibiricum exosome-like nanoparticles alleviate colitis by improving intestinal barrier through the TLR4/AKT pathway.
Modified Qianghuo Shengshi Decoction Ameliorates Osteoarthritis via Inhibiting PI3K/Akt Pathway-Related Ferroptosis.
Pasteurized Akkermansia muciniphila ameliorates preeclampsia via inhibiting mitochondrial dysfunction-mediated placental apoptosis in vivo and in vitro.
Integrating LC-MS and molecular docking technology to investigate the effect of Spatholobi caulis flavonoids in alleviating primary dysmenorrhea via regulating the RhoA/ROCK pathway.
Rosamultin attenuates cerebral ischemia/reperfusion injury by inhibiting autophagy via the PI3K/Akt/mTOR pathway.
Umbilical Cord-Mesenchymal Stromal Cell-Derived Extracellular Vesicles Target the Liver to Improve Neurovascular Health in Type 2 Diabetes With Non-Alcoholic Fatty Liver Disease.
C1q(+) Macrophage-Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma.
2-Hydroxy-3-Methylanthraquinone Suppresses Hepatocellular Carcinoma Progression by Blocking Annexin A5-Mediated Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling.
Embryonic stem cell-derived small extracellular vesicles alleviate lead-induced cochlear spiral ganglion neurons injury by activating PI3 K/AKT signaling pathway.
Network pharmacology and in vitro analyses reveal EGCG inhibits breast cancer progression via suppression of the EGFR/Src pathway.
Different neutrophil extracellular trap related Ewing sarcoma subtypes exhibit distinct prognosis, and immune microenvironment characteristics.
Elevated SLC4A11 expression promotes OV progression via interaction with EGFR.
BDNF improves fracture healing through promoting osteoblasts proliferation and migration via trkb/akt regulated NUCKS1 expression.
Unveiling XinJia-LuHuang Granules' protective mechanism against atherosclerosis: Integrating network pharmacology, metabolomics, and experimental validation.
Hedyotis chrysotricha aqueous extract inhibits hepatitis B surface antigen and viral replication via hepatocyte nuclear factor 4α regulation.
Integrating metabolomics and network pharmacology analysis provides new insights into the lipid metabolism disorder of Abrus mollis.
Exploring the mechanism of feiyanning formula and its extract apigenin against EGFR-TKIs resistance in non-small cell lung cancer based on UPLC-HRMS and experimental validation.
Cornus officinalis loganin attenuates acute lung injury in mice via regulating the PI3K/AKT/NLRP3 axis.
Ursolic acid affects autophagy and apoptosis of breast cancer through PLK1 via AKT/mTOR signaling pathway.
Matrix stiffness regulates glucose-6-phosphate dehydrogenase expression to mediate sorafenib resistance in hepatocellular carcinoma through the ITGB1-PI3K/AKT pathway.
Tryptophan-Rich Diet Improves High-Fat Diet-Induced Cognitive Dysfunction and Blood-Brain Barrier Disruption in C57BL/6 Mice through FFAR3 Activation.
TBB inhibits CK2/PD-L1/EGFR pathway-mediated tumor progression.
Exosomal SPRY4 from adipogenic BMSCs impairs angiogenesis via the PTPRB/TIE2/PI3K axis in Steroid-induced osteonecrosis of the femoral head.
Kushenol I combats ulcerative colitis via intestinal barrier preservation and gut microbiota optimization.
Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC.
MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization.
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction.
TRIM29 alleviates intervertebral disc degeneration through the PI3K/AKT/mTOR pathway.
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension.
Biodegradable Zn-xY alloys with enhanced osteogenesis and angiogenesis effects for bone implant applications.
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Tumor-associated macrophages derived exosomal circPLK1 promotes resistance to EGFR inhibitor osimertinib in non-small cell lung cancer.
ADCY4 inhibits cAMP-induced growth of breast cancer by inactivating FAK/AKT and ERK signaling but is frequently silenced by DNA methylation.
The mechanism of Bletilla striata inhibiting glioma proliferation through the PI3K/AKT/mTOR signaling pathway based on network Pharmacology analysis.
Traditional Chinese medicine combined with chemotherapy in the treatment of advanced non-small cell lung cancer: key drug screening and mechanism analysis.
Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K/AKT signaling pathway based on network pharmacology.
Enhancing miR-19a/b induced cardiomyocyte proliferation in infarcted hearts by alleviating oxidant stress and controlling miR-19 release.
Denervation‑induced NRG3 aggravates muscle heterotopic ossification via the ErbB4/PI3K/Akt signaling pathway.
Tumor-Derived GDF15 Induces Tumor Associated Fibroblast Transformation From BMSCs and Fibroblasts in Oral Squamous Cell Carcinoma.
Negative regulation of SREBP-1/FAS signaling molecules activates the RIG-1/TBK1-mediated IFN-I pathway to inhibit BVDV replication.
BIN1 deficiency enhances ULK3-dependent autophagic flux and reduces dendritic size in mouse hippocampal neurons.
Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage.
Chuanxiong Qingnao Granules (CQG) alleviates nitroglycerin-induced migraine-like pain in rats by glycerophospholipid metabolism and PI3K/Akt signaling pathway.
Punicalagin inhibits excessive autophagy and improves cerebral function in neonatal rats with hypoxia-ischemia brain injury by regulating AKT-FOXO4.
ACVR1 mediates renal tubular EMT in kidney fibrosis via AKT activation.
Mechanism of triiodothyronine alleviating acute alcoholic liver injury and delaying alcoholic liver fibrosis progression.
Halofuginone induces ERK phosphorylation and synergizes with trametinib in gastric cancer cells.
Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro.
Jaranol alleviates cognitive impairment in db/db mice through the PI3K/AKT pathway.
Cromolyn sodium reduces LPS-induced pulmonary fibrosis by inhibiting the EMT process enhanced by MC-derived IL-13.
Novel applications of metformin in the treatment of septic myocardial injury based on metabolomics and network pharmacology.
Astragaloside IV plays a neuroprotective role by promoting PPARγ in cerebral ischemia-reperfusion rats.
Integrating metabolomics and network pharmacology to investigate Da-Chai-Hu Decoction prevents kidney injury in diabetic mice.
Revealing the molecular mechanism of baohuoside I for the treatment of breast cancer based on network pharmacology and molecular docking.
HouShiHeiSan attenuates sarcopenia in middle cerebral artery occlusion (MCAO) rats.
Network pharmacology and experimental validation reveal the mechanisms of sniffing essential oil of Acori Tatarinowii rhizoma in treating olfactory dysfunction.
Exploration of the mechanism of Lithospermum erythrorhizon oil in treating atopic dermatitis based on network pharmacology and experimental validation of the PI3K-Akt pathway regulation.
Elucidating the mechanism of action of astragalus polysaccharide on ionizing radiation-induced myocardial damage based on network pharmacology and experimental research.
Natural Protein-Based Multifunctional Hydrogel Dressing Formed by Rapid Photocuring and Zinc Ion Coordination to Accelerate Wound Healing.
Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition.
Red and blue LED light increases the survival rate of random skin flaps in rats after MRSA infection.
Development of Sheep Intestinal Organoids for Studying Deoxynivalenol-Induced Toxicity.
Exploration of the Fasting Hypoglycemic Mechanism of Casein Hydrolysate Enriched with Glu/Gln and Glu/Gln-Containing Peptides in db/db Diabetic-like Mice Using Multiomics Analysis.
Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction.
Puerarin Promotes the Migration and Differentiation of Myoblasts by Activating the FAK and PI3K/AKT Signaling Pathways.
Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration.
Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1.
Umbilical cord mesenchymal stem cell-derived exosomal Follistatin inhibits fibrosis and promotes muscle regeneration in mice by influencing Smad2 and AKT signaling.
Inhibition of THBS1 axis contributes to the antitumor effect of PA-MSHA in anaplastic thyroid cancer.
Discovery of a potent anticancer agent against pancreatic ductal adenocarcinoma targeting FAK with DFG-out state and JAK/Aurora kinases.
Protein Coronation-Induced Cancer Staging-Dependent Multilevel Cytotoxicity: An All-Humanized Study in Blood Vessel Organoids.
Heterogeneous nuclear ribonucleoprotein C promotes non-small cell lung cancer progression by enhancing XB130 mRNA stability and translation.
TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis.
RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritis.
N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatocellular carcinoma.
Chronic exposure to low-dose MC-LR induces ileal inflammation in mice through the PI3K/AKT/mTOR pathway.
TREM2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via PI3K/Akt signaling pathway.
Galectin-1 Regulates Inflammatory Responses and Promotes Microglial M2 Polarization in Chronic Migraine.
LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis.
Antiviral mechanism of Fuzhengjiedu San against porcine reproductive and respiratory syndrome virus.
Hypericin mediated photodynamic therapy induces ferroptosis via inhibiting the AKT/mTORC1/GPX4 axis in cholangiocarcinoma.
LncRNA CCAT1 knockdown suppresses tongue squamous cell carcinoma progression by inhibiting the ubiquitination of PHLPP2.
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway.
Luteolin inhibits BHV-1 replication and alleviates virus-induced inflammatory responses by regulating PI3K/AKT pathway.
Lactobacillus acidophilus JYLA-126 Ameliorates Obesity-Associated Metabolic Disorders by Positively Regulating the AMPK Signaling Pathway Through the Gut-Liver Axis.
The effect and mechanism of atorvastatin regulating PI3K-Akt-mTOR pathway on radiosensitivity of hepatocellular carcinoma cells.
Insulin-like growth factor-1 promotes the testicular sperm production by improving germ cell survival and proliferation in high-fat diet-treated male mice.
Cis-Regulation of an m(6)A Eraser by an Insertion Variant Associated with Survival of Patients With Non-Small Cell Lung Carcinoma.
HECW1-Mediated Ubiquitination of HIPK2 Drives Metastasis in Gastric Cancer Through the AKT Signaling Pathway.
Establishment and characterization of three gemcitabine-resistant human intrahepatic cholangiocarcinoma cell lines.
Mechanistic insights into PROS1 inhibition of bladder cancer progression and angiogenesis via the AKT/GSK3β/β-catenin pathway.
Paeonol Inhibits the Replication of Bovine Herpesvirus Type 1 In Vitro Through Regulating the PI3K/AKT Pathway.
Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice.
Network pharmacology alliance with experimental validation unveils the anti-colorectal cancer mechanism of Xianlian Jiedu decoction.
Molecular Observations on the Regulation of hIAPP Aggregation Process and Enhancement of Autophagy by the Short Peptide LPFYPN and Its Modified Peptides of Coix Seed Prolamins.
Comprehensive characterization of early-onset lung cancer, in Chinese young adults.
Melatonin-pretreated mesenchymal stem cell-derived exosomes alleviate cavernous fibrosis in a rat model of nerve injury-induced erectile dysfunction via miR-145-5p/TGF-β/Smad axis.
In vitro analysis of the molecular mechanisms of ursolic acid against ovarian cancer.
Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K-AKT signaling in rheumatoid arthritis.
miR-212-5p Regulates PM(2.5)-Induced Apoptosis by Targeting LAMC2 and LAMA3.
Orally Administrated Precision Nanomedicine for Restoring the Intestinal Barrier and Alleviating Inflammation in Treatment of Inflammatory Bowel Disease.
Chemoresistance mechanisms to 5-Fluorouracil and reversal strategies in lung and breast cancer.
Microenvironment-Responsive Hydrogels Comprising Engineering Zeolitic Imidazolate Framework-8-Anchored Parathyroid Hormone-Related Peptide-1 for Osteoarthritis Therapy.
A comprehensive analysis-based study of Di-(2-ethylhexyl) phthalate (DEHP)-Environmental explanation of bladder cancer progression.
GPNMB attenuates neuroinflammation and improves ischemic stroke via modulation of PI3K/Akt and p38 MAPK signaling pathways.
Dissecting the mechanisms of velvet antler extract against diabetic osteoporosis via network pharmacology and proteomics.
P2Y12 receptor-independent antiplatelet mechanism of cryptotanshinone: Network pharmacology and experimental validation of multi-target signaling pathways.
Ferulic acid from Angelica sinensis (Oliv.) Diels ameliorates lipid metabolism in alcoholic liver disease via AMPK/ACC and PI3K/AKT pathways.
Network pharmacology, molecular docking and biological verification to explore the potential anti-prostate cancer mechanisms of Tripterygium wilfordii Hook. F.
RhFGF21 protected PC12 cells against mitochondrial apoptosis triggered by H(2)O(2) via the AKT-mediated ROS signaling pathway.
Thermoradiotherapy reverses proliferation, metastasis, and anoikis resistance in glioblastoma through ITGA5-PI3K/AKT axis.
Comprehensive analysis of the leukocyte immunoglobulin-like receptor family in clear cell renal cell carcinoma.
Acute carbon monoxide poisoning induces renal inflammation and apoptosis via CCL4 upregulation and activation of the PI3K/Akt pathway in mice.
RhoE downregulation leads to enhanced cholesterol biosynthesis and sorafenib resistance in hepatocellular carcinoma.
Astragaloside IV protects against high altitude hypoxia-induced cardiac injury through the CaSR-NF-kB and EGFR-PI3K-AKT-MDM2 pathways.
Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis.
Farnesyltransferase Inhibitor (R115777) Targets CENPF to Inhibit Breast Cancer Bone Metastasis by Regulating the PI3k/AKT/mTOR/PTHrP Pathway.
USP36 suppresses breast cancer cell ferroptosis by regulating the ubiquitination and stability of KIF2C.
Effects of proline on growth performance, protein synthesis and cold resistance in white shrimp (Litopenaeus vannamei).
ATP1B4 as a candidate upstream regulator of muscle atrophy in diabetic sarcopenia via PI3K/AKT/mTOR-mediated autophagy.
Ginsenoside Rb1 alleviates atherosclerosis by modulating vascular smooth muscle cell proliferation, foam cell formation, and autophagy.
Dietary urolithin A suppresses lung cancer via gut microbiota-mediated autophagy activation.
Hydroxytyrosol improved insulin resistance in male offspring born to high-fat diet dams by remodeling gut microbiota.
N2 neutrophils induce cell stemness reprogramming to promote gastric cancer progression via exosomal miRNAs.
Integration of scRNA-Seq and scATAC-Seq Reveals Malignant Characteristics of Sarcomatoid Clear Cell Renal Cell Carcinoma.
Therapeutic Potential of 6-Gingerol in Glioma: Mechanistic Insights and Experimental Validation.
Metformin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage Via Improving Endoplasmic Reticulum Stress and Mitochondrial Stress-Mediated Ca(2+) Imbalance.
Phosvitin-Derived Peptide Pt5-1c Is a Pro-Angiogenic Agent Capable of Enhancing Wound Healing.
Regulation of Melatonin on AQP4 Expression in Brain of SD Newborn Rats with Bilirubin Encephalopathy and Protection Mechanism.
Network Pharmacology and Untargeted Metabolomics Analysis of the Protective Mechanisms of Total Flavonoids from Chuju in Myocardial Ischemia-Reperfusion Injury.
Sestrin2 Knockdown Impairs Proliferation, Migration, Invasion, and Apoptosis in OSCC Cells via PI3K/AKT/mTOR and MAPK Pathways.
Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p.
Disruption of cerebral cholesterol homeostasis by PS-NPs: astrocytic endoplasmic reticulum stress.
miR-139-5p suppresses hepatocellular carcinoma progression by targeting SMOX to inhibit AKT-mTOR pathway and epithelial-mesenchymal transition.
IL-21 promotes the anti-tumor effect of anti-CD47 chimeric antigen receptor macrophages in ovarian cancer.
Protective effect of Lonicerae Japonicae Flos extract against doxorubicin-induced myocardial injury in mice and the possible mechanisms.
Promoting astrocyte-neuron triiodothyronine shuttling attenuates brain damage in neonatal hypoxic-ischemic encephalopathy.
Optogenetic control of biomolecular organization reveals distinct roles of phase separation in RTK signaling.
Knockdown of FXYD2 inhibits mepivacaine-induced cardiomyocyte injury by activating the PI3K/AKT signaling pathway.
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
Investigation of a Neuroprotective Peptide from Round Scad (Decapterus maruadsi): Bioactivity Validation, Gastrointestinal Digestion Stability, and Structure-Activity Relationship Analysis.
Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy.
Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds.
Citri grandis Exocarpium Extract Alleviates Atherosclerosis in ApoE(-/-) Mice by Modulating the Expression of TGF-β1, PI3K, AKT1, PPAR-γ, LXR-α, and ABCA1.
Pegmolesatide ameliorates indoxyl sulfate-induced cardiomyocyte hypertrophy through modulating the EPOR-CD131-dependent JAK2/STAT3 signaling pathway.
CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression.
SMURF2 Inhibits Autophagy and Growth in Ovarian Cancer by Regulating the RACK1/AKT/mTOR Pathway.
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy.
Treadmill Exercise Modulates the Leptin/LepR/GSK-3β Signalling Pathway to Improve Leptin Sensitivity and Alleviate Neuroinflammation in High-Fat Diet-Fed APP/PS1 Mice.
p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation.
Danggui Buxue Decoction Combined with Borneol Improves Cyclophosphamide-Induced Myelosuppression by Inhibiting CDK2.
Silencing PIM1 inhibits ENO1-induced AKT activation and attenuates fibrillogenesis during spinal cord injury-induced skeletal muscle atrophy.
Clostridium butyricum ameliorates post-gastrectomy insulin resistance by regulating the mTORC1 signaling pathway through the gut-liver axis.
Emodin Alleviates Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting Serum Exosomal miRNA-21-3p-Induced M1 Alveolar Macrophage Polarisation.
Heparanase inhibition mitigates bleomycin-induced pulmonary fibrosis in mice by reducing M2 macrophage polarization.
PIMREG modulation of PI3K/Akt pathway enhances sorafenib resistance in Huh7 cells.
l-theanine alleviates ulcerative colitis by repairing the intestinal barrier through regulating the gut microbiota and associated short-chain fatty acids.
Exogenous Nucleotides Supplementation Attenuates Age-Related Sarcopenia.
HnRNPR promotes non-small cell lung cancer progression by protecting XB130 mRNA from XRN1- and DIS3L2-mediated degradation.
Pig Liver Esterase Hydrolysis of 2-Arachidonoglycerol Exacerbates PRRSV-Induced Inflammation via PI3K-Akt-NF-κB Pathway.
G-protein coupled receptor 183 (GPR183) inhibits visceral metastasis of non-small cell lung cancer.
Apigenin mitigates intestinal barrier dysfunction in sepsis by modulating the AKT signaling pathway.
Non-SMC condensin I complex subunit H promotes cell proliferation and inhibits cell apoptosis of clear cell renal cell carcinoma by activating the PI3K/AKT pathway.
Mechanisms and synergistic effects of the active components of Xanthocerais lignum in inhibiting rheumatoid arthritis through the modulation of the biological behavior of synovial cells.
Sanleng Wan inhibits endometriosis progression by regulating sphingolipid metabolism via the S1P/S1PR1-Akt axis based on serum metabolomics and network pharmacology.
PHPT1 acts as an inhibitor in high-altitude pulmonary hypertension via negative TRPV5 signaling regulation.
Anti-Obesity Effects of Pea Peptides Modified by Steam Explosion on Obese Mice: Regulation of Gut Microbiota and Glucose Metabolism.
Senkyunolide H reverses depression-induced breast cancer progression by regulating CXCR2.
Structure-based drug design of small molecule AKT1 inhibitors to treat glioma.
METTL3 promotes peritoneal metastasis of colorectal cancer through regulating m6A modification of NRXN3 mRNA.
Reduced HSP70 expression under mild hypothermia is involved in bovine embryo growth suppression.
CXCR4-Mediated Chemokine Signaling Orchestrates the Progression of Conjunctival Melanocytic Lesions.
Epithelial cells and fibroblasts are both activated via TGF-β1 and GSK-3β pathways differentially in the comorbidity of pulmonary fibrosis with lung adenocarcinoma.
β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway.
TFAP4 Regulation of MCM5 Activates the PI3K/AKT Pathway to Promote Invasion and Metastasis of Gastric Cancer.
PRMT5 Inhibition Enhances Therapeutic Efficacy of Cisplatin via Mediating miR-29b-3p-Mcl-1 Expression in Lung Adenocarcinoma.
Network pharmacology-based strategy to reveal the mechanism of pinocembrin against ovarian cancer.
Exploring the anti-NSCLC mechanism of phillyrin targeting inhibition of the HSP90-AKT pathway.
Prunus mume Alleviates Hyperuricemic Renal Injury: Insights From Network Pharmacology and Experimental Models.
Cinobufacini Inhibits Survival and Metastasis of Hepatocellular Carcinoma via c-Met Signaling Pathway.
Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma.
Selenium nanoparticles attenuate retinal pathological angiogenesis by disrupting cell cycle distribution.
Glioblastoma- derived exosomes (GBM-Exo) regulate microglial M2 polarization via the RAC1/AKT/NRF2 pathway.
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.
Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway.
Network pharmacology-based exploration of the mechanism of Wenweishu granule in treating chronic atrophic gastritis with spleen-stomach cold deficiency syndrome.
Ethyl acetate extract from Herpetospermun cardigerum wall. Ameliorated concanavalin A-induced autoimmune hepatitis in mice by reprofiling gut microenvironment to modulate IDO1/KYN and PI3K/AKT/NF-κB pathways.
LC-MS/MS assay to confirm that the endogenous metabolite L-Arginine promotes trophoblast invasion in the placenta accreta spectrum through upregulation of the GPRC6A/PI3K/AKT pathway.
Vitexin alleviates lipid metabolism disorders and hepatic injury in obese mice through the PI3K/AKT/mTOR/SREBP-1c pathway.
3-Hydroxybutyrate Promotes Myoblast Proliferation and Differentiation through Energy Metabolism and GPR109a-Mediated Ca(2+)-NFAT Signaling Pathways.
Podophyllotoxin Alleviates DSS-Induced Ulcerative Colitis via PI3K/AKT Pathway Activation.
Orbital mesenchymal chondrosarcoma and its specific fusion gene HEY1-NCOA2.
Baicalin Relieves Glaesserella parasuis-Triggered Immunosuppression Through Polarization via MIF/CD74 Signaling Pathway in Piglets.
The Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) 3 Regulates the Myogenic Differentiation of Yunan Black Pig Muscle Satellite Cells (MuSCs) In Vitro via Iron Homeostasis and the PI3K/AKT Pathway.
Unveiling the multifaceted benefits of Simiao Pill in ulcerative colitis: Integrative analysis of signaling pathways, gut microbiota, and lipid metabolism.
Thesium chinense Turcz. and its compound astragalin alleviate lipopolysaccharide-induced acute lung injury via the PI3K/AKT/p53 signaling pathway.
Comprehensive characterisation of bioactive compounds in Boletus edulis as functional foods to improve muscle atrophy; through whole plant targeted metabolomics, network pharmacology, in vivo and in vitro experiments, molecular docking and molecular dynamics analysis.
Enriched environment alleviates NLRP3 inflammasome mediated neuroinflammation in diabetes complicated with depression rats.
Investigating the Effect and Mechanism of 3-Methyladenine Against Diabetic Encephalopathy by Network Pharmacology, Molecular Docking, and Experimental Validation.
Decursin induces FLT3-ITD acute myeloid leukemia cell apoptosis by increasing the expression of the ubiquitin-conjugase UBE2L6.
DCC-2036 inhibits osteosarcoma via targeting HCK and the PI3K/AKT-mTORC1 axis to promote autophagy.
ITGA5 induces mesenchymal transformation to promote gliomas progression via PI3K/AKT/mTORC1 signaling pathway.
PGRN knockdown alleviates pulmonary fibrosis regulating the Akt/GSK3β signaling pathway.
lncRNA NR_146969 promotes the progression of lung adenocarcinoma.
Mechanistic evaluation of Jiu Wei Qing Zhi Gao in non-alcoholic fatty liver disease: insights from network Pharmacology and experimental validation.
Bisphenol A-induced cancer-associated adipocytes promotes breast carcinogenesis via CXCL12/AKT signaling.
Cytotoxicity and inhibitory potential of CUDC-101 in non-small cell lung cancer cells with rare EGFR L861Q mutation.
ABCF1/CXCL12/CXCR4 Enhances Glioblastoma Cell Proliferation, Migration, and Invasion by Activating the PI3K/AKT Signal Pathway.
Exploring the Action Mechanism and Validation of the Key Pathways of Dendrobium officinale Throat-clearing Formula for the Treatment of Chronic Pharyngitis Based on Network Pharmacology.
mirna-383-5p Functions as an Anti-oncogene in Glioma through the Akt/mTOR Signaling Pathway by Targeting VEGFA.
IKBKE regulates renal cell carcinoma progression and sunitinib resistance through the RRM2-AKT pathway.
Hypoxia-driven TNS4 fosters HNSCC tumorigenesis by stabilizing integrin α5β1 complex and triggering FAK-mediated Akt and TGFβ signaling pathways.
GPR168 functions as a tumor suppressor in mouse melanoma by restraining Akt signaling pathway.
ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway.
Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke.
Probucol mitigates high-fat diet-induced cognitive and social impairments by regulating brain redox and insulin resistance.
Network Pharmacology-Based Strategy to Explore the Effect and Mechanism of Zhizhu Granule Improving Glucose-Lipid Metabolism in Rats with Metabolic Syndrome.
IRGM Deficiency Exacerbates Sepsis-Induced Acute Lung Injury by Inhibiting Autophagy Through the AKT/mTOR Signaling Pathway.
FBXL18 is required for ovarian cancer cell proliferation and migration through activating AKT signaling.
LncRNA PRKCA-AS1 promotes LUAD progression and function as a ceRNA to regulate S100A16 by sponging miR-508-5p.
PSAT1 mediated EMT of colorectal cancer cells by regulating Pl3K/AKT signaling pathway.
The mechanism of PDE7B inhibiting the development of hepatocellular carcinoma through oxidative stress.
Bacteroides fragilis capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota.
Research on the metabolic regulation mechanism of Yangyin Qingfei decoction plus in severe pneumonia caused by Mycoplasma pneumoniae in mice.
USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis.
The small protein LINC01547-ORF inhibits colorectal cancer progression by regulating the CLDN18-FAK-AKT axis.
Mechanical stimulation promotes fibrochondrocyte proliferation by activating the TRPV4 signaling pathway during tendon-bone insertion healing: CCN2 plays an important regulatory role.
Hypoxia macrophage-derived exosomal miR-26b-5p targeting PTEN promotes the development of keloids.
EMF treatment delays mesenchymal stem cells senescence during long-term in vitro expansion by modulating autophagy.
Dietary supplementation with Clostridium autoethanogenum protein improves growth performance and promotes muscle protein synthesis by activating the mTOR signaling pathway of the broiler.
Bioinformatics analysis and experimental verification of TIGD1 in non-small cell lung cancer.
FOXM1 Upregulates O-GlcNAcylation Level Via The Hexosamine Biosynthesis Pathway to Promote Angiogenesis in Hepatocellular Carcinoma.
TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer.
Enhancement of chemoresistance by claudin-1-mediated formation of amino acid barriers in human lung adenocarcinoma A549 cells.
Exosomal circZNF800 Derived from Glioma Stem-like Cells Regulates Glioblastoma Tumorigenicity via the PIEZO1/Akt Axis.
Remote Ischemia Postconditioning Mitigates Hippocampal Neuron Impairment by Modulating Cav1.2-CaMKIIα-Aromatase Signaling After Global Cerebral Ischemia in Ovariectomized Rats.
PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25.
Synaptotagmin 13 Could Drive the Progression of Esophageal Squamous Cell Carcinoma Through Upregulating ACRV1.
HGFIN deficiency exacerbates spinal cord injury by promoting inflammation and cell apoptosis through regulation of the PI3K/AKT signaling pathway.
The suppressive role of NLRP6 in host defense against Streptococcus suis infection.
Mechanism of Prunella vulgaris L. and luteolin in restoring Tfh/Tfr balance and alleviating oxidative stress in Graves' disease.
Gentiopicroside ameliorates glucose and lipid metabolism in T2DM via targeting FGFR1.
The role of α7nAchR and PD-L1 in neuroimmune regulation of keloid treatment.
Microglial activation in the medial prefrontal cortex after remote fear recall participates in the regulation of auditory fear extinction.
CD226 implicated in Akt-dependent apoptosis of CD4(+) T cell contributes to asthmatic pathogenesis.
PCK2 induces gefitinib resistance by suppresses ferroptosis in non-small cell lung cancer.
The expression of congenital Shoc2 variants induces AKT-dependent crosstalk activation of the ERK1/2 pathway.
mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis.
Schisandrin B attenuates bleomycin-induced pulmonary fibrosis in mice through AKT-mTOR pathway.
Epicatechin and β-Glucan from Whole Highland Barley Grain Synergistic Benefit on Attenuating Hyperglycemia via Improving Hepatic Glucose Metabolism in Diabetic C57BL/6J Mice.
Procyanidin B1 and p-coumaric acid from whole highland barley ameliorated HFD-induced impaired glucose tolerance via small intestinal barrier and hepatic glucose metabolism.
Da-Chai-Hu-Tang Formula inhibits the progression and metastasis in HepG2 cells through modulation of the PI3K/AKT/STAT3-induced cell cycle arrest and apoptosis.
Neohesperidin alleviates the inhibitory effect of bisphenol A on the myogenic differentiation of umbilical cord mesenchymal stem cells via the IGF1R/AKT1/RHOA signaling pathway.
Mechanisms of Yiai Fuzheng formula in the treatment of triple-negative breast cancer based on UPLC-Q-Orbitrap-HRMS, network pharmacology, and experimental validation.
Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway.
Sheng Xue Ning as a Novel Agent that Promotes SCF-Driven Hematopoietic Stem/Progenitor Cell Proliferation to Promote Erythropoiesis.
Network pharmacology prediction to discover the potential pharmacological action mechanism of Rhizoma Dioscoreae for liver regeneration.
Semi-synthesis and in vitro anti-cancer effects evaluation of novel xanthohumol derivatives.
Low-dose radiation promotes high-fat diet-induced atherosclerosis by activating cGAS signal pathway.
Phenylpropanoid-rich maize root extract serves as a natural antidepressant.
METTL14-mediated N6-methyladenosine modification of TCP1 mRNA promotes acute myeloid leukemia progression.
Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
Milk-Derived Extracellular Vesicles Carrying ssc-let-7c Alleviate Early Intestinal Inflammation and Regulate Macrophage Polarization via Targeting the PTEN-Mediated PI3K/Akt Pathway.
SMYD1 modulates the proliferation of multipotent cardiac progenitor cells derived from human pluripotent stem cells during myocardial differentiation through GSK3β/β-catenin&ERK signaling.
SMYD2 Promotes Calcium Oxalate-Induced Glycolysis in Renal Tubular Epithelial Cells via PTEN Methylation.
Aldo-keto reductase family 1 member C3 mediates radioresistance of esophageal cancer cells through suppressing MAPK and AKT signaling.
Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway.
CD74(+) fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloids.
Exploring the anti-inflammatory and immune regulatory effects of Taohe Chengqi decoction in sepsis-induced lung injury.
Colon Cancer-Derived Exosomal LncRNA-XIST Promotes M2-like Macrophage Polarization by Regulating PDGFRA.
[Aumolertinib combined with anlotinib inhibits proliferation of non-small cell lung cancer cells by down-regulating the PI3K/AKT pathway].
Ouabain Ameliorates Alzheimer's Disease-Associated Neuropathology and Cognitive Impairment in FAD(4T) Mice.
Exploring the Mechanism of Sempervirine Inhibiting Glioblastoma Invasion Based on Network Pharmacology and Bioinformatics.
A novel role for WZ3146 in the inhibition of cell proliferation via ERK and AKT pathway in the rare EGFR G719X mutant cells.
The Inhibition of Reactive Oxygen Species Modulator 1 Attenuates Sevoflurane-Induced Neural Injury via Reducing Apoptosis and Oxidative Stress.
Ginsenoside Re Regulates Oxidative Stress through the PI3K/Akt/Nrf2 Signaling Pathway in Mice with Scopolamine-Induced Memory Impairments.
Mechanisms of neural infiltration-mediated tumor metabolic reprogramming impacting immunotherapy efficacy in non-small cell lung cancer.
GL-V9 Promotes Autophagy-Mediated YAP1 Degradation and Activates Mitochondrial Apoptosis in PDAC Cells.
Vitexin Inhibits TNBC Progression and Metastasis by Modulating Macrophage Polarization Through EGFR Signaling.
NONRATT000538.2 promotes vascular smooth muscle cell phenotypic switch and in-stent restenosis.
The role of ALDH1A1 in glioblastoma proliferation and invasion.
STC2 knockdown inhibits cell proliferation and glycolysis in hepatocellular carcinoma through promoting autophagy by PI3K/Akt/mTOR pathway.
Calcium-sensing receptor regulates the angiogenic differentiation of LPS-treated human dental pulp cells via the phosphoinositide 3-kinase/Akt pathway in vitro.
CypA/TAF15/STAT5A/miR-514a-3p feedback loop drives ovarian cancer metastasis.
SPAG4 enhances mitochondrial respiration and aerobic glycolysis in colorectal cancer cells by activating the PI3K/Akt signaling pathway.
Long non-coding RNA AC010457.1 promotes the growth and EMT of gastric cancer via the PI3K/AKT axis.
Mechanism of Gastrodin against neurotoxicity based on network pharmacology, molecular docking and experimental verification.
Human placental mesenchymal stromal cells alleviate intestinal oxidative damage in mice with graft-versus-host disease via CD73/adenosine/PI3K/Akt/GSK-3β axis.
MTFR2 accelerates hepatocellular carcinoma mediated by metabolic reprogramming via the Akt signaling pathway.
Overexpression of microRNA-611 inhibits TGF-β-induced epithelial-mesenchymal transition and migration in lung cancer cells through MAPKAP1.
Taurine Inhibits Lung Metastasis in Triple-Negative Breast Cancer by Modulating Macrophage Polarization Through PTEN-PI3K/Akt/mTOR Pathway.
DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis.
Predicting the therapeutic role and potential mechanisms of Indole-3-acetic acid in diminished ovarian reserve based on network pharmacology and molecular docking.
Exploring the role of iNOS in HFpEF-Related myocardial fibrosis: Involvement of PTEN-PI3K/AKT signaling pathway.
EHD1 promotes breast cancer metastasis through upregulating HIF2a expression via activating mTOR pathway.
LINC00470 promotes malignant progression of testicular germ cell tumors.
Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway.
PRMT1-mediated methylation of ME2 promotes hepatocellular carcinoma growth by inhibiting ubiquitination.
Lanostane triterpenoids from Ganoderma calidophilum exhibit potent anti-tumor activity by inhibiting PTP1B.
Neuronostatin regulates neuronal function and energetic metabolism in Alzheimer's disease in a GPR107-dependent manner.
Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells.
Interleukin-22 Alleviates Caerulein-Induced Acute Pancreatitis by Activating AKT/mTOR Pathway.
The promoting effects of Grin2d expression in tumorigenesis and the aggressiveness of esophageal cancer.
Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.
Shengmaisan combined with Liuwei Dihuang Decoction alleviates chronic intermittent hypoxia-induced cognitive impairment by activating the EPO/EPOR/JAK2 signaling pathway.
Gallic acid ameliorates endometrial hyperplasia through the inhibition of the PI3K/AKT pathway and the down-regulation of cyclin D1 expression.
Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation.
Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer.
Tetramethylpyrazine-loaded electroconductive hydrogels promote tissue repair after spinal cord injury by protecting the blood-spinal cord barrier and neurons.
Dual roles of HK3 in regulating the network between tumor cells and tumor-associated macrophages in neuroblastoma.
Polymorphism rs2327430 in TCF21 predicts the risk and prognosis of gastric cancer by affecting the binding between TFAP2A and TCF21.
AGR2-mediated unconventional secretion of 14-3-3ε and α-actinin-4, responsive to ER stress and autophagy, drives chemotaxis in canine mammary tumor cells.
SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE(-/-) mice.
miR-122-5p Promotes Cowshed Particulate Matter2.5-Induced Apoptosis in NR8383 by Targeting COL4A1.
Si-Ni-San promotes liver regeneration by maintaining hepatic oxidative equilibrium and glucose/lipid metabolism homeostasis.
Anti-papillary thyroid carcinoma effects of dioscorea bulbifera L. through ferroptosis and the PI3K/AKT pathway based on network pharmacology and experimental validation.
An integrated network pharmacology, molecular docking and experiment validation study to investigate the potential mechanism of Isobavachalcone in the treatment of osteoarthritis.
Methionine and Leucine Promote mTOR Gene Transcription and Milk Synthesis in Mammary Epithelial Cells through the eEF1Bα-UBR5-ARID1A Signaling.
Methylation-regulated tumor suppressor gene PDE7B promotes HCC invasion and metastasis through the PI3K/AKT signaling pathway.
Inhibition of Nogo-B reduces the progression of pancreatic cancer by regulation NF-κB/GLUT1 and SREBP1 pathways.
Curdepsidone A Induces Intrinsic Apoptosis and Inhibits Protective Autophagy via the ROS/PI3K/AKT Signaling Pathway in HeLa Cells.
The Effects of Resveratrol and Apigenin on Jejunal Oxidative Injury in Ducks and on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
The polysaccharides from Balanophora polyandra enhanced neuronal autophagy to ameliorate brain function decline in natural aging mice through the PI3K/AKT/mTOR signaling pathway.
Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies.
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells.
β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer.
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation.
Macrophage-derived exosomal HMGB3 regulates silica-induced pulmonary inflammation by promoting M1 macrophage polarization and recruitment.
MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer.
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling.
The Chinese herbal prescription JZ-1 promotes extracellular vesicle production and protects against herpes simplex virus type 2 infection in vitro.
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.
An oxidized dextran-composite self-healing coated magnesium scaffold reduces apoptosis to induce bone regeneration.
Baiheqingjin formula reduces inflammation in mice with asthma by inhibiting the PI3K/AKT/NF-κb signaling pathway.
Exploring the potential mechanism of Heng-Gu-Gu-Shang-Yu-He-Ji therapy for osteoporosis based on network pharmacology and transcriptomics.
Lentinan mitigates pemetrexed chemoresistance by the PI3K/Akt pathway in non-small cell lung cancer.
PHPB ameliorates memory deficits and reduces oxidative injury in Alzheimer's disease mouse model by activating Nrf2 signaling pathway.
Investigation of the active ingredients and mechanism of Shuangling extract in dextran sulfate sodium salt induced ulcerative colitis mice based on network pharmacology and experimental verification.
cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity.
Pan-cancer analysis of DCTN2 and its tumour-promoting role in HCC by modulating the AKT pathway.
Porcine TLR8 signaling and its anti-infection function are disturbed by immune checkpoint receptor TIM-3 via inhibition of P13K-AKT pathway.
Eosinophil peroxidase promotes bronchial epithelial cells to secrete asthma-related factors and induces the early stage of airway remodeling.
A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.
Scutellarin alleviates microglia-mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3β signaling pathway.
Ginsenoside Rh4 alleviates gastrointestinal mucositis and enhances chemotherapy efficacy through modulating gut microbiota.
CYP2E1 deficit mediates cholic acid-induced malignant growth in hepatocellular carcinoma cells.
Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
lncRNA JPX Promotes Tumor Progression by Interacting with and Destabilizing YTHDF2 in Cutaneous Melanoma.
Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury.
CSF3 aggravates acute exacerbation of pulmonary fibrosis by disrupting alveolar epithelial barrier integrity.
Anemoside B4 attenuates necrotic enteritis of laying hens induced by Clostridium perfringens via inhibiting NF-κB and PI3K/Akt/mTOR signalling pathways.
IFI16 promotes the progression of clear cell renal cell carcinoma through the IL6/PI3K/AKT axis.
YY1 mediated DCUN1D5 transcriptional activation promotes triple-negative breast cancer progression by targeting FN1/PI3K/AKT pathway.
CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer.
NFIC mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to represses malignant phenotype of non-small cell lung cancer cells.
Calpain 8 as a potential biomarker regulates the progression of pancreatic cancer via EMT and AKT/ERK pathway.
Integrated component identification, network pharmacology, and experimental verification revealed mechanism of Dendrobium officinale Kimura et Migo against lung cancer.
Design, synthesis and biological evaluation of indoline-maleimide conjugates as potential antitumor agents for the treatment of colorectal cancer.
Direct contact between tumor cells and platelets initiates a FAK-dependent F3/TGF-β positive feedback loop that promotes tumor progression and EMT in osteosarcoma.
Ebselen improves fungal keratitis through exerting anti-inflammation, anti-oxidative stress, and antifungal effects.
Anthrahydroquinone‑2,6‑disulfonate attenuates PQ‑induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of the PI3K/AKT/eNOS pathway.
Influence of METTL3 knockdown on PDLSC osteogenesis in E. coli LPS-induced inflammation.
Fibroblast growth factor 21 alleviates idiopathic pulmonary fibrosis by inhibiting PI3K-AKT-mTOR signaling and stimulating autophagy.
Silibinin attenuates TGF-β2-induced fibrogenic changes in human trabecular meshwork cells by targeting JAK2/STAT3 and PI3K/AKT signaling pathways.
MICAL-L2, as an estrogen-responsive gene, is involved in ER-positive breast cancer cell progression and tamoxifen sensitivity via the AKT/mTOR pathway.
Grifolin Induces Cell Death of Human Lung Cancer A549 Cell Line via Inhibiting KRAS-Mediated Multiple Signaling Pathways.
LGR5 Modulates Differentiated Phenotypes of Chondrocytes Through PI3K/AKT Signaling Pathway.
Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis.
The combination of temozolomide and perifosine synergistically inhibit glioblastoma by impeding DNA repair and inducing apoptosis.
GPR30 selective agonist G-1 induced insulin resistance in ovariectomized mice on high fat diet and its mechanism.
Leveraging a rationally designed veliparib-based anilide eliciting anti-leukemic effects for the design of pH-responsive polymer nanoformulation.
A black phosphorus nanosheet-based RNA delivery system for prostate cancer therapy by increasing the expression level of tumor suppressor gene PTEN via CeRNA mechanism.
Echistatin/BYL-719 impedes epithelial-mesenchymal transition in pulmonary fibrosis induced by silica through modulation of the Integrin β1/ILK/PI3K signaling pathway.
Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/Akt/mTOR and RAS/MEK/ERK signalling pathways.
PHF12 regulates HDAC1 to promote tumorigenesis via EGFR/AKT signaling pathway in non-small cell lung cancer.
HMGB1/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4/Akt signaling.
Icariside II modulates pulmonary fibrosis via PI3K/Akt/β-catenin pathway inhibition of M2 macrophage program.
Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression.
RABV induces biphasic actin cytoskeletal rearrangement through Rac1 activity modulation.
Follicular Atresia in Buffalo: Cocaine- and Amphetamine-Regulated Transcript (CART) and the Underlying Mechanisms.
Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues.
Insulin receptor isoform B is required for efficient proinsulin processing in pancreatic β cells.
Glutamate rescues heat stress-induced apoptosis of Sertoli cells by enhancing the activity of antioxidant enzymes and activating the Trx1-Akt pathway in vitro.
The protective effects of aqueous extract of Schisandra sphenanthera against alcoholic liver disease partly through the PI3K-AKT-IKK signaling pathway.
CHRDL2 activates the PI3K/AKT pathway to ameliorate glucocorticoid-induced damages to bone microvascular endothelial cells (BMECs).
Maternal high fat diet programs spatial learning and central leptin signaling in mouse offspring in a sex-specific manner.
SLC7A11 promotes EMT and metastasis in invasive pituitary neuroendocrine tumors by activating the PI3K/AKT signaling pathway.
Multi-omics analyses reveal bacteria and catalase associated with keloid disease.
Circadian misalignment impairs oligodendrocyte myelination via Bmal1 overexpression leading to anxiety and depression-like behaviors.
Amplifying T cell-mediated antitumor immune responses in nonsmall cell lung cancer through photodynamic therapy and anti-PD1.
IGF-I protects porcine granulosa cells from hypoxia-induced apoptosis by promoting homologous recombination repair through the PI3K/AKT/E2F8/RAD51 pathway.
Berberine alleviates contrast-induced nephropathy by activating Akt/Foxo3a/Nrf2 signalling pathway.
Yi-qi-hua-yu-jie-du decoction induces ferroptosis in cisplatin-resistant gastric cancer via the AKT/GSK3β/NRF2/GPX4 axis.
Modified Guo-Min decoction ameliorates PM2.5-induced lung injury by inhibition of PI3K-AKT and MAPK signaling pathways.
Radix Astragali decoction improves liver regeneration by upregulating hepatic expression of aquaporin-9.
Curcumin suppresses metastasis, invasion, and proliferation in osteosarcoma cells by regulating the EGFR/Src signaling axis.
Lactate accumulation induced by Akt2-PDK1 signaling promotes pulmonary fibrosis.
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca(2+) antagonism and maintaining mitochondrial function.
Zearalenone triggers programmed cell death and impairs milk fat synthesis via the AKT-mTOR-PPARγ-ACSL4 pathway in bovine mammary epithelial cells.
RUNX1 targeting AKT3 promotes alveolar hypercoagulation and fibrinolytic inhibition in LPS induced ARDS.
Increased Circulating IL-32 Is Associated With Placenta Macrophage-derived IL-32 and Gestational Diabetes Mellitus.
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
SLFN11 promotes clear cell renal cell carcinoma progression via the PI3K/AKT signaling pathway.
Combining transcriptomics and network pharmacology to reveal the mechanism of Zuojin capsule improving spasmolytic polypeptide-expressing metaplasia.
Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K/AKT1/FOXO1 pathway.
Decreased AKAP4/PKA signaling pathway in high DFI sperm affects sperm capacitation.
Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway.
Efficacy of Ganshuang granules on non-alcoholic fatty liver and underlying mechanism: a network pharmacology and experimental verification.
4-octyl itaconate protects against oxidative stress-induced liver injury by activating the Nrf2/Sirt3 pathway through AKT and ERK1/2 phosphorylation.
Attenuation of pro-tumorigenic senescent secretory phenotype by StN, a novel derivative of stevioside, potentiates its inhibitory activity on hepatocellular carcinoma.
Tanshinone IIA ameliorates energy metabolism dysfunction of pulmonary fibrosis using (13)C metabolic flux analysis.
Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways.
Exploring the chemical components of Kuanchang-Shu granule and its protective effects of postoperative ileus in rats by regulating AKT/HSP90AA1/eNOS pathway.
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion.
5'-Cytimidine Monophosphate Ameliorates H(2)O(2)-Induced Muscular Atrophy in C2C12 Myotubes by Activating IRS-1/Akt/S6K Pathway.
Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice.
Integrated network pharmacology and metabolomics reveal the action mechanisms of vincristine combined with celastrol against colon cancer.
High expression of TBRG4 in relation to unfavorable outcome and cell ferroptosis in hepatocellular carcinoma.
Self-Healing Micro Arc Oxidation and Dicalcium Phosphate Dihydrate Double-Passivated Coating on Magnesium Membrane for Enhanced Bone Integration Repair.
Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells.
Erxian decoction ameliorates myocardial tissue damage through activating PI3K/AKT signaling pathway in ovariectomized rats.
TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis.
Cell Sheets Formation Enhances Therapeutic Effects of Human Umbilical Cord Mesenchymal Stem Cells on Spinal Cord Injury.
Taxifolin-loaded cellulose/l-arginine-chitosan hydrogel promoting bone defect repair through osteogenesis and angiogenesis.
Porcine reproductive and respiratory syndrome virus activates lipid synthesis through a ROS-dependent AKT/PCK1/INSIG/SREBPs axis.
Spatial dimension cues derived from fibrous scaffolds trigger mechanical activation to potentiate the paracrine and regenerative functions of MSCs via the FAK-PI3K/AKT axis.
New benzophenone analogs from Nigrospora sphaerica and their inhibitory activity against PD-1/PD-L1 interactions.
20(R)-ginsenoside Rg3 alleviates diabetic retinal injury in T2DM mice by attenuating ROS-mediated ER stress through the activation of the Nrf2/HO-1 axis.
Astragaloside IV and cycloastragenol promote liver regeneration through regulation of hepatic oxidative homeostasis and glucose/lipid metabolism.
Dang-Gui-Bu-Xue decoction against diabetic nephropathy via modulating the carbonyl compounds metabolic profile and AGEs/RAGE pathway.
Inhibiting TRIM8 alleviates adipocyte inflammation and insulin resistance by regulating the DUSP14/MAPKs pathway.
HNRNPD/MAD2L2 axis facilitates lung adenocarcinoma progression and is a potential prognostic biomarker.
LAMTOR1/mTORC1 promotes CD276 to induce immunosuppression via PI3K/Akt/MMP signaling pathway in Clostridium perfringens-induced necrotic enteritis of laying hens.
Identification and analysis of microplastic aggregation in CAR-T cells.
Cyberpharmacology uncover the mechanism of the total Rhizoma Coptidis extracts ameliorate chronic atrophic gastritis.
Albiflorin inhibits osteoclastogenesis and titanium particles-induced osteolysis via inhibition of ROS accumulation and the PI3K/AKT signaling pathway.
The role of the PI3K/AKT/mTOR pathway in mediating PD-L1 upregulation during fibroblast transdifferentiation.
Nuciferine ameliorates osteoarthritis: An in vitro and in vivo study.
Schisandrin C inhibits AKT1-regulated cell proliferation in A549 cells.
Liu-Shen-Wan inhibits PI3K/Akt and TRPV1 signaling alleviating bone cancer pain in rats.
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
EIF2S2 transcriptionally upregulates HIF1α to promote gastric cancer progression via activating PI3K/AKT/mTOR pathway.
Annexin A5 knockdown inhibits cardiomyocyte apoptosis and alleviates cardiac hypertrophy via activating the PI3K/AKT/Bcl-2 signaling pathway.
The Mitochondrial Fusion Promoter M1 Mitigates Cigarette Smoke-Induced Airway Inflammation and Oxidative Stress via the PI3K-AKT Signaling Pathway.
Resolvin D1 combined with exercise rehabilitation alleviates neurological injury in mice with intracranial hemorrhage via the BDNF/TrkB/PI3K/AKT pathway.
GPR37-enhanced ubiquitination of ATP1A1 inhibits tumor progression and radiation resistance in esophageal squamous cell carcinoma.
Discovery of SILA-123 as a Highly Potent FLT3 Inhibitor for the Treatment of Acute Myeloid Leukemia with Various FLT3 Mutations.
FERMT1 contributes to the epithelial-mesenchymal transition of chronic rhinosinusitis with nasal polyps via PI3K/Akt signaling.
CARD9 promotes cholangiocarcinoma by regulating the IL-17A/Hedgehog and the THEM4/AKT/mTOR signaling pathways.
Functional omics of ORP7 in primary endothelial cells.
Revealing the Mechanism of Hemerocallis citrina Baroni in Depression Treatment Through Integrated Network Pharmacology and Transcriptomic Analysis.
Phosphocholine inhibits proliferation and reduces stemness of endometrial cancer cells by downregulating mTOR-c-Myc signaling.
Elaiophylin targets EIF4B to suppress the growth of esophageal squamous cell carcinoma via the PI3K/AKT signaling pathway.
Dihydromyricetin-loaded oxidized polysaccharide/L-arginine chitosan adhesive hydrogel promotes bone regeneration by regulating PI3K/AKT signaling pathway and MAPK signaling pathway.
The involvement of lidocaine in amyloid-β1-42-dependent mitochondrial dysfunction and apoptosis in hippocampal neurons via nerve growth factor-protein kinase B pathway.
Ectopic endometrial stromal cell-derived extracellular vesicles encapsulating microRNA-25-3p induce endometrial collagen I deposition impairing decidualization in endometriosis.
F13B regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway.
SNX14 inhibits autophagy via the PI3K/AKT/mTOR signaling cascade in breast cancer cells.
MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway.
A p38 MAP kinase inhibitor suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss through the inhibition of bone turnover.
Targeting FTO suppresses hepatocellular carcinoma by inhibiting ERBB3 and TUBB4A expression.
Changes in PI3K/AKT and NRF2/HO-1 signaling expression and intestinal microbiota in bleomycin-induced pulmonary fibrosis.
Digirseophene A promotes recovery in injured developing cerebellum via AMPK/AKT/GSK3β pathway-mediated neural stem cell proliferation.
Isorhamnetin improves diabetes-induced erectile dysfunction in rats through activation of the PI3K/AKT/eNOS signaling pathway.
Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.
A Lipid-Sensitive Spider Peptide Toxin Exhibits Selective Anti-Leukemia Efficacy through Multimodal Mechanisms.
mRNA-Lipid Nanoparticle-Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple-Negative Breast Cancer.
Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo.
Network Pharmacological Analysis Combined with Experimental Verification to Explore the Effect of Ginseng Polypeptide on the Improvement of Diabetes Symptoms in db/db Mice.
Extract of Phyllanthus emblica L. fruit stimulates basal glucose uptake and ameliorates palmitate-induced insulin resistance through AMPK activation in C2C12 myotubes.
ITGB6 modulates resistance to anti-CD276 therapy in head and neck cancer by promoting PF4(+) macrophage infiltration.
Leptin protects chondrocytes by inhibiting autophagy via phosphoinositide 3 kinase/protein kinase B/mammalian target of rapamycin signaling pathway.
Does rAj-Tspin, a novel peptide from A. japonicus, exert antihepatocellular carcinoma effects via the ITGB1/ZYX/FAK/AKT signaling pathway?
The mechanism of extracellular CypB promotes glioblastoma adaptation to glutamine deprivation microenvironment.
CUDC-907 exhibits potent antitumor effects against ovarian cancer through multiple in vivo and in vitro mechanisms.
YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
DNAJC12 causes breast cancer chemotherapy resistance by repressing doxorubicin-induced ferroptosis and apoptosis via activation of AKT.
Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway.
Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3K/Akt/GSK3β pathway in stroke-prone renovascular hypertensive rats.
M2 macrophage-derived paracrine factor TNFSF13 affects the fibrogenic alterations in endothelial cells and cardiac fibroblasts by mediating the NF-κB and Akt pathway.
APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy.
PI3K/AKT mediated De novo fatty acid synthesis regulates RIG-1/MDA-5-dependent type I IFN responses in BVDV-infected CD8(+)T cells.
Retinoic acid induced specific changes in the phosphoproteome of C17.2 neural stem cells.
Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.
Arsenic disturbs neural tube closure involving AMPK/PKB-mTORC1-mediated autophagy in mice.
Ginsenoside Rg3 suppresses vasculogenic mimicry by impairing DVL3-maintained stemness via PAAD cell-derived exosomal miR-204 in pancreatic adenocarcinoma.
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.
Neonatal resveratrol administration promotes skeletal muscle growth and insulin sensitivity in intrauterine growth-retarded suckling piglets associated with activation of FGF21-AMPKα pathway.
Uncovering the key pharmacodynamic material basis and possible molecular mechanism of Xiaoke formulation improve insulin resistant through a comprehensive investigation.
Integration of network pharmacology and serum medicinal chemistry to investigate the pharmacological mechanisms of QiZhuYangGan Decoction in the treatment of hepatic fibrosis.
Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling.
KIF15 promotes the development and progression of chordoma via activating PI3K-AKT signalling pathway.
Diterpenoid tanshinones inhibit gastric cancer angiogenesis through the PI3K/Akt/mTOR signaling pathway.
Anti-hepatocellular carcinoma activity of Sorbaria sorbifolia by regulating VEGFR and c-Met/apoptotic pathway.
BMSCs attenuate radiation-induced brain injury induced hippocampal neuronal apoptosis through a PI3K/Akt/Bax/Bcl-2 signaling pathway.
Hepatic LGR4 aggravates cholestasis-induced liver injury in mice.
The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats.
Trimethylamine N-oxide Promotes Atherosclerosis by Regulating Low-Density Lipoprotein-Induced Autophagy in Vascular Smooth Muscle Cells Through PI3K/AKT/mTOR Pathway.
MiR-328-3p promotes TGF-β1-induced proliferation, migration, and inflammation of airway smooth muscle cells by regulating the PTEN/Akt pathway.
YWHAH activates the HMGA1/PI3K/AKT/mTOR signaling pathway by positively regulating Fra-1 to affect the proliferation of gastric cancer cells.
Resveratrol inhibits TGF-β1-induced fibrotic effects in human pterygium fibroblasts.
Penehyclidine Hydrochloride Protects Rat Cardiomyocytes from Ischemia- Reperfusion Injury by Platelet-derived Growth Factor-B.
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells.
Low Expression of GIGYF1 Inhibits Metastasis, Proliferation, and Promotes Apoptosis and Autophagy of Gastric Cancer Cells.
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy.
Network pharmacology reveals that Berberine may function against Alzheimer's disease via the AKT signaling pathway.
Molecular mechanism of miRNA-23a in sepsis-induced lung injury.
TREM2 as an independent predictor of poor prognosis promotes the migration via the PI3K/AKT axis in prostate cancer.
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
PLEKHG2 Promotes NSCLC Cell Growth by Increasing Glycolysis via Activated PI3K/AKT Pathway.
CSNK1G2-AS1 promotes metastasis, colony formation and serves as a biomarker in testicular germ cell tumor cells.
Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer.
Onvansertib inhibits the proliferation and improves the cisplatin-resistance of lung adenocarcinoma via β-catenin/c-Myc signaling pathway.
Characteristics of the immune microenvironment associated with RRM2 expression and its application to PD-L1/PD-1 inhibitors in lung adenocarcinoma.
S-Nitrosylation-mediated coupling of DJ-1 with PTEN induces PI3K/AKT/mTOR pathway-dependent keloid formation.
Daidzein alleviates osteoporosis by promoting osteogenesis and angiogenesis coupling.
Investigation of anti-diabetic effect of a novel coenzyme Q10 derivative.
Blockade of C5aR1 alleviates liver inflammation and fibrosis in a mouse model of NASH by regulating TLR4 signaling and macrophage polarization.
An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma.
Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression.
miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb the Proliferation and Functions of Chondrocytes.
Cinnamaldehyde protects donor heart from cold ischemia-reperfusion injury via the PI3K/AKT/mTOR pathway.
Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC.
Targeting of AKT1 by miR-143-3p Suppresses Epithelial-to-Mesenchymal Transition in Prostate Cancer.
Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.
Gastrodin relieves cognitive impairment by regulating autophagy via PI3K/AKT signaling pathway in vascular dementia.
Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer.
Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk.
METTL3 exerts synergistic effects on m6A methylation and histone modification to regulate the function of VGF in lung adenocarcinoma.
δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis.
Fagopyrum tataricum ethanol extract ameliorates symptoms of hyperglycemia by regulating gut microbiota in type 2 diabetes mellitus mice.
TIMELESS promotes the proliferation and migration of lung adenocarcinoma cells by activating EGFR through AMPK and SPHK1 regulation.
Proteomic analysis of uterine lavage fluid of dairy cows at different time after delivery by mass spectrometry.
TRIM11 regulated by m6A modification promotes the progression of cervical cancer by PHLPP1 ubiquitination.
Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis.
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway.
PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression.
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
A new peptide, VD11, promotes structural and functional recovery after spinal cord injury.
Equine β-defensin 1 regulates cytokine expression and phagocytosis in S. aureus-infected mouse monocyte macrophages via the Paxillin-FAK-PI3K pathway.
A network pharmacology approach to investigate dehydrocostus lactone inhibits the proliferation and epithelial-mesenchymal transition of human gastric cancer cells via regulating the PI3K/Akt and extracellular signal-regulated kinases/mitogen-activated protein kinase signalling pathways.
Network pharmacology integrated with experimental validation revealed potential molecular mechanisms of Camellia nitidissima C. W. Chi in the treatment of lung cancer.
Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus.
N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.
Effects of Gestational Diabetes Mellitus and Selenium Deficiency on the Offspring Growth and Blood Glucose Mechanisms of C57BL/6J Mice.
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer.
Scutellarin attenuates oxidative stress and neuroinflammation in cerebral ischemia/reperfusion injury through PI3K/Akt-mediated Nrf2 signaling pathways.
Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway.
RFC2 promotes aerobic glycolysis and progression of colorectal cancer.
FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
Paternal lipopolysaccharide exposure induced intrauterine growth restriction via the inactivation of placental MEST/PI3K/AKT pathway in mice.
Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study.
Catalpol Alleviates Ischemic Stroke Through Promoting Angiogenesis and Facilitating Proliferation and Differentiation of Neural Stem Cells via the VEGF-A/KDR Pathway.
6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice.
Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
Design and synthesis of 3,4-seco-lupane triterpene derivatives to resist myocardial ischemia-reperfusion injury by inhibiting oxidative stress-mediated mitochondrial dysfunction via the PI3K/AKT/HIF-1α axis.
Discovery of Novel Fourth-Generation EGFR Inhibitors to Overcome C797S-Mediated Resistance.
GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3‑ITD acute myeloid leukemia.
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3β/GLI1 pathway.
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway.
Leucine Supplementation Improves Diastolic Function in HFpEF by HDAC4 Inhibition.
Fibromodulin overexpression drives oral squamous cell carcinoma via activating downstream EGFR signaling.
Accelerating Wound Closure With Metrnl in Normal and Diabetic Mouse Skin.
Spermidine suppresses oxidative stress and ferroptosis by Nrf2/HO-1/GPX4 and Akt/FHC/ACSL4 pathway to alleviate ovarian damage.
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
MSC-EXO and tempol ameliorate bronchopulmonary dysplasia in newborn rats by activating HIF-1α.
IL1RAP Knockdown in LPS-Stimulated Normal Human Astrocytes Suppresses LPS-Induced Reactive Astrogliosis and Promotes Neuronal Cell Proliferation.
ZD6474 attenuates TGF-β1-induced fibrosis in human Tenon fibroblasts and inhibits neovascularization via AKT-mTOR signaling pathway.
Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway.
A low-salt diet with candesartan administration is associated with acute kidney injury in nephritis by increasing nitric oxide.
Integrating HPLC-Q-TOF-MS/MS, network pharmacology and experimental validation to decipher the chemical substances and mechanism of modified Gui-shao-liu-jun-zi decoction against gastric cancer.
Extracellular vesicles derived from Akkermansia muciniphila promote placentation and mitigate preeclampsia in a mouse model.
MAPK4 predicts poor prognosis and facilitates the proliferation and migration of glioma through the AKT/mTOR pathway.
Venlafaxine antagonizes the noradrenaline-promoted colon cancer progression by inhibiting the norepinephrine transporter.
Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC.
Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway.
Role of Protein Tyrosine Phosphatase 1B Inhibitor in Early Brain Injury of Subarachnoid Hemorrhage in Mice.
Cysteamine and N-Acetyl-cysteine Alleviate Placental Oxidative Stress and Barrier Function Damage Induced by Deoxynivalenol.
Antitumor mechanism of kangliu pill on gliomas in mice through PI3K-Akt signaling pathway.
Toxicity mechanism of peri-implantation pesticide beta-cypermethrin exposure on endometrial remodeling in early pregnant mice.
KIFC3 regulates progression of hepatocellular carcinoma via EMT and the AKT/mTOR pathway.
PD-1(+) mast cell enhanced by PD-1 blocking therapy associated with resistance to immunotherapy.
ZD6474 Attenuates Fibrosis and Inhibits Neovascularization in Human Pterygium by Suppressing AKT-mTOR Signaling Pathway.
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica.
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
hsa-mir-133a-2 promotes the proliferation and invasion of cervical cancer cells by targeting the LAMB3-mediated PI3K/ATK pathway.
Sustainably released nanoparticle-based rhynchophylline limits pulmonary fibrosis by inhibiting the TEK-PI3K/AKT signaling pathway.
Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.
The short isoform of MS4A7 is a novel player in glioblastoma microenvironment, M2 macrophage polarization, and tumor progression.
Chemical Constituents and Hypoglycemic Mechanisms of Dendrobium nobile in Treatment of Type 2 Diabetic Rats by UPLC-ESI-Q-Orbitrap, Network Pharmacology and In Vivo Experimental Verification.
AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer.
P53 Deficiency Accelerates Esophageal Epithelium Intestinal Metaplasia Malignancy.
The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways.
Harmine suppresses the malignant phenotypes and PI3K activity in breast cancer.
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Effect of isorhamnetin on carbonic anhydrase IX expression and tumorigenesis of bladder cancer by activating PPARγ/PTEN/AKT pathway.
LncRNA SLC7A11-AS1 promotes the progression of hepatocellular carcinoma by mediating KLF9 ubiquitination.
FAM83A promotes the progression and metastasis of human pancreatic neuroendocrine tumors by inducing the epithelial-mesenchymal transition via the PI3K/AKT and ERK pathways.
Glycoside combinations of Buyang Huanwu decoction ameliorate atherosclerosis via STAT3, HIF-1, and VEGF.
Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signalling pathway.
DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway.
Characterizing the specific mechanism of series processed Coptidis Rhizoma by multi-organ metabolomics combined with network pharmacology and molecular docking.
TWEAK Signaling-Induced ID1 Expression Drives Malignant Transformation of Hepatic Progenitor Cells During Hepatocarcinogenesis.
CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP-43 and Encoding A Novel TMEFF1-339aa Protein.
PTEN Inhibitor Treatment Lowers Muscle Plasma Membrane Damage and Enhances Muscle ECM Homeostasis after High-Intensity Eccentric Exercise in Mice.
Risk signature identification and NPRL2 affects sunitinib sensitivity in clear cell renal cell carcinoma.
Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production.
Patrinia villosa treat colorectal cancer by activating PI3K/Akt signaling pathway.
HNRNPA2B1-mediated m(6)A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis.
Arsenic interferes with spermatogenesis involving Rictor/mTORC2-mediated blood-testis barrier disruption in mice.
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
Autophagy-related gene PXN as a prognostic marker: Promotion of ovarian cancer progression by suppressing the p110β/Vps34/Beclin1 pathway.
TANGO1 interacts with NRTN to promote hepatocellular carcinoma progression by regulating the PI3K/AKT/mTOR signaling pathway.
Low Pi stress enhances the sensitivity of hepatocellular carcinoma to sorafenib.
Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma.
miR-221/222 Promote Endothelial Differentiation of Adipose-Derived Stem Cells by Regulation of PTEN/PI3K/AKT/mTOR Pathway.
A novel organic arsenic derivative MZ2 remodels metabolism and triggers mtROS-mediated apoptosis in acute myeloid leukemia.
Oral nano-formulation improves pancreatic islets dysfunction via lymphatic transport for antidiabetic treatment.
Inhibition of TREM-1 ameliorates Lipopolysaccharide-induced depressive-like behaviors by alleviating neuroinflammation in the PFC via PI3K/Akt signaling pathway.
Atractylenolide III Ameliorates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting the PI3K/AKT Pathway and Regulating Glutamine Metabolism.
Gypenosides suppress fibrosis of the renal NRK-49F cells by targeting miR-378a-5p through the PI3K/AKT signaling pathway.
Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model.
Periplocin inhibits hepatocellular carcinoma progression and reduces the recruitment of MDSCs through AKT/NF-κB pathway.
SFTS bunyavirus NSs protein sequestrates mTOR into inclusion bodies and deregulates mTOR-ULK1 signaling, provoking pro-viral autophagy.
Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co-expression network analysis.
HYOU1 promotes cell proliferation, migration, and invasion via the PI3K/AKT/FOXO1 feedback loop in bladder cancer.
Prefoldin 6 promotes glioma progression via the AKT signalling pathway.
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Triptolide inhibits intrahepatic cholangiocarcinoma growth by suppressing glycolysis via the AKT/mTOR pathway.
Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia.
Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1.
Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis.
Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion.
Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer.
Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice.
Betulinaldehyde exhibits effective anti-tumor effects in A549 cells by regulating intracellular autophagy.
Monotropein attenuates doxorubicin-induced oxidative stress, inflammation, and arrhythmia via the AKT signal pathway.
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting.
Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma.
S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.
LncRNA NR2F1-AS1 was involved in azacitidine resistance of THP-1 cells by targeting IGF1 with miR-483-3p.
Single-cell transcriptome analysis identifies Versican(+) myofibroblast as a hallmark for thoracic aortic aneurysm marked by activation of PI3K-AKT signaling pathway.
Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia.
Synergistic effects of L-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation.
Onchidium struma polysaccharides exhibit hypoglycemic activity and modulate the gut microbiota in mice with type 2 diabetes mellitus.
RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4.
Silk-Inorganic Nanoparticle Hybrid Hydrogel as an Injectable Bone Repairing Biomaterial.
Activation of long-non-coding RNA NEAT1 sponging microRNA-147 inhibits radiation damage by targeting PDPK1 in troxerutin radioprotection.
Cytosolic Release of Mitochondrial DNA and Associated cGAS Signaling Mediates Radiation-Induced Hematopoietic Injury of Mice.
Metformin regulates autophagy via LGMN to inhibit choriocarcinoma.
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK.
The role of PDIA3 in oral squamous cell carcinoma and its value as A diagnostic and prognostic biomarker.
AKAP12 inhibits esophageal squamous carcinoma cell proliferation, migration, and cell cycle via the PI3K/AKT signaling pathway.
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway.
Human Dental Pulp Stem Cells Are Subjected to Metabolic Reprogramming and Repressed Proliferation and Migration by the Sympathetic Nervous System via α1B-Adrenergic Receptor.
Acteoside Derived from Cistanche Improves Glucocorticoid-Induced Osteoporosis by Activating PI3K/AKT/mTOR Pathway.
Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes.
Integrated analysis of murine cornea identifies JAK/STAT signaling pathway upregulated specifically in female Vitamin A Deficient mice.
BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment.
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator.
Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells.
TPN10475 alleviates concanavalin A-induced autoimmune hepatitis by limiting T cell development and function through inhibition of PI3K-AKT pathway.
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics.
Combinational application of the natural products 1-deoxynojirimycin and morin ameliorates insulin resistance and lipid accumulation in prediabetic mice.
Comprehensive analysis of clinical prognosis and biological significance of CNIH4 in cervical cancer.
ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.
Phenolic Constituents from Black Quinoa Alleviate Insulin Resistance in HepG2 Cells via Regulating IRS1/PI3K/Akt/GLUTs Signaling Pathways.
RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells.
Nodakenin alleviates ovariectomy-induced osteoporosis by modulating osteoblastogenesis and osteoclastogenesis.
RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma.
FGFR2 modulates the Akt/Nrf2/ARE signaling pathway to improve angiotensin II-induced hypertension-related endothelial dysfunction.
Preclinical characterization of danatinib as a novel FLT3 inhibitor with excellent efficacy against resistant acute myeloid leukemia.
Tetrahydropalmatine: Orchestrating survival - Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps.
Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway.
A homozygous variant in INTS11 links mitosis and neurogenesis defects to a severe neurodevelopmental disorder.
Metabolites-Based Network Pharmacology to Preliminarily Verify In Vitro Anti-Inflammatory Effect of Ardisiacrispin B.
Ultrasound-targeted microbubble destruction promotes PDGF-primed bone mesenchymal stem cell transplantation for myocardial protection in acute Myocardial Infarction in rats.
Regulatory and Interacting Partners of PDLIM7 in Thyroid Cancer.
Cirsiliol induces autophagy and mitochondrial apoptosis through the AKT/FOXO1 axis and influences methotrexate resistance in osteosarcoma.
Blockade of CXCR4 promotes macrophage autophagy through the PI3K/AKT/mTOR pathway to alleviate coronary heart disease.
Pectolinarigenin attenuates hepatic ischemia/reperfusion injury via activation of the PI3K/AKT/Nrf2 signaling pathway.
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery.
NOX2 inhibition stabilizes vulnerable plaques by enhancing macrophage efferocytosis via MertK/PI3K/AKT pathway.
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
Exposure to MoS2 nanosheets or bulk activated Kruppel-like factor 4 in 3D Caco-2 spheroids in vitro and mouse intestines in vivo.
Danlou Tablet Protects Against Cardiac Remodeling and Dysfunction after Myocardial Ischemia/Reperfusion Injury through Activating AKT/FoxO3a Pathway.
Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B.
Immunosensitivity mediated by downregulated AKT1-SKP2 induces anti-PD-1-associated thyroid immune injury.
YY1 regulates the proliferation and invasion of triple-negative breast cancer via activating PLAUR.
Alteration of the N(6)-methyladenosine methylation landscape in a mouse model of polycystic ovary syndrome.
Sodium Butyrate Induces Mitophagy and Apoptosis of Bovine Skeletal Muscle Satellite Cells through the Mammalian Target of Rapamycin Signaling Pathway.
Exploring the Therapeutic Potential of Ethyl 3-Hydroxybutyrate in Alleviating Skeletal Muscle Wasting in Cancer Cachexia.
MicroRNA-144-3p protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles by targeting MAP3K9.
METTL3 regulatory TROAP can regulate the progression of non-small cell lung cancer through PI3K/AKT and EMT signaling pathway.
Analyzing roles of small nucleolar RNA host gene 25 from clinical, molecular target and tumor formation in prostate cancer.
The effect of PINK1/Parkin pathway on glucose homeostasis imbalance induced by tacrolimus in mouse livers.
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
SNORD60 promotes the tumorigenesis and progression of endometrial cancer through binding PIK3CA and regulating PI3K/AKT/mTOR signaling pathway.
Metformin alleviates ethanol-induced cardiomyocyte injury by activating AKT/Nrf2 signaling in an ErbB2-dependent manner.
The potential mechanism of Neu5Gc inducing colorectal cancer based on network pharmacology and experimental validation.
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.
Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling.
Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling.
Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities.
Budding uninhibited by benzimidazoles 1 overexpression is associated with poor prognosis and malignant phenotype: A promising therapeutic target for lung adenocarcinoma.
Acinetobacter baumannii outer membrane protein A induces autophagy in bone marrow-derived dendritic cells involving the PI3K/mTOR pathway.
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
An AKT1-and TRIM21-mediated phosphodegron controls proteasomal degradation of HuR enabling cell survival under heat shock.
[High expression of MYH9 inhibits apoptosis of non-small cell lung cancer cells through activating the AKT/c-Myc pathway].
Diluent pH affects sperm motility via GSK3 α/β-hexokinase pathway for the efficient enrichment of X-sperm to increase the female kids rate of dairy goats.
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
S-Equol enhances osteoblastic bone formation and prevents bone loss through OPG/RANKL via the PI3K/Akt pathway in streptozotocin-induced diabetic rats.
Suppression of SMOC2 alleviates myocardial fibrosis via the ILK/p38 pathway.
Beneficial effects of whey protein peptides on muscle loss in aging mice models.
ADAMTS8 Promotes Cardiac Fibrosis Partly Through Activating EGFR Dependent Pathway.
Exosomes derived from M2 macrophages induce angiogenesis to promote wound healing.
Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis.
Potential role of gut microbiota-LCA-INSR axis in high fat-diet-induced non-alcoholic fatty liver dysfunction: From perspective of radiation variation.
Huangqi-Honghua Combination Prevents Cerebral Infarction with Qi Deficiency and Blood Stasis Syndrome in Rats by the Autophagy Pathway.
Transcriptional Patterns of Lower-Grade Glioma Patients with Distinct Ferroptosis Levels, Immunotherapy Response, and Temozolomide Sensitivity.
Artesunate Suppresses the Growth of Lung Cancer Cells by Downregulating the AKT/Survivin Signaling Pathway.
Protective Effects of Herba Houttuyniae Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice.
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
MicroRNA-325-3p Targets Human Epididymis Protein 4 to Relieve Right Ventricular Fibrosis in Rats with Pulmonary Arterial Hypertension.
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice.
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells.
GNAI2 Is a Risk Factor for Gastric Cancer: Study of Tumor Microenvironment (TME) and Establishment of Immune Risk Score (IRS).
Celastrol inhibits the proliferation and migration of MCF-7 cells through the leptin-triggered PI3K/AKT pathway.
High-mobility Group Box 1 Contributes to Hypoxic-Ischemic Brain Damage by Facilitating Imbalance of Microglial Polarization through RAGE-PI3K/Akt Pathway in Neonatal Rats.
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
HNRNPK/CLCN3 axis facilitates the progression of LUAD through CAF-tumor interaction.
Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis.
Long non-coding RNA NEAT1 promotes angiogenesis in hepatoma carcinoma via the miR-125a-5p/VEGF pathway.
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression.
Network Pharmacology Integrated with Transcriptomics Analysis Reveals Ermiao Wan Alleviates Atopic Dermatitis via Suppressing MAPK and Activating the EGFR/AKT Signaling.
Effects of Lycium barbarum polysaccharide on the photoinduced autophagy of retinal pigment epithelium cells.
FGL2-MCOLN3-Autophagy Axis-Triggered Neutrophil Extracellular Traps Exacerbate Liver Injury in Fulminant Viral Hepatitis.
LncRNA LINC00460 facilitates the proliferation and metastasis of renal cell carcinoma via PI3K/AKT signaling pathway.
LHPP suppresses gastric cancer progression via the PI3K/AKT/mTOR signaling pathway.
Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma.
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome.
SMO mutation predicts the effect of immune checkpoint inhibitor: From NSCLC to multiple cancers.
D-tagatose protects against oleic acid-induced acute respiratory distress syndrome in rats by activating PTEN/PI3K/AKT pathway.
Azoxystrobin induces apoptosis via PI3K/AKT and MAPK signal pathways in oral leukoplakia progression.
Astragalus-Scorpion Drug Pair Inhibits the Development of Prostate Cancer by Regulating GDPD4-2/PI3K/AKT/mTOR Pathway and Autophagy.
Hydrogen Repairs LPS-Induced Endothelial Progenitor Cells Injury via PI3K/AKT/eNOS Pathway.
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway.
Rosmarinic Acid Ameliorates Pulmonary Ischemia/Reperfusion Injury by Activating the PI3K/Akt Signaling Pathway.
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
H(2)S Protects Against Immobilization-Induced Muscle Atrophy via Reducing Oxidative Stress and Inflammation.
ALG-bFGF Hydrogel Inhibiting Autophagy Contributes to Protection of Blood-Spinal Cord Barrier Integrity via PI3K/Akt/FOXO1/KLF4 Pathway After SCI.
Exploring the Anti-Pulmonary Fibrosis Mechanism of Jingyin Granule by Network Pharmacology Strategy.
Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy.
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
LYPD3, a New Biomarker and Therapeutic Target for Acute Myelogenous Leukemia.
Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells.
Farrerol prevents Angiotensin II-induced cardiac remodeling in vivo and in vitro.
Dynamic changes in human THP-1-derived M1-to-M2 macrophage polarization during Thelazia callipaeda MIF induction.
Platelet-rich plasma ameliorates lipopolysaccharide-induced cardiac injury by inflammation and ferroptosis regulation.
Identification of NLE1/CDK1 axis as key regulator in the development and progression of non-small cell lung cancer.
S645C Point Mutation Suppresses Degradation of EGFR to Promote Progression of Glioblastoma.
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma.
Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim-Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer.
Syntenin Regulated by miR-216b Promotes Cancer Progression in Pancreatic Cancer.
NUF2 overexpression contributes to epithelial ovarian cancer progression via ERBB3-mediated PI3K-AKT and MAPK signaling axes.
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
The Role of Syncytin in Placental Angiogenesis and Fetal Growth.
HIF-1α Regulates Osteogenesis of Periosteum-Derived Stem Cells Under Hypoxia Conditions via Modulating POSTN Expression.
HSPA6 is Correlated With the Malignant Progression and Immune Microenvironment of Gliomas.
Poloxamer 407 and Hyaluronic Acid Thermosensitive Hydrogel-Encapsulated Ginsenoside Rg3 to Promote Skin Wound Healing.
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
RNA-seq and ATAC-seq analyses of multilineage differentiating stress enduring cells: Comparison with dermal fibroblasts.
Calycosin suppresses colorectal cancer progression by targeting ERβ, upregulating PTEN, and inhibiting PI3K/Akt signal pathway.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Overexpression of SFXN1 indicates poor prognosis and promotes tumor progression in lung adenocarcinoma.
Trichodermin inhibits the growth of oral cancer through apoptosis-induced mitochondrial dysfunction and HDAC-2-mediated signaling.
Grass Carp Reovirus triggers autophagy enhancing virus replication via the Akt/mTOR pathway.
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Comprehensive analysis of the prognostic implications and functional exploration of PAK gene family in human cancer.
Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer.
Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation.
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism.
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.
Synthesis and biological evaluation of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine covalent inhibitors as potential agents for the treatment of acute myeloid leukemia.
Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway.
Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth.
Heterozygous LRP1 deficiency causes developmental dysplasia of the hip by impairing triradiate chondrocytes differentiation due to inhibition of autophagy.
Low-dose radiation exaggerates HFD-induced metabolic dysfunction by gut microbiota through PA-PYCR1 axis.
Network pharmacology and molecular docking study on the effect of Kaempferol in treatment of metabolic associated fatty liver disease.
3-Nitrobenzanthrone promotes malignant transformation in human lung epithelial cells through the epiregulin-signaling pathway.
A peptide translated from circPPP1R12A promotes the malignancy of non-small cell lung cancer cells through AKT signaling pathway.
The prognostic value and mechanisms of centromere protein M in patients with lung adenocarcinoma.
DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism.
Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.
Equus β-Defensin-1 Regulates Innate IMMUNE Response in S. aureus-Infected Mouse Monocyte Macrophage.
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages.
Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system.
Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma.
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis.
SIRT3 Promotes the Development of Esophageal Squamous Cell Carcinoma by Regulating Hexokinase 2 through the AKT Signaling Pathway.
Protective effect of 3-n-butylphthalide against intrastriatal injection of malonic acid-induced neurotoxicity and biochemical alteration in rats.
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
PSMB5 overexpression is correlated with tumor proliferation and poor prognosis in hepatocellular carcinoma.
Exercise attenuates angiotensinⅡ-induced muscle atrophy by targeting PPARγ/miR-29b.
Identification of FDFT1 as a potential biomarker associated with ferroptosis in ccRCC.
Lysine stimulates the development of the murine mammary gland at puberty via PI3K/AKT/mTOR signalling axis.
L-arginine stimulates the proliferation of mouse mammary epithelial cells and the development of mammary gland in pubertal mice by activating the GPRC6A/PI3K/AKT/mTOR signalling pathway.
A dynamic fluorescence probed glycolysis suppression process in HeLa cells treated with trichostatin A.
Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury.
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
Dietary N(ε)-(carboxymethyl) lysine affects cardiac glucose metabolism and myocardial remodeling in mice.
Lactate Activates AMPK Remodeling of the Cellular Metabolic Profile and Promotes the Proliferation and Differentiation of C2C12 Myoblasts.
NAP1L5 targeting combined with MYH9 Inhibit HCC progression through PI3K/AKT/mTOR signaling pathway.
Effects of apolipoprotein E on regulating insulin sensitivity via regulating insulin receptor signalosome in caveolae.
Gaseous signal molecule SO(2) regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes.
Collagen peptides from Acaudina molpadioides prevent CCl(4) -induced liver injury via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways.
Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of the AKT/Gsk-3β signal pathway.
Dictamnine inhibits pancreatic cancer cell growth and epithelial-mesenchymal transition by blocking the PI3K/AKT signaling pathway.
Macamide B Pretreatment Attenuates Neonatal Hypoxic-Ischemic Brain Damage of Mice Induced Apoptosis and Regulates Autophagy via the PI3K/AKT Signaling Pathway.
MMP-9 secreted by M2-type macrophages promotes Wilms' tumour metastasis through the PI3K/AKT pathway.
Platelet-rich plasma pretreatment protects anterior cruciate ligament fibroblasts correlated with PI3K-Akt-mTOR pathway under hypoxia condition.
Angiotensin-(1-7) improves diabetes mellitus-induced erectile dysfunction in rats by regulating nitric oxide synthase levels.
Anti-fatigue effects of fermented soybean protein peptides in mice.
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
Brasilterpenes A-E, Bergamotane Sesquiterpenoid Derivatives with Hypoglycemic Activity from the Deep Sea-Derived Fungus Paraconiothyrium brasiliense HDN15-135.
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
Xiao-Luo-Wan treats propylthiouracil-induced goiter with hypothyroidism in rats through the PI3K-AKT/RAS pathways based on UPLC/MS and network pharmacology.
Autophagy protects against high uric acid-induced hepatic insulin resistance.
Construction and a preliminary study of paracrine effect of bone marrow-derived endothelial progenitor cell sheet.
Azithromycin alleviates the severity of rheumatoid arthritis by targeting the unfolded protein response component of glucose-regulated protein 78 (GRP78).
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Cyclin D1 mediated by the nuclear translocation of nuclear factor kappa B exerts an oncogenic role in lung cancer.
Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification.
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling.
Network Pharmacology-Based Analysis on the Effects and Mechanism of the Wang-Bi Capsule for Rheumatoid Arthritis and Osteoarthritis.
Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway.
SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway.
Continuous wave irradiation at 0.1 terahertz facilitates transmembrane transport of small molecules.
Chelerythrine inhibits the progression of glioblastoma by suppressing the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway.
Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer.
CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases.
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
Restraint of FAM60A has a cancer-inhibiting role in pancreatic carcinoma via the effects on the Akt/GSK-3β/β-catenin signaling pathway.
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway.
Berberine attenuates sepsis-induced cardiac dysfunction by upregulating the Akt/eNOS pathway in mice.
MicroRNA-221-5p Promotes Ricin Toxin-induced Inflammation via PI3K/Akt signaling pathway by targeting COL4a5.
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
The molecular mechanism of baicalein repressing progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway.
Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.
PI3K inhibitor impairs tumor progression and enhances sensitivity to anlotinib in anlotinib-resistant osteosarcoma.
Delivery of engineered extracellular vesicles with miR-29b editing system for muscle atrophy therapy.
Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway.
Transcriptional landscape of human neuroblastoma cells in response to SARS-CoV-2.
Discovery of Novel Phosphoinositide-3-Kinase α Inhibitors with High Selectivity, Excellent Bioavailability, and Long-Acting Efficacy for Gastric Cancer.
Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis.
Remodeling on adipocytic physiology of organophosphorus esters in mature adipocytes.
The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats.
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway.
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Leptin relieves ischemia/reperfusion induced acute kidney injury through inhibiting apoptosis and autophagy.
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
A novel FBW7/NFAT1 axis regulates cancer immunity in sunitinib-resistant renal cancer by inducing PD-L1 expression.
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy.
FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.
Short-term starvation synergistically enhances cytotoxicity of Niraparib via Akt/mTOR signaling pathway in ovarian cancer therapy.
Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma.
Estrogen receptor-α36 is involved in diallyl sulfide-induced inhibition of malignant growth of HepG2 and Huh7 hepatocellular carcinoma cells.
MiR-195 promotes pancreatic β-cell dedifferentiation by targeting Mfn2 and impairing Pi3k/Akt signaling in type 2 diabetes.
SDF-1 inhibits the dedifferentiation of islet β cells in hyperglycaemia by up-regulating FoxO1 via binding to CXCR4.
Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis.
Therapeutic effect of adipose stromal vascular fraction spheroids for partial bladder outlet obstruction induced underactive bladder.
Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury through the PI3K/Akt/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression.
OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer.
Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation.
RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway.
Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.
The protective effect of proanthocyanidins on the psoriasis-like cell models via PI3K/AKT and HO-1.
Daidzein Activates Akt Pathway to Promote the Proliferation of Female Germline Stem Cells through Upregulating Clec11a.
IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice.
Deletion of large-conductance calcium-activated potassium channels promotes vascular remodelling through the CTRP7-mediated PI3K/Akt signaling pathway.
The Nrf2 inhibitor brusatol synergistically enhances the cytotoxic effect of lapatinib in HER2-positive cancers.
Corn oligopeptides inhibit Akt/NF-κB signaling pathway and inflammatory factors to ameliorate CCl(4) -induced hepatic fibrosis in mice.
Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway.
Growth arrest-specific transcript 5 represses endometrial cancer development by promoting antitumor function of tumor-associated macrophages.
Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity.
Discovery of highly potent and selective CRBN-recruiting EGFR(L858R/T790M) degraders in vivo.
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Investigation of the effects of high cervical spinal cord electrical stimulation on improving neurological dysfunction and its potential mechanism in rats with traumatic brain injury.
LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2.
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
miR-141-3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1.
FAM83A has a pro-tumor function in ovarian cancer by affecting the Akt/Wnt/β-catenin pathway.
Downregulating MFN2 Promotes the Differentiation of Induced Pluripotent Stem Cells into Mesenchymal Stem Cells through the PI3K/Akt/GSK-3β/Wnt Signaling Pathway.
Dietary intake of diosgenin delays aging of male fish Nothobranchius guentheri through modulation of multiple pathways that play prominent roles in ROS production.
GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSGL-1 in atherosclerosis.
Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway.
Structure-based discovery of a specific SHP2 inhibitor with enhanced blood-brain barrier penetration from PubChem database.
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
miR-486 attenuates cardiac ischemia/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection.
Bolbostemma paniculatum (Maxim.) Franquet extract suppresses the development of colorectal cancer through downregulation of PI3K/Akt pathway.
Mechanism exploration of ancient pharmaceutic processing (Paozhi) improving the gastroprotective efficacy of Aucklandiae Radix.
Brusatol inhibits the growth of renal cell carcinoma by regulating the PTEN/PI3K/AKT pathway.
GALNT8 suppresses breast cancer cell metastasis potential by regulating EGFR O-GalNAcylation.
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration via the miR-205-5p/PTEN/AKT pathway.
Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance.
Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways.
Increased Nuclear Transporter Importin 7 Contributes to the Tumor Growth and Correlates With CD8 T Cell Infiltration in Cervical Cancer.
NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.
Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.
lncRNA Gm16410 Mediates PM(2).(5)-Induced Macrophage Activation via PI3K/AKT Pathway.
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Taurine Protects C2C12 Myoblasts From Impaired Cell Proliferation and Myotube Differentiation Under Cisplatin-Induced ROS Exposure.
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Pentadecanoic acid promotes basal and insulin-stimulated glucose uptake in C2C12 myotubes.
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
Qingjie Fuzheng Granule Inhibits EMT and Induces Autophagy in Colorectal Cancer via mTOR Signaling Pathways.
Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G(0)/G(1) Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation.
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway.
A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke.
Evodiamine Inhibits Gastric Cancer Cell Proliferation via PTEN-Mediated EGF/PI3K Signaling Pathway.
Manual Acupuncture at ST37 Modulates TRPV1 in Rats with Acute Visceral Hyperalgesia via Phosphatidylinositol 3-Kinase/Akt Pathway.
Therapeutic Potential of RTA 404 in Human Brain Malignant Glioma Cell Lines via Cell Cycle Arrest via p21/AKT Signaling.
The Key Ingredient Acacetin in Weishu Decoction Alleviates Gastrointestinal Motility Disorder Based on Network Pharmacology Analysis.
The Effect of miR-520b on Macrophage Polarization and T Cell Immunity by Targeting PTEN in Breast Cancer.
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer.
Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Fatty Acid-Binding Protein 4 (FABP4) Suppresses Proliferation and Migration of Endometrial Cancer Cells via PI3K/Akt Pathway.
Downregulation of TAF9B by miR-7-5p Inhibits the Progression of Osteosarcoma.
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice.
GTW inhibits the Epithelial to Mesenchymal Transition of Epithelial Ovarian Cancer via ILK/AKT/GSK3β/Slug Signalling Pathway.
MRPS17 promotes invasion and metastasis through PI3K/AKT signal pathway and could be potential prognostic marker for gastric cancer.
Peroxisome Proliferator-Activated Receptor-Gamma Reduces ER Stress and Inflammation via Targeting NGBR Expression.
Diosgenin From Dioscorea Nipponica Rhizoma Against Graves' Disease-On Network Pharmacology and Experimental Evaluation.
ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway.
PARP Inhibitor Upregulates PD-L1 Expression and Provides a New Combination Therapy in Pancreatic Cancer.
Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.
Exploring the Critical Components and Therapeutic Mechanisms of Perilla frutescens L. in the Treatment of Chronic Kidney Disease via Network Pharmacology.
Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Pathway.
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.
Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice.
Rapamycin Modulates the Proinflammatory Memory-Like Response of Microglia Induced by BAFF.
Isovitexin Inhibits Ginkgolic Acids-Induced Inflammation Through Downregulating SHP2 Activation.
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
Human Mesenchymal Stem Cell-Derived Exosomal microRNA-143 Promotes Apoptosis and Suppresses Cell Growth in Pancreatic Cancer via Target Gene Regulation.
ADORA2A-AS1 Restricts Hepatocellular Carcinoma Progression via Binding HuR and Repressing FSCN1/AKT Axis.
TPL Inhibits the Invasion and Migration of Drug-Resistant Ovarian Cancer by Targeting the PI3K/AKT/NF-κB-Signaling Pathway to Inhibit the Polarization of M2 TAMs.
The EIF4A3/CASC2/RORA Feedback Loop Regulates the Aggressive Phenotype in Glioblastomas.
Transcriptomic Analyses Reveal B-Cell Translocation Gene 2 as a Potential Therapeutic Target in Ovarian Cancer.
A Novel Small Molecular Antibody, HER2-Nanobody, Inhibits Tumor Proliferation in HER2-Positive Breast Cancer Cells In Vitro and In Vivo.
The LncRNA CASC11 Promotes Colorectal Cancer Cell Proliferation and Migration by Adsorbing miR-646 and miR-381-3p to Upregulate Their Target RAB11FIP2.
Down-Regulating the Expression of miRNA-21 Inhibits the Glucose Metabolism of A549/DDP Cells and Promotes Cell Death Through the PI3K/AKT/mTOR/HIF-1α Pathway.
MiR-454-3p Promotes Oxaliplatin Resistance by Targeting PTEN in Colorectal Cancer.
MiR-338-5p Inhibits EGF-Induced EMT in Pancreatic Cancer Cells by Targeting EGFR/ERK Signaling.
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
Triclosan regulates the Nrf2/HO-1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons.
Low-dose repeated exposure to chemical surfactant impairs corneal epithelium: When personal cleaning products entering the eye.
A novel delivery nanobiotechnology: engineered miR-181b exosomes improved osteointegration by regulating macrophage polarization.
Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction.
miR-497 defect contributes to gastric cancer tumorigenesis and progression via regulating CDC42/ITGB1/FAK/PXN/AKT signaling.
Tanshinone IIA affects the malignant growth of Cholangiocarcinoma cells by inhibiting the PI3K-Akt-mTOR pathway.
PHLDA3 exerts an antitumor function in prostate cancer by down-regulating Wnt/β-catenin pathway via inhibition of Akt.
Midkine promotes glioblastoma progression via PI3K-Akt signaling.
Latcripin-7A from Lentinula edodes C(91-3) induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling.
Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.
Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes.
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway.
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
Methyl eugenol attenuates liver ischemia reperfusion injury via activating PI3K/Akt signaling.
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pathway.
miR-19a-3p downregulates tissue factor and functions as a potential therapeutic target for sepsis-induced disseminated intravascular coagulation.
Study on the potential nephrotoxicity and mutagenicity of aristolochic acid IVa and its mechanism.
Cathepsin B Regulates Mice Granulosa Cells' Apoptosis and Proliferation In Vitro.
A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties.
SUMO1 modification of IGF-1R combining with SNAI2 inhibited osteogenic differentiation of PDLSCs stimulated by high glucose.
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Abnormally elevated ubiquilin‑1 expression in breast cancer regulates metastasis and stemness via AKT signaling.
Protective effect of carvacrol on liver injury in type 2 diabetic db/db mice.
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression.
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
miR-30b-5p inhibits proliferation, invasion, and migration of papillary thyroid cancer by targeting GALNT7 via the EGFR/PI3K/AKT pathway.
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Long non-coding RNA SMASR inhibits the EMT by negatively regulating TGF-β/Smad signaling pathway in lung cancer.
Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT/mTOR and ERK1/2 signaling pathways.
Role of epigenetic m(6) A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling.
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Knockdown of CLN5 inhibits the tumorigenic properties of glioblastoma cells via the Akt/mTOR signaling pathway.
αKlotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy.
Bioactive glass activates VEGF paracrine signaling of cardiomyocytes to promote cardiac angiogenesis.
2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.
Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.
LRRC4 functions as a neuron-protective role in experimental autoimmune encephalomyelitis.
CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP-9/PI3K/AKT pathway.
Hypoxia-induced SPOP attenuates the mobility of trophoblast cells through inhibition of the PI3K/AKT/GSK3β pathway.
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Radiotherapy programs neutrophils to an antitumor phenotype by inducing mesenchymal-epithelial transition.
Angiotensin II-induced muscle atrophy via PPARγ suppression is mediated by miR-29b.
Inhibition of lncRNA MAAT Controls Multiple Types of Muscle Atrophy by cis- and trans-Regulatory Actions.
mTOR pathway regulates the differentiation of peripheral blood Th2/Treg cell subsets in patients with pemphigus vulgaris.
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway.
Iridoids from Gardeniae fructus ameliorates depression by enhancing synaptic plasticity via AMPA receptor-mTOR signaling.
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
ACTG1 regulates intervertebral disc degeneration via the NF-κB-p65 and Akt pathways.
FoxP3-miR-150-5p/3p suppresses ovarian tumorigenesis via an IGF1R/IRS1 pathway feedback loop.
The Effect of Hispidulin, a Flavonoid from Salvia plebeia, on Human Nasopharyngeal Carcinoma CNE-2Z Cell Proliferation, Migration, Invasion, and Apoptosis.
Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.
miR-20b and miR-125a promote tumorigenesis in radioresistant esophageal carcinoma cells.
FAM122A promotes acute myeloid leukemia cell growth through inhibiting PP2A activity and sustaining MYC expression.
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Sparstolonin B exerts beneficial effects on prostate cancer by acting on the reactive oxygen species-mediated PI3K/AKT pathway.
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway.
Longdan Xiegan Tang attenuates liver injury and hepatic insulin resistance by regulating the angiotensin-converting enzyme 2/Ang (1-7)/Mas axis-mediated anti-inflammatory pathway in rats.
Protective effect of scorpion venom heat-resistant synthetic peptide against PM(2.5)-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway.
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells.
MicroRNA-215-5p inhibits the proliferation of keratinocytes and alleviates psoriasis-like inflammation by negatively regulating DYRK1A and its downstream signalling pathways.
Downregulation of HOXA11 enhances endometrial cancer malignancy and cisplatin resistance via activating PTEN/AKT signaling pathway.
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
Enteric glial cells exert neuroprotection from hyperglycemia-induced damage via Akt/GSK3β pathway.
Identification and optimization of 3-bromo-N'-(4-hydroxybenzylidene)-4-methylbenzohydrazide derivatives as mTOR inhibitors that induce autophagic cell death and apoptosis in triple-negative breast cancer.
A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.
Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation.
FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer.
The role of PKA/PP2B-mediated Drp1 phosphorylation and the subsequent EGFR inhibition in Cr(VI)-induced premature senescence.
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Postnatal overfeeding induces hepatic microRNA-221 expression and impairs the PI3K/AKT pathway in adult male rats.
Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.
Blocking VRK2 suppresses pulmonary adenocarcinoma progression via ERK1/2/AKT signal pathway by targeting miR-145-5p.
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats.
Peptide OM-LV20 exerts neuroprotective effects against cerebral ischemia/reperfusion injury in rats.
Human Serum-derived Extracellular Vesicles Protect A549 from PM (2.5)-induced Cell Apoptosis.
Typical phthalic acid esters induce apoptosis by regulating the PI3K/Akt/Bcl-2 signaling pathway in rat insulinoma cells.
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Canstatin represses glioma growth by inhibiting formation of VM-like structures.
Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer.
RAB31 marks and controls an ESCRT-independent exosome pathway.
Liver paraoxonase 3 expression and the effect of liraglutide treatment in a rat model of diabetes.
Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2.
MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
ACTL6A knockdown inhibits cell migration by suppressing the AKT signaling pathway and enhances the sensitivity of glioma cells to temozolomide.
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes.
Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer.
Loss of STAT5A promotes glucose metabolism and tumor growth through miRNA-23a-AKT signaling in hepatocellular carcinoma.
G-Rh4 improves pancreatic β-cells dysfunction in vivo and in vitro by increased expression of Nrf2 and its target genes.
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1.
Pterostilbene inhibits gallbladder cancer progression by suppressing the PI3K/Akt pathway.
QiShenYiQi pill activates autophagy to attenuate reactive myocardial fibrosis via the PI3K/AKT/mTOR pathway.
Social context-dependent singing alters molecular markers of synaptic plasticity signaling in finch basal ganglia Area X.
DNA damage promotes microtubule dynamics through a DNA-PK-AKT axis for enhanced repair.
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation.
Lobetyolin inhibits the proliferation of breast cancer cells via ASCT2 down-regulation-induced apoptosis.
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice.
ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma.
Knockdown of METTL14 suppresses the malignant progression of non-small cell lung cancer by reducing Twist expression.
miR-199b-5p mediates adriamycin-induced podocyte apoptosis by inhibiting the expression of RGS10.
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Silencing FYVE, RhoGEF, and PH domain containing 1 (FGD1) suppresses melanoma progression by inhibiting PI3K/AKT signaling pathway.
The effects of Omarigliptin on promoting osteoblastic differentiation.
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
Gsα deficiency facilitates cardiac remodeling via CREB/ Bmp10-mediated signaling.
Nutrient metabolism in the liver and muscle of juvenile blunt snout bream (Megalobrama amblycephala) in response to dietary methionine levels.
A maternal high-fat/low-fiber diet impairs glucose tolerance and induces the formation of glycolytic muscle fibers in neonatal offspring.
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
DNAJC2 is reversely regulated by miR‑627‑3p, promoting the proliferation of colorectal cancer.
The active ingredients and mechanisms of Longchai Jiangxue Formula in treating PV, based on UPLC/Q-TOF-MS/MS, systematic pharmacology, and molecular biology validation.
Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.
Yak milk-derived exosomes alleviate lipopolysaccharide-induced intestinal inflammation by inhibiting PI3K/AKT/C3 pathway activation.
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
TLR7/8 signalling affects X-sperm motility via the GSK3 α/β-hexokinase pathway for the efficient production of sexed dairy goat embryos.
Helicobacter urease suppresses cytotoxic CD8+ T-cell responses through activating Myh9-dependent induction of PD-L1.
Advanced oxidation protein products impair autophagic flux in macrophage by inducing lysosomal dysfunction via activation of PI3K-Akt-mTOR pathway in Crohn's disease.
[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling.
Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study.
NCX3 alleviates ethanol-induced apoptosis of SK-N-SH cells via the elimination of intracellular calcium ions.
IARS2 regulates proliferation, migration, and angiogenesis of human umbilical vein endothelial cells.
Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect.
Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway.
KLF5-mediated Eppk1 expression promotes cell proliferation in cervical cancer via the p38 signaling pathway.
1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells.
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
LF-rTMS ameliorates social dysfunction of FMR1(-/-) mice via modulating Akt/GSK-3β signaling.
The anti-rotavirus effect of baicalin via the gluconeogenesis-related p-JNK-PDK1-AKT-SIK2 signaling pathway.
Biocompatible Chitin Hydrogel Incorporated with PEDOT Nanoparticles for Peripheral Nerve Repair.
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
The protein kinase D1-mediated inflammatory pathway is involved in olanzapine-induced impairment of skeletal muscle insulin signaling in rats.
SPANXN2 functions a cell migration inhibitor in testicular germ cell tumor cells.
miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism.
Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.
Bta-miR-223 Targeting CBLB Contributes to Resistance to Staphylococcus aureus Mastitis Through the PI3K/AKT/NF-κB Pathway.
PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1R/VEGFR2 Pathway in Papillary Thyroid Carcinoma.
Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling.
Tianma Gouteng Decoction Exerts Cardiovascular Protection by Upregulating OPG and TRAIL in Spontaneously Hypertensive Rats.
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma.
miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway.
Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40.
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
Apatinib suppresses tumor progression and enhances cisplatin sensitivity in esophageal cancer via the Akt/β-catenin pathway.
Effects of Kindlin-2 on proliferation and migration of VSMC and integrinβ1 andβ3 activity via FAK-PI3K signaling pathway.
TiO(2) Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
Insulin-Like Growth Factor-1 Down-Regulates the Phosphorylation of FXYD1 and Rescues Behavioral Deficits in a Mouse Model of Rett Syndrome.
RPL38 Regulates the Proliferation and Apoptosis of Gastric Cancer via miR-374b-5p/VEGF Signal Pathway.
Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-β/Smad3 signaling and promoting angiogenesis.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Rutaecarpine Ameliorates Ethanol-Induced Gastric Mucosal Injury in Mice by Modulating Genes Related to Inflammation, Oxidative Stress and Apoptosis.
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
Facilitating Granule Cell Survival and Maturation in Dentate Gyrus With Baicalin for Antidepressant Therapeutics.
Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling.
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
HPV16 E6/E7 promote the translocation and glucose uptake of GLUT1 by PI3K/AKT pathway via relieving miR-451 inhibitory effect on CAB39 in lung cancer cells.
Metformin activates the STING/IRF3/IFN-β pathway by inhibiting AKT phosphorylation in pancreatic cancer.
Precise and efficient silencing of mutant Kras(G12D) by CRISPR-CasRx controls pancreatic cancer progression.
LRRC4 Suppresses E-Cadherin-Dependent Collective Cell Invasion and Metastasis in Epithelial Ovarian Cancer.
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
Targeting CPT1B as a potential therapeutic strategy in castration-resistant and enzalutamide-resistant prostate cancer.
KLHL22 promotes malignant melanoma growth in vitro and in vivo by activating the PI3K/Akt/mTOR signaling pathway.
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway.
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.
RNA-binding protein CUGBP1 controls the differential INSR splicing in molecular subtypes of breast cancer cells and affects cell aggressiveness.
Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop.
FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis.
Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.
Sphingomyelin Synthase 2 Participate in the Regulation of Sperm Motility and Apoptosis.
Neuronostatin Promotion Soluble Aβ1-42 Oligomers: Induced Dysfunctional Brain Glucose Metabolism in Mice.
Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.
LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene.
Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway.
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Paired like homeodomain 1 and SAM and SH3 domain-containing 1 in the progression and prognosis of head and neck squamous cell carcinoma.
Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors.
Myostatin-1 Inhibits Cell Proliferation by Inhibiting the mTOR Signal Pathway and MRFs, and Activating the Ubiquitin-Proteasomal System in Skeletal Muscle Cells of Japanese Flounder Paralichthys olivaceus.
Phosphatidylinositol 4-kinase β is required for the ciliogenesis of zebrafish otic vesicle.
Bazedoxifene inhibits PDGF-BB induced VSMC phenotypic switch via regulating the autophagy level.
Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway.
Lamin B1 deficiency promotes malignancy and predicts poor prognosis in gastric cancer.
Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma.
Pea-derived peptides, VLP, LLP, VA, and LL, improve insulin resistance in HepG2 cells via activating IRS-1/PI3K/AKT and blocking ROS-mediated p38MAPK signaling.
Hydroquinone inhibits PRV infection in neurons in vitro and in vivo.
The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model.
Establishment and characterization of a docetaxel-resistant human prostate cancer cell line.
SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway.
Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate-induced colitis.
Extracellular ubiquitin protects cardiomyocytes during ischemia/hypoxia by inhibiting mitochondrial apoptosis pathway through CXCR4.
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Arsenic induces hepatic insulin resistance via mtROS-NLRP3 inflammasome pathway.
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Kp-10 promotes bovine mammary epithelial cell proliferation by activating GPR54 and its downstream signaling pathways.
MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
CRISPR/Cas9-Mediated miR-29b Editing as a Treatment of Different Types of Muscle Atrophy in Mice.
MiR-193b-5p inhibits proliferation and enhances radio-sensitivity by downregulating the AKT/mTOR signaling pathway in tongue cancer.
Silencing of DHX32 increases the proliferation of liver cancer cells.
Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes.
Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury.
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Do You Know the Details of Your PAX8 Antibody? Monoclonal PAX8 (MRQ-50) Is Not Expressed in a Series of 45 Medullary Thyroid Carcinomas.
Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats.
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
miR-552 Regulates Liver Tumor-Initiating Cell Expansion and Sorafenib Resistance.
Galectin-1 Overexpression Activates the FAK/PI3K/AKT/mTOR Pathway and Is Correlated with Upper Urinary Urothelial Carcinoma Progression and Survival.
LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway.
Tolfenamic acid inhibits GSK-3β and PP2A mediated tau hyperphosphorylation in Alzheimer's disease models.
lncRNA PVT1 Promotes Tumorigenesis of Colorectal Cancer by Stabilizing miR-16-5p and Interacting with the VEGFA/VEGFR1/AKT Axis.
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro.
TSPO ligand Ro5-4864 modulates microglia/macrophages polarization after subarachnoid hemorrhage in mice.
LAMC2 modulates the acidity of microenvironments to promote invasion and migration of pancreatic cancer cells via regulating AKT-dependent NHE1 activity.
Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway.
Prenatal High-Salt Diet-Induced Metabolic Disorders via Decreasing Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in Adult Male Rat Offspring.
Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.
TGF‑β1 induces CREB1‑mediated miR‑1290 upregulation to antagonize lung fibrosis via Napsin A.
Fluid shear stress induces Runx-2 expression via upregulation of PIEZO1 in MC3T3-E1 cells.
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway.
miR‑96 exerts an oncogenic role in the progression of cervical cancer by targeting CAV‑1.
A novel antitumor dithiocarbamate compound inhibits the EGFR/AKT signaling pathway and induces apoptosis in esophageal cancer cells.
PRR11 and SKA2 promote the proliferation, migration and invasion of esophageal carcinoma cells.
MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.
Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma.
Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.
Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy.
PCNA and GSK3β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis.
Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway.
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.
Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway.
Alisol A-24-acetate promotes glucose uptake via activation of AMPK in C2C12 myotubes.
FAM60A, increased by Helicobacter pylori, promotes proliferation and suppresses apoptosis of gastric cancer cells by targeting the PI3K/AKT pathway.
MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury.
RETRACTED: Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis.
Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.
Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis.
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
Anti-insulin resistance effects of salidroside through mitochondrial quality control.
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
Involvement of neurotrophic signaling in doxorubicin-induced cardiotoxicity.
Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress.
The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice.
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.
Lycium barbarum polysaccharide protects against Homocysteine-induced Vascular smooth muscle cell proliferation and phenotypic transformation via PI3K/Akt pathway.
Heat stress activates YAP/TAZ to induce the heat shock transcriptome.
Zinc application alleviates the adverse renal effects of arsenic stress in a protein quality control way in common carp.
DHPAC, a novel microtubule depolymerizing agent, suppresses angiogenesis and vasculogenic mimicry formation of human non-small cell lung cancer.
Ssc-miR-21-5p regulates endometrial epithelial cell proliferation, apoptosis and migration via the PDCD4/AKT pathway.
Exploration of the Effects of Substrate Stiffness on Biological Responses of Neural Cells and Their Mechanisms.
MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway.
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Transplanting Rac1-silenced bone marrow mesenchymal stem cells promote neurological function recovery in TBI mice.
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.
Liraglutide-loaded PLGA/gelatin electrospun nanofibrous mats promote angiogenesis to accelerate diabetic wound healing via the modulation of miR-29b-3p.
Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer.
NCOA5 is a master regulator of amino acid-induced mTOR activation and β-casein synthesis in bovine mammary epithelial cells.
Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway.
Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21(Waf1) signalling pathway.
MicroRNA‑22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway.
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Suppression of CLEC3A inhibits osteosarcoma cell proliferation and promotes their chemosensitivity through the AKT1/mTOR/HIF1α signaling pathway.
Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1.
Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease.
Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice.
Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs.
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
CAPE-pNO(2) Inhibited the Growth and Metastasis of Triple-Negative Breast Cancer via the EGFR/STAT3/Akt/E-Cadherin Signaling Pathway.
Hsa_circ_001569 is an unfavorable prognostic factor and promotes cell proliferation and metastasis by modulating PI3K-AKT pathway in breast cancer.
A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation.
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway.
Oleic Acid Protects against Hepatic Ischemia and Reperfusion Injury in Mice by Inhibiting AKT/mTOR Pathways.
VEGF Induce Vasculogenic Mimicry of Choroidal Melanoma through the PI3k Signal Pathway.
Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB).
MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway.
CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression.
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways.
Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K/Akt pathway.
ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma.
Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin.
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
A combination of low-dose decitabine and chidamide resulted in synergistic effects on the proliferation and apoptosis of human myeloid leukemia cell lines.
Rutin suppresses FNDC1 expression in bone marrow mesenchymal stem cells to inhibit postmenopausal osteoporosis.
HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells.
Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway.
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Hydroxytyrosol Improves Obesity and Insulin Resistance by Modulating Gut Microbiota in High-Fat Diet-Induced Obese Mice.
The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.
Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt.
RasGRP1 is a target for VEGF to induce angiogenesis and involved in the endothelial-protective effects of metformin under high glucose in HUVECs.
Catalpol ameliorates advanced glycation end product-induced dysfunction of glomerular endothelial cells via regulating nitric oxide synthesis by inducible nitric oxide synthase and endothelial nitric oxide synthase.
Hedyotis diffusa Willd. inhibits VEGF‑C‑mediated lymphangiogenesis in colorectal cancer via multiple signaling pathways.
DEPDC1 drives hepatocellular carcinoma cell proliferation, invasion and angiogenesis by regulating the CCL20/CCR6 signaling pathway.
Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8(+) T cell recruitment.
Hydroxytyrosol prevents PM(2.5)-induced adiposity and insulin resistance by restraining oxidative stress related NF-κB pathway and modulation of gut microbiota in a murine model.
Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia.
Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma.
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
The double inhibition of PDK1 and STAT3-Y705 prevents liver metastasis in colorectal cancer.
MiR-92a regulates endothelial progenitor cells (EPCs) by targeting GDF11 via activate SMAD2/3/FAK/Akt/eNOS pathway.
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells.
TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation.
Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration.
CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK(½)/mTOR signaling pathways in oral squamous cell carcinomas.
The clinical characteristics and molecular mechanism of pituitary adenoma associated with meningioma.
NT3(P75-2) gene-modified bone mesenchymal stem cells improve neurological function recovery in mouse TBI model.
12N-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells.
MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis.
Brain-derived neurotrophic factor induces thioredoxin-1 expression through TrkB/Akt/CREB pathway in SH-SY5Y cells.
Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways.
Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.
Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells.
MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte.
Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN.
Knockdown of endothelin receptor B inhibits the progression of triple-negative breast cancer.
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Taurine protects against arsenic trioxide-induced insulin resistance via ROS-Autophagy pathway in skeletal muscle.
Thyroid hormone (T(3)) is involved in inhibiting the proliferation of newborn calf Sertoli cells via the PI3K/Akt signaling pathway in vitro.
Characterization, functional and signaling elucidation of pigeon (Columba livia) interferon-α: Knockdown p53 negatively modulates antiviral response.
Everolimus Reverses Palbociclib Resistance in ER+ Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase(PI3K)/Akt/Mammalian Target of Rapamycin (mTOR) Pathway.
Involvement of Hepatic SHIP2 and PI3K/Akt Signalling in the Regulation of Plasma Insulin by Xiaoyaosan in Chronic Immobilization-Stressed Rats.
Long noncoding FOXD2-AS1 is activated by CREB1 and promotes cell proliferation and metastasis in glioma by sponging miR-185 through targeting AKT1.
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Testosterone preserves endothelial function through regulation of S1P1/Akt/FOXO3a signalling pathway in the rat corpus cavernosum.
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells.
Low density lipoprotein mimics insulin action on autophagy and glucose uptake in endothelial cells.
Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury.
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Indoxyl sulfate-induced calcification of vascular smooth muscle cells via the PI3K/Akt/NF-κB signaling pathway.
Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model.
PP2Ac upregulates PI3K-Akt signaling and induces hepatocyte apoptosis in liver donor after brain death.
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways.
Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling.
Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K /Akt/mTOR pathway.
Paper/polymer composited microfluidic platform for screening cell viability and protein expression under a chemical gradient environment.
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway.
Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells.
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3β pathway in lung adenocarcinoma.
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Taurine improves low-level inorganic arsenic-induced insulin resistance by activating PPARγ-mTORC2 signalling and inhibiting hepatic autophagy.
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
TMEM30A deficiency in endothelial cells impairs cell proliferation and angiogenesis.
Immunomodulatory effects of an acidic polysaccharide fraction from herbal Gynostemma pentaphyllum tea in RAW264.7 cells.
Protective Effect of Extract of Bletilla Striata on Isoflurane Induced Neuronal Injury By Altering PI3K/Akt Pathway.
A somatic mutation of RasGRP3 decreases Na(+)/I(-) symporter expression in metastases of radioactive iodine-refractory thyroid cancer by stimulating the Akt signaling pathway.
Astragaloside IV Improves Vasodilatation Function by Regulating the PI3K/Akt/eNOS Signaling Pathway in Rat Aorta Endothelial Cells.
The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction.
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Epithelial Cells Attenuate Toll-Like Receptor-Mediated Inflammatory Responses in Monocyte-Derived Macrophage-Like Cells to Mycobacterium tuberculosis by Modulating the PI3K/Akt/mTOR Signaling Pathway.
CD300A inhibits tumor cell growth by downregulating AKT phosphorylation in human glioblastoma multiforme.
BCAT1 promotes proliferation of endometrial cancer cells through reprogrammed BCAA metabolism.
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
GPX3 suppresses tumor migration and invasion via the FAK/AKT pathway in esophageal squamous cell carcinoma.
Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway.
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart.
UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT pathway in N2A cells.
Triptolide protects podocytes via autophagy in immunoglobulin A nephropathy.
miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN.
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway.
ZKSCAN3 promotes breast cancer cell proliferation, migration and invasion.
Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor κB-Matrix Metalloproteinase Signaling.
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase(mTORC2/AKT) to Promote Ca(2+)Production.
PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells in vitro.
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
Soluble epoxide hydrolase inhibition alleviated cognitive impairments via NRG1/ErbB4 signaling after chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis in mice.
Saponins from Boussingaultia gracilis prevent obesity and related metabolic impairments in diet-induced obese mice.
SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
Patulin induced ROS-dependent autophagic cell death in Human Hepatoma G2 cells.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Knockdown of hnRNP A2/B1 inhibits cell proliferation, invasion and cell cycle triggering apoptosis in cervical cancer via PI3K/AKT signaling pathway.
Marine Bacterial Polysaccharide EPS11 Inhibits Cancer Cell Growth via Blocking Cell Adhesion and Stimulating Anoikis.
Increased ZNF84 expression in cervical cancer.
Small interfering RNA-mediated silencing of G-protein-coupled receptor 137 inhibits growth of osteosarcoma cells.
A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy.
Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic reticulum stress and prevents hepatic steatosis in diet-induced obesity mice.
Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression.
Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p.
Thioredoxin-interacting protein deficiency ameliorates diabetic retinal angiogenesis.
UNBS5162 inhibits the proliferation of human A549 non-small-cell lung cancer cells by promoting apoptosis.
Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation.
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus.
UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway.
Pramlintide regulation of extracellular matrix (ECM) and apoptosis through mitochondrial-dependent pathways in human nucleus pulposus cells.
Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy.
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout.
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
Interleukin‑10 promotes proliferation and migration, and inhibits tendon differentiation via the JAK/Stat3 pathway in tendon‑derived stem cells in vitro.
LASP1 promotes glioma cell proliferation and migration and is negatively regulated by miR-377-3p.
4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling.
AAED1 modulates proliferation and glycolysis in gastric cancer.
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells.
Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Lactobacillus rhamnosus GG Affects Microbiota and Suppresses Autophagy in the Intestines of Pigs Challenged with Salmonella Infantis.
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells.
Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1-42)-Induced Rat Model of Alzheimer's Disease.
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells.
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Lithium alleviates neurotoxic prion peptide-induced synaptic damage and neuronal death partially by the upregulation of nuclear target REST and the restoration of Wnt signaling.
Mono-(2-ethylhexyl) phthalate induced ROS-dependent autophagic cell death in human vascular endothelial cells.
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
RasGRP3 controls cell proliferation and migration in papillary thyroid cancer by regulating the Akt-MDM2 pathway.
Maslinic acid inhibits impairment of endothelial functions induced by high glucose in HAEC cells through improving insulin signaling and oxidative stress.
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs.
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways.
miR-29b contributes to multiple types of muscle atrophy.
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis.
Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-κB signaling pathways in RAW264.7 cells.
PTEN/PI3k/AKT Regulates Macrophage Polarization in Emphysematous mice.
Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway.
Down-regulation of islet amyloid polypeptide expression induces death of human annulus fibrosus cells via mitochondrial and death receptor pathways.
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice.
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles.
Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.
MicroRNA-302a enhances 5-fluorouracil-induced cell death in human colon cancer cells.
PRL-3 Is Involved in Estrogen- and IL-6-Induced Migration of Endometrial Stromal Cells From Ectopic Endometrium.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.
TRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway.
miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway.
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.
Scutellaria barbata D. Don inhibits migration and invasion of colorectal cancer cells via suppression of PI3K/AKT and TGF-β/Smad signaling pathways.
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice.
Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway.
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Gx-50 Inhibits Neuroinflammation via α7 nAChR Activation of the JAK2/STAT3 and PI3K/AKT Pathways.
siRNA knockdown validation 101: Incorporating negative controls in antibody research.
Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.
Dexmedetomidine Inhibits Maturation and Function of Human Cord Blood-Derived Dendritic Cells by Interfering with Synthesis and Secretion of IL-12 and IL-23.
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma.
Oral kanglaite injection (KLTI) attenuates the lung cancer-promoting effect of high-fat diet (HFD)-induced obesity.
Thioredoxin-interacting protein regulates lipid metabolism via Akt/mTOR pathway in diabetic kidney disease.
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis.
17β-Estradiol Inhibites Tumor Necrosis Factor-α Induced Apoptosis of Human Nucleus Pulposus Cells via the PI3K/Akt Pathway.
The membrane complement regulatory protein CD59 promotes tumor growth and predicts poor prognosis in breast cancer.
AKT/TSC2/p70S6K signaling pathway is involved in quinocetone-induced death-promoting autophagy in HepG2 cells.
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.
Apelin-13 Protects PC12 Cells from Corticosterone-Induced Apoptosis Through PI3K and ERKs Activation.
Preventive Effects of a Novel Polysaccharide from Sepia esculenta Ink on Ovarian Failure and Its Action Mechanisms in Cyclophosphamide-Treated Mice.
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Dysregulation of Neuregulin-1/ErbB signaling in the prefrontal cortex and hippocampus of rats exposed to chronic unpredictable mild stress.
bFGF Protects Against Blood-Brain Barrier Damage Through Junction Protein Regulation via PI3K-Akt-Rac1 Pathway Following Traumatic Brain Injury.
Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.
miR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis.
Paper-based microreactor array for rapid screening of cell signaling cascades.
CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.
Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice.
Down-regulation of ribosomal protein S15A inhibits proliferation of human glioblastoma cells in vivo and in vitro via AKT pathway.
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth.
TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Inhibitive effects of 15-deoxy-Δ(12),(14)-prostaglandin J2 on hepatoma-cell proliferation through reactive oxygen species-mediated apoptosis.
NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/mTOR phosphorylation.
Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis.
Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway.
Low dose photodynamic-therapy induce immune escape of tumor cells in a HIF-1α dependent manner through PI3K/Akt pathway.
Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas.
Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway.
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Activated estrogen receptor-mitogen-activated protein kinases cross talk confer acquired resistance to lapatinib.
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3.
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways.
Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells.
Quetiapine inhibits osteoclastogenesis and prevents human breast cancer-induced bone loss through suppression of the RANKL-mediated MAPK and NF-κB signaling pathways.
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.
Salidroside stimulates mitochondrial biogenesis and protects against H₂O₂-induced endothelial dysfunction.
11-epi-Sinulariolide acetate reduces cell migration and invasion of human hepatocellular carcinoma by reducing the activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR signaling pathways.
The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF.
Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.
ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21((CIP1/WAF1)) in human cancer cells.
The mechanisms of EGFR in the regulation of axon regeneration.
Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia.
Ubiquitin‑specific protease 22‑induced autophagy is correlated with poor prognosis of pancreatic cancer.
Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition.
MiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGF-VEGFR2 pathway.
Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway.
Effects of PI3K inhibitor NVP-BKM120 on acquired resistance to gefitinib of human lung adenocarcinoma H1975 cells.
Facio-genital dysplasia-5 regulates matrix adhesion and survival of human endothelial cells.
Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma.
Wang X, Tan Y, Wang Y, Li L, Xiang T, Chen Y, Peng W, Qiu Z, Li H, Ren G, Tao Q
International journal of biological sciences 2026;22(3):1480-1495
International journal of biological sciences 2026;22(3):1480-1495
Evaluation of the mechanism underlying melatonin action in cholestatic liver disease treatment via network pharmacology, molecular docking, and in vivo experiments.
Li T, ZhenYu J, Jing W
PloS one 2026;21(2):e0342978
PloS one 2026;21(2):e0342978
Identification of Anti-Inflammatory and Analgesic Mechanisms of Naru-3 Wei Pill Using Animal Models, UHPLC-QE-MS, and Integrated Network Pharmacology.
Han Z, Kang H, Zhang A, Qigeqin, Baolechaolu, Wulanqiqige, Wang H, Xu Y, HaSi, Anda, Xue L
Mediators of inflammation 2026;2026(1):e5579410
Mediators of inflammation 2026;2026(1):e5579410
FGF7-FGFR2 Signaling Enhances Contractile Activation of CAFs in Ovarian Cancer: Integrative Single-Cell and Spatial Transcriptomics.
Feng S, Ding Z, Wang Y, Zhu Z, Zhong W, Zhang K, Zhang Y, Chen L, Ma Y
Journal of inflammation research 2026;19:571158
Journal of inflammation research 2026;19:571158
Mechanisms of Yiqi Huoxue Granule in Atherosclerosis Treatment: Insights from UPLC-Q-Exactive Orbitrap-MS Analysis, Network Pharmacology, Molecular Docking, and Experimental Verification.
Wang X, Liu S, Lei Z, Cao P, Shi W, Gao S, Wu H
Journal of inflammation research 2026;19:566368
Journal of inflammation research 2026;19:566368
AK3 as a Hypoxia-Angiogenesis-Related Prognostic Biomarker and Therapeutic Target in Clear Cell Renal Cell Carcinoma.
Zhou D, Zheng M, Cui D, Guan B, Luo C
International journal of general medicine 2026;19:552108
International journal of general medicine 2026;19:552108
Potential Anti-Cancer Drug 6RK73 Suppresses Ovarian Cancer Growth by Inactivating the AKT1/Sp1 Induced c-Myc Signaling Pathway.
Kuang S, Feng W, He S, Meng W, Yang C, Ning Y
Journal of Cancer 2026;17(2):245-256
Journal of Cancer 2026;17(2):245-256
Multi-omics analysis reveals the mechanism of verbenalin in treating gout via modulating purine metabolism, gut microbiota, and inflammatory pathways.
Xiao Y, Zhang T, Chen Q, Zhang Y, Chen B, Wang M, Zhang Y, Huang M, Su Y, Guo J
Frontiers in immunology 2026;17:1761558
Frontiers in immunology 2026;17:1761558
A berberine-loaded hydrogel for the treatment of atopic dermatitis through antibacterial activity, inhibition of inflammation and modulation of oxidative stress.
Peng Z, Wei XY, Zeng X, Anwaier G, Zhou X, Shi BJ
Frontiers in immunology 2026;17:1740911
Frontiers in immunology 2026;17:1740911
Crocin protects against smoke-induced chronic obstructive pulmonary disease by regulating AKT1.
Zhu Y, Jiang Y, Xu J, Yan S, Ma Z
Frontiers in pharmacology 2026;17:1687752
Frontiers in pharmacology 2026;17:1687752
Novel prognostic signature unveils PSEN1 contributes to depression-induced lung adenocarcinoma progression.
Zheng Q, Zhuoga J, Li C, Chen W, Yalikun M, Fu P, Dong Z, Dong J
Frontiers in immunology 2026;17:1681306
Frontiers in immunology 2026;17:1681306
Microbiota-driven therapeutic efficacy of Hyperoside in ulcerative colitis and associated anxiety.
Yin L, Xu L, Shan YN, He Z, Li Y, Chen W
Frontiers in cellular and infection microbiology 2026;16:1734356
Frontiers in cellular and infection microbiology 2026;16:1734356
Gastrodia elata fermentation alleviates methamphetamine-induced neuroinflammation and anxiety- and depression-like behaviors by regulating the PI3K-AKT signaling pathway.
Liu Y, Yang H, Li H, Zhang S, Yang H, Luo Y, Hu T, Zhang Z, Peng X, Wang Y, Wei S, Xia B, Luo P
Frontiers in medicine 2026;13:1768944
Frontiers in medicine 2026;13:1768944
Synergistic mitochondrial homeostasis regulation and cholinergic circuits reconstruction via a one-step synthesized multifunctional hydrogel facilitates spinal cord injury repair.
Luo Y, Jiang P, Huang D, Li H, He J, Shen R, Jiang Y, Rong L, Liu B
Bioactive materials 2026 May;59:370-395
Bioactive materials 2026 May;59:370-395
Cinnamaldehyde inhibits the progression of gastric cancer by regulating glycolysis through PTP1B/PI3K/AKT/mTOR signaling pathway.
Qiao X, Xue D, Hu Z, Wang H, Mu L
Toxicology and applied pharmacology 2026 May;510:117775
Toxicology and applied pharmacology 2026 May;510:117775
Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3-Mediated Mitophagy.
Huang C, Zhang G, Ma YK, Ma XN, Lv SC
The Kaohsiung journal of medical sciences 2026 May;42(5):e70131
The Kaohsiung journal of medical sciences 2026 May;42(5):e70131
Peroxiredoxin 4 suppresses ferroptosis in esophageal squamous cell carcinoma by activating the phosphoinositide 3-kinase signaling pathway.
Li K, Xu S, Liu H, Fan T, Li Y, Ren R, Xu Y, Li S, Liu Y
Biomedical reports 2026 May;24(5):60
Biomedical reports 2026 May;24(5):60
Luteolin prevents hyperoxaluria-induced renal injury by inhibiting crystal deposition and renal inflammation.
Jin Z, Zhu S, Wang C, Wang T, Liu J, Wu Y
The international journal of biochemistry & cell biology 2026 May;194:106909
The international journal of biochemistry & cell biology 2026 May;194:106909
MFAP2 promotes metastasis and drug resistance by regulating epithelial-to-mesenchymal transition through EGFR signaling pathway in colorectal cancer cells.
He Z, Chen Y, Yang S, Chen C, He Y, Liu S
Genes & diseases 2026 May;13(3):101800
Genes & diseases 2026 May;13(3):101800
Eupalinolide B ameliorates liver fibrosis by targeting PKCα to suppress the AKT/mTOR axis in hepatic stellate cells.
Wang A, Dong H, Cui Y, Xiong Y, Jin L, Zhang Q, Zhu W, Ye J, Lin M, Luo W, Liang G, Sun J
Journal of ethnopharmacology 2026 May 23;363:121421
Journal of ethnopharmacology 2026 May 23;363:121421
Lithocarpus litseifolius leaf extract alleviate hyperuricemia-induced renal injury by regulating uric acid metabolism and inhibiting the AKT/S6K pathway.
Yang W, Gui R, Liu Y, Zou H, Xiao L, Deng G, Wan Z, Yu X, Feng X, Long H, Wang Y, Li D, He X, Xu K
Journal of ethnopharmacology 2026 May 10;362:121362
Journal of ethnopharmacology 2026 May 10;362:121362
Analysis of Reactive Oxygen Species-Induced Cellular Damage in Cervical Cancer.
Chan HCC, Bhoora S, Zhou E, Marais S, Punchoo R
Current protocols 2026 Mar;6(3):e70328
Current protocols 2026 Mar;6(3):e70328
Homoharringtonine inhibits growth and migration in non-small cell lung cancer via PDIA4-mediated modulation of autophagy and EMT.
Ma X, Lei P, Ren B, Xie S, Zhang Y, Wang Y, Ma W
Archives of pharmacal research 2026 Mar;49(3):357-374
Archives of pharmacal research 2026 Mar;49(3):357-374
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.
Wang J, Liu WW, Huang QL, Ning HJ, Wang JY, Han XH
Acta pharmacologica Sinica 2026 Mar;47(3):735-749
Acta pharmacologica Sinica 2026 Mar;47(3):735-749
Galangin 3-methyl ether alleviates mouse hypertrophic cardiomyopathy via targeting HDAC2 and subsequently inactivating the PI3K-AKT signaling pathway.
Zhang K, Xu T, Heng XY, Lei JZ, Han DS, Huang SH, He MQ, Pu L, Wu YY, Sun N, Yang H, Ye C
Acta pharmacologica Sinica 2026 Mar;47(3):636-651
Acta pharmacologica Sinica 2026 Mar;47(3):636-651
Unraveling the Therapeutic Mechanisms of Shanzhen Mingmu Pill in Diabetic Retinopathy: An Integration of Serum Pharmacochemistry, Network Pharmacology, and Experimental Validation.
Yang S, Mo G, Pi X, Xiong T, Cheng L, Meng Y, Hu J, Jiang W, Shi Z
Phytochemical analysis : PCA 2026 Mar;37(2):287-304
Phytochemical analysis : PCA 2026 Mar;37(2):287-304
Isolation, structural characterization and immunoregulatory activity of a novel acidic polysaccharide from Ganoderma sinense.
Zhang M, Wu J, Xu J, Hu X, Shi H, Huang W, Song L, Zhu J, Tan H, Yu R
International journal of biological macromolecules 2026 Mar;352:151196
International journal of biological macromolecules 2026 Mar;352:151196
Insulin-like growth factor 2 alleviates metabolic inflammation and associated cognitive impairment in diet-induced obesity mice.
Liu X, Chen L, Chen Y, Huang Y, Xiao X, Zhong X
Diabetes, obesity & metabolism 2026 Mar;28(3):1800-1816
Diabetes, obesity & metabolism 2026 Mar;28(3):1800-1816
Multiscale analysis of resolvin D1 biosynthesis and its neuroprotective role in intracerebral hemorrhage.
Xiaoyu L, Ziyou Z, Zhenlin L, Zhuang L, Kai S, Siqi W, Tong L, Yunfei L, Weixiu Z, Yifan W, Chun S, Bensi Z
Prostaglandins & other lipid mediators 2026 Mar;183:107063
Prostaglandins & other lipid mediators 2026 Mar;183:107063
Novel Ce/Cu-modified black ceramics disrupted mitochondrial dysfunction and tricarboxylic acid cycle to induce cuproptosis in osteosarcoma cells.
Zhang R, Yin X, Xu Z, Yan Q
Biomaterials advances 2026 Mar;180:214576
Biomaterials advances 2026 Mar;180:214576
A novel proteolysis-targeting chimera strategy targeting multiple immune checkpoints containing ITIMs enhances antitumor immunity.
Qiu YY, Wang ZW, He L, Shi GG, Li ZZ, Ma SX, Yu D, Du HC, Xie F, Zhang C, Zhang YQ, Li M, Li WN
Journal of pharmaceutical analysis 2026 Mar;16(3):101511
Journal of pharmaceutical analysis 2026 Mar;16(3):101511
Transdermal Delivery of Icariin via Microneedle Patches Attenuates Phthalate-Induced Testicular Injury.
Fang C, Li Y, You R, Wong KH, Cai T, Gan RY, Ye Y
Advanced healthcare materials 2026 Mar;15(9):e03925
Advanced healthcare materials 2026 Mar;15(9):e03925
AURKA Activates FOXO3a to Form a Positive Feedback Loop in the Proliferation and Migration of Keloid Fibroblasts.
Chu X, Sun J, Dai S, Liang Y, Qian X, Xu J, Zhang J
Advances in wound care 2026 Mar;15(3):168-180
Advances in wound care 2026 Mar;15(3):168-180
Gut-Metabolome-Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses.
Yang T, Gao Z, Huang H, Zhang C, Tang Y, Qu Q, Li H, Ke J, Chen Z, Feng M, Zhou H, Shu Y, Yuan W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e14269
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e14269
An integrated network pharmacology and proteomics approach reveals the anti-fibrotic effect of Fushen Granule on peritoneal fibrosis.
Yang K, Li J, Wang L, Yu H, Liu X, Gao Z, Wang Z, Zhang L, Yang H
BMC complementary medicine and therapies 2026 Mar 9;26(1)
BMC complementary medicine and therapies 2026 Mar 9;26(1)
A novel triaptosis-related prognostic signature to assess the clinical value in HER2-low breast cancer: evidence from clinical cohorts and experimental validation.
Liu J, Guan X, Dou M, Shi M, Yuan P
Apoptosis : an international journal on programmed cell death 2026 Mar 7;31(3)
Apoptosis : an international journal on programmed cell death 2026 Mar 7;31(3)
Unraveling the Molecular Mechanisms Linking Cigarette Smoke Exposure to Skin Damage.
Tan Z, Wei Y, Zhang S, Song J, Zhu W
International journal of molecular sciences 2026 Mar 4;27(5)
International journal of molecular sciences 2026 Mar 4;27(5)
Stigmasterol upregulates Akt/mTOR/p70S6K signaling through SYVN1 to alleviate osteoporosis in ovariectomized rats.
Zhu F, Li W, Cao Y, Dai B, Wu H, Zhu Y, Liu H
European journal of nutrition 2026 Mar 26;65(3)
European journal of nutrition 2026 Mar 26;65(3)
CBX2 phase-separation contributes to homologous recombination repair and drug resistance in ovarian cancer.
Sun S, Huang L, Ma Y, Wei Z, Zhu M, Chen M, Ying F, Zhou X, Yang P, Wen Y, Yang Q, Cai L, Zhang Y, Cai J
Cell death & disease 2026 Mar 26;17(1)
Cell death & disease 2026 Mar 26;17(1)
TRIM21-Mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma.
Guan B, Tang H, Yuan Z, Yao J, Cui D, Hao Z, Li X
Cellular and molecular life sciences : CMLS 2026 Mar 21;83(1)
Cellular and molecular life sciences : CMLS 2026 Mar 21;83(1)
Ephrin-A4 ligand promotes gastric cancer cell epithelial-mesenchymal transition via the PI3K/AKT signaling pathway.
Huang C, Li M, Hong JJ, Mo SY, Kuang JJ, Li JZ, Huang JA
Discover oncology 2026 Mar 21;17(1)
Discover oncology 2026 Mar 21;17(1)
ITGA5 as a Dual Regulator of Epithelial-Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction.
Wang T, Rao L, Li X, Zhang M, Huang H, Luo Z, Liao G, Jiang Y, Zhan S, Liu Q, Huang X
Cell proliferation 2026 Mar 2;:e70190
Cell proliferation 2026 Mar 2;:e70190
Mycobacterial metallophosphatase MmpE acts as a nucleomodulin to regulate host gene expression and promote intracellular survival.
Chen L, Duan B, Jiang Q, Wang Y, Chen Y, Zhang L, Guo A
eLife 2026 Mar 18;14
eLife 2026 Mar 18;14
AG1295 Attenuates High-Glucose-Induced Proliferation, Migration, Phenotype Transition, and Interleukin-6 Expression in Human Corneal Stromal Fibroblasts.
Zheng Y, Jiang H, Wang J, Zhang Q, Wan Q, Wang Y
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2026 Mar 18;:10807683261433333
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2026 Mar 18;:10807683261433333
Tanshinone IIA-pretreated mesenchymal stem cells alleviate neuroinflammation in 3×Tg-AD mice via the TREM2/PI3K/Akt pathway.
Wu J, Ge Y, Zhang L, Huang J, Huang N, Luo Y
Stem cell research & therapy 2026 Mar 17;17(1)
Stem cell research & therapy 2026 Mar 17;17(1)
The Mechanism of Combined Exposure of Polystyrene Microplastics and Cadmium Inducing Hepatic Injury through the Modulation of PI3K/AKT/mTOR-Mediated Autophagy.
Li S, Zhang Q, Hao Y, Liu X, Li Y, Yan L, Pan G, Sun W
Chemical research in toxicology 2026 Mar 16;39(3):293-304
Chemical research in toxicology 2026 Mar 16;39(3):293-304
tLyP-1 peptide-modified MnO₂ co-delivering si-SLC16A1 and temozolomide synergistically suppresses glioblastoma via hypoxia modulation and metabolic stress.
Zhao H, Meng L, Du P, Chen Y, Gong M, Zan B, Chen J, Zeng M, Liao Y
Journal of nanobiotechnology 2026 Mar 16;
Journal of nanobiotechnology 2026 Mar 16;
Integrating neurotrophic and anti-inflammatory pathways: press-needle acupuncture as a multi-target therapy for adolescent depression.
Zhang H, Rong Y, Ning R, Yan Z, Zhao Y, Chen Y
The International journal of neuroscience 2026 Mar 12;:1-16
The International journal of neuroscience 2026 Mar 12;:1-16
The E3 ubiquitin ligase RNF180 modulates the EGFR/PI3K/AKT pathway to reduce cisplatin resistance in non-small cell lung cancer.
Song X, Jiang W, Wei H, Zhu Y, Shu J, Zhu C, Chen F
Scientific reports 2026 Mar 10;16(1)
Scientific reports 2026 Mar 10;16(1)
Acrylamide exposure induces neurotoxicity via the PI3K/Akt/NF-κB pathway: Evidence from network toxicology and experimental validation.
Duan Z, Yu C, Yu Q, Yang W, Zhang R, Ruan Q, Zhao Y, Yan S
Ecotoxicology and environmental safety 2026 Mar 1;312:119922
Ecotoxicology and environmental safety 2026 Mar 1;312:119922
Androsin alleviates colorectal cancer by inhibiting the PI3K/Akt-centered signaling pathway.
Zhang Y, Luo H, Ma P, Leng Y, Tan Y, Zhuo S, Tan C, Xu D
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2026 Mar 1;30(2):155-168
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2026 Mar 1;30(2):155-168
The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson's disease.
Yue M, Chen T, Chen W, Wei J, Liao B, Zhang J, Li F, Hong D, Fang X
Neural regeneration research 2026 Mar 1;21(3):1211-1221
Neural regeneration research 2026 Mar 1;21(3):1211-1221
Butyrate protects against Klebsiella pneumoniae-induced oxidative stress in alveolar macrophages via p62-Keap1-Nrf2 pathway.
Meng B, Li H, Tang M, Zhu J, Yao R, Xu Y, Zhang Q, Zhu R, Guo Y, Xu Y, Shu Y, Yu L, Li Y, Yang Y, Liu Y, Wu T, Li J
Redox biology 2026 Jun;93:104156
Redox biology 2026 Jun;93:104156
RRP9 suppresses hepatocellular carcinoma progression by inhibiting the PI3K/AKT/mTOR pathway.
Fu Z, Li M, Dong K, Feng J, Wang W
International journal of oncology 2026 Jun;68(6)
International journal of oncology 2026 Jun;68(6)
Integrated fabrication of a shape-adaptable, antioxidative composite stent for effective closure and biological repair of enteroatmospheric fistula.
Qu G, Li Z, Yang S, Huang L, Liu Y, Li S, Liu J, Yu L, Ma R, Teng Y, Li H, Huang J, Ren J, Wu X
Bioactive materials 2026 Jun;60:55-73
Bioactive materials 2026 Jun;60:55-73
Ophiopogonin B inhibits triple-negative breast cancer progression via suppressing PTP1B and regulating the PI3K/Akt pathway.
Cheng Y, Luo X, Lin L, Xu Y, Zhao S
Toxicology and applied pharmacology 2026 Jun;511:117787
Toxicology and applied pharmacology 2026 Jun;511:117787
ACE2 impairs epidermal regeneration by inhibiting TNC expression and PI3K/AKT/mTOR signaling.
Guo Y, Bai R, Liang B, Liu W, Wen Z, Wang Z, Zhang Y, Du J, Song Y, Ma X, Yu Z
Pathology, research and practice 2026 Jun;282:156468
Pathology, research and practice 2026 Jun;282:156468
Resveratrol triggers autophagy-dependent apoptosis via suppressing the PI3K/AKT/mTOR pathway in Chlamydia psittaci-infected cells.
Zeng X, Li Y, Wang X, Luo X, Wang C, Li Z, Bai Q, Chen S, Chen L
Microbial pathogenesis 2026 Jun;215:108442
Microbial pathogenesis 2026 Jun;215:108442
Impatiens shenglanii exerts antithrombotic effects by inhibiting the PI3K/Akt/GSK3B signaling pathway and reprogramming arachidonic acid metabolism.
Wang S, Zhou H, Peng K, Li Y, Luo Z, Sun W, Yang Y, Wu H
Fitoterapia 2026 Jun;191:107200
Fitoterapia 2026 Jun;191:107200
Exploring the potential of heterocyclic-containing tail approach in the development of novel covalent inhibitors dual-targeting EGFR and HER-2: design, synthesis and biological evaluation.
Hao S, Yan JH, Wang R, Ge GH, Si MC, Niu YF, Cai ZH, Zheng WX, Zhao CG, Li X, Cai S, Zhang TJ, Meng FH
Bioorganic & medicinal chemistry 2026 Jun;137:118637
Bioorganic & medicinal chemistry 2026 Jun;137:118637
Therapeutic mechanism of Polygonum multiflorum Thunb. in premature ovarian insufficiency: an integration of network pharmacology, molecular docking, and experimental validation.
Li J, Liu Y, You H, Li S, Lin C, Zhu C
Journal of the science of food and agriculture 2026 Jun;106(8):4666-4677
Journal of the science of food and agriculture 2026 Jun;106(8):4666-4677
Therapeutic mechanism of Changyong Decoction in suppressing colorectal cancer progression and inducing ferroptosis via the PIEZO1-PI3K/AKT signaling axis.
Han M, Shi S, Guan Z, Ma W, Wang X, Jiang H, Man S
Tissue & cell 2026 Jun;100:103379
Tissue & cell 2026 Jun;100:103379
Aconitum septentrionale Koelle extract alleviates cigarette smoke and lipopolysaccharide-induced chronic obstructive pulmonary disease in mice by modulating the MAPK pathway.
Bao F, Wang N, Guo Q, Li J, Zhang W, Song W, Chen X, Ma A, Yi L, Wang M
Journal of ethnopharmacology 2026 Jun 28;365:121389
Journal of ethnopharmacology 2026 Jun 28;365:121389
Investigating the mechanism of Rehmannia glutinosa-Ephedra sinica in heart failure with preserved ejection fraction by network pharmacology, metabolomics and experimental validation.
Cao Y, Li S, Zhang Y, He M, Shen Y
Journal of ethnopharmacology 2026 Jun 12;364:121511
Journal of ethnopharmacology 2026 Jun 12;364:121511
ACOT8-mediated palmitate accumulation promotes M1 macrophage polarization in renal ischemia-reperfusion injury via activation of the cGAS-STING pathway.
Zhang H, Liu X, Ji X, Zhang G, Wang B, Xiong F, Sun D, Wang C
International immunopharmacology 2026 Jun 1;178:116558
International immunopharmacology 2026 Jun 1;178:116558
Downregulation of TDP43 by atovaquone inhibits oxidative phosphorylation and enhances sensitivity of triple-negative breast cancer to EGFR-TKIs.
Lin L, Ke H, Chen M, Zhang Y, Fu S, Yu F, Su J, Yang X, Guo Y, Ding Q, Zhang Y, Zhao L
Free radical biology & medicine 2026 Jul;250:64-79
Free radical biology & medicine 2026 Jul;250:64-79
Design, synthesis, and biological evaluation of selective cytotoxicity-derived Miliusol derivatives inducing profound TNBC regression in vivo.
Cheng X, Chen W, Hao W, Guo Y, Zhang J, Song C, He Z, Wu H, Yao D
Bioorganic & medicinal chemistry 2026 Jul;138:118680
Bioorganic & medicinal chemistry 2026 Jul;138:118680
Discovery of 1H-pyrazolo[3,4-d]pyrimidin-4-ylamine derivatives as potent PI3Kδ/BTK dual-target inhibitors for the treatment of B-cell lymphoma.
Wang Z, Ye Y, Kang Y, Zheng H, Chang X, Xu X, Zhang C, Huang W
Bioorganic & medicinal chemistry 2026 Jul;138:118660
Bioorganic & medicinal chemistry 2026 Jul;138:118660
Characterization of a polysaccharide from Rhodobryum giganteum and its activation effects on TLR4/PI3K-Akt/IκBα pathway.
Geng JM, Zhu PF, Xu LS, Liu JL, Yang ZQ, Yang ZY, Jin Q, Liu L
Carbohydrate polymers 2026 Jul 1;383:125319
Carbohydrate polymers 2026 Jul 1;383:125319
Basement membrane-associated gene P3H2 regulates osteosarcoma progression and epithelial-mesenchymal transition through AKT/mTOR signaling axis.
Pan R, Zhang Y, Wang H, Guan J, Chen Z, Xiao L, Ru N, Zhao J, Cheng Y, Feng S, Zheng X
Translational oncology 2026 Jan;63:102569
Translational oncology 2026 Jan;63:102569
HOMER3 drives oral squamous cell carcinoma progression through TRPV6 calcium influx and TUBB3 microtubule stabilization.
Xu C, Zhang J, Zhang H, Chen L, Zhao J, Yang G, Xiao R, Zhu J, Fan C, Yao Y, Sun S
Oncogene 2026 Jan;45(2):278-294
Oncogene 2026 Jan;45(2):278-294
m6A-Modified BASP1 Regulates IL6 Expression to Induce TAM Infiltration to Promote Gastric Cancer Progression.
Liu G, Liu Y, Zhao H, Sun J, Yang H, Ding Q
Journal of gastroenterology and hepatology 2026 Jan;41(1):189-201
Journal of gastroenterology and hepatology 2026 Jan;41(1):189-201
Oroxin A suppresses non-small cell lung cancer via the HSP90AA1/AKT signaling pathway.
Wang M, Zhang Y, Liu R, Lin J, Wang T, Dong H, Yang J, Li X, Yu D
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(2):2291-2305
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(2):2291-2305
Resveratrol can inhibit porcine reproductive and respiratory syndrome virus infection in vitro and in vivo by inhibiting PI3K/Akt signaling pathway.
Chen Y, Chen W, Song X, Zhao X, Yang L, Zhao R, Song M, Zhang B, Sun D
Veterinary microbiology 2026 Jan;312:110823
Veterinary microbiology 2026 Jan;312:110823
IMPDH2 facilitates CD4+ T cell activation through AKT/mTOR pathway by upregulating SRPK1 in myasthenia gravis.
Ren Y, Wu T, Liu Z, Li L, Li Y, Xin G, Peng S, Niu J, Chen B, Cai H, Tian Q, Wang L, Zhang H
Clinical immunology (Orlando, Fla.) 2026 Jan;282:110634
Clinical immunology (Orlando, Fla.) 2026 Jan;282:110634
Ecdysteroid-enriched fraction of Cyathula officinalis suppresses synovial proliferation and inflammation to ameliorate RA by inhibiting the AKT/PI3K/mTOR signaling pathway.
Huang YH, Qiu L, Peng Y, Cai R, Xiao QQ, Li MC, Xu LJ, Fu Q
Journal of Asian natural products research 2026 Jan;28(1):175-197
Journal of Asian natural products research 2026 Jan;28(1):175-197
Selaginella Tamariscina extract reduces UVA-induced skin photodamage via regulating apoptosis and autophagy by AKT phosphorylation.
Zhao N, Zhou X, Li Z, Liang L, Bao J, Chen X, Shu P, Zhong J
Journal of photochemistry and photobiology. B, Biology 2026 Jan;274:113343
Journal of photochemistry and photobiology. B, Biology 2026 Jan;274:113343
Downregulation of BST2 Rescues Cochlear Nerve Demyelination in Age-Related Hearing Loss via Enhancing Schwann Cell Migration.
Liu M, Li Q, Cao H, Yin H, Yang J, Liu T, Wang J, Zhao L, Wang B
Aging cell 2026 Jan;25(1):e70325
Aging cell 2026 Jan;25(1):e70325
Effects of repetitive transcranial magnetic stimulation on apoptosis and MAPK/PI3K-AKT signaling pathways in rats with spinal cord injury.
Xu Q, Su J, Lei Q, Liu J, Wang J, Yang M, Song J, Chen H, Lu J
Brain research bulletin 2026 Jan;234:111687
Brain research bulletin 2026 Jan;234:111687
Salidroside ameliorates experimental autoimmune neuritis by dually modulating neuroinflammation and immune homeostasis via PI3K/AKT signaling.
Gu T, Wang L, Kang X, Yu C, Shen K, Song M, Gao Y, Wang G, Wang Z
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2026 Jan;23(1):e00769
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2026 Jan;23(1):e00769
CDX2 Promotes Hepatic Specification of hiPSC-derived Endoderm Through the PI3K-Akt-GSK3β Pathway for Improved Therapeutic Efficacy.
Bai F, Duan J, Yang D, Lai X, Ji H, Zhu X, He X, Hu A
Stem cell reviews and reports 2026 Jan;22(1):503-522
Stem cell reviews and reports 2026 Jan;22(1):503-522
Verticinone inhibits cell growth and induces pyroptosis via regulating AKT pathway in papillary thyroid cancer.
Liu X, Liu Y
Molecular immunology 2026 Jan;189:41-52
Molecular immunology 2026 Jan;189:41-52
Isoimperatorin inhibits cell proliferation and induces apoptosis via regulating PI3K/AKT pathway in acute lymphoblastic leukemia.
Xiao J, Wang Y
Molecular immunology 2026 Jan;189:181-191
Molecular immunology 2026 Jan;189:181-191
The Tetradium ruticarpum-Zingiber officinale Roscoe herb pair inhibits atherogenic events: A study of the synergistic effects and active ingredient combination of a two-herb formula.
Chi C, Yang X, Li C, Li Z, Yang S, Du Y, Huang W, Liu R
Fitoterapia 2026 Jan;188:107030
Fitoterapia 2026 Jan;188:107030
Toonasonoids A-K, limonoids from Toona ciliata M. Roem, attenuate inflammatory response through mediating the PI3K/AKT/NF-κB pathway.
Zhao KH, Fang XT, Deng JL, Yue HL, Shi QQ
Fitoterapia 2026 Jan;188:106962
Fitoterapia 2026 Jan;188:106962
Adipose-derived stem cells (ADSCs)-derived DKK1 promotes cutaneous wound healing by inducing M2 macrophage polarization via PI3K/AKT and JNK activation.
Liu D, Liu N, Liu X, Liu Y, Zhang H, Zhou Z, Zheng J, Tian Y
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120077
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120077
A pH-Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury.
Zhang S, Xie Y, Zhang L, Qi Y, Liao Q, Xu C, Yang S, Zhou H, Tan Q, Qi S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e15664
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e15664
NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex.
Kuang S, Liu T, Wei Z, Xu J, Han J, Wang J, Zhai F, Tian Y, Liang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e04316
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e04316
Circ_0005372 targets the miR-153-3p/ITGB3 axis to stimulate the PI3K/AKT signaling pathway to facilitate the occurrence and development of congenital heart disease and pulmonary arterial hypertension in children.
Zhu M, Li G, Li Y, Chen J
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2026 Jan-Feb;80:107768
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2026 Jan-Feb;80:107768
CCT3 Facilitates the Malignant Progression of NSCLC and SCLC via PI3 K/AKT-EMT Axis and Emerges as a Novel Serum Diagnostic Biomarker.
Song G, Han K, Xiang L, Peng T, Chen H, Tang A, Li Y, Lan T, Ying H, Cheng X
Technology in cancer research & treatment 2026 Jan-Dec;25:15330338251412203
Technology in cancer research & treatment 2026 Jan-Dec;25:15330338251412203
HSP90AA1 restrains clear cell renal cell carcinoma progression by promoting CADM1 expression and suppressing the PI3K-AKT pathway through interaction with FBXO7.
Yang W, Li Y, Li Z, Jiang C, Deng X, Peng D
Cell death discovery 2026 Jan 8;12(1):6
Cell death discovery 2026 Jan 8;12(1):6
EIF4A3/circPTGR1/miR-4725-5p positive- feedback loop promotes colorectal cancer progression via FAK/AKT signaling pathway.
Dong Y, Ding YH, Yang X, Song XH, Lei XT, Tang YN, Zhang XE, Huang WC, Zhang K, Chen JS
Molecular cancer 2026 Jan 5;25(1):28
Molecular cancer 2026 Jan 5;25(1):28
Mechanistic insights into myricetin-regulated autophagy via the PI3K/Akt and PINK1/Parkin pathway in diabetic kidney disease treatment.
Liu X, Wang PY, Tang SQ, Zhang ML, Fan XF, Sun SQ, Guo Y, Wu JX, Su ZH, Zheng H
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120613
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120613
PDK4-driven metabolic reprogramming enhances mesothelial cell invasion in colorectal cancer peritoneal metastasis.
Han L, Zhang Q, Wu Y, Luo W, Mo S, Fang H, Li Q, Wang R, Cai G, Dai W
Acta biochimica et biophysica Sinica 2026 Jan 28;58(3):638-648
Acta biochimica et biophysica Sinica 2026 Jan 28;58(3):638-648
Quercetin alleviates LPS-induced inflammatory response in dairy cow lamellar keratinocytes through PI3K/Akt/NF-κB signaling pathway.
Zhai C, Wu Q, Yang X, Xie Y, Mu J, Lei L, Shi M, Wu W, Li G, Ding J
BMC veterinary research 2026 Jan 28;22(1)
BMC veterinary research 2026 Jan 28;22(1)
SULT1E1 exerts a protective role in COPD by inhibiting the AKT pathway: an in vivo and in vitro study.
Song W, Zhang W, Wang F, Pang S, Zhou J, Li X
Scientific reports 2026 Jan 26;16(1):6238
Scientific reports 2026 Jan 26;16(1):6238
Danthron Attenuates Intestinal Inflammation by Modulating Oxidative Stress via the EGFR-PI3K-AKT and Nrf2-HO-1 Pathways.
Ni C, Liu H, Jiang H, Lin Z, Wu K, Wang R, Yang H, Li W, Fan C, Zhao Y
Antioxidants (Basel, Switzerland) 2026 Jan 23;15(2)
Antioxidants (Basel, Switzerland) 2026 Jan 23;15(2)
TRPS1 confers paclitaxel resistance in TNBC through dual activation of the PDE4D-cAMP-AKT pathway and microtubule destabilization.
He X, Tong W, Chen X, Huang H, Wei N, Ma J, Liu Y, Ma Y, Li S, Li W, Li H, Ren H
Breast cancer research : BCR 2026 Jan 20;28(1):47
Breast cancer research : BCR 2026 Jan 20;28(1):47
A Molecular and Functional Investigation of the Anabolic Effect of an Essential Amino Acids' Blend Which Is Active In Vitro in Supporting Muscle Function.
d'Adduzio L, Fanzaga M, Musco MS, Sindaco M, D'Incecco P, Boschin G, Bollati C, Lammi C
Nutrients 2026 Jan 20;18(2)
Nutrients 2026 Jan 20;18(2)
Inhibition of GALNT7 suppresses cell proliferation and invasiveness while elevating cell apoptosis via the inactivation of the AKT pathway in non-small cell lung cancer.
Zhou Y, Shi Y, Zhou J, Zhu X, Wei Z, Zhang Y
BMJ open respiratory research 2026 Jan 20;13(1)
BMJ open respiratory research 2026 Jan 20;13(1)
Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis.
Chen JY, Ji Z, Guo K, Wang HN, Zhu CC, Li T, Zhao XB, Wang YT, Li Q, Jin PS, Li XY
World journal of diabetes 2026 Jan 15;17(1):112942
World journal of diabetes 2026 Jan 15;17(1):112942
ACAT1 inhibitor Avasimibe suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via CKB/PI3K-AKT signaling.
Zhao X, Cai C, Zhang Z, Tang C, Huang X, Zhang Y, Yang S, Qiu H, Wen X, Chu T
International immunopharmacology 2026 Jan 15;169:115973
International immunopharmacology 2026 Jan 15;169:115973
Enhancing the Osseointegration of Titanium Implants by Modulating M1/M2 Macrophage Polarization through PI3K-Akt Signal Pathway on a "Cortex-like" Microarc Oxidation Coating.
Zhang Z, Sui Q, Fu W, Dong X, Liu X, He Y, Zang Y, Wang W, Kou N, Liu H
ACS applied materials & interfaces 2026 Jan 14;18(1):714-731
ACS applied materials & interfaces 2026 Jan 14;18(1):714-731
Microenvironment-targeted strontium delivery system reshapes redox homeostasis to halt degenerative cascades in intervertebral discs.
Cheng H, A C, Shu Z, Zhao H, Wang L, Huang C, Li W, Fang X, Wu H, Bao X, Fang Z
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114449
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114449
Fici hirtae radix alleviates influenza A virus-induced acute lung injury via TLR4-PI3K-AKT/p38 MAPK-NF-κB signaling pathway.
Liang WT, Li JJ, Lv ZR, Chen ZH, Yang YD, Xie TY, Ruan YJ, Tu XP, Zeng FF, Wei Shi, Yang X, Zhang FX
Journal of ethnopharmacology 2026 Jan 10;354:120522
Journal of ethnopharmacology 2026 Jan 10;354:120522
Coptisine mitigates acute lung injury by alleviating ferroptosis through the PI3K/AKT/Nrf2 pathway.
Zhou L, Xu H, Lei X, Yu H, Xia L, Liu X, He J, Lin P, Zhou Y, Chen C, Li Y
Journal of ethnopharmacology 2026 Jan 10;354:120472
Journal of ethnopharmacology 2026 Jan 10;354:120472
Ginsenoside Rb1 mitigates diabetes-induced erectile dysfunction in rats by reducing oxidative stress and modulating the PI3K/AKT/eNOS pathway.
Liu ZH, Chen WB, Li JZ, Wang XS, Liu L, Liu HW, Chen GZ, Pan C, Yuan MZ
Asian journal of andrology 2026 Jan 1;28(1):57-63
Asian journal of andrology 2026 Jan 1;28(1):57-63
Construction and clinical validation of a machine-learning-based consensus prognostic signature (MLPS) for osteosarcoma via multi-cohort data integration.
Chen L, Wu H, Ren R, Zhang Y, Zhu Z, Chen X, Wang L, Gan X, Kang H, Pu H, Xiong W
International immunopharmacology 2026 Jan 1;168(Pt 1):115831
International immunopharmacology 2026 Jan 1;168(Pt 1):115831
Adiponectin attenuates atherosclerosis via macrophage polarization-mediated T Cell exhaustion by modulating the NF-κB p65/PI3K/Akt signaling pathway.
Qin M, Xu S, Chen Y, Luo X, Tang X, Zhang L, Xu Q
Tissue & cell 2026 Feb;98:103150
Tissue & cell 2026 Feb;98:103150
Nitazoxanide reverses pulmonary vascular remodeling in pulmonary hypertension by targeting the IMPA1-RAGE signaling axis.
Wang D, Huang N, Cai M, Huang R, Zhu X, Hu C
Toxicology and applied pharmacology 2026 Feb;507:117657
Toxicology and applied pharmacology 2026 Feb;507:117657
Identification of a Potential Biomarker PDGFRA for Endometriosis Based on Comprehensive Analysis of Multiple Omics Data.
Chen S, Jiang Y, Chai X, Wu X
Reproductive sciences (Thousand Oaks, Calif.) 2026 Feb;33(2):358-371
Reproductive sciences (Thousand Oaks, Calif.) 2026 Feb;33(2):358-371
The role of DNAJC3 in enhancing glioma progression and regulating the tumor immune microenvironment.
Shi Y, Wang W, Liu C, Wu N, Wei X, Wang L, Wang H
The Journal of biological chemistry 2026 Feb;302(2):111059
The Journal of biological chemistry 2026 Feb;302(2):111059
Exocarpium Citri Grandis-Derived Extracellular Vesicle-Like Particles for Accelerating Wound Healing via Regulating the Protein Expression on the VEGF/AKT Signaling Pathway.
Xiong Y, Luo Z, Zhao J, Fu C, Song Y, He J, Gao J, Su Z, Liu L, Teng X, Xu J
Food science & nutrition 2026 Feb;14(2):e71472
Food science & nutrition 2026 Feb;14(2):e71472
DOT1L promotes phenotypic transition of vascular smooth muscle cells following vascular injury in diabetes through activation of the FGFR4/PI3K/AKT/Jag/Notch signaling pathway.
Zhang J, Wu D, Cheng C, Yang Z, Chen Z, Liu L, Li W, Wang W, Huang C, Yang J
Cellular signalling 2026 Feb;138:112223
Cellular signalling 2026 Feb;138:112223
A Unique Chimeric RNA: ERCC1-iASPP Drives Benzo[a]pyrene-Induced Lung Carcinogenesis via Dual Coding and Non-Coding Mechanisms.
Shan M, Xiao M, Zhang L, Wang S, Wu J, Cao K, Li Y, Zhang G, Xie J, Lu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e07217
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e07217
Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance.
Tang J, Ye W, He L, Dan Z, Chang L, You Z, Jiang Y, Tang G, Deng L, Li C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e12424
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e12424
Ursodeoxycholic acid alleviates α-Casein-induced cow's milk protein allergy via the TGR5/NF-κB signaling pathway.
Yu Z, Wang Z, Yue L, Wang Y, Sun B, Wang R, Zhu X, Li L, Zhang W, Li X
Scientific reports 2026 Feb 9;16(1)
Scientific reports 2026 Feb 9;16(1)
Liver-muscle metabolic crosstalk: xanthosine as a key effector of broiler myogenesis.
Chen Y, Ding C, Ren M, Li Z, Liu S, Sun H, Yu S, Niu Q, Li X, Li B, Li L, Yang X, Sun Q
Journal of animal science and biotechnology 2026 Feb 8;17(1):24
Journal of animal science and biotechnology 2026 Feb 8;17(1):24
Neuron-Derived Sema3B Facilitates Microglial Hematoma Clearance After Intracerebral Hemorrhage.
Huang B, Chen A, Zhou T, Xu Y, Sun Y, He Q
Antioxidants (Basel, Switzerland) 2026 Feb 8;15(2)
Antioxidants (Basel, Switzerland) 2026 Feb 8;15(2)
Single-Nucleus RNA Sequencing Reveals SPP1(+) Macrophages Induce Cardiomyocyte Apoptosis to Promote Atrial Fibrillation Susceptibility.
Wang W, Dong Y, Yi H, He L, Jiang Y, Long L, Xia Z, Li J
Journal of cardiovascular development and disease 2026 Feb 5;13(2)
Journal of cardiovascular development and disease 2026 Feb 5;13(2)
C5aR1(+) microglia exacerbate neuroinflammation and cerebral edema in acute brain injury.
Zhou J, Ma S, Feng D, Tian Y, Li L, Guo H, Shi Y, Cui W, Dong J, Hao S, Guo C, Xu M, Han L, Bai H, He D, Cui X, Chen L, Wu X, Gao F, Hu Q, Zhang Z, Wang K, Zhou G, Feng T, Xue D, Lin Q, Wang L, Gao L, Heng L, Zhao T, Luo T, Tian B, Zhang X, Guo W, Li Z, Liu H, Ge S, Liu Q, Qu Y
Neuron 2026 Feb 4;114(3):444-462.e9
Neuron 2026 Feb 4;114(3):444-462.e9
Deciphering the molecular mechanisms underlying of Xin Xue Granule on LPS-induced pyrexia rats: A multi-omics analysis.
Zhang K, Shi Y, Zhang X, Zhai B, Sun J, Guo D, Feng L, Yang X, Luan F, Zou J
Journal of ethnopharmacology 2026 Feb 28;357:120888
Journal of ethnopharmacology 2026 Feb 28;357:120888
Cardiospermum halicacabum Extract Attenuates UVB-Induced Photoaging in Human Skin Fibroblasts via Inhibition of the PI3K/Akt/mTOR Signaling Pathway.
Zhao K, Zhang C, Deng C, Zhu W
International journal of molecular sciences 2026 Feb 28;27(5)
International journal of molecular sciences 2026 Feb 28;27(5)
IGFBP-5/TGF-β1 mediated crosstalk between endothelial and tubular epithelial cells promotes interstitial fibrosis.
Wang S, Song C, Chi K, Fu Z, Zhang X, Geng X, Liu C, Cai G, Chen X, He JC, Hong Q, Wu D
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2026 Feb 27;41(3):531-544
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2026 Feb 27;41(3):531-544
Uncovering the Potential Mechanisms of Ergothioneine in Neuroinflammation Through Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Validation.
Cao D, Jia J, Yin Y, Lu W
International journal of molecular sciences 2026 Feb 26;27(5)
International journal of molecular sciences 2026 Feb 26;27(5)
Analysis of the proliferative role and prognostic value of GPR173 in gastric cancer.
Dai L, Yu K, Chen G, Deng S, He J, Feng Y
World journal of surgical oncology 2026 Feb 23;24(1)
World journal of surgical oncology 2026 Feb 23;24(1)
Exosomes derived from bone marrow mesenchymal stem cells facilitate repair of radiation-Induced skin injury by attenuating inflammation and apoptosis.
Wen Y, Song Y, Pan S, Zhang N, Tong X
Scientific reports 2026 Feb 2;16(1):6918
Scientific reports 2026 Feb 2;16(1):6918
Growth differentiation factor 15 promotes the malignant progression of multiple myeloma via activation of PI3K/Akt/NF-κB signaling pathway.
Fan H, Wu Y, Peng Y, Wang L, Tu S, Peng H, Yang J, Li X, Shi Z, Li M, Song K
Journal of translational medicine 2026 Feb 17;24(1)
Journal of translational medicine 2026 Feb 17;24(1)
Neonatal inflammation induces ventral hippocampal microglial priming via epigenetic regulation of BAG3 to enhance adult depression susceptibility in mice.
Yang Y, Rong J, Zhang Y, Zhu Y, Wang X, Sha S, Yao J, Du J, Zhou R
Brain, behavior, and immunity 2026 Feb 16;135:106494
Brain, behavior, and immunity 2026 Feb 16;135:106494
Elucidating the PTK2-Targeted Anti-Hepatocellular Carcinoma Effects of Euphorbia helioscopia L. via Integrated Network Pharmacology, Mendelian Randomization, and Experimental Validation.
Zhu J, Qian L, Yuan C, Sun J, Pan J, Liu T, Jin Y, Li Y, Zheng L, Liu C, Lu Y
Current issues in molecular biology 2026 Feb 14;48(2)
Current issues in molecular biology 2026 Feb 14;48(2)
Association and Toxic Mechanism Between Foodborne OTA Exposure and Embryonic Development.
Yao T, Zhu X, Ma J, Song G, Hu Y, Yan Y
Journal of applied toxicology : JAT 2026 Feb 12;
Journal of applied toxicology : JAT 2026 Feb 12;
Investigating the Mechanisms of Prunella vulgaris against Acute Lymphoblastic Leukemia through Network Pharmacology and Experimental Validation.
Xu X, Zhou S, Li C, Liu X, Cao X, Wang X, Zhang B
ACS omega 2026 Feb 10;11(5):7756-7768
ACS omega 2026 Feb 10;11(5):7756-7768
Mechanistic insights into PI3K/Akt-MMP9 signaling in Crotonis Fructus-induced reproductive toxicity via integrated network toxicology and multi-model validation.
Mou Q, Zhang Z, Yan X, Zhang Y, Wu W, Peng C, Liu W, Yan M, Tang H, Liang J, Pan X
Toxicon : official journal of the International Society on Toxinology 2026 Feb 1;270:108929
Toxicon : official journal of the International Society on Toxinology 2026 Feb 1;270:108929
Peripheral regional anesthesia alleviates skeletal muscle injury and inflammation caused by acute compartment syndrome by inhibiting PI3K/AKT/NF-kB pathway and regulating macrophage polarization.
Wang T, Cao J, Zhang J, Deng Y, Hou Z, Zhang Q
Cellular signalling 2026 Aug;144:112511
Cellular signalling 2026 Aug;144:112511
Anmei decoction alleviates myocardial injury in sleep-deprived rats by PI3K/Akt/mTOR/HIF-1 pathway.
Xu B, Zhu M, Sun K, Feng QQ, Zhang Z, Xia J, Xie GJ, Liu Y, Chen LL, Wang P
Journal of ethnopharmacology 2026 Aug 10;367:121697
Journal of ethnopharmacology 2026 Aug 10;367:121697
OSBPL3 promotes LUAD metastasis and glycolysis through transcriptional upregulation of PLAU via NFE2L2.
Zhang Q, Zhang J, Li J, Chen S, Liu Y, Li K, Guo M
Translational oncology 2026 Apr;66:102693
Translational oncology 2026 Apr;66:102693
Piperlongumine Inhibits Malignant Progression of Esophageal Squamous Cells Through the PI3K/AKT Signaling Pathway.
Wang J, Chu Y, Hu G, Liang S, Cui Y, Zuo J, Luo Z, Chen X, Wang X, Yu Z, Zhang Z, Wang X
Biochemical genetics 2026 Apr;64(2):2254-2271
Biochemical genetics 2026 Apr;64(2):2254-2271
Transcription factor HOXA4 promotes HBV replication and hepatocellular carcinoma proliferation by activating KIF11 transcription.
Ma J, Liao D
In vitro cellular & developmental biology. Animal 2026 Apr;62(4):546-558
In vitro cellular & developmental biology. Animal 2026 Apr;62(4):546-558
Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells.
Fu W, Lin L, Li J, Qin F, Chen C, Cai Y, Cai Y, Huang Y, Yang W, Zhu S
Oncology reports 2026 Apr;55(4)
Oncology reports 2026 Apr;55(4)
Ginkgetin inhibits non-small cell lung cancer via the HSP90-AKT signaling pathway.
Li R, Gao H, Wang M, Zhang Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Apr;399(7):10815-10830
Naunyn-Schmiedeberg's archives of pharmacology 2026 Apr;399(7):10815-10830
Alendronic acid modified PLGA drug delivery system loaded with 17β-Estradiol and vitamin D3 has anti-osteoporotic effect.
Wang Y, Zhang S, Ma X, Hu D, Liu J, Wei L, Lei X, Hu Y, Li F, Gao Y
Materials today. Bio 2026 Apr;37:102789
Materials today. Bio 2026 Apr;37:102789
The Dual Role of Gastrodin in Spinal Cord Injury: Microglial Phenotype Switching and Neuronal Survival via PI3K/AKT Activation.
Feng J, Gao S, Hu Y, Sheng W
CNS neuroscience & therapeutics 2026 Apr;32(4):e70811
CNS neuroscience & therapeutics 2026 Apr;32(4):e70811
HIF-1α/Netrin-4 Axis Mediates RIPC-Induced Angiogenesis and Neurogenesis After Ischemic Stroke.
Feng Z, Liu Z, Tang S, Pan M, Zhu K, Liu Y, Wang C, Yao R, Wei X, Liu H
Journal of cellular and molecular medicine 2026 Apr;30(7):e71121
Journal of cellular and molecular medicine 2026 Apr;30(7):e71121
Senescence-Driven Remodeling Defines an Aggressive and Immunomodulatory Subtype of Endometriosis.
Liu J, Han W, Tang J, Wan H, Wang H, Peng J, Ma W, Hu M, Hong L
Aging cell 2026 Apr;25(4):e70463
Aging cell 2026 Apr;25(4):e70463
Caffeine Sodium Benzoate-Induced Macrophage M1 Polarization Promotes Endothelial Progenitor Cell Dysfunction by Inducing Mitochondrial Dysfunction Via Targeting let-7a-5p/OPA1 Axis.
Yu T, Yuan Y, Suo F, Guo R, Li W, Wang X, Suriguga, Zhao H, Tian L, Yang H, Yan Q, Feng L
Applied biochemistry and biotechnology 2026 Apr;198(4):2918-2940
Applied biochemistry and biotechnology 2026 Apr;198(4):2918-2940
From computational prediction to in vitro experimental validation: Identifying active compounds in longan leaves and their anti-colorectal cancer mechanisms.
Wei J, Xie Y, Qin J, Ouyang Y, Qin H, Zhou D, Wang H, Wei M, Wu L
Fitoterapia 2026 Apr;190:107178
Fitoterapia 2026 Apr;190:107178
High-throughput screening of EGFR/Ca(2+) signaling modulators in cardiac hypertrophy using a tetrahedral DNA nanostructure-based hESC platform.
Wu KJ, Dai YF, Wang ZQ, Sun W, Zhu YN, Chen F, Shao L, Huang YY, Chen Q, Liu X, Li Y, David Wang HM, Ning Sun
Journal of pharmaceutical analysis 2026 Apr;16(4):101479
Journal of pharmaceutical analysis 2026 Apr;16(4):101479
Ascites circRNA ASCOR Drives Platinum Resistance of High-Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation.
Liu H, Zhu C, Yao X, Liu Y, Zhu J, Li Y, Xu H, Peng C, Shan G, Chen L, Zhou Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e18922
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e18922
Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression.
Guo S, Chen X, Wang H, Zhou J, Lu P, Liu J, Chai K, Zhang J, Yang S, Lu S, Gao Y, Jin Z, Tao X, Hu Z, Li Q, Wu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e07008
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(23):e07008
MiR-93-5p Loaded Lipid Nanoparticles Break the Dry Eye Vicious Cycle via Targeting MAP3K8.
Xu B, Ji X, Li L, Zhu L, Wang L, Kang J, Yang S, Fan T
ACS applied materials & interfaces 2026 Apr 8;18(13):18740-18754
ACS applied materials & interfaces 2026 Apr 8;18(13):18740-18754
Tongnao Decoction Exerts a Treatment Effect on Ischemic Stroke by IL-6/PI3K/Akt/GSK-3β Pathway: Based on the Network Pharmacology and Molecular Docking.
Gan J, Cong Y, Li L, Ma F, Yang X, Deng Y, Liu Y, Wu Y, Jiang H, Chen Z, Li W, Zhu Y, Wu M
Assay and drug development technologies 2026 Apr 7;:1540658X261438876
Assay and drug development technologies 2026 Apr 7;:1540658X261438876
KAT2B inhibits cholangiocarcinoma proliferation by binding with histone demethylase KDM6B.
Qiu R, Xu Z, Meng H, Wang Y, Wu Q, Zeng L, Zhao H, Mao Z, Weng Q, Tu J, Zhao Z, Chen M, Yang Y, Ji J
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 6;1872(6):168242
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 6;1872(6):168242
Multiomics Analysis Reveals the Potential Sleep-Enhancing Peptide from Milk Casein Hydrolysate and Its Synergic Mechanism via Regulating the Key Hub CaMKII Pathway in Chronic Stressed Mice.
Qian J, Huang Z, Zheng L, Zhao M
Journal of agricultural and food chemistry 2026 Apr 29;74(16):12929-12944
Journal of agricultural and food chemistry 2026 Apr 29;74(16):12929-12944
Neudesin modulates IGF1 and insulin signaling pathways by regulating the surface expression of IGF1R through a conserved WPE motif.
Nakayama Y, Nonaka M, Masuda Y, Matsumoto H, Higashi K, Pak Y, Komoda S, Tagawa A, Shimizu R, Mikami T, Nadanaka S, Yamasaki T, Sano K, Mukai T, Kitagawa H, Konishi M
The FEBS journal 2026 Apr 25;
The FEBS journal 2026 Apr 25;
Discovery of FLC-8 as the First Covalent FLT3 Inhibitor Targeting Cys807 for FLT3 Mutant Acute Myeloid Leukemia.
Wang ZX, Jing XL, Liu Q, Xian T, Yang J, Zhang MY, Li QQ, Cai J, Yu YC, Sun SL, Li NG, Shi ZH
Journal of medicinal chemistry 2026 Apr 23;69(8):9635-9663
Journal of medicinal chemistry 2026 Apr 23;69(8):9635-9663
Choline kinase beta promotes psoriasis pathogenesis by regulating sphingolipid metabolism and activating the PI3K/Akt/GSK3β signaling pathway.
Luo M, Gao J, Jiang M, Zhang Y, Long D, Yan Y, Pan Y, Zhou R, Fang H, Wang H
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 23;1872(6):168275
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 23;1872(6):168275
Nerves Stimulate Cross-talk Between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression.
Liao F, Tong Y, Sun H, Chen S, Wen S, Du YE, Jiang L, Huang T, Liu M, Chen W, Yang L
Cancer research 2026 Apr 15;86(8):1968-1986
Cancer research 2026 Apr 15;86(8):1968-1986
A Pathological Microenvironment-Responsive Catalytic Carbon Nanodots Release Platform Intercepting the ROS-Inflammation Cascade to Alleviate Intervertebral Disc Degeneration.
Luo X, Xie J, Yan F, Peng Z, Pan C, Hu Y, Zhang J, Cai C, Yuan J, Li Y, Miao X, He D, Cheng X
Advanced healthcare materials 2026 Apr 14;:e71151
Advanced healthcare materials 2026 Apr 14;:e71151
The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib.
Zhang J, Wang Z, Wei X, Han M, Yan R, Ma L, Pan Y
Current research in pharmacology and drug discovery 2025;8:100212
Current research in pharmacology and drug discovery 2025;8:100212
Wenweishu Granule Plays a Protective Role against Stress-Induced Gastric Ulcers by Inhibiting the PI3K/AKT Signaling Pathway.
Zheng J, Jiao Z, Yang X, Ruan Q, Huang Y, Jin C, Gui S, Xuan Z, Jia X
Biological & pharmaceutical bulletin 2025;48(6):849-859
Biological & pharmaceutical bulletin 2025;48(6):849-859
FR429 from Polygonum capitatum Demonstrates Potential as an Anti-hepatic Injury Agent by Modulating PI3K/Akt Signaling Pathway.
Yang Y, He L, He M, Zhang X, Liao S, Zeng Z, Lin Y, Tu B
Biological & pharmaceutical bulletin 2025;48(4):372-382
Biological & pharmaceutical bulletin 2025;48(4):372-382
OTUB2 promotes proliferation and metastasis of triple-negative breast cancer by deubiquitinating TRAF6.
Qiu YU, Liu R, Huang S, Cai Q, Xie YI, He Z, Tan W, Xie X
Oncology research 2025;33(5):1135-1147
Oncology research 2025;33(5):1135-1147
Ubiquitin C-terminal hydrolase L5 promotes the development of renal cell carcinoma through the glycolysis mediated by the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway.
Ruan L, Li S, Xu L
CytoJournal 2025;22:99
CytoJournal 2025;22:99
BRD7 Inhibited Immune Escape in Nasopharyngeal Carcinoma via Inhibiting PD-L1 Expression.
Guo Y, Lu J, Li X, Yan S, Zhou J, Tian Z, Liu Y, Li N, Zhou Q, Li X, Shi L, Jiang S, Li M, Zhou X, Huang D, Zeng Z, Fan S, Xiong W, Zhou M, Li G, Zhang W
International journal of biological sciences 2025;21(5):1914-1931
International journal of biological sciences 2025;21(5):1914-1931
Astragaloside IV Alleviates H(2)O(2)-Induced Mitochondrial Dysfunction and Inhibits Mitophagy Via PI3K/AKT/mTOR Pathway.
Qi M, Wang Q, Sun R, Cheng Z, Li M, Fan X, Bai F, Yu J
Cardiovascular therapeutics 2025;2025:9549175
Cardiovascular therapeutics 2025;2025:9549175
Methionine Promoted the Growth of Golden Pompano by Activating Intestinal Transport and TOR Signaling Pathway.
Song Z, Zhou Y, Li Y, Chen Z, Liu X, Liu X, Sun Z, Ye C
Aquaculture nutrition 2025;2025:8592097
Aquaculture nutrition 2025;2025:8592097
TRIM6 affects the prognosis of acute myeloid leukemia through the PI3K/AKT signaling pathway and is associated with immune infiltration.
Zhang J, Zhou W, Liu Y, Hu C, Wang S, Xu J, Wei S
PloS one 2025;20(9):e0329560
PloS one 2025;20(9):e0329560
High SRD5A3 expression is correlated with promotion of proliferation and inhibition of apoptosis in B-cell non-Hodgkin lymphoma and suggests a poor prognosis.
Wei S, Sun J, Wen J, Yu J, Xuan Y, Huang J, Yang J, Zhang J
PloS one 2025;20(5):e0323965
PloS one 2025;20(5):e0323965
Exploring the level of metabolic reprogramming and the role of prognostic factor SF3A3 in hepatocellular carcinoma through integrated single-cell landscape analysis.
Wei W, Gan Y, Zhang X, Chen Y, Huang Z, Wang S, Xie X, Li Y, Qin P, Jiang L
PloS one 2025;20(5):e0323559
PloS one 2025;20(5):e0323559
Nitroxyl protects H9C2 cells from H/R-induced damage and inhibits autophagy via PI3K/Akt/mTOR pathway.
Li L, Wang Z, Lyu Y, Guo Y
PloS one 2025;20(1):e0314500
PloS one 2025;20(1):e0314500
ADH5 inhibits proliferation but promotes EMT in non-small cell lung cancer cell through activating Smad2/Smad3.
Tan X, Huang Y, Li X, Xu F, Xu X
Open life sciences 2025;20(1):20251148
Open life sciences 2025;20(1):20251148
Lymph Node Exosomes Delivery Attenuates Myocardial Ischemia-Reperfusion Injury via Regulating PTEN-PI3K/Akt Pathway Mediated Myocardiocyte Apoptosis.
Qiao S, Wu B, Chen L, Ma L, Wang Y, Xu B, Gu R
International journal of nanomedicine 2025;20:4967-4981
International journal of nanomedicine 2025;20:4967-4981
Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases.
Zhou L, Yan M, Luo Q, Qiu W, Guo YR, Guo XQ, Yu HB, Huo JR, Feng YL, Wang DP, Sun T, Wang KF, Shi JY, Shang X, Wu MN, Wang L, Cao JM
Cellular and molecular gastroenterology and hepatology 2025;19(3):101439
Cellular and molecular gastroenterology and hepatology 2025;19(3):101439
Hepatic Stellate Cell TM4SF1 Accelerates Hepatic Fibrosis Progression via Interacting With the Tyrosine Kinase c-Src.
Liu S, Tan P, Chen J, Huang Z, Ren B, Jiang Z, Gu B, Yu W, Sun L, Chen Y, Ruan J, Fu W
Cellular and molecular gastroenterology and hepatology 2025;19(10):101559
Cellular and molecular gastroenterology and hepatology 2025;19(10):101559
RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells.
Zhang Y, Liu H, Wang K, Zheng J, Luan H, Xin M
Drug design, development and therapy 2025;19:67-82
Drug design, development and therapy 2025;19:67-82
Inhibition of Colorectal Cancer by Perillaldehyde Through Targeting SRD5A1 to Induce Autophagy via the PI3K/AKT Pathway.
Leng Z, Zhang Y, Guo M, Chen Y, Wang Z
Drug design, development and therapy 2025;19:6399-6412
Drug design, development and therapy 2025;19:6399-6412
Network Pharmacology, Molecular Docking, and in vitro Experiments Reveal the Role and Mechanism of Tanshinone IIA in Colorectal Cancer Treatment Through the PI3K/AKT Pathway.
Sun J, Qi X, Yang C, Wang S, Jiang J, Wang L, Song J, Yu B, Sun M
Drug design, development and therapy 2025;19:2959-2977
Drug design, development and therapy 2025;19:2959-2977
Mechanism of the Traditional Chinese Medicine Simiao Biejia Decoction Improves the Diabetes Mellitus-Induced Erectile Dysfunction in Rats.
Liu Y, Sun D, Xing D, Rui Y, Jin Y, Wang P, Cai B, Li C, Gao C, Cui Y, Jin B
Drug design, development and therapy 2025;19:2609-2628
Drug design, development and therapy 2025;19:2609-2628
Thyroid Stimulating Hormone May Facilitates Adipose Tissue Insulin Resistance by Inducing M1 Macrophage Polarization.
Fu M, Wang H, Zhang Y, Yang L, Chen Y, Chen X, Wang Z, Sun H
Journal of inflammation research 2025;18:8331-8343
Journal of inflammation research 2025;18:8331-8343
Ethyl Acetate Extract of Elsholtzia bodinieri Vaniot Attenuates Oxidative Stress in ALI Mice.
Yin H, Hu J, Li Y, Feng Y, Li Z, Sun R, Tian L, Li Y
Journal of inflammation research 2025;18:7323-7336
Journal of inflammation research 2025;18:7323-7336
IGFBP1 is One of 10 Metabolic Factors Predicting Recurrence Free Survival in Gastric Cancer and Promotes Cancer Progression via ZFX-IGFBP1 Axis.
Liu H, Huang Y, Fu G, Lei B, Liu K
OncoTargets and therapy 2025;18:717-732
OncoTargets and therapy 2025;18:717-732
MAP17 is a Novel NASH Progression Biomarker Associated with Macrophage Infiltration, Immunotherapy Response, and Oxidative Stress.
Huang Z, Chen J, Liu S, Xiang X, Long Y, Tan P, Fu W
Journal of inflammation research 2025;18:601-619
Journal of inflammation research 2025;18:601-619
Network Pharmacology, Experimental Validation Explored Kakkalide to Ameliorate Endothelial Cell Dysfunction and Inflammatory Response.
Li J, Yang S, Pan J, Qin Y, Ye H, Liao S, Shao Z, Rong G, Xia Z, Sun J, Shao Y
Journal of inflammation research 2025;18:11737-11753
Journal of inflammation research 2025;18:11737-11753
Erianin inhibits endometrial cancer cell proliferation and migration by modulating glutamine metabolism through the ERK signaling pathway.
Huang Q, Xu Y, Li H, Zhang T
American journal of translational research 2025;17(11):8964-8972
American journal of translational research 2025;17(11):8964-8972
Network Pharmacology and Experimental Validation of the Therapeutic Effect of Baji Capsule on LPS-Induced Osteoporosis.
Li Q, Li D, Tian C, Liu X, Wang H, Liu H
Orthopedic research and reviews 2025;17:61-81
Orthopedic research and reviews 2025;17:61-81
Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway.
Huang L, Li Q, Wu J, He Y, Huang J, Xie S, Yang C, Ruan Q, Zhou Z, Deng M
Frontiers in aging neuroscience 2025;17:1568002
Frontiers in aging neuroscience 2025;17:1568002
Xingxiao Pill Suppressed the Progression of Non-Small Cell Lung Cancer by Targeting SREBP1/FASN-Induced Fatty Acid Biosynthesis via PI3K/AKT/mTOR Signaling Pathway.
Zhou X, Hu X, Zhang Z, Lin S, Lin X, Zhou T, Bai Y, Hu K
Cancer management and research 2025;17:1487-1501
Cancer management and research 2025;17:1487-1501
LncRNA HOXB-AS4 Promotes Tumor Malignant Phenotype in Head and Neck Squamous Cell Carcinoma and Serves as a Prognosis Marker.
Lv S, Guo J, Du L, Luo Y, Tian H, Liu Y
Journal of Cancer 2025;16(9):2997-3014
Journal of Cancer 2025;16(9):2997-3014
Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways.
Yuan Q, Jiang H, Zhu M, Chu Y, Zhang Y, Bie J, Li L
Journal of Cancer 2025;16(3):765-783
Journal of Cancer 2025;16(3):765-783
Longikaurin A, a natural ent-kaurane, suppresses proliferation, invasion and tumorigenicity in oral squamous cell carcinoma cell by via inhibiting PI3K/Akt pathway in vitro and in vivo.
Luo Y, Wang Z, Li Y, Zhang L
Journal of Cancer 2025;16(3):708-719
Journal of Cancer 2025;16(3):708-719
Lentinan inhibits melanoma development by regulating the AKT/Nur77/Bcl-2 signaling axis.
Lai X, Chen Y, Huang R, Zhu F, Huang L, Chen N, Li G, Hou W, Pan Y, Alitongbieke G
Journal of Cancer 2025;16(2):543-557
Journal of Cancer 2025;16(2):543-557
NCAPG promotes the malignant progression of endometrioid cancer through LEF1/SEMA7A/PI3K-AKT.
Ren Z, Li X, Fu C
Journal of Cancer 2025;16(2):445-459
Journal of Cancer 2025;16(2):445-459
γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway.
Wei J, Xie J, He Z, Feng X
Frontiers in pharmacology 2025;16:1742401
Frontiers in pharmacology 2025;16:1742401
RARS1 inhibits ENO1 ubiquitination and degradation to protect against ferroptosis in hepatocellular carcinoma.
Zang S, Ma J, Chen L, Cui D, Yu J
Frontiers in immunology 2025;16:1686597
Frontiers in immunology 2025;16:1686597
Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis.
Cheng FE, Zhang Y, Zheng S, Qi W, Zhang X, Li S, Wang Q, Zou X, Li X, Ye Y, Zao X
Frontiers in pharmacology 2025;16:1686535
Frontiers in pharmacology 2025;16:1686535
Unveiling the novel value of TREM1 in the proneural-mesenchymal transition of glioma via tumor-associated macrophages.
Zhang C, Hu B, Wang C, Hou S, Lin N
Frontiers in immunology 2025;16:1662351
Frontiers in immunology 2025;16:1662351
Targeted ferroptosis of myofibroblasts by tubeimoside I attenuates hypertrophic scar formation.
Wang J, Wang C, Jia Y, Chen F, Wang Y, Du J
Frontiers in pharmacology 2025;16:1654108
Frontiers in pharmacology 2025;16:1654108
Identify GDPD3 as a key regulator of epithelial-mesenchymal transition and prostate adenocarcinoma progression via the LPA/LPAR1/AKT axis: transcriptomic and experimental study.
Hao L, Chen X, He T, Wu T, Wen Z, Ji Z, Zheng X, Zheng Q, Zhou Q, He C, Long Q, Sun D
Frontiers in immunology 2025;16:1637325
Frontiers in immunology 2025;16:1637325
MK2-mediated AKT/MYC signaling activation promotes epithelial-mesenchymal transition in lung adenocarcinoma.
Qi R, Fang C, Liu P, Gu W, Shi C, Zhang G, Qiu F
Frontiers in genetics 2025;16:1615018
Frontiers in genetics 2025;16:1615018
Jianpi-Huayu-Jiedu formula improves metabolic dysfunction-associated steatohepatitis through ameliorateing hepatic oxidative stress and lipid accumulation in vivo and in vitro.
Wu X, Chen T, Zhang Z, Wang D, Zhou K, Li J, Xu L, Meng C, Pan H, Huang J, Gao Y, Li S
Frontiers in pharmacology 2025;16:1612726
Frontiers in pharmacology 2025;16:1612726
Shikonin as a therapeutic agent in renal cell carcinoma: insights from TEK-related causal association with glaucoma.
Jia R, Liang Y, Zou B, Li X, Chen T, Zhang C, Bian J, Guo R
Frontiers in pharmacology 2025;16:1580704
Frontiers in pharmacology 2025;16:1580704
Bletilla striata polysaccharide induces autophagy through PI3K/AKT signaling pathway to promote the survival of cross-boundary flap in rats.
Yue Q, Zeng X, Yang M, Chen J, Liu L, Liu H
Frontiers in pharmacology 2025;16:1544932
Frontiers in pharmacology 2025;16:1544932
Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer.
Zhang LT, Zhou Y, Wang T, Chen B, Cai Z, Wang S, Tong G
Frontiers in pharmacology 2025;16:1541820
Frontiers in pharmacology 2025;16:1541820
Yiqi Qingre Gao alleviates renal fibrosis in UUO mice via PI3K/AKT pathway.
Jin Q, Li Q, Yang L, Ma F, Mao H, Wang Y, Liu T, Peng L, Li P, Zhan Y
Frontiers in pharmacology 2025;16:1538061
Frontiers in pharmacology 2025;16:1538061
Therapeutic potential of isochlorogenic acid A from Taraxacum officinale in improving immune response and enhancing the efficacy of PD-1/PD-L1 blockade in triple-negative breast cancer.
Wang T, Sun J, Wang L, Lin Y, Wu Z, Jia Q, Zhang S, An J, Ma X, Wu Q, Su Z, Wang H
Frontiers in immunology 2025;16:1529710
Frontiers in immunology 2025;16:1529710
Harmine derivative B-9-3 inhibits non-small cell lung cancer via the VEGFA/PI3K/AKT pathway.
Wu Y, Wang B, Mao X, Chen W, Akber Aisa H
Frontiers in pharmacology 2025;16:1526952
Frontiers in pharmacology 2025;16:1526952
Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning.
Zhou T, Zhu C, Zhang W, Wu Q, Deng M, Jiang Z, Peng L, Geng H, Tuo Z, Zou C
Frontiers in immunology 2025;16:1511529
Frontiers in immunology 2025;16:1511529
An anti-FAP-scFv-functionalized exosome-carrying hydrogel delivers SKI mRNA to fibrotic nucleus pulposus cells to alleviate intervertebral disc degeneration by regulating FOXO3.
Li Y, Zhai Y, Wang T, Wang S, Tian Y, Bian Z, Zhang Y, Zhang C, Liu M, Li C
Theranostics 2025;15(9):3877-3899
Theranostics 2025;15(9):3877-3899
Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons.
Li J, Zhou Z, Wu Y, Zhao J, Duan H, Peng Y, Wang X, Fan Z, Yin L, Li M, Liu F, Yang Y, Du L, Li J, Zhong H, Hou W, Zhang F, Ma H, Zhang X
Theranostics 2025;15(4):1376-1398
Theranostics 2025;15(4):1376-1398
Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma.
Fu X, Huang J, Chen X, Xie D, Chen H, Liang Z, Wang Z, Liang Y, Lu A, Liang C
Theranostics 2025;15(1):103-121
Theranostics 2025;15(1):103-121
DDX49 as a novel prognostic biomarker regulates colorectal cancer cell proliferation through the TIMM44-PI3K-AKT pathway.
Huang B, Yin Z, Gao G, Li L, Yang M
Frontiers in oncology 2025;15:1707092
Frontiers in oncology 2025;15:1707092
EMP1 regulates cell proliferation, migration and invasion in triple negative breast cancer through PI3K-AKT signaling.
Shu Z, Li Y, Zhu B, Zhou Q, Li N, Shan Z, Zhang M
Frontiers in oncology 2025;15:1701470
Frontiers in oncology 2025;15:1701470
The genetic landscape of primary malignant melanoma of the cervix using integrated bioinformatics analysis and whole-exome sequencing.
Zhou J, Xu T, Chen C, Ping Y
Frontiers in oncology 2025;15:1597153
Frontiers in oncology 2025;15:1597153
Qing-Re-Hua-Shi Decoction ameliorates DSS-induced colitis by modulating multiple signaling pathways and remodeling the gut microbiota and metabolite profile.
Chen W, Xu L, Wang L, Shan YN, Li Y, Zhu JS
Frontiers in cellular and infection microbiology 2025;15:1541289
Frontiers in cellular and infection microbiology 2025;15:1541289
Acetylated Dendrobium huoshanense polysaccharide: a novel inducer of apoptosis in colon cancer cells via Fas-FasL pathway activation and metabolic reprogramming.
Yao L, Gu C, Ge R, Zhang X, Meng X, Wang L, Peng D, Li G
Frontiers in oncology 2025;15:1529868
Frontiers in oncology 2025;15:1529868
Isowighteone attenuates vascular calcification by targeting HSP90AA1-mediated PI3K-Akt pathway and suppressing osteogenic gene expression.
Mo Y, Jin A, Hong W, Peng J, Yang R, Song Q, Liu Y, Cheng Y, Wong WT, Huang Q, Jiang L, Xu Z, Tan N
Frontiers in bioengineering and biotechnology 2025;13:1636883
Frontiers in bioengineering and biotechnology 2025;13:1636883
IL-6 signaling is required for the development and regeneration of ear cartilage in microtia.
Luan W, Fan S, Jiang H, Jiang D, Yang J, He L
Frontiers in cell and developmental biology 2025;13:1625058
Frontiers in cell and developmental biology 2025;13:1625058
Identification of a key environment-responsive gene mediating environmental impact on postmenopausal osteoporosis.
Wan B, Zhou J, Teng Y, Tong Y, Zong S
Frontiers in public health 2025;13:1536851
Frontiers in public health 2025;13:1536851
Matrix stiffness boosts PDAC chemoresistance via SCD1-dependent lipid metabolic reprogramming.
Zhang X, Zhu B, Yan J, Chen X, Wu D, Wang Z, Guan X, Huang Y, Zhao Y, Yang Y, Guo Y
Regenerative biomaterials 2025;12:rbaf056
Regenerative biomaterials 2025;12:rbaf056
Exploration of the Mechanism of Action of Dendrobium officinale in the Treatment of Liver Cancer Based on Network Pharmacology, Molecular Docking and in vitro Validation.
Zhan S, Lu X, Guo H, Liu Y, Li Z, Xu W, Xia F, Tang H, Tian Y, Chen J, Lin X
Journal of hepatocellular carcinoma 2025;12:1973-1990
Journal of hepatocellular carcinoma 2025;12:1973-1990
Vitamin K protects against lipopolysaccharide-induced intestinal inflammation in piglets by inhibiting the MAPK and PI3K-AKT pathways.
Wang H, Ma R, Qi R, Liu Z, Li Y, Wu X, Zhao C, Ma Q, Zhan K
Frontiers in nutrition 2025;12:1704168
Frontiers in nutrition 2025;12:1704168
Dihydromyricetin preserves β-cell function in type 1 diabetes via PI3K/AKT-mediated metabolic reprogramming.
Li J, Li L, Lin T, Huang H, Ren J, Yao J
Frontiers in nutrition 2025;12:1682308
Frontiers in nutrition 2025;12:1682308
Zingiber striolatum phytochemicals ameliorated hyperglycemia symptoms by modulating gut microbial communities in mice with type 2 diabetes mellitus.
Liu T, Ge X, Song L, Wu H, Qian X, Jia B, Zhao C, Zhuang Y
Frontiers in nutrition 2025;12:1537932
Frontiers in nutrition 2025;12:1537932
TUFT1 Modulates Cell Proliferation, Migration, Invasion, Stemness and EGFR Signaling in Cervical Cancer through Interacting with and Targeting ATF1.
Han C, Gao H, Li F, Lin L, Qian M, Feng L
Cell biochemistry and biophysics 2025 Sep;83(3):2881-2894
Cell biochemistry and biophysics 2025 Sep;83(3):2881-2894
Berberine triggers apoptosis through the PI3K/Akt pathways and Nrf2 by inducing ROS in papillary thyroid cancer.
Li J, Zhu Z, Ni J, Ye L, Huang X, Jing D, Lu Y, Yue L
Archives of biochemistry and biophysics 2025 Sep;771:110481
Archives of biochemistry and biophysics 2025 Sep;771:110481
EIF3B‑METTL3 complex promotes cell proliferation, invasion and EGFR/AKT signaling in cervical cancer.
Zhang C, Fan X, Yang J, Zhu P
Oncology reports 2025 Sep;54(3)
Oncology reports 2025 Sep;54(3)
Ginsenoside Rg5 enhances Abemaciclib sensitivity in ER+ breast cancer by modulating cell cycle proteins via transcriptional and post-translational levels.
Chen J, Liao D, Wu C, Liu L, Luo J, Li G, Cao L
Journal of ginseng research 2025 Sep;49(5):594-603
Journal of ginseng research 2025 Sep;49(5):594-603
Insights Into the Mechanism of Action for Qingzhi Decoction for the Treatment of Non-Alcoholic Fatty Liver Disease via Regulation of the IRS/PI3K/Akt Signaling Pathway and the NRLP3 Inflammasome.
Yan J, Hou Q, Liu J, Li W
Biomedical chromatography : BMC 2025 Sep;39(9):e70156
Biomedical chromatography : BMC 2025 Sep;39(9):e70156
Upregulation of has_circ_0008389 promotes esophageal squamous cell carcinoma progression via miR-761 sponging and P2RY2 mRNA stabilization.
Shao Z, Xiao R, Hu B, Wu B, Zheng D, Li N
International journal of biological macromolecules 2025 Sep;323(Pt 1):147099
International journal of biological macromolecules 2025 Sep;323(Pt 1):147099
Resveratrol alleviates lipopolysaccharide-induced acute lung injury through blocking the excessive autophagy/mitophagy via SIRT1/PGC-1α and TNF/NF-κB/JNK pathways.
Li H, Wang X, Deng Y, Liu M, Li W, Wang J, Zeng C, Dai H
International journal of biological macromolecules 2025 Sep;321(Pt 3):146500
International journal of biological macromolecules 2025 Sep;321(Pt 3):146500
Glyphosate targets FYN to regulate glycolysis and promote glioblastoma proliferation: A network toxicology study.
Ma A, Yang Z, He Q, Wang W, Ren H, Zhai C, Lan J
International journal of biological macromolecules 2025 Sep;321(Pt 3):146486
International journal of biological macromolecules 2025 Sep;321(Pt 3):146486
Ovotransferrin ameliorated intestinal barrier dysfunction in DSS-induced ulcerative colitis mice via inhibition of PI3K-Akt/MAPK signaling pathways and modulation of tissue metabolism.
Zheng D, Ma L, Xin X, Gao Y, Dong S, Huang Y, Wu J, Huo J, Li S
International journal of biological macromolecules 2025 Sep;321(Pt 1):146274
International journal of biological macromolecules 2025 Sep;321(Pt 1):146274
20-Acetylsinularolide B (ASB) From Lobophytum crassum Exhibits Anticancer Activity In Vitro Through IGF1R/PI3K/AKT/mTOR Pathway.
Chang Y, Shen S, Zhang L, Zeng J, Sun J, Guo YW, Su MZ
Chemistry & biodiversity 2025 Sep;22(9):e202500114
Chemistry & biodiversity 2025 Sep;22(9):e202500114
Indole-3-propionic acid enhances glycolytic myofiber formation in piglets through PI3K-mTOR activation and gut microbiota-driven tryptophan metabolic alteration.
Kong Y, Wang Q, Wang J, Qiu X, Yang Y, Liu J, Yang F, Qi R
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Sep;22:363-374
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Sep;22:363-374
IAV NS1 carried by exosomes promotes IL-10 production by the PI3K-AKT-GSK3β-CREB pathway.
Huang HM, Yang HH, Qin YC, Luo JY, Jiang ZS, Zhang ZR, Ning LJ, Li L, Wu Y
Microbial pathogenesis 2025 Sep;206:107777
Microbial pathogenesis 2025 Sep;206:107777
MSC-EVs alleviate sepsis-induced acute lung injury through inhibiting NET-triggered damage to adherens junctions of endothelial cells.
Shao Y, Wu D, Miao C, Zhang H
Molecular immunology 2025 Sep;185:6-17
Molecular immunology 2025 Sep;185:6-17
Optimized synthesis of 5N-D and the exploration of its role as a promising anti-aging agent via AKR1B1 inhibition and PI3K/Akt/Nrf2 regulation.
Liu L, Wang C, Chen Z, Yin M, Zhang K, Zhang C, Peng S, Li M, Jiang S, Chen H
Bioorganic chemistry 2025 Sep;164:108886
Bioorganic chemistry 2025 Sep;164:108886
Regulatory role of ATF2 in trophoblast ferroptosis via the PI3K/Akt/Nrf2 pathway in gestational diabetes mellitus.
Xia D, Zhang Y, Zhang C, Wang H
Journal of diabetes investigation 2025 Sep;16(9):1720-1732
Journal of diabetes investigation 2025 Sep;16(9):1720-1732
Irisin/FNDC5 Regulates Endothelial Function to Improve Post-Stroke-Induced Cognitive Dysfunction by Stimulating AMPK-eNOS Signaling.
Guo HH, Liang JJ, Pan RH, Zheng MF, Qiu YX, Jiang SS, Fu XY, Tsang HW, Yau SY, Ou HN
Brain and behavior 2025 Sep;15(9):e70767
Brain and behavior 2025 Sep;15(9):e70767
Ginger-processed Magnoliae Officinalis Cortex ameliorates ovalbumin-induced asthma by alleviating inflammation via the gut-lung axis.
Li J, Hu J, Zhuo D, Yang L, Wang L, Yang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156971
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156971
Integrated metabolomics and network pharmacology reveal the PI3K/Akt-mediated therapeutic mechanism of Abrus cantoniensis in lipid metabolism disorders.
Wang X, Huang M, Lu Y, Li L, Chen W, Wu Q, Huang R, Chen K, Fan L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156953
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156953
Lactate induces oxidative phosphorylation in osteoblasts via Gpr81-Stat3 signaling.
Hu X, Shen J, Wang R, Han C, Shi X, Hu J, Zhang M, Wang P, Zhang X, Wu Y
Cellular signalling 2025 Sep;133:111877
Cellular signalling 2025 Sep;133:111877
Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.
Zhang C, Song Y, Jin X, Xu Q, Ye H, Wu Z, Lin H, Hu J, Huang C, Zhou J, Lian J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e14659
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e14659
Rictor Ameliorates Acute Antibody-Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65-NLRP3 Axis.
Ni B, Yang C, Zhang J, Hang Z, Zheng M, Feng D, Shen Q, Miao J, Sun X, Sun L, Shen B, Gu M, Wang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e17119
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e17119
Exploring the mechanism of action of trastuzumab-induced cardiomyocyte atrophy based on the FN1/PI3K/AKT-mediated mTOR-independent signaling pathway.
Zhu M, Yang Y, Fang H, Chen R
Genomics 2025 Sep;117(5):111087
Genomics 2025 Sep;117(5):111087
Investigation of the anti-inflammatory mechanisms of fermented Chinese herbal residue solution in an APEC-Infected HD11 cell model through the PI3K/AKT and NF-κB pathways.
Huang B, Mo S, He C, Zhu J, Tan Z, Chen L, Wang Y, Ma H
Poultry science 2025 Sep;104(9):105383
Poultry science 2025 Sep;104(9):105383
Investigating the role of 1,8-Cineole in mitigating ferroptosis in a HFSD/STZ diabetes mellitus type 2-induced model: A GEO data analysis approach.
Yang H, Chen Y, Wu G, Ren P, Chen T, Liu J, Zhang B, Ma X, Jiang F, Li Y, Tao L, Shen X
European journal of pharmacology 2025 Sep 5;1002:177846
European journal of pharmacology 2025 Sep 5;1002:177846
Peripheral blood mesenchymal stem cells repair oxidative damage and apoptosis in an H(2)O(2)-induced vitiligo oxidative stress in vitro model via the IL-10-mediated PI3K/AKT pathway.
Yang RL, Yang YB, Wei HX, Zhang M, Yang K, Zhao YJ, Yan W, Yang Y, Zhang T
European journal of medical research 2025 Sep 30;30(1):919
European journal of medical research 2025 Sep 30;30(1):919
Eucommia ulmoides (Duzhong) extract alleviates cerebral stroke by inhibiting ferroptosis-related gene DNA Damage-Inducible Transcript 4 (DDIT4) expression.
Qi X, Deng M, Li M, Ma W, Zhou Y
Human cell 2025 Sep 29;38(6):166
Human cell 2025 Sep 29;38(6):166
Yolk extract-derived vitellogenin 2 ameliorates muscle atrophy in mice via the PI3K/AKT/mTOR pathway.
Li Y, Song P, Wang J, Tong Y, Hao X, Shi H, Ma P, Ji S, Yu X, Yan Y, Lu J, Luo X, Dong Y, Wang H
Food & function 2025 Sep 29;16(19):7663-7677
Food & function 2025 Sep 29;16(19):7663-7677
Mechanisms of Saposhnikovia divaricata in attenuating NaAsO(2)-induced neural injury via the PI3K/AKT pathway.
Gu D, Chen XL, He HL, Xia M, Huang JY, He GH, Wang XY, Chen YY, Kang WR, Sun BF, Liu XH, Zhou W, Zhuo XL, Pan JG
Scientific reports 2025 Sep 26;15(1):33303
Scientific reports 2025 Sep 26;15(1):33303
Cyclic Heptapeptide FZ1 Acts as an Integrin αvβ3 Agonist to Facilitate Diabetic Skin Wound Healing by Enhancing Angiogenesis.
Wang L, Fu Z, Su Y, Yin W, Wang X, Zhao W, Wang J, Li Y, Liu N, Su W, He L, Yin S, Wang Y, Yang X
Journal of medicinal chemistry 2025 Sep 25;68(18):19503-19520
Journal of medicinal chemistry 2025 Sep 25;68(18):19503-19520
Design, Synthesis and Biological Evaluation of 7-(1-Methyl-1H-indole-3-yl)-5H-pyrrolo[2,3-b]pyrazine Derivatives as Novel Covalent pan-FGFR Inhibitors to Overcome Clinical Resistance.
Deng W, Chen X, Yan L, Xiang S, Song X, Zhang L, Li X, Zhu W, Pei J, Lin X, Patterson AV, Smaill JB, Li B, Tu Z, Zhou Y, Chen Y, Lu X
Journal of medicinal chemistry 2025 Sep 25;68(18):19415-19437
Journal of medicinal chemistry 2025 Sep 25;68(18):19415-19437
Protective effects of Dachengqi Decoction in sepsis-associated liver injury based on network pharmacology analysis and experimental validation.
Liu Y, Lei Y, Shang L, Yu Z, Wang L, Zhou J, Pan G
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120450
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120450
Integration of network pharmacology and transcriptomics to reveal the mechanism of Paeoniae Radix Alba Polysaccharide in alleviating hepatic fibrosis.
Fan X, Gao J, Liu S, Hua J, Shao D, Jia L, Shen Y, Wang Z, Jin Z, Wang J
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120357
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120357
Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism.
Sun L, Wang Y, Zhang K, Chen X, Shi H
BMC musculoskeletal disorders 2025 Sep 24;26(1):857
BMC musculoskeletal disorders 2025 Sep 24;26(1):857
CCDC137 knockdown suppresses bladder cancer progression by downregulating SCD.
Zhang H, Huang W, Cai Z, Mou S, Liu Y, Yan B, Jiang W, Liu Y, Mei Q, Liao X, Liu Y, Mei H
Journal of translational medicine 2025 Sep 24;23(1):1013
Journal of translational medicine 2025 Sep 24;23(1):1013
Geniposide Inhibits Oral Squamous Cell Carcinoma by Regulating PI3K-Akt Signaling-Mediated Apoptosis: A Multi-Method Validation Study.
Wang X, Wang J, Hua H, Wei P, Chen X, Peng Y, Liu L, Yu D, You X, Yang S
Current issues in molecular biology 2025 Sep 22;47(9)
Current issues in molecular biology 2025 Sep 22;47(9)
Orthosteric-allosteric dual inhibitors of PI5P4Kγ with potent antitumor activity in non-small cell lung cancer.
Xiong L, Tang 唐磊 L, Zhao W, Wang R, Cheng C, Wang D, Xu Y, Tang 汤磊 L, Fan Y
Journal of advanced research 2025 Sep 22;
Journal of advanced research 2025 Sep 22;
Nanopuerarin Improves Doxorubicin Therapeutic Efficacy by Inhibiting Angiogenesis via Regulating NSUN2 in Hepatocellular Carcinoma.
Feng N, Chang J, Yu H, Li T, Lei L, Huang X, Shi D, Liu R, Zhang W, He X
ACS omega 2025 Sep 2;10(34):38452-38462
ACS omega 2025 Sep 2;10(34):38452-38462
Study on Antitumor Secondary Metabolites from Euphorbia ebracteolata Hayata: Structural Characterization, Network Pharmacology, Molecular Docking and In Vitro.
Xu NW, Yang YH, Ding L, Cai BX, Li MM, Wang JT, Zheng H, Yu Y
ACS omega 2025 Sep 16;10(36):41479-41491
ACS omega 2025 Sep 16;10(36):41479-41491
Dibutyl phthalate promotes COAD cells growth and migration via the TIMP1/PI3K/AKT signaling axis.
Huang Q, Chen X, Ge X, Wang Y, Zhang C, Huang M, Xiao Y, Zhu N, Wang S, Mei Q
Ecotoxicology and environmental safety 2025 Sep 15;303:118931
Ecotoxicology and environmental safety 2025 Sep 15;303:118931
Ginsenoside F4 inhibits colorectal cancer progression by boosting dendritic cell maturation and remodeling the tumor microenvironment.
Xie W, Li XJ, Zhong YS, Fang J, Qi H, Yang M, Ying HZ, Yu CH
World journal of gastrointestinal oncology 2025 Sep 15;17(9):108892
World journal of gastrointestinal oncology 2025 Sep 15;17(9):108892
CCP1 Inhibits Pulmonary Fibrosis by Suppressing Fibrotic Progression Through the EIF4B/PI3K/AKT Pathways.
Ren Q, Pan Y, Tian Z, Jiao G, Liu X
Cell biology international 2025 Oct;49(10):1245-1261
Cell biology international 2025 Oct;49(10):1245-1261
IRGM Inhibits the AKT/mTOR Signaling Pathway by Interacting with TRIM21 to Alleviate Sepsis-Induced Acute Lung Injury.
Guo N, Xia Y, He N, Zhang L, Liu J
Inflammation 2025 Oct;48(5):3282-3299
Inflammation 2025 Oct;48(5):3282-3299
MiRNA-634 promotes apoptosis in HEI-OC1 cells by regulating AK4 and AKT/mTOR signaling pathways.
Wang Y, Liu Y
Hearing research 2025 Oct;466:109386
Hearing research 2025 Oct;466:109386
ESE-1 Regulates CREB-Mediated PTEN Expression to Activate the PI3K/Akt Pathway and Promote High-Glucose-Induced Endothelial Cell Injury.
Liu T, Hu JJ
Current medical science 2025 Oct;45(5):1195-1208
Current medical science 2025 Oct;45(5):1195-1208
Endothelial LRP1 activation mitigates microthrombosis after traumatic brain injury in mice.
Yan R, Wang J, Wu J, Qiu X, Yang L, Yang J, Jiang Y, Peng J
Experimental neurology 2025 Oct;392:115324
Experimental neurology 2025 Oct;392:115324
Synergistic exacerbation of periprosthetic osteolysis by inflammatory bowel disease and titanium ions: Impaired osteogenesis of BMSCs via PI3K/AKT signaling.
Ming P, Li K, Zhu W
Materials today. Bio 2025 Oct;34:102236
Materials today. Bio 2025 Oct;34:102236
ER‑α36 knockdown is associated with lysosomal dysfunction and proliferation inhibition in liver cancer cells.
He H, Wang X, Wei Z, Wang A, Fang X, He H, Wu Z, Shu X, Sun B, Chen Q, Huang X, Zhou H, Liu Y, Fu Z
Molecular medicine reports 2025 Oct;32(4)
Molecular medicine reports 2025 Oct;32(4)
Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice.
Yu C, Cai L, Zhuang L, Wu Y, Wu Q, Liang H, Shi M, Miao J, Song H, Jin H, Pan Y
Free radical biology & medicine 2025 Oct;238:206-219
Free radical biology & medicine 2025 Oct;238:206-219
Research on the Pharmacodynamic Substances and Mechanism of Action of Tibetan Medicine Liuwei Muxiang Powder in the Treatment of Ethanol-Induced Gastric Ulcer Model of GES1 Cell.
Lu H, Zhang T, Liang J, Zeng J, He J, Zhu J, Yuan J, Fu X, Li H, Zhong G
Chemistry & biodiversity 2025 Oct;22(10):e00722
Chemistry & biodiversity 2025 Oct;22(10):e00722
CDDO-Me triggers ROS-dependent ferroptosis and apoptosis in cervical cancer via targeting PI3K/Nrf2 pathway.
Li W, Wang M, Du P, Han A, Feng X, Chen L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115664
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115664
Linarin alleviates high-fat diet-induced NAFLD via modulating the PI3K/Akt/mTOR pathway, autophagy, and gut microbiota.
Lv M, Zhai Y, Yu H, Cheng J, Wei Y, Zhang Y, Zhang Y, Feng H
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Oct;1870(7):159666
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Oct;1870(7):159666
Anti-inflammatory lathyrane diterpenoids from the aerial parts of Euphorbia wallichii.
Ma RF, Zhuang XC, Wu Q, Zhang H
Fitoterapia 2025 Oct;186:106855
Fitoterapia 2025 Oct;186:106855
The Acetic Acid Produced by Lactobacillus Species Regulates Immune Function to Alleviate PEDV Infection in Piglets.
Sun MJ, Xing JH, Yan QS, Zou BS, Wang YJ, Niu TM, Yu T, Huang HB, Zhang D, Zhang SM, Sun WS, Zou RN, Wang CF, Shi CW
Probiotics and antimicrobial proteins 2025 Oct;17(5):2962-2979
Probiotics and antimicrobial proteins 2025 Oct;17(5):2962-2979
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway.
Wang M, Han Q, Zhang X, Dong X, Ran J, Wei F, Luo Y, Sun X
Chinese herbal medicines 2025 Oct;17(4):756-767
Chinese herbal medicines 2025 Oct;17(4):756-767
Exploring the mechanism of Levistolide A in the treatment of lung cancer cells based on network analysis, molecular docking and experimental validation.
Zhao L, Wang J, Han Y, Wang Q, Yang W, Zhang Y, Lin Z, Zhu L, Piao J
Bioorganic chemistry 2025 Oct;165:109002
Bioorganic chemistry 2025 Oct;165:109002
High-Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice.
Son JS, Chae SA, Chun YH, Wang H, Jiang Z, Du M
Journal of cachexia, sarcopenia and muscle 2025 Oct;16(5):e70027
Journal of cachexia, sarcopenia and muscle 2025 Oct;16(5):e70027
Targeting the Phosphoinositide 3-Kinase/Protein Kinase B Pathway Suppresses Y-Box Binding Protein 1 Expression and Inhibits Colorectal Cancer Progression.
Shan H, Wang Y, Hu S, Wang Y, Qin R, Zhang N, Tian G, Qiu Z
World journal of oncology 2025 Oct;16(5):487-501
World journal of oncology 2025 Oct;16(5):487-501
Artificial intelligence combined with affinity chromatography discover that 7-Epitaxol promotes autophagy in NSCLC cells by interacting with EGFR: Discovery of novel EGFR antagonist based on DL and CMC.
Bai H, Wu T, Lv Y, Chen W, Jiang Y, Chen F, Su P, Yu H, He L, Li Z, Han S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157127
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157127
NSUN2-mediated m5C hypermethylation of hsa_circ_0004516 promotes breast cancer brain metastasis by activating AKT signaling.
Li M, Li J, Wen H, Li J, Wang S, Guo J, Zhang D, Zhang A, Cui C, Fu R, An M, Zhang W, Fu B
Non-coding RNA research 2025 Oct;14:177-190
Non-coding RNA research 2025 Oct;14:177-190
Angiotensin (1-7) decreases the fibrotic process by modulating the TGF-β1/AKT pathway in rat corpus cavernosum smooth muscle cells.
Xu Y, Lu Y, Liu G, Wang C, Tian S, Xiao H, Li W
Sexual medicine 2025 Oct;13(5):qfaf080
Sexual medicine 2025 Oct;13(5):qfaf080
Critical role of the β isoform of protein kinase C (PKCβ) in angiotensin II-induced oxidative stress in vascular smooth muscle cells.
Tajima H, Naganishi S, Mukohda M, Ishida M, Hamada N, Shigemi N, Yamasaki T, Nakamura S, Matsui T, Mizuno R, Ozaki H
Physiological reports 2025 Oct;13(20):e70595
Physiological reports 2025 Oct;13(20):e70595
USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF.
Zhang W, Chen L, Zhao J, Ma A, Shi W, Zhang Y, Tang Z, Guo J, Xu Z, Zhou J, Tang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e03106
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e03106
Long Non-Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R-AKT-mTOR Axis and Hepatocellular Carcinoma.
Zhang J, Gao C, Li H, Chen Y, Yang L, Jin Q, Feng L, Wang X, Liu X, Chen H, Ye R, Xue Y, Wang H, Zeng M, Yang M, Ju H, Gao C, Zhou G, Zhang Q, Zhang Q, Qin G, Li Y, Wang Y, Yang A, Si A, Song Q, He F, Cao P, Zhou G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e07676
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e07676
Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long-Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells.
Su Q, Wang J, Song Y, Zhang Z, Cai B, Xiaohalati X, Liu J, Li H, Wang Z, Chang J, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e07241
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e07241
Nanovesicles Synergistically Regulate Ferroptosis Characteristic Macrophage-Induced Angiogenesis via Ferritin Heavy Chain 1/Glutathione Peroxidase 4 Pathway to Promote Peripheral Nerve Regeneration.
Huo N, Xu G, Zhou H, Liu Y, Li S, Yang X, Liu J, Wang W, Yang N, Zhou N
ACS applied materials & interfaces 2025 Oct 8;17(40):55876-55894
ACS applied materials & interfaces 2025 Oct 8;17(40):55876-55894
Non canonical BRCA1 promotes cell survival via modulating PARP13-mediated SEC61G mRNA decay.
Sun B, Li Y, Wu Y, Wang C, Zhu J, Zhang W, Li D, Que W, Chen G
Oncogenesis 2025 Oct 6;14(1):35
Oncogenesis 2025 Oct 6;14(1):35
SIRT3 mediates Tubeimoside I's inhibition on pulmonary artery smooth muscle cell proliferation and oxidative stress in pulmonary arterial hypertension.
Li Y, Zhang Y, Chen Y, Qiao Z, Wang D, Yang Y, Huang W, Yan J
European journal of pharmacology 2025 Oct 5;1004:177938
European journal of pharmacology 2025 Oct 5;1004:177938
Myeloperoxidase inhibits prostate cancer progression, suppresses the PI3K/AKT signaling pathway and reshapes the immune microenvironment.
Zhou M, Liu N, Xie J, Zeng F, Zou S, Ju Y, Xiong X
Translational andrology and urology 2025 Oct 31;14(10):2885-2901
Translational andrology and urology 2025 Oct 31;14(10):2885-2901
SIRT7 drives energy metabolic shifts in endometriosis via interaction with TUFM and Rhoa/Rock/Akt pathway activation.
Zhang H, Chen J, Yang M, Ding X, Chai G, Huang R, Lin D, Huang Z, Chen Q
Cellular and molecular life sciences : CMLS 2025 Oct 30;82(1):381
Cellular and molecular life sciences : CMLS 2025 Oct 30;82(1):381
Natsudaidain alleviates acute lung injury through the PI3K/Akt and P53 signaling pathways by inhibiting MLE-12 apoptosis: a network pharmacology study and experimental validation.
Xia L, Lei X, Zhou L, Liu X, Lin P, Hou T, Xu H, Su S, Yang L, Chen C, Li Y
International immunopharmacology 2025 Oct 30;164:115396
International immunopharmacology 2025 Oct 30;164:115396
Neuronal pentraxin 1 accelerates post-stroke atherosclerosis by inducing endothelial cell senescence.
Wu Y, Luo R, Guan H, Zhang X, Yang X, Wang W, Li Q
International immunopharmacology 2025 Oct 30;164:115363
International immunopharmacology 2025 Oct 30;164:115363
Poliumoside Alleviates Neuroinflammation and Oxidative Stress After Spinal Cord Injury by Activating the PI3K/AKT/mTOR Signaling Pathway.
Li Q, Hong H, Xu G, Xia M, Wang T, Zhou Z, Huang J, Fu Q, Cui Z
Journal of integrative neuroscience 2025 Oct 29;24(10):43900
Journal of integrative neuroscience 2025 Oct 29;24(10):43900
Dietary quercetin supplementation alleviates claw lesions in dairy cows by modulating the PI3K/Akt and NF-κB signaling pathways.
Zhai C, Lin J, Yang X, Mu J, Lei L, Wu W, Zheng Y, Shi M, Ma C, Peng H, Li G, Ding J
BMC veterinary research 2025 Oct 29;21(1):636
BMC veterinary research 2025 Oct 29;21(1):636
Novel magnolol-sulforaphane hybrids as potent antitumor agents: synthesis and biological characterization.
Peng Y, Liu B, Guo Y, Chen J, Chen H, Liu X, Huang J, Luo D, Hong Y, Wu D, Chen Z, Lin X, Tao C
RSC medicinal chemistry 2025 Oct 29;16(12):6380-96
RSC medicinal chemistry 2025 Oct 29;16(12):6380-96
Paeoniflorin inhibits glioblastoma proliferation and promotes autophagy through the AKT/mTOR pathway.
Li H, Ouyang J, Zhang Y, Zhang Z, Sun M, Liu R, Qian C
Scientific reports 2025 Oct 29;15(1):37897
Scientific reports 2025 Oct 29;15(1):37897
Eleutheroside E Ameliorates D-Gal-Induced Senescence in Human Skin Fibroblasts Through PI3K/AKT Signaling.
Ma X, Han L, Xu M, Feng Y, Liu C, Zhao Y, Zhang M, Xu G, Sun X
Current issues in molecular biology 2025 Oct 28;47(11)
Current issues in molecular biology 2025 Oct 28;47(11)
The SP1-SuperEnhancer-SPHK1 Axis Mediates Niraparib Resistance in TNBC.
Yuan YX, Chen RJ, Tu GH, Li CQ, Xu LL, Lu YL, Wu LX
Pharmaceuticals (Basel, Switzerland) 2025 Oct 27;18(11)
Pharmaceuticals (Basel, Switzerland) 2025 Oct 27;18(11)
Endoplasmic reticulum-resident protein DNAJC10 inhibits glioblastoma metastasis by suppressing XBP-1s-driven EGFR transcription.
Zhao E, Yu Y, Gao Y, Li T, Hao S, Chen M, Xu M, Arjun S, Yang C, Yin Y, Li M
Molecular biomedicine 2025 Oct 24;6(1):84
Molecular biomedicine 2025 Oct 24;6(1):84
[Pinostrobin targets the PI3K/AKT/CCL(2) axis in intestinal epithelial cells to inhibit intestinal macrophage infiltration and alleviate dextran sulfate sodium-induced colitis in mice].
Zhang K, Qiao T, Yin L, Huang J, Geng Z, Zuo L, Hu J, Li J
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Oct 20;45(10):2199-2209
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Oct 20;45(10):2199-2209
Novel E-F ring derivatives of aconitine scaffold as potent Hsp90 inhibitors for the treatment of colorectal cancer.
Zhang Y, Wang YP, Guo S, Li TT, Wang QY, Zhang X, Zheng YM, Wen YQ, Meng FH, Zhang TJ
European journal of medicinal chemistry 2025 Oct 15;296:117895
European journal of medicinal chemistry 2025 Oct 15;296:117895
Pregnane X receptor (PXR) as a prognostic marker and therapeutic target in kidney renal clear cell carcinoma (KIRC) via AMPK pathway regulation.
Hu WJ, Liu M, Bao YN, Su BW, Sui X, Cui XH, Wang GY, Wen L, Wen RK, Wang WH, Yang HX, Luan ZL
Scientific reports 2025 Oct 14;15(1):35808
Scientific reports 2025 Oct 14;15(1):35808
Silibinin accelerates diabetic wound healing through PI3K/Akt-mediated immunomodulation-angiogenesis crosstalk.
Zhou H, Qiao J, Su H, Guo J, He Z, Ma X, Qin Y, Zhang X
Biochemical and biophysical research communications 2025 Oct 10;784:152649
Biochemical and biophysical research communications 2025 Oct 10;784:152649
Salvigenin inhibits gastric cancer progression by suppressing the EGFR/PI3K/AKT pathway.
Qiao K, Yang Z, Fang Y, Fang C
Biochemical and biophysical research communications 2025 Oct 10;784:152645
Biochemical and biophysical research communications 2025 Oct 10;784:152645
Mechanism of silica nanoparticles induced pulmonary epithelial-mesenchymal transition mediated by exosomal HNRNPAB.
Zhao X, Pan Y, Yan G, Yu Y, Song Y
Ecotoxicology and environmental safety 2025 Oct 1;304:119162
Ecotoxicology and environmental safety 2025 Oct 1;304:119162
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
Zou X, Li S, Huang S, Niu R, Liu G, Wang Z
International journal of oncology 2025 Nov;67(5)
International journal of oncology 2025 Nov;67(5)
Metformin carbon dots-based osteogenic and protein delivery system to promote bone regeneration in periodontitis.
Wei J, Wang K, Li Y, Huang J, Deng P, Xia X, Yang C, Xu L, Xu J
Bioactive materials 2025 Nov;53:459-479
Bioactive materials 2025 Nov;53:459-479
Prolactin impairs erectile function via eNOS suppression independently of testosterone.
Cheng X, Xiao Y, Qiu D, Li L, Peng Q, Liu Y, Tian Y, Zhou E, Zhou H
Toxicology and applied pharmacology 2025 Nov;504:117532
Toxicology and applied pharmacology 2025 Nov;504:117532
NPB-1575 attenuates neuroinflammation and resists ferroptosis in rat ischemic stroke via IRS2 signaling pathway.
Li XN, Shang NY, Liu MY, Sui SY, Tang JS, Lan JQ, Kang YY, Zhang BD, Wen ZP, Feng XH, Wu L, Dai JG, Peng Y
Acta pharmacologica Sinica 2025 Nov;46(11):2893-2907
Acta pharmacologica Sinica 2025 Nov;46(11):2893-2907
Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2/STAT3 and PI3K/AKT Pathways.
Zhang Q, Yang Z, Ou X, Zhang M, Ji R, Wu G
Phytotherapy research : PTR 2025 Nov;39(11):5174-5197
Phytotherapy research : PTR 2025 Nov;39(11):5174-5197
Study on the anticancer mechanism of hydroxygenkwanin in esophageal cancer via the ESRRA signaling pathway.
Wang Y, Xin Wan L, Zhang Y, Jia Q, Li C, Cui X
Cancer genetics 2025 Nov;298-299:180-192
Cancer genetics 2025 Nov;298-299:180-192
Reynoutrin targets EphB4 to ameliorate hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus.
Lyu D, Xiao H, Shao Z, Li S, Li M, Pan L, Li Z, Huang H
Biochemical pharmacology 2025 Nov;241:117132
Biochemical pharmacology 2025 Nov;241:117132
Olaparib synergy screen reveals Exemestane induces replication stress in triple-negative breast cancer.
Yusoh NA, Su L, Chia SL, Tian X, Ahmad H, Gill MR
Molecular oncology 2025 Nov;19(11):3387-3408
Molecular oncology 2025 Nov;19(11):3387-3408
Age-Dependent Amino Acid Metabolism.
You C, Long X, Wei H, Lu Y, Guo X, Wang S, Sun Z
The Journal of nutrition 2025 Nov;155(11):3791-3808
The Journal of nutrition 2025 Nov;155(11):3791-3808
Dendrobin A inhibits gastric cancer: Mechanistic insights supported by integrated evidence.
Fan Y, Chen Y, Lu W, Shi K, Zhao Y, Zhang C, Shen Z, Zheng S, Jie W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157215
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157215
N-glycosylation stabilized TNFAIP6 promotes ovarian cancer metastasis by activating the PI3K-AKT signaling pathway.
Liu X, Ji D, Wen Z, Tang Q, Chen Y
Cellular signalling 2025 Nov;135:112013
Cellular signalling 2025 Nov;135:112013
PDCD4 exacerbates myocardial ischemia-reperfusion injury via AKT-mediated apoptosis.
Zhang Z, Yang Z, Ge H, Liu C, Fan R, Yuan C, You S, Hong C
Cellular signalling 2025 Nov;135:111999
Cellular signalling 2025 Nov;135:111999
GCN2 promotes fatty acid metabolism through the activation of PI3K/AKT signaling in gastric cancer.
Sun D, Sun X, Wang X, Zhang J, Liu L, Xie J
Cellular signalling 2025 Nov;135:111984
Cellular signalling 2025 Nov;135:111984
EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy.
Wang D, Liu Y, Chen Y, Dai C, Hu W, Han J, Li Z, Yin F, Zhang Y, Shi C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e10197
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e10197
DHCR7 Promotes Liver Metastasis of Pancreatic Cancer Through PI3K-Akt Signaling Pathway.
Xie Y, Zhou Z, Song J, Wang C, Ding Y, Qiu Y, Fang L, Cheng H
Cancer science 2025 Nov;116(11):3196-3208
Cancer science 2025 Nov;116(11):3196-3208
7,8-dihydroxyflavone attenuates NIH IIIA subtype chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) via TrkB/AKT/SIRT3 signaling activation.
Li W, Zhao P, Shen C, Song Y, Shen B, He Y, Jin J, He Z, Gao J
Translational andrology and urology 2025 Nov 30;14(11):3613-3626
Translational andrology and urology 2025 Nov 30;14(11):3613-3626
Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway.
Li Z, Zhao M, Ma S, Lei S
European journal of medical research 2025 Nov 27;30(1):1292
European journal of medical research 2025 Nov 27;30(1):1292
Panax notoginseng saponins suppress the PI3K/AKT pathway to enhance autophagy and apoptosis in pulmonary fibrosis.
Hou J, Li L, Sun CB, Li TG, Zhang SQ, Liang PT, Jin YL, Yuan JL, Li L, Yan JY, Fu Y, Yang ZS
Scientific reports 2025 Nov 27;15(1):43622
Scientific reports 2025 Nov 27;15(1):43622
KAL suppresses cholangiocarcinoma growth via downregulating miR-21 and modulating the PTEN/AKT signaling pathway.
Huang J, Chi Z, Lin X, Yan L
Scientific reports 2025 Nov 25;15(1):45326
Scientific reports 2025 Nov 25;15(1):45326
Exploring the effect and mechanism of baicalin on sepsis-induced acute lung injury based on network pharmacology and experimental verification.
Wang P, Zhang R, Liu M, Gao J, Zhang Y, Liu X, Li C, Zhao Y, Zhu T, Zhao X, Deng Z
Scientific reports 2025 Nov 25;15(1):41959
Scientific reports 2025 Nov 25;15(1):41959
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Bian WH, Wang SH, Kang ZC, Xu Y, Li YN, Yang MZ, Yang JH, Liu JY, Cheng YL, Chang D, Xie X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Silencing Clusterin Could Attenuate the Cell Properties of HCV Core Protein-Expressing HCC Cell Line.
Han F, Cui C, Cui J, Zang S, Zhao Z, Ren W, Zhang Q, Liu L, Dong S, Fu N, Nan Y
Digestive diseases and sciences 2025 Nov 25;
Digestive diseases and sciences 2025 Nov 25;
The TRPV4-YAP axis mediates cytoskeletal and extracellular matrix remodeling in trabecular meshwork cells as a novel glaucoma mechanism.
Xu J, Liu K, Wang F, Su Y
Scientific reports 2025 Nov 24;15(1):41644
Scientific reports 2025 Nov 24;15(1):41644
Diosgenin activates ERα-dependent PI3K/AKT/GSK3β signaling to enhance brain-derived serotonin and alleviate postmenopausal bone loss.
Chen X, Zhang M, Qian L, Guo Y, Zhu Y, Taxi W, Liu M, Wang K, Song L, Zhang C, Zhang Y, Wang L, Ma Y, Hu Y
Journal of advanced research 2025 Nov 24;
Journal of advanced research 2025 Nov 24;
LRP12 promotes gastric cancer progression through AKT/mTOR signaling and M2 macrophage-mediated immunosuppression.
Wang Y, Yin X, Wang M, Zhu M, Xue Y
Scientific reports 2025 Nov 23;15(1):45183
Scientific reports 2025 Nov 23;15(1):45183
Dual Mechanisms of Cognitive Function and Pathological Improvements by the Selective S1PR1/5 Modulator Siponimod in 3xTg-AD Mice.
Tang C, Ding Y, Yang S, Lei X, Zhang M, Xu B, He D
Molecular neurobiology 2025 Nov 22;63(1):133
Molecular neurobiology 2025 Nov 22;63(1):133
Network pharmacology, molecular docking, and experimental validation-based approach to explore the mechanism of action of ginsenoside Rh4 on acute myeloid leukemia cells.
Zhang X, Sun P, Liang X, Shen Y, Lin J, Guo JK, Chang F
Medical oncology (Northwood, London, England) 2025 Nov 20;43(1):8
Medical oncology (Northwood, London, England) 2025 Nov 20;43(1):8
Integrative Transcriptomic and Metabolomic Analysis Reveals That Acanthopanax senticosus Fruit Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing the NF-κB/PI3K-AKT Pathway via UGT1A1 Regulation.
Han L, Tang Z, Ma X, Zhang Q, Han Y, Wang Q, Liu J, Bian X, Gao L, Xu M, Sun X
International journal of molecular sciences 2025 Nov 18;26(22)
International journal of molecular sciences 2025 Nov 18;26(22)
IRF1 regulates apoptosis and osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates osteoporosis by activating the PI3K/AKT signaling pathway.
Hu M, Wei E, Wu L, Pan X, Zhu Q, Xv X, Dong X, Wu W, Liu H, Liu Y
Journal of advanced research 2025 Nov 16;
Journal of advanced research 2025 Nov 16;
Structure-guided expansion strategy unveils potent allosteric SHP2 inhibitors with synergistic efficacy against AML through MCL-1 co-targeting.
Zhang M, Wu S, Liu M, Li H, Wang L, Duan F, Han R, Shan C, Jiang Z, Liao J, Zhang Y, Li W, Wang B
European journal of medicinal chemistry 2025 Nov 15;298:117988
European journal of medicinal chemistry 2025 Nov 15;298:117988
TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice.
Yang H, Shen T, Qi Z, Yang Z, Zhang M, Jiang J, Sun Z, Lu C
Neuropharmacology 2025 Nov 15;279:110638
Neuropharmacology 2025 Nov 15;279:110638
Mongolian medicine Qiqirigan-8 inhibition of PI3K/AKT/mTOR signaling pathway activation to ameliorate non-alcoholic Steatohepatitis.
Yang D, Namila, Hashentuya, Tana, Wuyunsiqin, Zhao W, Menggenduxi, Wang M
Journal of pharmaceutical and biomedical analysis 2025 Nov 15;265:116975
Journal of pharmaceutical and biomedical analysis 2025 Nov 15;265:116975
RNF180 suppressed aggressiveness by degrading NOTCH1, TRIM24 and FOXC1, and chemoresistance by degrading ACC1 and ACLY in colorectal cancer.
Li N, Zhang R, Zhao XX, Zhou L, Li YL, Cui ZG, Zheng HC
International immunopharmacology 2025 Nov 14;165:115445
International immunopharmacology 2025 Nov 14;165:115445
GABA treatment promoting cell apoptosis in meningioma correlates with EGFR/BCL-2/BAX axis.
Yang X, Wang L, Wu H, Li C, Zhang L
Journal of neuro-oncology 2025 Nov 11;176(1):78
Journal of neuro-oncology 2025 Nov 11;176(1):78
Folate Attenuates Ulcerative Colitis via PI3K/AKT/NF-κB/MLCK Axis Inhibition to Restore Intestinal Barrier Integrity.
Zhang S, Cheng T, Chen Y, Wang M, Wang G, Aa J
Biology 2025 Nov 10;14(11)
Biology 2025 Nov 10;14(11)
A kinase-independent Bcr-Abl function mediating an Hsp70-Bim protein-protein interaction in chronic myeloid leukemia.
Zhang H, Song T, Song Y, Hu Z, Soliman MES, Jiang M, Yin F, Yang Z, Wang Z, Zhang Z
International journal of biological macromolecules 2025 May;310(Pt 3):143249
International journal of biological macromolecules 2025 May;310(Pt 3):143249
Investigating the molecular mechanism of purslane‑based vitiligo treatment using network pharmacology, molecular docking and in vitro analyses.
Zhang X, Meng L, Ran X, Li S, Wen C
Molecular medicine reports 2025 May;31(5)
Molecular medicine reports 2025 May;31(5)
Lactoferrin ameliorates cognitive impairment in D-galactose-induced aging mice by regulating the PI3K/Akt/mTOR signaling pathway and the microbiome-gut-brain axis.
Wang M, Wang Y, Wang X, Qiu Y, Li C, Li H, Li H, Yu J
International journal of biological macromolecules 2025 May;309(Pt 4):143033
International journal of biological macromolecules 2025 May;309(Pt 4):143033
The important role of TLR2/MyD88/JNK in regulating the pathogenesis and inflammation induced by pseudorabies virus in mice.
Niu J, Li G, Liu Y, Wan C, Li Y, Dai Y, Hu H, Peng L, Fang R, Ye C
Veterinary microbiology 2025 May;304:110496
Veterinary microbiology 2025 May;304:110496
Claudin-9 (CLDN9) promotes gastric cancer progression by enhancing the glycolysis pathway and facilitating PD-L1 lactylation to suppress CD8(+) T cell anti-tumor immunity.
Hu X, Ouyang W, Chen H, Liu Z, Lai Z, Yao H
Cancer pathogenesis and therapy 2025 May;3(3):253-266
Cancer pathogenesis and therapy 2025 May;3(3):253-266
The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism.
Chen J, Xu W, Meng L, Zhang X, Lin M, Zhang S, Liu Y, Guo F
Journal of cellular and molecular medicine 2025 May;29(10):e70616
Journal of cellular and molecular medicine 2025 May;29(10):e70616
Neuroprotective effects of bone marrow mesenchymal stem cells combined with mannitol on radiation-induced brain injury by regulating autophagy via the PI3K/AKT/mTOR signaling pathway.
Pan S, Wen Y, Liu Z, Xu K, Zhang N, Tong X, Teng Y, Song X, Tong X
Brain research bulletin 2025 May;224:111326
Brain research bulletin 2025 May;224:111326
PTPRG-AS1 regulates the KITLG/KIT pathway through the ceRNA axis to promote the malignant progression of gastric cancer and the intervention effect of Compound Kushen injection on it.
Wu C, Gao Y, Jin Z, Huang Z, Wang H, Lu S, Guo S, Zhang F, Zhang J, Huang J, Tao X, Liu X, Zhang X, You L, Li Q, Wu J
Pharmacological research 2025 May;215:107743
Pharmacological research 2025 May;215:107743
Autophagy induction by piplartine ameliorates axonal degeneration caused by mutant HSPB1 and HSPB8 in Charcot-Marie-Tooth type 2 neuropathies.
Sisto A, van Wermeskerken T, Pancher M, Gatto P, Asselbergh B, Assunção Carreira ÁS, De Winter V, Adami V, Provenzani A, Timmerman V
Autophagy 2025 May;21(5):1116-1143
Autophagy 2025 May;21(5):1116-1143
Hypoglycemic effect of dietary fibers from Moringa oleifera leaves: In vitro and in vivo studies.
Li X, Yong J, Zhao B, Zhu Y, Luo J, Sheng J, Tian Y
Food research international (Ottawa, Ont.) 2025 May;209:116196
Food research international (Ottawa, Ont.) 2025 May;209:116196
Grafting of syringic acid onto fucoidan: Enhanced functional properties and therapeutic potential in histamine-induced liver injury.
Zhang M, Tang J, Wang J, Qi C, Chen G, Chen W, Wang C
Food research international (Ottawa, Ont.) 2025 May;208:116161
Food research international (Ottawa, Ont.) 2025 May;208:116161
Melanocortin 5 receptor signaling protects against podocyte injury in proteinuric glomerulopathies.
Chen B, Chen M, Chang M, Ge Y, Gunning W, Assaly R, Dworkin LD, Qiao YJ, Gong R
Kidney international 2025 May;107(5):835-851
Kidney international 2025 May;107(5):835-851
Design, Synthesis and Biological Evaluation of POLRMT Inhibitors for the Treatment of Acute Myeloid Leukemia.
Liu T, Cheng X, Wang Y, Hao W, Wang H, Zhang K, Wang J
Chemical biology & drug design 2025 May;105(5):e70127
Chemical biology & drug design 2025 May;105(5):e70127
Novel Phenoxyacetic Acid (4-Aminophenoacetic Acid) Shikonin Ester Kills KRAS Mutant Colon Cancer Cells via Targeting the Akt Allosteric Site.
Ma Y, Sun Y, Tu Q, Lin F, Mei F, Chen Q, Fu T, Yang L, Lai X, Yang M, Yin T, Lu G, Qi J, Lin H, Wen Z, Yang Y, Han H
Chemical biology & drug design 2025 May;105(5):e70125
Chemical biology & drug design 2025 May;105(5):e70125
ESPN activates ZEB1-mediated EMT through the PI3K/AKT/mTOR axis to promote osteosarcoma metastasis.
Zhou R, Wu H, You H, Wang X, Yuan X, Sun Z, Zhou D, Jiang Y, Shen Y
Journal of translational medicine 2025 May 9;23(1):527
Journal of translational medicine 2025 May 9;23(1):527
INSL3 promotes macrophage polarization to an immunosuppressive phenotype via the cAMP downstream signaling pathway and Akt/mTOR pathway.
Zhou M, Liu Y, Li C, Yang X, Ji C, Li W, Song M, Yang Z, Liu G, Liang X, Liang J, Zhang B, Wang L
International immunopharmacology 2025 May 8;154:114540
International immunopharmacology 2025 May 8;154:114540
Metabolites from the Dendrobium Endophyte Pseudomonas protegens CM-YJ44 Alleviate Insulin Resistance in HepG2 Cells via the IRS1/PI3K/Akt/GSK3β/GLUT4 Pathway.
Qin L, Zhou Y, Fan B, Zheng J, Diao R, Liu J, Wang F
Pharmaceuticals (Basel, Switzerland) 2025 May 29;18(6)
Pharmaceuticals (Basel, Switzerland) 2025 May 29;18(6)
Aryl Hydrocarbon Receptor-Dependent miRNA-382-5p Mediates the Classical Pyroptosis Induced by Foodborne Benzo(a)pyrene through Targeting IκB in Liver.
Meng Y, Jia Y, He Z, Li J, Yuan L
Journal of agricultural and food chemistry 2025 May 28;73(21):12978-12992
Journal of agricultural and food chemistry 2025 May 28;73(21):12978-12992
Pyrotinib promotes the antitumor effect of T-DM1 by increasing drug endocytosis in HER2-positive breast cancer.
Ren W, Liu J, Zhao R, Zhao F, Zhang Y, Mu J, Zhu T
Scientific reports 2025 May 28;15(1):18625
Scientific reports 2025 May 28;15(1):18625
Single cell RNA sequencing reveals the role of local renin-angiotensin system in regulating ovarian physiological cycle and promoting PCOS.
Wei L, Bo L, Jiang W, Qi R, Luo C, Qian F, Ma P, Qiu J, Mao C
Cell death discovery 2025 May 27;11(1):255
Cell death discovery 2025 May 27;11(1):255
LncRNA SNHG15 promotes angiogenesis and improves cardiac repair after myocardial infarction through MiR-665-mediated KDR expression.
Liang X, Liu S, Liu G, Fan Q, Ma F, Yin Y, Li Z, Wu Y, Zheng M
Cellular and molecular life sciences : CMLS 2025 May 26;82(1):211
Cellular and molecular life sciences : CMLS 2025 May 26;82(1):211
MiR-485-3p/MELK cascade mediates tumor progression in pancreatic cancer.
Huang Y, Yang T, Yang C, Tang B, Su B, Yang X
Scientific reports 2025 May 22;15(1):17870
Scientific reports 2025 May 22;15(1):17870
Epigenetic activation of PTEN by valproic acid inhibits PI3K/AKT signaling and Burkitt lymphoma cell growth.
Li C, Liu S, Gao J, Xu Y, Peng Q, Weng D, Wang D, Yang W, Yi P, Lin Z, Chen J
Gene 2025 May 20;950:149369
Gene 2025 May 20;950:149369
Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-induced β-cell dedifferentiation.
Wang LK, Kong CC, Yu TY, Sun HS, Yang L, Sun Y, Li MY, Wang W
World journal of diabetes 2025 May 15;16(5):95431
World journal of diabetes 2025 May 15;16(5):95431
Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma.
Ma T, Guo WW, Zhang M, He W, Dongzhi C, Gongye X, Xia P, Chai Y, Chen Z, Zhu Y, Qu C, Liu J, Yang Z, Ma W, Tian M, Yuan Y
Cell death & disease 2025 May 15;16(1):382
Cell death & disease 2025 May 15;16(1):382
Novel application of CHUANG BI FU biologic protein sponge in promoting peripheral nerve injury repair by regulating vascular regeneration.
Cai Y, Liu J, Han R, Ma Z, Yu K, Wu P, Li X, Wang Z, Wang J
European journal of medical research 2025 May 14;30(1):380
European journal of medical research 2025 May 14;30(1):380
Suppression of FOXO3 by BMP signaling contribute to the different primordial germ cell proliferation between layers and broilers†.
Ma Y, Meng L, Wei J, Wu W, Zhang Y, Wang X, Guo X, Wang F, Mao Y, Zhu G
Biology of reproduction 2025 May 13;112(5):942-954
Biology of reproduction 2025 May 13;112(5):942-954
Lan-Qin oral liquid alleviates influenza A virus-induced acute lung injury by regulating monocyte-derived macrophages and TLR4-PI3K-AKT-NF-κB signal pathways.
Chen ZH, Li JJ, Liu CJ, Chen DJ, Yang YD, Xie TY, Liang WT, Tu XP, Shi W, Yang X, Chen ZF, Zhang FX
Journal of ethnopharmacology 2025 May 12;347:119787
Journal of ethnopharmacology 2025 May 12;347:119787
Integrating metabolomics and network pharmacology to investigate Mu Jin Powder prevents ethanol-induced gastric ulcer in rats.
Shi JX, Huo JN, Luo X, Zhang Q, Han LY, Wu X, Bao YR, Wang S, Li TJ, Dong BQ, Meng XS
Journal of ethnopharmacology 2025 May 12;347:119730
Journal of ethnopharmacology 2025 May 12;347:119730
Dendrobium nobile lindl extract modulates integrin αIIbβ3-mediated signaling pathways to inhibit platelet activation and thrombosis.
Hua C, Wu M, Xiao Y, Zhang R, Yuan Y, Zhang L, Guo F, Liu J, Yang Z, Liu G
Journal of ethnopharmacology 2025 May 12;347:119728
Journal of ethnopharmacology 2025 May 12;347:119728
Combining network pharmacology and transcriptomics to validate and explore the efficacy and mechanism of Huayu Wan in treating non-small cell lung cancer.
Gao T, Hu S, Jiang M, Ou G, Zhong R, Sun J, Yang Q, Hu K, Gao L
Journal of ethnopharmacology 2025 May 12;347:119724
Journal of ethnopharmacology 2025 May 12;347:119724
Penta-1,4-dien-3-one and quinoxaline conjugates as potential anticancer agents via inhibiting EphB3/SRC/AKT axis.
Li Q, Zhou M, Yang Y, Jiang Y, Chen C, Hu E, Chen J, Wang D
Life sciences 2025 May 1;368:123510
Life sciences 2025 May 1;368:123510
Prognostic role and tumor-suppressive effects of CADM family members and the potential molecular mechanisms of CADM1 in neuroblastoma.
Wang Y, Zheng L, Liu J, Zhang M, Kan Y, Wang W, Yang J
Discover oncology 2025 May 1;16(1):648
Discover oncology 2025 May 1;16(1):648
Interplay and cooperation between GLI2 and master transcription factors promote progression of esophageal squamous cell carcinoma.
Liu YQ, Zheng ZJ, Fang WK, Li YS, Li C, Yang M, Han DC, Zhou JH, Xie YH, Zhang YY, Kang ZY, Xu YW, Xie JJ
American journal of human genetics 2025 May 1;112(5):1039-1061
American journal of human genetics 2025 May 1;112(5):1039-1061
Exercise-induced Activation of SIRT1/BDNF/mTORC1 Signaling Pathway: A Novel Mechanism to Reduce Neuroinflammation and Improve Post-stroke Depression.
Tang J, Lu L, Yuan J, Feng L
Actas espanolas de psiquiatria 2025 Mar;53(2):366-378
Actas espanolas de psiquiatria 2025 Mar;53(2):366-378
Melatonin Alleviates Behavioral and Neurodevelopmental Abnormalities in Offspring Caused by Prenatal Stress.
Wu D, Du J, Zhao T, Li N, Qiao X, Peng F, Wang D, Shi J, Zhang S, Diao C, Wang L, Zhou W, Hao A
CNS neuroscience & therapeutics 2025 Mar;31(3):e70347
CNS neuroscience & therapeutics 2025 Mar;31(3):e70347
Integrating network pharmacology to investigate the mechanism of quercetin's action through AKT inhibition in co-expressed genes associated with polycystic ovary syndrome and endometrial cancer.
Li M, Cui Y, Wu X, Yang X, Huang C, Yu L, Yi P, Chen C
International journal of biological macromolecules 2025 Mar;297:139468
International journal of biological macromolecules 2025 Mar;297:139468
The MCM6-c-Myc positive feedback loop mediates bladder cancer progression and cisplatin resistance.
Wang J, Li X, Zhao L, Fan X, Cao J, Wang S, Li K, Wang H, Zhang Y, Wang H, Xu C, Ding L, Che T, Chen S, Yang L
International journal of biological macromolecules 2025 Mar;296:139777
International journal of biological macromolecules 2025 Mar;296:139777
Single-cell RNA sequencing and cell-cell communication analysis reveal tumor microenvironment associated with chemotherapy responsiveness in ovarian cancer.
Jiang X, Chen N, Wei Q, Luo X, Liu X, Xie L, Yi P, Xu J
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2025 Mar;27(3):1000-1012
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2025 Mar;27(3):1000-1012
Oral exposure to nanoplastics altered lipid profiles in mouse intestine.
Luo S, Zhao X, Wang Y, Jiang M, Cao Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115304
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115304
The Role of Chemokine (C-C Motif) Ligand 7 (CCL7) in Hepatocellular Carcinoma: Expression, Function, and Mechanisms.
Luo Y, Wan F, Zhang Z, Qin Z, Ren Y
Cancer medicine 2025 Mar;14(5):e70701
Cancer medicine 2025 Mar;14(5):e70701
Quercetagetin alleviates inflammatory osteoclastogenesis and collagen antibody-induced arthritis via Nrf2 signaling and Pten/AKT/Nfatc1 axis.
Wang H, Yuan T, Wang J, Li D, Lee WY, Li Z, Sun S
Arthritis research & therapy 2025 Mar 8;27(1):54
Arthritis research & therapy 2025 Mar 8;27(1):54
Comparative effects of different sugar substitutes: Mogroside V, stevioside, sucralose, and erythritol on intestinal health in a type 2 diabetes mellitus mouse.
Huang H, Liu S, Peng Z, Wang B, Zhan S, Huang S, Li W, Liu D, Yang X, Zhu Y, Xiao W
Food & function 2025 Mar 3;16(5):2108-2123
Food & function 2025 Mar 3;16(5):2108-2123
FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD(+) acute myeloid leukemia.
Zhou Q, Li Z, Zhao P, Guan Y, Chu H, Xi Y
Oncogenesis 2025 Mar 29;14(1):7
Oncogenesis 2025 Mar 29;14(1):7
Cyanidin-3-glucoside upregulated NDRG2 through the PI3K/AKT pathway to alleviate EMT and ECM in renal fibrosis.
Lu Q, Liu J, Xiong Y, Jian J, Wang J, Chen Z, Wan S, Liu X, Wang L
Scientific reports 2025 Mar 28;15(1):10695
Scientific reports 2025 Mar 28;15(1):10695
Wedelolactone activates the PI3K/AKT/NRF2 and SLC7A11/GPX4 signalling pathways to alleviate oxidative stress and ferroptosis and improve sepsis-induced liver injury.
Yin Y, Mu F, Zhang L, Zhao J, Gong R, Yin Y, Zheng L, Du Y, Jin F, Wang J
Journal of ethnopharmacology 2025 Mar 26;344:119557
Journal of ethnopharmacology 2025 Mar 26;344:119557
Umbelliferone attenuates calcium oxalate crystal-induced renal injury and inflammation by attenuating autophagy through the PI3K/AKT pathway.
Xu Y, Liang H, Xia K, Yao J, Chen Y, Hou B, Hao Z
International immunopharmacology 2025 Mar 26;150:114250
International immunopharmacology 2025 Mar 26;150:114250
MiR-101-3p targets the PI3K-AKT signaling pathway via Birc5 to inhibit invasion, proliferation, and epithelial-mesenchymal transition in hepatocellular carcinoma.
Zhu W, Ni Q, Wang Z, Zhang R, Liu F, Chang H
Clinical and experimental medicine 2025 Mar 19;25(1):88
Clinical and experimental medicine 2025 Mar 19;25(1):88
MYBL2 promotes cell proliferation and inhibits cell apoptosis via PI3K/AKT and BCL2/BAX/Cleaved-caspase-3 signaling pathway in gastric cancer cells.
Chen J, Ji Z, Wu D, Wei S, Zhu W, Peng G, Hu M, Zhao Y, Wu H
Scientific reports 2025 Mar 17;15(1):9148
Scientific reports 2025 Mar 17;15(1):9148
5-Aminolaevulinic Acid-Mediated Photodynamic Therapy Combined with Tirapazamine Enhances Efficacy in Ovarian Cancer.
Wang Q, Suo Y, Tian X
Biomedicines 2025 Mar 16;13(3)
Biomedicines 2025 Mar 16;13(3)
Network pharmacology and experimental analysis reveal Ethyl caffeate delays osimertinib resistance in lung cancer by suppression of MET.
Sang S, Han Y, Zhou H, Kang X, Gong Y
Cancer cell international 2025 Mar 15;25(1):99
Cancer cell international 2025 Mar 15;25(1):99
Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway.
Chen H, Liu S, Xing J, Wen Y, Chen L
Bone & joint research 2025 Mar 14;14(3):245-258
Bone & joint research 2025 Mar 14;14(3):245-258
Lactobacillus plantarum SMUM211204 Exopolysaccharides Have Tumor-Suppressive Effects on Colorectal Cancer by Regulating Autophagy via the mTOR Pathway.
Wang Z, Chen H, Xiong S, Chen X, Gao X, Huang P, Zou J, Cao H
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5931-5946
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5931-5946
Blueberry Anthocyanin Extracts (BAEs) Protect Retinal and Retinal Pigment Epithelium Function from High-Glucose-Induced Apoptosis by Activating GLP-1R/Akt Signaling.
Li R, Du S, Ye Z, Yang W, Liu Y
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5886-5898
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5886-5898
Gengnianchun formula ameliorates insulin resistance-induced diminished ovarian reserve via the estrogen signaling pathway: evidence from network pharmacology and experimental validation.
Rao Y, Li J, Xu T, Gao L, Wang W
Journal of ovarian research 2025 Mar 11;18(1):51
Journal of ovarian research 2025 Mar 11;18(1):51
Bisphenol A exposure enhances proliferation and tumorigenesis of papillary thyroid carcinoma through ROS generation and activation of NOX4 signaling pathways.
Wang Y, Su X, Wang Q, Zhang L, Yu Y, Zhao Y, Liu Z
Ecotoxicology and environmental safety 2025 Mar 1;292:117946
Ecotoxicology and environmental safety 2025 Mar 1;292:117946
Topical transdermal administration of lenalidomide nanosuspensions-based hydrogels against melanoma: In vitro and in vivo studies.
Zhang M, Qiu H, Han Z, Ma Y, Hou J, Yuan J, Jia H, Zhou M, Lu H, Wu Y
International journal of pharmaceutics: X 2025 Jun;9:100316
International journal of pharmaceutics: X 2025 Jun;9:100316
Sirt4 Overexpression Modulates the JAK2/STAT3 and PI3K/AKT/mTOR Axes to Alleviate Sepsis-Induced Acute Lung Injury.
Xie C, Wang T, Liu A, Huang B, Zeng W, Li Z, Peng S, Wu S
Cell biochemistry and biophysics 2025 Jun;83(2):1785-1798
Cell biochemistry and biophysics 2025 Jun;83(2):1785-1798
Administration with Yangxinshi ameliorates the progression of atrial fibrillation by affecting atrial remodeling and oxidative stress via the activation of the PI3K/AKT signaling.
Zhang B, Hou J, Dong L, Sun M, Dong Y, Dong Y
Cytotechnology 2025 Jun;77(3):121
Cytotechnology 2025 Jun;77(3):121
Inhibition of serotonin-Htr2b signaling in skeletal muscle mitigates obesity-induced insulin resistance.
Park S, Kim H, Shin S, Kim Y, Kang Y, Cha HN, Park SY, Park S, Oh CM
Experimental & molecular medicine 2025 Jun;57(6):1177-1188
Experimental & molecular medicine 2025 Jun;57(6):1177-1188
Melatonin attenuates brain edema via the PI3K/Akt/Nrf2 pathway in rats with cerebral ischemia-reperfusion injury.
Liu Y, Wang X, Li Z, Gao X, Wu X, Pi J, Wang X, Wang Q, Zhou F, Wang X
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jun;34(6):108299
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jun;34(6):108299
A pectic polysaccharide from wax gourd peel improves ethanol-induced gastric ulcer injury in mice via the PI3K/AKT signaling pathway.
Luo B, Cai M, Huang H, Zhang Y, Chen P, Ji R, Wang F, Liao P, Xian M
International journal of biological macromolecules 2025 Jun;316(Pt 2):144755
International journal of biological macromolecules 2025 Jun;316(Pt 2):144755
MicroRNA-9-3p inhibits endothelial pyroptosis in atherosclerosis by targeting the PTEN/AKT axis.
Wu Y, Ma Q, Meng X, Sun Q, Wang Z, Zhang W
International journal of biological macromolecules 2025 Jun;315(Pt 1):144289
International journal of biological macromolecules 2025 Jun;315(Pt 1):144289
Tributyltin affects the growth of ovarian granulosa cells in polycystic ovary syndrome by upregulating YY1-mediated CDKN1C via the PI3K/AKT pathway.
Dong S, Liu Y, Yang Z
Reproductive biology 2025 Jun;25(2):101020
Reproductive biology 2025 Jun;25(2):101020
The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy.
Zhang R, Li N, Yu K, Wang Q, Fan M, Zhang X, Liu X
Pharmacological research 2025 Jun;216:107763
Pharmacological research 2025 Jun;216:107763
Macrophages-derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression.
Tu M, Liu AM, Huang W, Wang D, Chen HQ, Hu XY
Journal of cell communication and signaling 2025 Jun;19(2):e70008
Journal of cell communication and signaling 2025 Jun;19(2):e70008
S-phase kinase-associated protein 1 inhibits orbital fibroblasts adipogenesis to improve thyroid-associated ophthalmopathy (TAO).
Lu S, Xiong W, Yi J, Liu S, Zhang F
Biochimica et biophysica acta. Molecular cell research 2025 Jun;1872(5):119937
Biochimica et biophysica acta. Molecular cell research 2025 Jun;1872(5):119937
Aloe Vera flowers extracts inhibit melanogenesis via activating PI3K/Akt signaling pathway: Network pharmacology and experimental validation.
Li J, Zou W, Li M, Yan Y, Yu Y, Li X, Ma YL
Fitoterapia 2025 Jun;183:106530
Fitoterapia 2025 Jun;183:106530
ROS-Responsive Hydrogel Delivering METRNL Enhances Bone Regeneration via Dual Stem Cell Homing and Vasculogenesis Activation.
Xu Y, Huang R, Shi W, Zhou R, Xie X, Wang M, Wang Y, Gu P, Ni N, Bi X
Advanced healthcare materials 2025 Jun;14(16):e2500060
Advanced healthcare materials 2025 Jun;14(16):e2500060
LRP1 regulates asthmatic airway smooth muscle proliferation through FGF2/ERK signaling.
Deng Y, Zhao J, Gong C, Ding W, Fang L, Liu H, Li M, Shen B, Ding S
JCI insight 2025 Jun 9;10(11)
JCI insight 2025 Jun 9;10(11)
S100 A16 promotes the progression of osteosarcoma by activating the PI3 K/AKT signaling pathway through ANXA2.
Xiang YY, Liu JH, Yi X, Luo JY, Yu Y, Yi GL
Scientific reports 2025 Jun 6;15(1):19962
Scientific reports 2025 Jun 6;15(1):19962
Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics.
Wu Y, Li A, Sun N, Jiang Z, Li Y, Zhou Z, Li X, Zhao D, Leng X, Dong H
International immunopharmacology 2025 Jun 5;157:114785
International immunopharmacology 2025 Jun 5;157:114785
TCN1 as an inflammatory regulator in psoriasis: Activation of the NF-κB pathway and potential therapeutic target.
Huang J, Yu H, Yuan X, Zhong Y, Li X, Chen Y
International immunopharmacology 2025 Jun 5;157:114784
International immunopharmacology 2025 Jun 5;157:114784
Astragaloside's Role in Microglial Neuroinflammation: A Multi-Method Study Combining Experimental and Computational Analyses.
Ou D, Li J, Shi Y, Liu X, Deng N, Peng L, Li Y, Xiong T, Bai Y, Zhang W, Ding H
Neurochemical research 2025 Jun 23;50(4):205
Neurochemical research 2025 Jun 23;50(4):205
IGFBP2 Modulates Trophoblast Function and Epithelial-Mesenchymal Transition in Preeclampsia via the PI3K/AKT Signaling Pathway.
Meng S, Qin Y, Lyu C, Wang S
Current issues in molecular biology 2025 Jun 20;47(7)
Current issues in molecular biology 2025 Jun 20;47(7)
MiR-124-3p/EIF3B Regulates Host Cell Apoptosis Induced by Chlamydia psittaci Through PI3K/AKT Signaling Pathway.
Tong T, Li Y, Zhou Y, Zeng X, Xiao C, Cao S, Wang C, Li Z, Zhou Z, Bai Q, Chen S, Yan S, Chen L
The Journal of infectious diseases 2025 Jun 2;231(5):1165-1175
The Journal of infectious diseases 2025 Jun 2;231(5):1165-1175
Mechanism study on the regulation of autophagy and oxidative stress through SIRT1/PI3K/AKT pathway by Liuwei Dihuang pill to improve ovarian function.
Zhong J, Lan G, Ma X, Zhang W, Jiang B, Qin L, Li X, Nian Y
Journal of ovarian research 2025 Jun 2;18(1):118
Journal of ovarian research 2025 Jun 2;18(1):118
Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer.
Liu Y, Hua H, Cao Y, Li M, Zhang H, Du S, Liu J, Luo T, Jiang Y
Cell chemical biology 2025 Jun 19;32(6):854-871.e6
Cell chemical biology 2025 Jun 19;32(6):854-871.e6
Generation of a spontaneous murine HPV + oral cancer model with site-specific oncogene insertion using CRISPR-SONIC.
Tao J, Murray J, Tu HF, Fan D, Tsai YC, Hu MH, Wu AA, Xing D, Hung CF, Wu TC
Cell & bioscience 2025 Jun 18;15(1):84
Cell & bioscience 2025 Jun 18;15(1):84
NR4A3 suppresses bladder cancer progression by modulating autophagy via the PI3K/AKT/mTOR pathway.
Fan L, Xu F, Liu S, Wu D, Wang S, Pan X, Zhou Y, Qu L, Zhou W
European journal of histochemistry : EJH 2025 Jun 17;69(3)
European journal of histochemistry : EJH 2025 Jun 17;69(3)
RRP9 promotes prostate cancer metastasis and epithelial-mesenchymal transition through activation of the AKT/GSK3β/β-Catenin signaling pathway.
Da Z, Du Y, Chen Y, Da M, Zhou F
Discover oncology 2025 Jun 17;16(1):1129
Discover oncology 2025 Jun 17;16(1):1129
A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer.
Yu Y, Gao X, Zhao H, Sun J, Wang M, Xiong X, Li J, Huang C, Zhang H, Jiang G, Xiao X
Cancer research 2025 Jun 16;85(12):2288-2301
Cancer research 2025 Jun 16;85(12):2288-2301
Aspirin Suppresses Aromatase-Mediated Estrogen Biosynthesis to Alleviate Polycystic Ovary Syndrome by the Inhibition of Adenylate Cyclase.
Shi XK, Sheng YW, Cao DY, Shi N, Zhang GL, Wang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70688
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70688
The crosstalk between lung adenocarcinoma cells and M2 macrophages promotes cancer cell development via the SFRS1/miR-708-5p/PD-L1 axis.
Xu L, Li K, Li J, Xu F, Liang S, Kong Y, Chen B
Life sciences 2025 Jun 15;371:123599
Life sciences 2025 Jun 15;371:123599
A novel Quinazoline derivative exerts anti-tumor effects in non-small cell lung cancer through Wnt/β-catenin pathway inhibition.
Zhao M, Wu D, Qiu W, Zhang H, Chen M, Zhou H, Ye X, Han Z, Shi X
Bioorganic chemistry 2025 Jun 15;160:108481
Bioorganic chemistry 2025 Jun 15;160:108481
Novel ALK inhibitors containing DAAP fragments: Rational drug design and anti-tumor activity research.
Wang R, Li X, Long L, Li M, Chen H, Zhang H, Ruan W, Zhang H, Zheng P, Xu S
Bioorganic chemistry 2025 Jun 15;160:108416
Bioorganic chemistry 2025 Jun 15;160:108416
Adipose-derived stem cells extracellular vesicles enhance diabetic wound healing via CCN2/PI3K/AKT pathway: therapeutic potential and mechanistic insights.
Zhou YL, Ogura S, Ma H, Liang RB, Fang SY, Wang YM, Wo Y, Wang WJ, Liu DW
Stem cell research & therapy 2025 Jun 15;16(1):304
Stem cell research & therapy 2025 Jun 15;16(1):304
Limosilactobacillus reuteri SXDT-32-derived shikimic acid protects against colonic inflammation in piglets by inhibiting the PI3K-Akt pathway.
Chen Y, Luo C, Zhan Z, Liu S, Teng C, Mao R, Zhang S, Zhang X, Meng Q, Zhong R, Chen L, Zhang H
Journal of animal science and biotechnology 2025 Jun 13;16(1):84
Journal of animal science and biotechnology 2025 Jun 13;16(1):84
Di (2-ethylhexyl) Phthalate decrease pregnancy rate via disrupting the microbe-gut-hypothalamic-pituitary-ovarian axis in mice.
Xu L, Yan J, Yin T, Pan Y, Chen M, Wang X, Wu L, Ding H
NPJ biofilms and microbiomes 2025 Jun 13;11(1):107
NPJ biofilms and microbiomes 2025 Jun 13;11(1):107
Nobiletin from Citrus reticulata Blanco alleviates pulmonary fibrosis through inhibiting the PI3K/AKT pathway and epithelial-mesenchymal transition.
Yu S, Liu K, Zhou F, Yang X, Zhang J, Yu K, Zhu Y, Qin L, Peng T, Zhang C, He Y
Journal of ethnopharmacology 2025 Jun 12;349:119965
Journal of ethnopharmacology 2025 Jun 12;349:119965
Time Does Matter: The Cellular Response to Resveratrol Varies Depending on the Exposure Duration.
Gramatyka M
International journal of molecular sciences 2025 Jun 10;26(12)
International journal of molecular sciences 2025 Jun 10;26(12)
Regulation of perinatal estrogen levels on primordial follicle formation and activation in mouse.
Xu R, Yin L, Zhang Y, Niu Y, Lu S, Tang Y, Peng S, Pan M, Ma B
American journal of physiology. Endocrinology and metabolism 2025 Jun 1;328(6):E772-E786
American journal of physiology. Endocrinology and metabolism 2025 Jun 1;328(6):E772-E786
Lysosomal EGFR acts as a Rheb-GEF independent of its kinase activity to activate mTORC1.
He X, Wang QX, Wei D, Lin Y, Zhang X, Wu Y, Qian X, Lin Z, Xiao B, Wu Q, Wang Z, Zhou F, Wei Z, Wang J, Gong R, Zhang R, Zhang Q, Ding K, Gao S, Kang T
Cell research 2025 Jul;35(7):497-509
Cell research 2025 Jul;35(7):497-509
Quercetin protects against neuronal toxicity by activating the PI3K/Akt/GSK-3β pathway in vivo models of MPTP-induced Parkinson's disease.
Li Y, Man M, Tian Y, Zhao G, Liu F, Zhao J, Huang S, Xue J, Chang W
Inflammopharmacology 2025 Jul;33(7):4063-4076
Inflammopharmacology 2025 Jul;33(7):4063-4076
Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy.
Wang H, Cheng G, Zhang S, Qu H, Zhao X, Yang A, Sun X, Pan H
Molecular medicine reports 2025 Jul;32(1)
Molecular medicine reports 2025 Jul;32(1)
Indolepropionic acid modulates the immune response in allergic rhinitis through the AKT/CEBPB/IL‑10 signaling pathway.
Gao L, Song Y, Zhang F, Zhao Y, Hu H, Feng Y
Molecular medicine reports 2025 Jul;32(1)
Molecular medicine reports 2025 Jul;32(1)
miR166u -enriched Polygonatum sibiricum exosome-like nanoparticles alleviate colitis by improving intestinal barrier through the TLR4/AKT pathway.
Wei C, Chen Y, Chen J, Cao F, Cheng J, Pan C, Wei Y, Liu T, Jin Y, Yang G
International journal of biological macromolecules 2025 Jul;318(Pt 1):144802
International journal of biological macromolecules 2025 Jul;318(Pt 1):144802
Modified Qianghuo Shengshi Decoction Ameliorates Osteoarthritis via Inhibiting PI3K/Akt Pathway-Related Ferroptosis.
Zhuang C, Li E, Li WK, Geng X, Hong C, Pan Y, Yang L
Journal of cellular and molecular medicine 2025 Jul;29(13):e70691
Journal of cellular and molecular medicine 2025 Jul;29(13):e70691
Pasteurized Akkermansia muciniphila ameliorates preeclampsia via inhibiting mitochondrial dysfunction-mediated placental apoptosis in vivo and in vitro.
Wang H, Wang Y, Zhong Y, Yu B, Liu D, Jia C, Wu J, Zeng G, Wang Q, Liu F, Sheng C, Huang L
Free radical biology & medicine 2025 Jul;234:233-247
Free radical biology & medicine 2025 Jul;234:233-247
Integrating LC-MS and molecular docking technology to investigate the effect of Spatholobi caulis flavonoids in alleviating primary dysmenorrhea via regulating the RhoA/ROCK pathway.
Zhang X, Weng J, Luo Y, Liu H, Yan J, Gong Z, Kong C, Li X, Yang L, Jiang M
Fitoterapia 2025 Jul;184:106631
Fitoterapia 2025 Jul;184:106631
Rosamultin attenuates cerebral ischemia/reperfusion injury by inhibiting autophagy via the PI3K/Akt/mTOR pathway.
Zhang H, Zhou B, Liu J, Tang B, Xie Z, Li J
Journal of pharmacological sciences 2025 Jul;158(3):182-192
Journal of pharmacological sciences 2025 Jul;158(3):182-192
Umbilical Cord-Mesenchymal Stromal Cell-Derived Extracellular Vesicles Target the Liver to Improve Neurovascular Health in Type 2 Diabetes With Non-Alcoholic Fatty Liver Disease.
Du M, Yang H, Niu J, Huang J, Wang L, Xi J, Meng P, Liu Z, Ma G, Li J, Liu X, Guo L, Hu M, Tian Z, Liu B, Liu W, Shetty AK, Wu S, Baskys A, Long Q
Journal of extracellular vesicles 2025 Jul;14(7):e70125
Journal of extracellular vesicles 2025 Jul;14(7):e70125
C1q(+) Macrophage-Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma.
Liu Y, Huang C, Luo M, Lu W, Zhang B, Bai L, Zheng S, Tan Y, Li S, Wang H, Gong L, Guan X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2503434
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2503434
2-Hydroxy-3-Methylanthraquinone Suppresses Hepatocellular Carcinoma Progression by Blocking Annexin A5-Mediated Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling.
Luo M, Mo J, Huang C, Mao Y, Wang H, Wang X
Chemical biology & drug design 2025 Jul;106(1):e70161
Chemical biology & drug design 2025 Jul;106(1):e70161
Embryonic stem cell-derived small extracellular vesicles alleviate lead-induced cochlear spiral ganglion neurons injury by activating PI3 K/AKT signaling pathway.
Wang L, Bai Y, Sun Y, Li L, He Y, Li G, Liu D, Huang Z, Song J, Wu H, Li H, Wu X
Science progress 2025 Jul-Sep;108(3):368504251358007
Science progress 2025 Jul-Sep;108(3):368504251358007
Network pharmacology and in vitro analyses reveal EGCG inhibits breast cancer progression via suppression of the EGFR/Src pathway.
Liu H, Li Z, Xu X, Xu B, Li Z
Biochemical and biophysical research communications 2025 Jul 8;769:151942
Biochemical and biophysical research communications 2025 Jul 8;769:151942
Different neutrophil extracellular trap related Ewing sarcoma subtypes exhibit distinct prognosis, and immune microenvironment characteristics.
Li S, Hou Y, Zhang L, Zhang H, Wang C
Scientific reports 2025 Jul 8;15(1):24523
Scientific reports 2025 Jul 8;15(1):24523
Elevated SLC4A11 expression promotes OV progression via interaction with EGFR.
Peng Q, Sun Y, Wang R, Zhang S, Hu L, Teng Y, Zhu X
Scientific reports 2025 Jul 28;15(1):27439
Scientific reports 2025 Jul 28;15(1):27439
BDNF improves fracture healing through promoting osteoblasts proliferation and migration via trkb/akt regulated NUCKS1 expression.
Meng W, Meng X, Han C, Li Y, Qian X, Zhang Z
Scientific reports 2025 Jul 25;15(1):27107
Scientific reports 2025 Jul 25;15(1):27107
Unveiling XinJia-LuHuang Granules' protective mechanism against atherosclerosis: Integrating network pharmacology, metabolomics, and experimental validation.
Liu X, Liu L, Ren X, Chen Y, Yin M, Xie H, Sun T, Tan Y, Wang S, Xu D, Tang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156919
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156919
Hedyotis chrysotricha aqueous extract inhibits hepatitis B surface antigen and viral replication via hepatocyte nuclear factor 4α regulation.
Yu Y, Hu H, Zhang Y, Zhang Z, Ying S, Dong S, Dai J, Hong Y, Qiu Y, Lou Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156726
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156726
Integrating metabolomics and network pharmacology analysis provides new insights into the lipid metabolism disorder of Abrus mollis.
Huang M, Wang X, Lu Y, Zhou Q, Liang J, Li Q, Li L, Fan L
Journal of ethnopharmacology 2025 Jul 24;351:120127
Journal of ethnopharmacology 2025 Jul 24;351:120127
Exploring the mechanism of feiyanning formula and its extract apigenin against EGFR-TKIs resistance in non-small cell lung cancer based on UPLC-HRMS and experimental validation.
Han Y, Jiao L, Zhou H, Sang S, A G, Liu R, Du Y, Wang M, Kang X, Wang Q, Gong Y
Journal of ethnopharmacology 2025 Jul 24;351:120120
Journal of ethnopharmacology 2025 Jul 24;351:120120
Cornus officinalis loganin attenuates acute lung injury in mice via regulating the PI3K/AKT/NLRP3 axis.
Liu Y, Wang C, Hui T, Yuan Y, Chen S, Li Y, Wang G, Kang J, Xue X
Journal of ethnopharmacology 2025 Jul 24;351:120104
Journal of ethnopharmacology 2025 Jul 24;351:120104
Ursolic acid affects autophagy and apoptosis of breast cancer through PLK1 via AKT/mTOR signaling pathway.
Yang K, Xie Z, Liu S, Xu R, Mao J, Feng W, Zhao X, Dai Y, Zou Y, Qian R, Qian R
Medical oncology (Northwood, London, England) 2025 Jul 21;42(8):358
Medical oncology (Northwood, London, England) 2025 Jul 21;42(8):358
Matrix stiffness regulates glucose-6-phosphate dehydrogenase expression to mediate sorafenib resistance in hepatocellular carcinoma through the ITGB1-PI3K/AKT pathway.
Ren R, Zhang S, Peng Z, Ji X, Song H, Wang Q, Sun X, Wang H, Dong Y
Cell death & disease 2025 Jul 20;16(1):538
Cell death & disease 2025 Jul 20;16(1):538
Tryptophan-Rich Diet Improves High-Fat Diet-Induced Cognitive Dysfunction and Blood-Brain Barrier Disruption in C57BL/6 Mice through FFAR3 Activation.
Pan C, Wang J, Mao Z, Jiang X, Xu Y, Zhang Y, Chen L, Zhang ZY, Wang X
Journal of agricultural and food chemistry 2025 Jul 16;73(28):17696-17712
Journal of agricultural and food chemistry 2025 Jul 16;73(28):17696-17712
TBB inhibits CK2/PD-L1/EGFR pathway-mediated tumor progression.
Che S, Zhang Y, Xu H, Shi J, Hou Y
European journal of pharmacology 2025 Jul 15;999:177689
European journal of pharmacology 2025 Jul 15;999:177689
Exosomal SPRY4 from adipogenic BMSCs impairs angiogenesis via the PTPRB/TIE2/PI3K axis in Steroid-induced osteonecrosis of the femoral head.
Xiang D, Zhou Y, Wang H, Chen Y, Bai H, Wang Z, Tan S, Wu D, Yan W, Huang X, Chen T, Lian C, Zhang J
Stem cell research & therapy 2025 Jul 15;16(1):375
Stem cell research & therapy 2025 Jul 15;16(1):375
Kushenol I combats ulcerative colitis via intestinal barrier preservation and gut microbiota optimization.
He XD, Li M, Zuo XD, Ni HY, Han YX, Hu YK, Yu J, Yang XX
World journal of gastroenterology 2025 Jul 14;31(26):105656
World journal of gastroenterology 2025 Jul 14;31(26):105656
Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC.
Zang S, Chen H, Han Y, Cui D, Yu J
Scientific reports 2025 Jul 11;15(1):25065
Scientific reports 2025 Jul 11;15(1):25065
MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization.
Zhang J, Zhan Y, Deng Z, Chen S, Yang R, Zhang Y, Fu H, Huang Q, Wu J, Gu Y, Xie J
Respiratory research 2025 Jul 10;26(1):238
Respiratory research 2025 Jul 10;26(1):238
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction.
Ye Y, Shen F, Yan M, Zhan C, Lv J, Zou M, Wang Z, Ning S, Gao Y, Wu J, Li W
Cell death & disease 2025 Jul 10;16(1):509
Cell death & disease 2025 Jul 10;16(1):509
TRIM29 alleviates intervertebral disc degeneration through the PI3K/AKT/mTOR pathway.
Yang Q, Feng J, Xu H, Kang T, Wei Q, Jiang H
Scientific reports 2025 Jul 10;15(1):24797
Scientific reports 2025 Jul 10;15(1):24797
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension.
Qi R, Chang Z, Zhao W, Qiu Y, Chang W, Zhang Y, Hu X, Li Z
Cell biology and toxicology 2025 Jul 1;41(1):110
Cell biology and toxicology 2025 Jul 1;41(1):110
Biodegradable Zn-xY alloys with enhanced osteogenesis and angiogenesis effects for bone implant applications.
Liang S, Du S, Zheng Y, Xia D, Zhou Y
Acta biomaterialia 2025 Jul 1;201:684-702
Acta biomaterialia 2025 Jul 1;201:684-702
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Fan Y, Wu H, Yin D, Liu Q, Yuan C, Zhong T, Xia B, Xiong L, Li Y, Zeng L, Li Y, Li Y, Tang L
Bioorganic chemistry 2025 Jul 1;161:108547
Bioorganic chemistry 2025 Jul 1;161:108547
Tumor-associated macrophages derived exosomal circPLK1 promotes resistance to EGFR inhibitor osimertinib in non-small cell lung cancer.
Li C, Sun X, Wang Z
Discover oncology 2025 Jul 1;16(1):1196
Discover oncology 2025 Jul 1;16(1):1196
ADCY4 inhibits cAMP-induced growth of breast cancer by inactivating FAK/AKT and ERK signaling but is frequently silenced by DNA methylation.
Pan G, Huang M, Fu S, Wang Y, He L, Wu B, Yang J, Lin S, Fan Y
Scientific reports 2025 Jul 1;15(1):20426
Scientific reports 2025 Jul 1;15(1):20426
The mechanism of Bletilla striata inhibiting glioma proliferation through the PI3K/AKT/mTOR signaling pathway based on network Pharmacology analysis.
Ren F, Wang Y, He C, Zheng X, Zhou C, Zhong X
Scientific reports 2025 Jul 1;15(1):20415
Scientific reports 2025 Jul 1;15(1):20415
Traditional Chinese medicine combined with chemotherapy in the treatment of advanced non-small cell lung cancer: key drug screening and mechanism analysis.
Tang Y, Xian Z, Wu F, Cao H, Wang L, Tang Q, Du Y, Zheng X
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):843-854
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):843-854
Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K/AKT signaling pathway based on network pharmacology.
Ji M, Weng S, Li X, Xiao Q, Tong Y, Zhou Y, Luo T, Liu Z
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):833-842
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):833-842
Enhancing miR-19a/b induced cardiomyocyte proliferation in infarcted hearts by alleviating oxidant stress and controlling miR-19 release.
Wang K, Wen J, Liang T, Hu H, Li S, Shen L, Ren T, Yao Y, Xie J, Ding J, Chen J, Tang YD, Zhu Y, Gao C
Biomaterials 2025 Jan;312:122732
Biomaterials 2025 Jan;312:122732
Denervation‑induced NRG3 aggravates muscle heterotopic ossification via the ErbB4/PI3K/Akt signaling pathway.
Ma L, Kang X, Tan J, Wang Y, Liu X, Tang H, Guo L, Tang K, Bian X
Molecular medicine reports 2025 Jan;31(1)
Molecular medicine reports 2025 Jan;31(1)
Tumor-Derived GDF15 Induces Tumor Associated Fibroblast Transformation From BMSCs and Fibroblasts in Oral Squamous Cell Carcinoma.
Zhao J, Li Y, Huang Y, Su P, Nie F, Yang P, Yang C
Journal of cellular physiology 2025 Jan;240(1):e31498
Journal of cellular physiology 2025 Jan;240(1):e31498
Negative regulation of SREBP-1/FAS signaling molecules activates the RIG-1/TBK1-mediated IFN-I pathway to inhibit BVDV replication.
Liu S, Luo A, Que T, Liang Y, Song Y, Liu T, Li J, Li N, Zhang Z, Liu Y, Zhang Z, Zhou Y, Wang X, Zhu Z
Antiviral research 2025 Jan;233:106054
Antiviral research 2025 Jan;233:106054
BIN1 deficiency enhances ULK3-dependent autophagic flux and reduces dendritic size in mouse hippocampal neurons.
Jin Y, Zhao L, Zhang Y, Chen T, Shi H, Sun H, Ding S, Chen S, Cao H, Zhang G, Li Q, Gao J, Xiao M, Sheng C
Autophagy 2025 Jan;21(1):223-242
Autophagy 2025 Jan;21(1):223-242
Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage.
Tian S, Li R, Li J, Zou J
Environment international 2025 Jan;195:109258
Environment international 2025 Jan;195:109258
Chuanxiong Qingnao Granules (CQG) alleviates nitroglycerin-induced migraine-like pain in rats by glycerophospholipid metabolism and PI3K/Akt signaling pathway.
Hou JY, Wang LH, Ni LQ, Hou BW, Wang K, Zhu NQ, Yang HJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156336
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156336
Punicalagin inhibits excessive autophagy and improves cerebral function in neonatal rats with hypoxia-ischemia brain injury by regulating AKT-FOXO4.
Shen M, Lu J, Li C, Li Y, Yu Q, Gao X, Wang Z, Yang G, Li S, Lin Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156330
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156330
ACVR1 mediates renal tubular EMT in kidney fibrosis via AKT activation.
Yu T, Mai Z, Zhang S, Wang S, Yang W, Ruan Z, Li P, Guo F, Zhang Y, Li J, Wang L, Lin C, Zheng L
Cellular signalling 2025 Jan;125:111521
Cellular signalling 2025 Jan;125:111521
Mechanism of triiodothyronine alleviating acute alcoholic liver injury and delaying alcoholic liver fibrosis progression.
Luo R, Li S, Yang M, Wu J, Feng J, Sun Y, Zhao Y, Mao L
Human & experimental toxicology 2025 Jan-Dec;44:9603271251332505
Human & experimental toxicology 2025 Jan-Dec;44:9603271251332505
Halofuginone induces ERK phosphorylation and synergizes with trametinib in gastric cancer cells.
Sun Y, Wang P, Bai X, Tian L, Zhong Y
International journal of immunopathology and pharmacology 2025 Jan-Dec;39:3946320251359860
International journal of immunopathology and pharmacology 2025 Jan-Dec;39:3946320251359860
Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro.
Xu FZ, Zheng LL, Qin JB, Li YX, Chen KH, Dai LH, Zhu QL, Sang JF
Integrative cancer therapies 2025 Jan-Dec;24:15347354251339073
Integrative cancer therapies 2025 Jan-Dec;24:15347354251339073
Jaranol alleviates cognitive impairment in db/db mice through the PI3K/AKT pathway.
Qian Y, Xu Y, Zhang Q, Huang C, Li H, Gao L, Wu S, Qi C, Wen X, Zhou X, Ying C
Metabolic brain disease 2025 Jan 6;40(1):88
Metabolic brain disease 2025 Jan 6;40(1):88
Cromolyn sodium reduces LPS-induced pulmonary fibrosis by inhibiting the EMT process enhanced by MC-derived IL-13.
Tan C, Zhou H, Xiong Q, Xian X, Liu Q, Zhang Z, Xu J, Yao H
Respiratory research 2025 Jan 6;26(1):3
Respiratory research 2025 Jan 6;26(1):3
Novel applications of metformin in the treatment of septic myocardial injury based on metabolomics and network pharmacology.
Li X, Zhang Z, Li C, Liu J, Fang Q, Zhang M, Huang J
European journal of pharmacology 2025 Jan 5;986:177141
European journal of pharmacology 2025 Jan 5;986:177141
Astragaloside IV plays a neuroprotective role by promoting PPARγ in cerebral ischemia-reperfusion rats.
Ding Y, Jie K, Xin L, Shao B
Behavioural brain research 2025 Jan 5;476:115267
Behavioural brain research 2025 Jan 5;476:115267
Integrating metabolomics and network pharmacology to investigate Da-Chai-Hu Decoction prevents kidney injury in diabetic mice.
Wang X, Zhong ZJ, Chen PF, Deng CF, Chen XM, Xin GZ, Tang D
Journal of ethnopharmacology 2025 Jan 31;340:119158
Journal of ethnopharmacology 2025 Jan 31;340:119158
Revealing the molecular mechanism of baohuoside I for the treatment of breast cancer based on network pharmacology and molecular docking.
Mu J, Li Y, Chen Q, Xiao Y, Hu M, He Z, Zeng J, Ding Y, Song P, He X, Yang X, Zhang X
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118918
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118918
HouShiHeiSan attenuates sarcopenia in middle cerebral artery occlusion (MCAO) rats.
Qi H, Gao Y, Zhang Z, Zhang X, Tian D, Jiang Y, Zhang L, Zeng N, Yang R
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118917
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118917
Network pharmacology and experimental validation reveal the mechanisms of sniffing essential oil of Acori Tatarinowii rhizoma in treating olfactory dysfunction.
Zhao Y, Hu Y, Yang J, Qi Y, Miao J, Miao M
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118851
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118851
Exploration of the mechanism of Lithospermum erythrorhizon oil in treating atopic dermatitis based on network pharmacology and experimental validation of the PI3K-Akt pathway regulation.
Hu W, Wang Y, Zhou Y, Shi J, Li Z, Jiang X, Wu Q, Zhong C, Weng H, Ouyang S, Jing Y, Cai X, Ye M, Huang N
Heliyon 2025 Jan 30;11(2):e41707
Heliyon 2025 Jan 30;11(2):e41707
Elucidating the mechanism of action of astragalus polysaccharide on ionizing radiation-induced myocardial damage based on network pharmacology and experimental research.
Jiang B, Wang Y, Zhi X, Liu A, Wang L, Wang X, Wang Z, Duan Y, Li Y, Zhang Z
International immunopharmacology 2025 Jan 3;145:113758
International immunopharmacology 2025 Jan 3;145:113758
Natural Protein-Based Multifunctional Hydrogel Dressing Formed by Rapid Photocuring and Zinc Ion Coordination to Accelerate Wound Healing.
Li Q, Hou Y, Sun D, Zhu C, Wu R, Feng G, Zhang L, Song Y
ACS applied materials & interfaces 2025 Jan 29;17(4):5719-5734
ACS applied materials & interfaces 2025 Jan 29;17(4):5719-5734
Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition.
Zhang J, Peng J, Wang S, Wang L, Sun Y, Xia J, Cheng B, Hu Q
Cell death discovery 2025 Jan 28;11(1):30
Cell death discovery 2025 Jan 28;11(1):30
Red and blue LED light increases the survival rate of random skin flaps in rats after MRSA infection.
Tu Y, Pan C, Huang Y, Ye Y, Zheng Y, Cao D, Lv Y
Lasers in medical science 2025 Jan 23;40(1):34
Lasers in medical science 2025 Jan 23;40(1):34
Development of Sheep Intestinal Organoids for Studying Deoxynivalenol-Induced Toxicity.
Wang H, He X, Zhang M, Fan N, Yang Z, Shen T, Guo J, Song Y, Cao G, Liu Y, Li X, Nashun B
International journal of molecular sciences 2025 Jan 23;26(3)
International journal of molecular sciences 2025 Jan 23;26(3)
Exploration of the Fasting Hypoglycemic Mechanism of Casein Hydrolysate Enriched with Glu/Gln and Glu/Gln-Containing Peptides in db/db Diabetic-like Mice Using Multiomics Analysis.
Wang C, Xu R, Udenigwe CC, Lin L, Zheng L, Zhao M
Journal of agricultural and food chemistry 2025 Jan 22;73(3):1902-1916
Journal of agricultural and food chemistry 2025 Jan 22;73(3):1902-1916
Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction.
Qu X, Yang P, Jiao L, Yin Y
Frontiers in bioscience (Landmark edition) 2025 Jan 20;30(1):25565
Frontiers in bioscience (Landmark edition) 2025 Jan 20;30(1):25565
Puerarin Promotes the Migration and Differentiation of Myoblasts by Activating the FAK and PI3K/AKT Signaling Pathways.
Fang X, Xu H, Fan Z, Yang H, Huang Y, Xu L, Rong Y, Ma W, Pei L, Liang H
Biology 2025 Jan 20;14(1)
Biology 2025 Jan 20;14(1)
Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration.
Li Z, Zhang C, Wang L, Zhang Q, Dong Y, Sha X, Wang B, Zhu Z, Wang W, Wang Y, Zhou Y, Zhang Y
Scientific reports 2025 Jan 2;15(1):556
Scientific reports 2025 Jan 2;15(1):556
Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1.
Jin S, Zhou Y, Lv J, Lu Y, Zhang Y, Li M, Feng N
Molecular medicine (Cambridge, Mass.) 2025 Jan 16;31(1):14
Molecular medicine (Cambridge, Mass.) 2025 Jan 16;31(1):14
Umbilical cord mesenchymal stem cell-derived exosomal Follistatin inhibits fibrosis and promotes muscle regeneration in mice by influencing Smad2 and AKT signaling.
Hu H, Yin Y, Zhou H, Jiang B, Cai T, Wu S, Guo S
Experimental cell research 2025 Jan 15;444(2):114396
Experimental cell research 2025 Jan 15;444(2):114396
Inhibition of THBS1 axis contributes to the antitumor effect of PA-MSHA in anaplastic thyroid cancer.
Li Z, He T, Xing Z, Zhu J, Wu W, Su A
Experimental cell research 2025 Jan 15;444(2):114373
Experimental cell research 2025 Jan 15;444(2):114373
Discovery of a potent anticancer agent against pancreatic ductal adenocarcinoma targeting FAK with DFG-out state and JAK/Aurora kinases.
Zhang RH, Chen T, Xiong QQ, Wang S, Chen GQ, Zhang WL, Yuan HF, Zhao YL, Liu T, Huang Y, Zhou M, Yang CL, Liao SG, Li YJ
European journal of medicinal chemistry 2025 Jan 15;282:117059
European journal of medicinal chemistry 2025 Jan 15;282:117059
Protein Coronation-Induced Cancer Staging-Dependent Multilevel Cytotoxicity: An All-Humanized Study in Blood Vessel Organoids.
Wang C, Quan Y, Jiang J, Yu H, Liu J, Tang W, Li X, Wang S, Huo D, Jiang GL, Yang Y, Ding Q
ACS nano 2025 Jan 14;19(1):345-368
ACS nano 2025 Jan 14;19(1):345-368
Heterogeneous nuclear ribonucleoprotein C promotes non-small cell lung cancer progression by enhancing XB130 mRNA stability and translation.
Wang Q, Gou X, Liu L, Deng D, Zhao Y, Zhou J, Xie Y, Jiang Y, Li J, Zhang J, Liu Y
Cancer cell international 2025 Jan 13;25(1):10
Cancer cell international 2025 Jan 13;25(1):10
TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis.
Wang L, Ouyang D, Li L, Cao Y, Wang Y, Gu N, Zhang Z, Li Z, Tang S, Tang H, Zhang Y, Sun X, Yan J
Journal of neuroinflammation 2025 Jan 13;22(1):6
Journal of neuroinflammation 2025 Jan 13;22(1):6
RICTOR-mediated activation of AKT/mTOR signaling and autophagy inhibition promote osteoarthritis.
Xu J, Wang G, Hou Y, Sun K, Zheng Z, Guo Z, Hou L, Zhang X, Ruan Z, Ye Y, Guo F
International immunopharmacology 2025 Jan 10;144:113681
International immunopharmacology 2025 Jan 10;144:113681
N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatocellular carcinoma.
Fang R, Jia Z, Xin Y, Zhao K, Qin W, Lu H, Zhou Y, Yang Y, Fang H
Cell death discovery 2025 Jan 10;11(1):3
Cell death discovery 2025 Jan 10;11(1):3
Chronic exposure to low-dose MC-LR induces ileal inflammation in mice through the PI3K/AKT/mTOR pathway.
Yang M, Zheng S, Zeng W, Zhan C, Yang Y, Yang F
Journal of toxicology and environmental health. Part A 2025 Jan 10;:1-9
Journal of toxicology and environmental health. Part A 2025 Jan 10;:1-9
TREM2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via PI3K/Akt signaling pathway.
Tang S, Xing W, Yan J, Wang L, Li Z, Wang Y, Gu N, Sun X
Brain research 2025 Jan 1;1846:149235
Brain research 2025 Jan 1;1846:149235
Galectin-1 Regulates Inflammatory Responses and Promotes Microglial M2 Polarization in Chronic Migraine.
Xiao Y, Han W, Yu M, Jiang J, Zhu Y
The European journal of neuroscience 2025 Feb;61(3):e70010
The European journal of neuroscience 2025 Feb;61(3):e70010
LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis.
Bin Y, Liu M, He R, Tang P, Qu W, Wu D, Tan L, Wang Q, Jiang P, Hu H
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):228-244
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):228-244
Antiviral mechanism of Fuzhengjiedu San against porcine reproductive and respiratory syndrome virus.
Song XQ, Zhao XY, Chen WS, Yang L, Liu DY, Chen YP
Virology 2025 Feb;603:110382
Virology 2025 Feb;603:110382
Hypericin mediated photodynamic therapy induces ferroptosis via inhibiting the AKT/mTORC1/GPX4 axis in cholangiocarcinoma.
An W, Zhang K, Li G, Zheng S, Cao Y, Liu J
Translational oncology 2025 Feb;52:102234
Translational oncology 2025 Feb;52:102234
LncRNA CCAT1 knockdown suppresses tongue squamous cell carcinoma progression by inhibiting the ubiquitination of PHLPP2.
Liu F, Yang H, Liu X, Ning Y, Wu Y, Yan X, Zheng H, Liu C
Molecular and cellular biochemistry 2025 Feb;480(2):1063-1075
Molecular and cellular biochemistry 2025 Feb;480(2):1063-1075
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway.
Xu M, Chen J, Gao L, Cai S, Dong H
Ecotoxicology and environmental safety 2025 Feb;291:117828
Ecotoxicology and environmental safety 2025 Feb;291:117828
Luteolin inhibits BHV-1 replication and alleviates virus-induced inflammatory responses by regulating PI3K/AKT pathway.
Li C, Zhao Z, Yuan X, Wang X, Wang H, Fan J, Liu Y, Zhou Y, Zhu Z, Zhang Z
Microbial pathogenesis 2025 Feb;199:107258
Microbial pathogenesis 2025 Feb;199:107258
Lactobacillus acidophilus JYLA-126 Ameliorates Obesity-Associated Metabolic Disorders by Positively Regulating the AMPK Signaling Pathway Through the Gut-Liver Axis.
Li P, He X, Feng E, Wei J, Tu H, Chen T
Probiotics and antimicrobial proteins 2025 Feb;17(1):62-80
Probiotics and antimicrobial proteins 2025 Feb;17(1):62-80
The effect and mechanism of atorvastatin regulating PI3K-Akt-mTOR pathway on radiosensitivity of hepatocellular carcinoma cells.
Deng Z, Guo J, Zhu Z, Qing Q, Wan D, Lei P, Liu Q, Huang B
Toxicology research 2025 Feb;14(1):tfae202
Toxicology research 2025 Feb;14(1):tfae202
Insulin-like growth factor-1 promotes the testicular sperm production by improving germ cell survival and proliferation in high-fat diet-treated male mice.
Liu G, Liu D, Zhu M, Zhang M, Li C, Xu X, Pan F
Andrology 2025 Feb;13(2):342-358
Andrology 2025 Feb;13(2):342-358
Cis-Regulation of an m(6)A Eraser by an Insertion Variant Associated with Survival of Patients With Non-Small Cell Lung Carcinoma.
Cheng L, Hu Q, Wang Y, Nie W, Lu H, Zhang B, Zhao G, Ding S, Pan F, Shen Y, Zhong R, Zhang R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2407652
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2407652
HECW1-Mediated Ubiquitination of HIPK2 Drives Metastasis in Gastric Cancer Through the AKT Signaling Pathway.
Zhang G, Qu W, Huang X, Yi J, Gao H, He J, Xue W
Laboratory investigation; a journal of technical methods and pathology 2025 Feb;105(2):102202
Laboratory investigation; a journal of technical methods and pathology 2025 Feb;105(2):102202
Establishment and characterization of three gemcitabine-resistant human intrahepatic cholangiocarcinoma cell lines.
Li J, Hu Y, Zhang J, Zhang W, Yu J, Lu B
Scientific reports 2025 Feb 9;15(1):4813
Scientific reports 2025 Feb 9;15(1):4813
Mechanistic insights into PROS1 inhibition of bladder cancer progression and angiogenesis via the AKT/GSK3β/β-catenin pathway.
Fan XP, Wang JR, Chen SY, Li XR, Cao JL, Wang HB, Ding LY, Che TJ, Yang L
Scientific reports 2025 Feb 8;15(1):4748
Scientific reports 2025 Feb 8;15(1):4748
Paeonol Inhibits the Replication of Bovine Herpesvirus Type 1 In Vitro Through Regulating the PI3K/AKT Pathway.
Yuan X, Wang H, Zhao Z, Li C, Wang X, Liu Y, Zhou Y, Zhu Z, Zhang Z
Current microbiology 2025 Feb 3;82(3):110
Current microbiology 2025 Feb 3;82(3):110
Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice.
Lin YK, Pan YF, Jiang TY, Chen YB, Shang TY, Xu MY, Feng HB, Ma YH, Tan YX, Wang HY, Dong LW
Journal of biomedical science 2025 Feb 28;32(1):31
Journal of biomedical science 2025 Feb 28;32(1):31
Network pharmacology alliance with experimental validation unveils the anti-colorectal cancer mechanism of Xianlian Jiedu decoction.
Fan X, Yan Q, Xu W, Chen H, Xu Y, Lu S, Xu C, Tan J, Yu C, Lai Y, Fan M, Tao L, Li L, Shen W, Cheng H, Sun D
Journal of ethnopharmacology 2025 Feb 27;342:119361
Journal of ethnopharmacology 2025 Feb 27;342:119361
Molecular Observations on the Regulation of hIAPP Aggregation Process and Enhancement of Autophagy by the Short Peptide LPFYPN and Its Modified Peptides of Coix Seed Prolamins.
Zhang S, Sun J, Yu S, Fu T, Feng Y, Li Z, Zhang D, Wang C
Journal of agricultural and food chemistry 2025 Feb 26;73(8):4659-4672
Journal of agricultural and food chemistry 2025 Feb 26;73(8):4659-4672
Comprehensive characterization of early-onset lung cancer, in Chinese young adults.
Tian Y, Ma R, Zhao W, Wang S, Zhou C, Wu W, Yang B, Xin H, Wang H, Li P, Li R, Liu C, Lu Y, Yu Q, Song C, Zhang H, Liang R, Zhang L, Zhou D, Zhao X, Wu Z, Qi Y, Wang R, Fei T, Yang X
Nature communications 2025 Feb 26;16(1):1976
Nature communications 2025 Feb 26;16(1):1976
Melatonin-pretreated mesenchymal stem cell-derived exosomes alleviate cavernous fibrosis in a rat model of nerve injury-induced erectile dysfunction via miR-145-5p/TGF-β/Smad axis.
Zhang X, Yang M, Chen X, Zhang M, Peng Y, Lu M
Stem cell research & therapy 2025 Feb 25;16(1):96
Stem cell research & therapy 2025 Feb 25;16(1):96
In vitro analysis of the molecular mechanisms of ursolic acid against ovarian cancer.
Zhang R, Zhang Z, Xie L, Yu Z, Gao R, Zhang ZR, Zhang Y, Wei X, Chen Y, Jiao S, Gao Y, Guo JP
BMC complementary medicine and therapies 2025 Feb 21;25(1):65
BMC complementary medicine and therapies 2025 Feb 21;25(1):65
Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K-AKT signaling in rheumatoid arthritis.
Liu T, Jin C, Sun J, Zhu L, Wang C, Xiao F, Liu X, Lv L, Yang X, Zhou W, Tan C, Wang X, Wei W
Chinese medical journal 2025 Feb 20;138(4):441-451
Chinese medical journal 2025 Feb 20;138(4):441-451
miR-212-5p Regulates PM(2.5)-Induced Apoptosis by Targeting LAMC2 and LAMA3.
Jia Y, Zhang X, Zhao C, Ma Z, Sun K, Sun Y, Du X, Liu M, Liang X, Yu X, Gao Y
International journal of molecular sciences 2025 Feb 19;26(4)
International journal of molecular sciences 2025 Feb 19;26(4)
Orally Administrated Precision Nanomedicine for Restoring the Intestinal Barrier and Alleviating Inflammation in Treatment of Inflammatory Bowel Disease.
Wang D, Jiang Q, Li P, Yu C, Yuan R, Dong Z, Meng T, Hu F, Wang J, Yuan H
ACS applied materials & interfaces 2025 Feb 19;17(7):10986-11001
ACS applied materials & interfaces 2025 Feb 19;17(7):10986-11001
Chemoresistance mechanisms to 5-Fluorouracil and reversal strategies in lung and breast cancer.
Zhong C, Wang S, Jiang WJ, Li Z, Wang X, Fan S, Huang J, Wu HJ, Sheng R, Fei T
Scientific reports 2025 Feb 19;15(1):6074
Scientific reports 2025 Feb 19;15(1):6074
Microenvironment-Responsive Hydrogels Comprising Engineering Zeolitic Imidazolate Framework-8-Anchored Parathyroid Hormone-Related Peptide-1 for Osteoarthritis Therapy.
Shi G, Wu Z, Hao Z, Zhu M, Shu F, Yang Z, Wang J, Wang C, Chen R, Li Z, Wei R, Li J
ACS nano 2025 Feb 18;19(6):6529-6553
ACS nano 2025 Feb 18;19(6):6529-6553
A comprehensive analysis-based study of Di-(2-ethylhexyl) phthalate (DEHP)-Environmental explanation of bladder cancer progression.
Lin F, Zheng WC, Ke ZB, Chen DN, Xue YT, Lin YZ, Li XD, Zheng QS, Wei Y, Xue XY, Xu N
Environmental pollution (Barking, Essex : 1987) 2025 Feb 15;367:125625
Environmental pollution (Barking, Essex : 1987) 2025 Feb 15;367:125625
GPNMB attenuates neuroinflammation and improves ischemic stroke via modulation of PI3K/Akt and p38 MAPK signaling pathways.
Ping Y, Li J, Xie L, Zhao J, Chen X, Chen D, Wang Y, Jiang C, Li X
Brain research 2025 Feb 15;1849:149381
Brain research 2025 Feb 15;1849:149381
Dissecting the mechanisms of velvet antler extract against diabetic osteoporosis via network pharmacology and proteomics.
Wang M, Zhou Z, Wei Y, He R, Yang J, Zhang X, Li X, Zhao D, Li Z, Leng X, Dong H
Journal of ethnopharmacology 2025 Feb 11;341:119334
Journal of ethnopharmacology 2025 Feb 11;341:119334
P2Y12 receptor-independent antiplatelet mechanism of cryptotanshinone: Network pharmacology and experimental validation of multi-target signaling pathways.
Xiao Y, Zhang R, Hua C, Wu M, Yuan Y, Zhang L, Guo F, Liu J, Yang Z, Liu G
Journal of ethnopharmacology 2025 Feb 11;341:119321
Journal of ethnopharmacology 2025 Feb 11;341:119321
Ferulic acid from Angelica sinensis (Oliv.) Diels ameliorates lipid metabolism in alcoholic liver disease via AMPK/ACC and PI3K/AKT pathways.
Lu J, Wang C
Journal of ethnopharmacology 2025 Feb 10;338(Pt 3):119118
Journal of ethnopharmacology 2025 Feb 10;338(Pt 3):119118
Network pharmacology, molecular docking and biological verification to explore the potential anti-prostate cancer mechanisms of Tripterygium wilfordii Hook. F.
Sang Y, Hu Y, Zhang Y, Chen L, Lu Y, Gao L, Lu Y, Cao X, Zhang Y, Chen G
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119071
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119071
RhFGF21 protected PC12 cells against mitochondrial apoptosis triggered by H(2)O(2) via the AKT-mediated ROS signaling pathway.
Lin J, Wu J, Xu Y, Zhao Y, Ye S
Experimental cell research 2025 Feb 1;445(1):114417
Experimental cell research 2025 Feb 1;445(1):114417
Thermoradiotherapy reverses proliferation, metastasis, and anoikis resistance in glioblastoma through ITGA5-PI3K/AKT axis.
Shi Y, An H, Wang W, Nan D, Cui Y, He M, Lian J, Zhang X, Peng J, Yang X, Liu P
Translational oncology 2025 Dec;62:102552
Translational oncology 2025 Dec;62:102552
Comprehensive analysis of the leukocyte immunoglobulin-like receptor family in clear cell renal cell carcinoma.
He W, Cong Z, Niu C, Sun X, Yao Z, Zhang Y, Jiang X, Niu Z, Fu Q
Annals of medicine 2025 Dec;57(1):2546684
Annals of medicine 2025 Dec;57(1):2546684
Acute carbon monoxide poisoning induces renal inflammation and apoptosis via CCL4 upregulation and activation of the PI3K/Akt pathway in mice.
Ni Y, Jiang X, Wang S, Pu T, Yan T, Yu A, Liu Q
Molecular medicine reports 2025 Dec;32(6)
Molecular medicine reports 2025 Dec;32(6)
RhoE downregulation leads to enhanced cholesterol biosynthesis and sorafenib resistance in hepatocellular carcinoma.
Feng J, Ye L, Chen C, Zhu Y, Liu R, Yu H, Lu L, Gong K, Li W
The Journal of biological chemistry 2025 Dec;301(12):110918
The Journal of biological chemistry 2025 Dec;301(12):110918
Astragaloside IV protects against high altitude hypoxia-induced cardiac injury through the CaSR-NF-kB and EGFR-PI3K-AKT-MDM2 pathways.
Li X, Cao R, Zhang L, Chen J, Qin Z, Huang D, Nie Y, Duan Z, Pu L, Wang Z, Li R, Wang X, Liu W, Chen Z
Apoptosis : an international journal on programmed cell death 2025 Dec;30(11-12):3169-3189
Apoptosis : an international journal on programmed cell death 2025 Dec;30(11-12):3169-3189
Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis.
Tan SM, Luo L, He YF, Li W, Wan XX
Cancer biology & therapy 2025 Dec;26(1):2442556
Cancer biology & therapy 2025 Dec;26(1):2442556
Farnesyltransferase Inhibitor (R115777) Targets CENPF to Inhibit Breast Cancer Bone Metastasis by Regulating the PI3k/AKT/mTOR/PTHrP Pathway.
Liu J, Sun J, Fang H, Luo J, Phangphongphanh M, Zou Y, Jin Y, Tao X, Zhou K, Deng Y, Liu L, Xiao G, Li N, Liu X
Clinical breast cancer 2025 Dec;25(8):e1112-e1121
Clinical breast cancer 2025 Dec;25(8):e1112-e1121
USP36 suppresses breast cancer cell ferroptosis by regulating the ubiquitination and stability of KIF2C.
Chen Y, Hong S, Wu F, Xu S, Yang Y, Xu J
Biochemical pharmacology 2025 Dec;242(Pt 2):117196
Biochemical pharmacology 2025 Dec;242(Pt 2):117196
Effects of proline on growth performance, protein synthesis and cold resistance in white shrimp (Litopenaeus vannamei).
Zou D, Yang M, Chen Z, Lin P, Li Y, Liu X, Tan B, Ye C
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Dec;23:220-234
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2025 Dec;23:220-234
ATP1B4 as a candidate upstream regulator of muscle atrophy in diabetic sarcopenia via PI3K/AKT/mTOR-mediated autophagy.
Duan T, Jia S, Zhou D, Zhao L
The international journal of biochemistry & cell biology 2025 Dec;189:106869
The international journal of biochemistry & cell biology 2025 Dec;189:106869
Ginsenoside Rb1 alleviates atherosclerosis by modulating vascular smooth muscle cell proliferation, foam cell formation, and autophagy.
Yuan HH, Yi ZY, Xie LL, Bu LL, Guo MH, Zheng XL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157503
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157503
Dietary urolithin A suppresses lung cancer via gut microbiota-mediated autophagy activation.
Zhang J, Li X, Sun L, Chen B, Zhang R, Duan J
The Journal of nutritional biochemistry 2025 Dec;146:110080
The Journal of nutritional biochemistry 2025 Dec;146:110080
Hydroxytyrosol improved insulin resistance in male offspring born to high-fat diet dams by remodeling gut microbiota.
Yi D, Li T, Xiao Y, Li X, Shao B, Wu Z, Hao Q, Zhang F, Zhang X, Yang G, Zhang C, Deng H, Sun X, Wang N
The Journal of nutritional biochemistry 2025 Dec;146:110041
The Journal of nutritional biochemistry 2025 Dec;146:110041
N2 neutrophils induce cell stemness reprogramming to promote gastric cancer progression via exosomal miRNAs.
Tang H, Zhong Y, Wang J, Meng S, Yu D, Fan B, Dong X, Wang M, Fu M, Qian Y, Zhang X, Ji R, Zhang X, Fang X, Zhang J
Cellular signalling 2025 Dec;136:112085
Cellular signalling 2025 Dec;136:112085
Integration of scRNA-Seq and scATAC-Seq Reveals Malignant Characteristics of Sarcomatoid Clear Cell Renal Cell Carcinoma.
Lu W, Liu Y, Cen J, Huang S, Wen Z, Li J, Mo Z, Liang X, Lu Z, Su C, Yu Z
Cancer science 2025 Dec;116(12):3503-3518
Cancer science 2025 Dec;116(12):3503-3518
Therapeutic Potential of 6-Gingerol in Glioma: Mechanistic Insights and Experimental Validation.
Miao S, Hua W, Wang J, Li L, Sun Y, Shi X, Ma S
Chemical biology & drug design 2025 Dec;106(6):e70217
Chemical biology & drug design 2025 Dec;106(6):e70217
Metformin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage Via Improving Endoplasmic Reticulum Stress and Mitochondrial Stress-Mediated Ca(2+) Imbalance.
Zhang Z, Zhang J, Li L, Zong L
Molecular neurobiology 2025 Dec 5;63(1):256
Molecular neurobiology 2025 Dec 5;63(1):256
Phosvitin-Derived Peptide Pt5-1c Is a Pro-Angiogenic Agent Capable of Enhancing Wound Healing.
Xuan C, Li M, Zhang P, Wang Y, Li H, Gao Z, Zhang S, Wu F
Biomolecules 2025 Dec 31;16(1)
Biomolecules 2025 Dec 31;16(1)
Regulation of Melatonin on AQP4 Expression in Brain of SD Newborn Rats with Bilirubin Encephalopathy and Protection Mechanism.
Xue K, Cheng X, Qian W, Mistry H, Fan P, Hu J, Chen C, Zhang L, Vazirinasab P, Huang J, Lu W, Xu J, Zhu S, Qiu G, Ran J, Gan S
Molecular neurobiology 2025 Dec 3;63(1):239
Molecular neurobiology 2025 Dec 3;63(1):239
Network Pharmacology and Untargeted Metabolomics Analysis of the Protective Mechanisms of Total Flavonoids from Chuju in Myocardial Ischemia-Reperfusion Injury.
Shi G, Meng H, Zhang Z, Zhang G, Li Y, Yu H
Pharmaceuticals (Basel, Switzerland) 2025 Dec 29;19(1)
Pharmaceuticals (Basel, Switzerland) 2025 Dec 29;19(1)
Sestrin2 Knockdown Impairs Proliferation, Migration, Invasion, and Apoptosis in OSCC Cells via PI3K/AKT/mTOR and MAPK Pathways.
Yang W, Wang W, Zhang Z, Zhao Z, Li K, Liu Z, Xu L, Shi M, Li Y, Wang H
Current issues in molecular biology 2025 Dec 26;48(1)
Current issues in molecular biology 2025 Dec 26;48(1)
Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p.
Zeng ZF, Rao J, Xia XB, Chen XY, He HX, Liu B, Chen Q, Liu YD, Wang GJ, Cheng PC, Wang JN, Wang P, Yu Y, Wang ZN
World journal of stem cells 2025 Dec 26;17(12):112207
World journal of stem cells 2025 Dec 26;17(12):112207
Disruption of cerebral cholesterol homeostasis by PS-NPs: astrocytic endoplasmic reticulum stress.
Tian L, Wei Y, Ma J, Zhao Y, Mi Y, Zhang L, Wang B, Chen J, Li K, Shi Y, Lai W, Liu H, Lin B
Journal of nanobiotechnology 2025 Dec 24;23(1):790
Journal of nanobiotechnology 2025 Dec 24;23(1):790
miR-139-5p suppresses hepatocellular carcinoma progression by targeting SMOX to inhibit AKT-mTOR pathway and epithelial-mesenchymal transition.
Pei W, Li K, Bai Y, Ren L, Mo A, Mei J, Ding H, Wang R, Zhao Q, Wang H
Scientific reports 2025 Dec 24;16(1):3602
Scientific reports 2025 Dec 24;16(1):3602
IL-21 promotes the anti-tumor effect of anti-CD47 chimeric antigen receptor macrophages in ovarian cancer.
Chen Y, Zhu X, Chen Y, Yang Z, Shen Z, Chen M, Liu C, Zhou Y, Wang H, Zhu M, Qiu J, Huang J, Han X, Wei W, Ruilin L, Hong W, Tu J
Communications biology 2025 Dec 23;9(1):63
Communications biology 2025 Dec 23;9(1):63
Protective effect of Lonicerae Japonicae Flos extract against doxorubicin-induced myocardial injury in mice and the possible mechanisms.
Xia S, Wei H, Hong W, Zhang Y, Yin F, Zhang Y, Zhang L, Gao Q, Ye H
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Dec 20;45(12):2527-2540
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Dec 20;45(12):2527-2540
Promoting astrocyte-neuron triiodothyronine shuttling attenuates brain damage in neonatal hypoxic-ischemic encephalopathy.
Yu G, Yang Y, Zhou W, Wang X, Feng Y, Wang X, Lin Z
Journal of neuroinflammation 2025 Dec 2;23(1):5
Journal of neuroinflammation 2025 Dec 2;23(1):5
Optogenetic control of biomolecular organization reveals distinct roles of phase separation in RTK signaling.
Zhou M, Shi N, Li P
Cell chemical biology 2025 Dec 18;32(12):1503-1516.e5
Cell chemical biology 2025 Dec 18;32(12):1503-1516.e5
Knockdown of FXYD2 inhibits mepivacaine-induced cardiomyocyte injury by activating the PI3K/AKT signaling pathway.
Cheng L, Wang B, Chen J, Qiao X, Jiang J, Sun Y
European journal of medical research 2025 Dec 18;31(1):121
European journal of medical research 2025 Dec 18;31(1):121
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
Zhang X, Jiang Q, Deng W, Tang H, Liu Y, Xu Z, Guo K, Liu N, Wang H, Cui T, Wang F, Qiu J
Arthritis research & therapy 2025 Dec 18;28(1):16
Arthritis research & therapy 2025 Dec 18;28(1):16
Investigation of a Neuroprotective Peptide from Round Scad (Decapterus maruadsi): Bioactivity Validation, Gastrointestinal Digestion Stability, and Structure-Activity Relationship Analysis.
Zhang Q, Zhao L, Li C, Chang X, Zhu L, Zhang Y, Ding W
Journal of agricultural and food chemistry 2025 Dec 17;73(50):32302-32314
Journal of agricultural and food chemistry 2025 Dec 17;73(50):32302-32314
Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy.
Ge X, Yu L, Zhang L, Jia L, Meng M, He J, Bu F, Song Y, Sun G, Lv S, Mei D, Yang Y, Xu D, Zhang J, Zhang S, Wang C, Jia D, Chen Y, Gao Y, He B
Nature communications 2025 Dec 14;17(1):623
Nature communications 2025 Dec 14;17(1):623
Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds.
Zhao Y, Hu W, Wang X, Ren Z, Gong Y, Liu L, Sun Y
International journal of molecular sciences 2025 Dec 12;26(24)
International journal of molecular sciences 2025 Dec 12;26(24)
Citri grandis Exocarpium Extract Alleviates Atherosclerosis in ApoE(-/-) Mice by Modulating the Expression of TGF-β1, PI3K, AKT1, PPAR-γ, LXR-α, and ABCA1.
Xu J, Wen WZ, Zhao JH, Guo JR, Zhang ZY, Xiong P
Foods (Basel, Switzerland) 2025 Dec 11;14(24)
Foods (Basel, Switzerland) 2025 Dec 11;14(24)
Pegmolesatide ameliorates indoxyl sulfate-induced cardiomyocyte hypertrophy through modulating the EPOR-CD131-dependent JAK2/STAT3 signaling pathway.
Zhang X, Li S, Lin T, Gan L, Zhu L, Zuo L
International immunopharmacology 2025 Dec 10;167:115643
International immunopharmacology 2025 Dec 10;167:115643
CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression.
Hao J, Zheng J, Liu C, Lu J, Tan M, Li J, Mao J, Yu Y, Wang H, Zhang Y, Shen H
International immunopharmacology 2025 Dec 10;167:115594
International immunopharmacology 2025 Dec 10;167:115594
SMURF2 Inhibits Autophagy and Growth in Ovarian Cancer by Regulating the RACK1/AKT/mTOR Pathway.
Wu L, Xiao Z, Zhang S, Guo L, Liu X, Zhang L, Xu J, Lv M, Wang J
American journal of reproductive immunology (New York, N.Y. : 1989) 2025 Aug;94(2):e70140
American journal of reproductive immunology (New York, N.Y. : 1989) 2025 Aug;94(2):e70140
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy.
Huang G, Cai Y, Ren M, Zhang X, Fu Y, Cheng R, Wang Y, Miao M, Zhu L, Yan T
Journal of advanced research 2025 Aug;74:589-607
Journal of advanced research 2025 Aug;74:589-607
Treadmill Exercise Modulates the Leptin/LepR/GSK-3β Signalling Pathway to Improve Leptin Sensitivity and Alleviate Neuroinflammation in High-Fat Diet-Fed APP/PS1 Mice.
Wang J, Liao M, Tong Z, Yuan S, Hu Z, Chen Z, Zeng F, Zou R, Chen D, Chen G, Wang Z, Liu W
Molecular neurobiology 2025 Aug;62(8):9651-9669
Molecular neurobiology 2025 Aug;62(8):9651-9669
p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation.
Song ML, Sun YY, Yin HJ, Li Y, Yang H
Acta pharmacologica Sinica 2025 Aug;46(8):2136-2150
Acta pharmacologica Sinica 2025 Aug;46(8):2136-2150
Danggui Buxue Decoction Combined with Borneol Improves Cyclophosphamide-Induced Myelosuppression by Inhibiting CDK2.
Li K, Wu R, Zhou T, Xiong J
Cancer biotherapy & radiopharmaceuticals 2025 Aug;40(6):426-440
Cancer biotherapy & radiopharmaceuticals 2025 Aug;40(6):426-440
Silencing PIM1 inhibits ENO1-induced AKT activation and attenuates fibrillogenesis during spinal cord injury-induced skeletal muscle atrophy.
Yu X, Cao J, Wang B, Fu J, Liu J, Sui T, Wang Z, Wu C, Chang J, Cao X, Zhang S
The Journal of biological chemistry 2025 Aug;301(8):110398
The Journal of biological chemistry 2025 Aug;301(8):110398
Clostridium butyricum ameliorates post-gastrectomy insulin resistance by regulating the mTORC1 signaling pathway through the gut-liver axis.
He Z, Xiong H, Cai Y, Chen W, Shi M, Liu L, Wu K, Deng X, Deng X, Chen T
Microbiological research 2025 Aug;297:128154
Microbiological research 2025 Aug;297:128154
Emodin Alleviates Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting Serum Exosomal miRNA-21-3p-Induced M1 Alveolar Macrophage Polarisation.
Lan B, Dong X, Yang Q, Wen H, Zhang Y, Li F, Cao Y, Chen Z, Chen H
Journal of cellular and molecular medicine 2025 Aug;29(16):e70758
Journal of cellular and molecular medicine 2025 Aug;29(16):e70758
Heparanase inhibition mitigates bleomycin-induced pulmonary fibrosis in mice by reducing M2 macrophage polarization.
He L, Lv Q, Luo J, Guo YD, Sun H, Zong M, Fan LY
Immunology letters 2025 Aug;274:107006
Immunology letters 2025 Aug;274:107006
PIMREG modulation of PI3K/Akt pathway enhances sorafenib resistance in Huh7 cells.
Zhang L, Gao A, Peng K
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2025 Aug;26(3):241-249
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2025 Aug;26(3):241-249
l-theanine alleviates ulcerative colitis by repairing the intestinal barrier through regulating the gut microbiota and associated short-chain fatty acids.
Liu A, Wang B, Wang M, Tang R, Xu W, Xiao W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Aug;202:115497
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Aug;202:115497
Exogenous Nucleotides Supplementation Attenuates Age-Related Sarcopenia.
Wu X, Liu R, Zhu N, Wang X, Wei C, An X, Xu M, Li Y
Journal of cachexia, sarcopenia and muscle 2025 Aug;16(4):e70002
Journal of cachexia, sarcopenia and muscle 2025 Aug;16(4):e70002
HnRNPR promotes non-small cell lung cancer progression by protecting XB130 mRNA from XRN1- and DIS3L2-mediated degradation.
Wang QR, Liu LL, Gou XJ, Liu Y, Zhao Y, Zhang T, Jiang YH, Zhou JJ, Li JL, Zhang J, Xie Y
Cellular signalling 2025 Aug;132:111816
Cellular signalling 2025 Aug;132:111816
Pig Liver Esterase Hydrolysis of 2-Arachidonoglycerol Exacerbates PRRSV-Induced Inflammation via PI3K-Akt-NF-κB Pathway.
Fu Y, Zhu H, Xiao Q, Chen Q, Zhou Q, Wang X, Shi D
Cells 2025 Aug 8;14(16)
Cells 2025 Aug 8;14(16)
G-protein coupled receptor 183 (GPR183) inhibits visceral metastasis of non-small cell lung cancer.
Cheng L, Li S, Cui Z, Sun X, Gong M, Chen Y, Meng L, Liao Y
Clinical & experimental metastasis 2025 Aug 4;42(5):44
Clinical & experimental metastasis 2025 Aug 4;42(5):44
Apigenin mitigates intestinal barrier dysfunction in sepsis by modulating the AKT signaling pathway.
Lijun Z, Liping W, Dandan Z, Wenjie Z, Renjie X, Xueyan J, Wenqing C, Chen L, Lu Z
BMC gastroenterology 2025 Aug 30;25(1):626
BMC gastroenterology 2025 Aug 30;25(1):626
Non-SMC condensin I complex subunit H promotes cell proliferation and inhibits cell apoptosis of clear cell renal cell carcinoma by activating the PI3K/AKT pathway.
Ha H, Wang J, Zhang X, Du Y, Xiong W, Li S, Shang P
Translational andrology and urology 2025 Aug 30;14(8):2153-2170
Translational andrology and urology 2025 Aug 30;14(8):2153-2170
Mechanisms and synergistic effects of the active components of Xanthocerais lignum in inhibiting rheumatoid arthritis through the modulation of the biological behavior of synovial cells.
Qian H, Bai C, Jia X, Yang Y, Tian X, Wang X
Journal of ethnopharmacology 2025 Aug 29;352:120200
Journal of ethnopharmacology 2025 Aug 29;352:120200
Sanleng Wan inhibits endometriosis progression by regulating sphingolipid metabolism via the S1P/S1PR1-Akt axis based on serum metabolomics and network pharmacology.
Fu Z, Zhou H, Liu H, Li X, Cao L, Zheng W
Journal of ethnopharmacology 2025 Aug 29;352:120153
Journal of ethnopharmacology 2025 Aug 29;352:120153
PHPT1 acts as an inhibitor in high-altitude pulmonary hypertension via negative TRPV5 signaling regulation.
Guo G, Zhu MX, Xu X, Li X, Chen YB, Shen YY, Li HL, Cheng LT, He KL, Yao YM, Liu CL
Journal of translational medicine 2025 Aug 28;23(1):968
Journal of translational medicine 2025 Aug 28;23(1):968
Anti-Obesity Effects of Pea Peptides Modified by Steam Explosion on Obese Mice: Regulation of Gut Microbiota and Glucose Metabolism.
Tu J, Liu C, Zhang J, Li T, Zhu J, Wang Q, Wu R, Wang T
Foods (Basel, Switzerland) 2025 Aug 28;14(17)
Foods (Basel, Switzerland) 2025 Aug 28;14(17)
Senkyunolide H reverses depression-induced breast cancer progression by regulating CXCR2.
Wu Y, Cui J, Chen L, Chen J, Huang J, Yang C, Liang Y, Chen Q, Zuo Q
Natural products and bioprospecting 2025 Aug 21;15(1):57
Natural products and bioprospecting 2025 Aug 21;15(1):57
Structure-based drug design of small molecule AKT1 inhibitors to treat glioma.
Jia X, Han Q, Ma X, Sun Z
Journal of computer-aided molecular design 2025 Aug 19;39(1):69
Journal of computer-aided molecular design 2025 Aug 19;39(1):69
METTL3 promotes peritoneal metastasis of colorectal cancer through regulating m6A modification of NRXN3 mRNA.
Lan TH, Li W, Wang X, Geng YJ, Pang B, Kang LF, Li DY, Pang LY, Zhang XX, Zhang CQ, Wang GQ, Li ZX, Zhou CM, Jiang X, Zhao ZR
iScience 2025 Aug 15;28(8):113165
iScience 2025 Aug 15;28(8):113165
Reduced HSP70 expression under mild hypothermia is involved in bovine embryo growth suppression.
Ishii T, Nakamura S, Ohkura S, Matsuyama S
The Journal of reproduction and development 2025 Aug 1;71(4):195-200
The Journal of reproduction and development 2025 Aug 1;71(4):195-200
CXCR4-Mediated Chemokine Signaling Orchestrates the Progression of Conjunctival Melanocytic Lesions.
Huang Z, Zhu T, Chen J, Qiu M, Rao Y, Jia R, Xu S
Investigative ophthalmology & visual science 2025 Aug 1;66(11):23
Investigative ophthalmology & visual science 2025 Aug 1;66(11):23
Epithelial cells and fibroblasts are both activated via TGF-β1 and GSK-3β pathways differentially in the comorbidity of pulmonary fibrosis with lung adenocarcinoma.
Yang C, Qin Z, Ma H, Liu H, Hou M, Wei J, Guo H, An X, Yang F, Yang A, Dang Y, Zhang F
Life sciences 2025 Aug 1;374:123696
Life sciences 2025 Aug 1;374:123696
β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway.
Chen L, Zeng L, Pan S, Zu L, Pan H, Fan L
Cytotechnology 2025 Apr;77(2):76
Cytotechnology 2025 Apr;77(2):76
TFAP4 Regulation of MCM5 Activates the PI3K/AKT Pathway to Promote Invasion and Metastasis of Gastric Cancer.
Yuan YW, Yue ZQ, Zhou Q, Sheng J, Zou YH, Fan LJ, Xu H, Xin L
Digestive diseases and sciences 2025 Apr;70(4):1411-1427
Digestive diseases and sciences 2025 Apr;70(4):1411-1427
PRMT5 Inhibition Enhances Therapeutic Efficacy of Cisplatin via Mediating miR-29b-3p-Mcl-1 Expression in Lung Adenocarcinoma.
Li H, Fan J, Shen W, Zhang Y, Zhu X, Li P, Gu Z, Jing P
Cell biology international 2025 Apr;49(4):407-418
Cell biology international 2025 Apr;49(4):407-418
Network pharmacology-based strategy to reveal the mechanism of pinocembrin against ovarian cancer.
Wang G, Cheng J, Yao M, Li J, Chen T, Zhang J, Du W, Chen Y
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):3803-3815
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):3803-3815
Exploring the anti-NSCLC mechanism of phillyrin targeting inhibition of the HSP90-AKT pathway.
Duan Q, Li R, Wang M, Cui Z, Zhu X, Chen F, Han F, Ma J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):3789-3802
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):3789-3802
Prunus mume Alleviates Hyperuricemic Renal Injury: Insights From Network Pharmacology and Experimental Models.
Zheng S, Li S, Diao X, Chen N
Biomedical chromatography : BMC 2025 Apr;39(4):e70035
Biomedical chromatography : BMC 2025 Apr;39(4):e70035
Cinobufacini Inhibits Survival and Metastasis of Hepatocellular Carcinoma via c-Met Signaling Pathway.
Ma YN, Jiang XM, Hu XQ, Wang L, Gao JJ, Liu H, Qi FH, Song PP, Tang W
Chinese journal of integrative medicine 2025 Apr;31(4):311-325
Chinese journal of integrative medicine 2025 Apr;31(4):311-325
Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma.
Zeng W, Liu F, Liu Y, Zhang Z, Hu H, Ning S, Zhang H, Chen X, Liao Z, Zhang Z
Clinical and molecular hepatology 2025 Apr;31(2):489-508
Clinical and molecular hepatology 2025 Apr;31(2):489-508
Selenium nanoparticles attenuate retinal pathological angiogenesis by disrupting cell cycle distribution.
Nie Z, Liu Y, Xu L, Wang Y, Wang M, Zhou W, Zhu H, Zhao M, Wang S, Zhang H, Geng M, Peng M, Zeng H, Zhang Y, Zhu P, Shen W
Nanomedicine (London, England) 2025 Apr;20(8):803-816
Nanomedicine (London, England) 2025 Apr;20(8):803-816
Glioblastoma- derived exosomes (GBM-Exo) regulate microglial M2 polarization via the RAC1/AKT/NRF2 pathway.
Wu Q, Chen S, Xie X, Yan H, Feng X, Su G, Zhang Z
Journal of neuro-oncology 2025 Apr;172(2):447-460
Journal of neuro-oncology 2025 Apr;172(2):447-460
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.
Zhang P, Liu Z, Ma G, Wang J, Shao J, Ma C, Wang L, Ma C
Archives of physiology and biochemistry 2025 Apr;131(2):285-292
Archives of physiology and biochemistry 2025 Apr;131(2):285-292
Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway.
Zhao J, Fan Y, Li H, Wang C, Fan S, Sun H, Liu M
Food science & nutrition 2025 Apr;13(4):e70177
Food science & nutrition 2025 Apr;13(4):e70177
Network pharmacology-based exploration of the mechanism of Wenweishu granule in treating chronic atrophic gastritis with spleen-stomach cold deficiency syndrome.
Zheng J, Jiao Z, Yang X, Ruan Q, Huang Y, Jin C, Gui S, Xuan Z, Jia X
Journal of ethnopharmacology 2025 Apr 9;345:119591
Journal of ethnopharmacology 2025 Apr 9;345:119591
Ethyl acetate extract from Herpetospermun cardigerum wall. Ameliorated concanavalin A-induced autoimmune hepatitis in mice by reprofiling gut microenvironment to modulate IDO1/KYN and PI3K/AKT/NF-κB pathways.
Xiao Y, Luo T, Duan C, Wang X, Yang Y, Li R, Deng J, Zhao Q
Journal of ethnopharmacology 2025 Apr 9;345:119578
Journal of ethnopharmacology 2025 Apr 9;345:119578
LC-MS/MS assay to confirm that the endogenous metabolite L-Arginine promotes trophoblast invasion in the placenta accreta spectrum through upregulation of the GPRC6A/PI3K/AKT pathway.
Gao Z, Xue M, Wang Z
BMC pregnancy and childbirth 2025 Apr 7;25(1):402
BMC pregnancy and childbirth 2025 Apr 7;25(1):402
Vitexin alleviates lipid metabolism disorders and hepatic injury in obese mice through the PI3K/AKT/mTOR/SREBP-1c pathway.
Liu B, Yao Z, Song L, Sun C, Shen C, Cheng F, Cheng Z, Zhang R, Liu R
European journal of medicinal chemistry 2025 Apr 5;287:117379
European journal of medicinal chemistry 2025 Apr 5;287:117379
3-Hydroxybutyrate Promotes Myoblast Proliferation and Differentiation through Energy Metabolism and GPR109a-Mediated Ca(2+)-NFAT Signaling Pathways.
Qiu X, Wu W, Zhang S, Huang C, Lin D
Journal of proteome research 2025 Apr 4;24(4):2063-2080
Journal of proteome research 2025 Apr 4;24(4):2063-2080
Podophyllotoxin Alleviates DSS-Induced Ulcerative Colitis via PI3K/AKT Pathway Activation.
Li T, Wang X, Wang J
Physiological research 2025 Apr 30;74(2):287-300
Physiological research 2025 Apr 30;74(2):287-300
Orbital mesenchymal chondrosarcoma and its specific fusion gene HEY1-NCOA2.
Lin JQ, Liu X, Zhao JZ, Wang Q, Zhu LM, Lin TT
BMC ophthalmology 2025 Apr 29;25(1):258
BMC ophthalmology 2025 Apr 29;25(1):258
Baicalin Relieves Glaesserella parasuis-Triggered Immunosuppression Through Polarization via MIF/CD74 Signaling Pathway in Piglets.
Fu S, Dong Q, Fu Y, Luo R, Li J, Sun Y, Liu S, Qiu Y, Guo L, Hu J
Biomolecules 2025 Apr 29;15(5)
Biomolecules 2025 Apr 29;15(5)
The Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) 3 Regulates the Myogenic Differentiation of Yunan Black Pig Muscle Satellite Cells (MuSCs) In Vitro via Iron Homeostasis and the PI3K/AKT Pathway.
Zhang W, Zhang M, Zhang J, Chen S, Zhang K, Xie X, Guo C, Shen J, Zhang X, Sun H, Guo L, Wen Y, Wang L, Hu J
Cells 2025 Apr 29;14(9)
Cells 2025 Apr 29;14(9)
Unveiling the multifaceted benefits of Simiao Pill in ulcerative colitis: Integrative analysis of signaling pathways, gut microbiota, and lipid metabolism.
Peng X, Zou Q, Yang C, Pu X, Yang H, Wang M, Chen S, Pu S, Chen X, He H, Li Y
Journal of ethnopharmacology 2025 Apr 25;346:119714
Journal of ethnopharmacology 2025 Apr 25;346:119714
Thesium chinense Turcz. and its compound astragalin alleviate lipopolysaccharide-induced acute lung injury via the PI3K/AKT/p53 signaling pathway.
Xu H, Zhang F, Che Y, Sun T, Che K, Cui Y, Zhou N, Wan J, Chang W, Guan Y, Huang Y, Chen H
Journal of ethnopharmacology 2025 Apr 25;346:119691
Journal of ethnopharmacology 2025 Apr 25;346:119691
Comprehensive characterisation of bioactive compounds in Boletus edulis as functional foods to improve muscle atrophy; through whole plant targeted metabolomics, network pharmacology, in vivo and in vitro experiments, molecular docking and molecular dynamics analysis.
Zhang M, Chen M, Yan Y, Lu J, Sheng J, Gui M, Ma X
Journal of ethnopharmacology 2025 Apr 25;346:119685
Journal of ethnopharmacology 2025 Apr 25;346:119685
Enriched environment alleviates NLRP3 inflammasome mediated neuroinflammation in diabetes complicated with depression rats.
Wang H, Liang Q, Wen Z, Ma W, Ji S, Zhang H, Zhang X
Scientific reports 2025 Apr 23;15(1):14214
Scientific reports 2025 Apr 23;15(1):14214
Investigating the Effect and Mechanism of 3-Methyladenine Against Diabetic Encephalopathy by Network Pharmacology, Molecular Docking, and Experimental Validation.
Chu J, Song J, Fan Z, Zhang R, Wang Q, Yi K, Gong Q, Liu B
Pharmaceuticals (Basel, Switzerland) 2025 Apr 22;18(5)
Pharmaceuticals (Basel, Switzerland) 2025 Apr 22;18(5)
Decursin induces FLT3-ITD acute myeloid leukemia cell apoptosis by increasing the expression of the ubiquitin-conjugase UBE2L6.
Zhang T, Li Y, Liao W, Mou Y, Zhan X, Hu Q, Zhao Z, Xiong D
Cell communication and signaling : CCS 2025 Apr 2;23(1):162
Cell communication and signaling : CCS 2025 Apr 2;23(1):162
DCC-2036 inhibits osteosarcoma via targeting HCK and the PI3K/AKT-mTORC1 axis to promote autophagy.
He J, Yin L, Yuan Q, Su X, Shen Y, Deng Z
World journal of surgical oncology 2025 Apr 2;23(1):115
World journal of surgical oncology 2025 Apr 2;23(1):115
ITGA5 induces mesenchymal transformation to promote gliomas progression via PI3K/AKT/mTORC1 signaling pathway.
Zhang M, Li J, Meng X, Sun Q, Xue Z, Wang M, Du F, Zhang J
Scientific reports 2025 Apr 19;15(1):13539
Scientific reports 2025 Apr 19;15(1):13539
PGRN knockdown alleviates pulmonary fibrosis regulating the Akt/GSK3β signaling pathway.
Xie T, Zheng Y, Zhang L, Zhao J, Wu H, Li Y
International immunopharmacology 2025 Apr 16;152:114443
International immunopharmacology 2025 Apr 16;152:114443
lncRNA NR_146969 promotes the progression of lung adenocarcinoma.
Chen Y, Wang J, Gu L, Chen H, Gai Z, Hu R, Qing B, Yuan Y, Xia Z
Experimental cell research 2025 Apr 15;447(2):114535
Experimental cell research 2025 Apr 15;447(2):114535
Mechanistic evaluation of Jiu Wei Qing Zhi Gao in non-alcoholic fatty liver disease: insights from network Pharmacology and experimental validation.
Chen Q, Hu Q, Zhang F, Lu W, Yuan Z, Qiao F
Hereditas 2025 Apr 12;162(1):59
Hereditas 2025 Apr 12;162(1):59
Bisphenol A-induced cancer-associated adipocytes promotes breast carcinogenesis via CXCL12/AKT signaling.
Dong Z, He L, Wu J, Xie C, Geng S, Wu J, Zhong C, Li X
Molecular and cellular endocrinology 2025 Apr 1;599:112473
Molecular and cellular endocrinology 2025 Apr 1;599:112473
Cytotoxicity and inhibitory potential of CUDC-101 in non-small cell lung cancer cells with rare EGFR L861Q mutation.
Chu C, Xu H, Liu C, Wei X, Li L, Wang R, Cui W, Zhang G, Liu C, Wang K, An L, He F
Current research in toxicology 2024;7:100194
Current research in toxicology 2024;7:100194
ABCF1/CXCL12/CXCR4 Enhances Glioblastoma Cell Proliferation, Migration, and Invasion by Activating the PI3K/AKT Signal Pathway.
Yin X, Xia K, Peng S, Tan B, Huang Y, Wang M, He M
Developmental neuroscience 2024;46(3):210-220
Developmental neuroscience 2024;46(3):210-220
Exploring the Action Mechanism and Validation of the Key Pathways of Dendrobium officinale Throat-clearing Formula for the Treatment of Chronic Pharyngitis Based on Network Pharmacology.
Fang X, Jiang XF, Zhang YP, Zhou CL, Dong YJ, Bo-Li, Lv GY, Chen SH
Combinatorial chemistry & high throughput screening 2024;27(3):479-496
Combinatorial chemistry & high throughput screening 2024;27(3):479-496
mirna-383-5p Functions as an Anti-oncogene in Glioma through the Akt/mTOR Signaling Pathway by Targeting VEGFA.
Liu Y, Wang Z, Tang Z, Fu Y, Wang L
Current cancer drug targets 2024;24(4):463-475
Current cancer drug targets 2024;24(4):463-475
IKBKE regulates renal cell carcinoma progression and sunitinib resistance through the RRM2-AKT pathway.
Liu S, Li J, Zhang J, Wan F, Hong Z, Hong Z, Dai B
International journal of biological sciences 2024;20(15):6146-6161
International journal of biological sciences 2024;20(15):6146-6161
Hypoxia-driven TNS4 fosters HNSCC tumorigenesis by stabilizing integrin α5β1 complex and triggering FAK-mediated Akt and TGFβ signaling pathways.
Zhao X, Mai Z, Liu L, Lu Y, Cui L, Yu J
International journal of biological sciences 2024;20(1):231-248
International journal of biological sciences 2024;20(1):231-248
GPR168 functions as a tumor suppressor in mouse melanoma by restraining Akt signaling pathway.
Guo X, Guo Z, Bai P, Guo C, Liu X, Zhu K, Li X, Zhao Y
PloS one 2024;19(5):e0302061
PloS one 2024;19(5):e0302061
ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway.
Wang Y, Chang J, Wang F, Lai L, Yang S, Fu Y, Ma X, Yun C
Open medicine (Warsaw, Poland) 2024;19(1):20241037
Open medicine (Warsaw, Poland) 2024;19(1):20241037
Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke.
Yao Y, Hu L, Li D, Wang Y, Pan J, Fan D
Frontiers in neuroscience 2024;18:1520710
Frontiers in neuroscience 2024;18:1520710
Probucol mitigates high-fat diet-induced cognitive and social impairments by regulating brain redox and insulin resistance.
Wu HM, Yang YV, Huang NJ, Fan LP, Dai YY, Hu KT, Tang TY, Liu L, Xu Y, Liu DT, Cai ZX, Niu XY, Ren XY, Yao ZH, Qin HY, Chen JZ, Huang X, Zhang C, You X, Wang C, He Y, Hong W, Sun YX, Zhan YH, Lin SY
Frontiers in neuroscience 2024;18:1368552
Frontiers in neuroscience 2024;18:1368552
Network Pharmacology-Based Strategy to Explore the Effect and Mechanism of Zhizhu Granule Improving Glucose-Lipid Metabolism in Rats with Metabolic Syndrome.
Wang J, Liu Y, Xiu C, Wang X, Liu Y, Hu Y, Yang J, Lei Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:3833-3846
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:3833-3846
IRGM Deficiency Exacerbates Sepsis-Induced Acute Lung Injury by Inhibiting Autophagy Through the AKT/mTOR Signaling Pathway.
Guo N, Xia Y, He N, Cheng H, Zhang L, Liu J
Journal of inflammation research 2024;17:10255-10272
Journal of inflammation research 2024;17:10255-10272
FBXL18 is required for ovarian cancer cell proliferation and migration through activating AKT signaling.
Zhuang Y, Xue J, Qiu X, Zhu Y, Lv J, Xia F
American journal of translational research 2024;16(5):1977-1990
American journal of translational research 2024;16(5):1977-1990
LncRNA PRKCA-AS1 promotes LUAD progression and function as a ceRNA to regulate S100A16 by sponging miR-508-5p.
Wu C, Yang J, Lin X, Wu J, Yang C, Chen S
Journal of Cancer 2024;15(6):1718-1730
Journal of Cancer 2024;15(6):1718-1730
PSAT1 mediated EMT of colorectal cancer cells by regulating Pl3K/AKT signaling pathway.
Wang M, Zhang H, Lu Z, Su W, Tan Y, Wang J, Jia X
Journal of Cancer 2024;15(10):3183-3198
Journal of Cancer 2024;15(10):3183-3198
The mechanism of PDE7B inhibiting the development of hepatocellular carcinoma through oxidative stress.
Luo Y, Gao H, Zhao J, Chen L, Shao J, Ju L
Frontiers in immunology 2024;15:1469740
Frontiers in immunology 2024;15:1469740
Bacteroides fragilis capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota.
Zhong Y, Chang X, Zhao Z, Zheng L, Kuang G, Li P, Liu C, Fan Y, Liang Z, Zhuang K, Xie Q, Liu Y
Frontiers in pharmacology 2024;15:1402465
Frontiers in pharmacology 2024;15:1402465
Research on the metabolic regulation mechanism of Yangyin Qingfei decoction plus in severe pneumonia caused by Mycoplasma pneumoniae in mice.
Zhang T, Zhao X, Zhang X, Liang X, Guan Z, Wang G, Liu G, Wu Z
Frontiers in pharmacology 2024;15:1376812
Frontiers in pharmacology 2024;15:1376812
USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis.
Zhao C, Mu M, Li X, Dong Z, Wang J, Yao C, Zheng J, Sun X, Yu J
Frontiers in immunology 2024;15:1326137
Frontiers in immunology 2024;15:1326137
The small protein LINC01547-ORF inhibits colorectal cancer progression by regulating the CLDN18-FAK-AKT axis.
Zhang S, Xu S, Li D, Wu S, Han M, Han Y, Wang Z, Qiao D, Yuan H, Du B, Chen H, Zhang Z
American journal of cancer research 2024;14(11):5504-5520
American journal of cancer research 2024;14(11):5504-5520
Mechanical stimulation promotes fibrochondrocyte proliferation by activating the TRPV4 signaling pathway during tendon-bone insertion healing: CCN2 plays an important regulatory role.
Bian X, Liu X, Zhou M, Tang H, Wang R, Ma L, He G, Xu S, Wang Y, Tan J, Tang K, Guo L
Burns & trauma 2024;12:tkae028
Burns & trauma 2024;12:tkae028
Hypoxia macrophage-derived exosomal miR-26b-5p targeting PTEN promotes the development of keloids.
Dai S, Xu M, Pang Q, Sun J, Lin X, Chu X, Guo C, Xu J
Burns & trauma 2024;12:tkad036
Burns & trauma 2024;12:tkad036
EMF treatment delays mesenchymal stem cells senescence during long-term in vitro expansion by modulating autophagy.
Cai W, Xiao Y, Yan J, Peng H, Tu C
Frontiers in cell and developmental biology 2024;12:1489774
Frontiers in cell and developmental biology 2024;12:1489774
Dietary supplementation with Clostridium autoethanogenum protein improves growth performance and promotes muscle protein synthesis by activating the mTOR signaling pathway of the broiler.
Shan C, Liu Y, Ma C, Li C, Liu Q, Liu S, Jiang G, Tian J
Frontiers in veterinary science 2024;11:1389738
Frontiers in veterinary science 2024;11:1389738
Bioinformatics analysis and experimental verification of TIGD1 in non-small cell lung cancer.
Xia L, Yang Z, Xv M, Wang G, Mao Y, Yang Y, Tang J
Frontiers in medicine 2024;11:1374260
Frontiers in medicine 2024;11:1374260
FOXM1 Upregulates O-GlcNAcylation Level Via The Hexosamine Biosynthesis Pathway to Promote Angiogenesis in Hepatocellular Carcinoma.
Zhang X, Zhong Y, Yang Q
Cell biochemistry and biophysics 2024 Sep;82(3):2767-2785
Cell biochemistry and biophysics 2024 Sep;82(3):2767-2785
TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer.
Wang L, Wu Z, Wang Y, Chen C, Li Y, Dong H, Yao T, Jin G, Wang Z
Cell biochemistry and biophysics 2024 Sep;82(3):2717-2726
Cell biochemistry and biophysics 2024 Sep;82(3):2717-2726
Enhancement of chemoresistance by claudin-1-mediated formation of amino acid barriers in human lung adenocarcinoma A549 cells.
Kimura R, Hashimoto S, Eguchi H, Morikawa Y, Suenami K, Yoshino Y, Matsunaga T, Endo S, Ikari A
Archives of biochemistry and biophysics 2024 Sep;759:110106
Archives of biochemistry and biophysics 2024 Sep;759:110106
Exosomal circZNF800 Derived from Glioma Stem-like Cells Regulates Glioblastoma Tumorigenicity via the PIEZO1/Akt Axis.
Zhang N, Wu P, Mu M, Niu C, Hu S
Molecular neurobiology 2024 Sep;61(9):6556-6571
Molecular neurobiology 2024 Sep;61(9):6556-6571
Remote Ischemia Postconditioning Mitigates Hippocampal Neuron Impairment by Modulating Cav1.2-CaMKIIα-Aromatase Signaling After Global Cerebral Ischemia in Ovariectomized Rats.
Wang L, Gao F, Chen L, Sun W, Liu H, Yang W, Zhang X, Bai J, Wang R
Molecular neurobiology 2024 Sep;61(9):6511-6527
Molecular neurobiology 2024 Sep;61(9):6511-6527
PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25.
Zhang W, Yu L, Xu C, Tang T, Cao J, Chen L, Pang X, Ren W
Cell biology international 2024 Sep;48(9):1285-1300
Cell biology international 2024 Sep;48(9):1285-1300
Synaptotagmin 13 Could Drive the Progression of Esophageal Squamous Cell Carcinoma Through Upregulating ACRV1.
Shao L, Li B
DNA and cell biology 2024 Sep;43(9):452-462
DNA and cell biology 2024 Sep;43(9):452-462
HGFIN deficiency exacerbates spinal cord injury by promoting inflammation and cell apoptosis through regulation of the PI3K/AKT signaling pathway.
Ding Q, Gao H, Hu X, Gao W
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Sep;33(9):929-940
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Sep;33(9):929-940
The suppressive role of NLRP6 in host defense against Streptococcus suis infection.
Hu X, Lu Y, Yu X, Jia K, Xiong Q, Fang R
Veterinary microbiology 2024 Sep;296:110166
Veterinary microbiology 2024 Sep;296:110166
Mechanism of Prunella vulgaris L. and luteolin in restoring Tfh/Tfr balance and alleviating oxidative stress in Graves' disease.
Zhang Y, Qu X, Xu N, He H, Li Q, Wei X, Chen Y, Xu Y, Li X, Zhang R, Zhong R, Liu C, Xiang P, Zhu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155818
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155818
Gentiopicroside ameliorates glucose and lipid metabolism in T2DM via targeting FGFR1.
Xu Z, Huang J, Wen M, Zhang X, Lyu D, Li S, Xiao H, Li M, Shen C, Huang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155780
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155780
The role of α7nAchR and PD-L1 in neuroimmune regulation of keloid treatment.
Luo Z, Zheng S, Liu J, Qi F
Cellular signalling 2024 Sep;121:111275
Cellular signalling 2024 Sep;121:111275
Microglial activation in the medial prefrontal cortex after remote fear recall participates in the regulation of auditory fear extinction.
Zou GJ, Chen ZR, Wang XQ, Cui YH, Li F, Li CQ, Wang LF, Huang FL
European journal of pharmacology 2024 Sep 5;978:176759
European journal of pharmacology 2024 Sep 5;978:176759
CD226 implicated in Akt-dependent apoptosis of CD4(+) T cell contributes to asthmatic pathogenesis.
Zhang Y, Xie Y, Zhang X, Duan C, Ma J, Wang Y, Wu Y, Shan N, Cheng K, Zhuang R, Bian K
Cell death & disease 2024 Sep 30;15(9):705
Cell death & disease 2024 Sep 30;15(9):705
PCK2 induces gefitinib resistance by suppresses ferroptosis in non-small cell lung cancer.
Yan T, Zhang N, Liu F, Wang H, Zhang J, Jin X, Jiang S
Biochemical and biophysical research communications 2024 Sep 3;723:150200
Biochemical and biophysical research communications 2024 Sep 3;723:150200
The expression of congenital Shoc2 variants induces AKT-dependent crosstalk activation of the ERK1/2 pathway.
Wilson PG, Abdelmoti L, Gao T, Galperin E
Human molecular genetics 2024 Sep 3;33(18):1592-1604
Human molecular genetics 2024 Sep 3;33(18):1592-1604
mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis.
Zhao S, Hao S, Zhou J, Chen X, Zhang T, Qi Z, Zhang T, Jalal S, Zhai C, Yin L, Bo Y, Teng H, Wang Y, Gao D, Zhang H, Huang L
Cellular & molecular biology letters 2024 Sep 27;29(1):125
Cellular & molecular biology letters 2024 Sep 27;29(1):125
Schisandrin B attenuates bleomycin-induced pulmonary fibrosis in mice through AKT-mTOR pathway.
Yang J, Zhou D, Hu J, Yang DH, Cai Y, Lu Q
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 2024 Sep 24;41(3):e2024034
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 2024 Sep 24;41(3):e2024034
Epicatechin and β-Glucan from Whole Highland Barley Grain Synergistic Benefit on Attenuating Hyperglycemia via Improving Hepatic Glucose Metabolism in Diabetic C57BL/6J Mice.
Liu Z, Zhang Z, Tang R, Liu J, Yang Y
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20458-20469
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20458-20469
Procyanidin B1 and p-coumaric acid from whole highland barley ameliorated HFD-induced impaired glucose tolerance via small intestinal barrier and hepatic glucose metabolism.
Liu Z, Yang Y, Xu Y, Zhang Z, Tang R, Liu J, Jiang H, Zhao R
Food & function 2024 Sep 16;15(18):9272-9283
Food & function 2024 Sep 16;15(18):9272-9283
Da-Chai-Hu-Tang Formula inhibits the progression and metastasis in HepG2 cells through modulation of the PI3K/AKT/STAT3-induced cell cycle arrest and apoptosis.
Duan ZW, Liu Y, Zhang PP, Hu JY, Mo ZX, Liu WQ, Ma X, Zhou XH, Wang XH, Hu XH, Wei SL
Journal of ethnopharmacology 2024 Sep 15;331:118293
Journal of ethnopharmacology 2024 Sep 15;331:118293
Neohesperidin alleviates the inhibitory effect of bisphenol A on the myogenic differentiation of umbilical cord mesenchymal stem cells via the IGF1R/AKT1/RHOA signaling pathway.
Yang J, Qin S, Sun N, Cai Y, Li J, Zhai Z, An J, Wang H, Du R, Qin J
Ecotoxicology and environmental safety 2024 Sep 15;283:116804
Ecotoxicology and environmental safety 2024 Sep 15;283:116804
Mechanisms of Yiai Fuzheng formula in the treatment of triple-negative breast cancer based on UPLC-Q-Orbitrap-HRMS, network pharmacology, and experimental validation.
Li R, Ke H, Liu P, Yang Q, Li Y, Ke L, Wang X, Wu C, Zhang Y
Heliyon 2024 Sep 15;10(17):e36579
Heliyon 2024 Sep 15;10(17):e36579
Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway.
Cao Z, Ma N, Shan M, Wang S, Du J, Cheng J, Sun P, Sun N, Jin L, Fan K, Yin W, Li H, Yin C, Sun Y
International journal of molecular sciences 2024 Sep 14;25(18)
International journal of molecular sciences 2024 Sep 14;25(18)
Sheng Xue Ning as a Novel Agent that Promotes SCF-Driven Hematopoietic Stem/Progenitor Cell Proliferation to Promote Erythropoiesis.
Zeng Y, Li C, Yang F, Zhang L, Xu W, Wang L, Wu A, Zou W, Wu J, Huang F
Biomolecules 2024 Sep 11;14(9)
Biomolecules 2024 Sep 11;14(9)
Network pharmacology prediction to discover the potential pharmacological action mechanism of Rhizoma Dioscoreae for liver regeneration.
Liu W, Wang W, Tian C, Sun MZ, Liu S, Liu Q
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2024 Sep 1;28(5):479-491
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2024 Sep 1;28(5):479-491
Semi-synthesis and in vitro anti-cancer effects evaluation of novel xanthohumol derivatives.
Sun X, Chen J, Huang D, Ding F, Zhao L, Li HM, Wang XS, Zhang YX, Wu CZ
Molecular diversity 2024 Oct;28(5):2749-2758
Molecular diversity 2024 Oct;28(5):2749-2758
Low-dose radiation promotes high-fat diet-induced atherosclerosis by activating cGAS signal pathway.
Liu X, Huang X, Luo J, Gao SN, Bai C, Xie D, Gao SS, Guan H, Huang R, Zhou PK
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167443
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167443
Phenylpropanoid-rich maize root extract serves as a natural antidepressant.
Zhong T, Zhang Y, Yang H, Luo F, Xu Y, Fan Y, Liu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155893
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155893
METTL14-mediated N6-methyladenosine modification of TCP1 mRNA promotes acute myeloid leukemia progression.
Zhang M, Xie Z, Tan Y, Wu Y, Wang M, Zhang P, Yuan Y, Li J
Cellular signalling 2024 Oct;122:111304
Cellular signalling 2024 Oct;122:111304
Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
Gao X, Fu S, Wen J, Yan A, Yang S, Zhang Y, Liu D, He D
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22115-22131
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22115-22131
Milk-Derived Extracellular Vesicles Carrying ssc-let-7c Alleviate Early Intestinal Inflammation and Regulate Macrophage Polarization via Targeting the PTEN-Mediated PI3K/Akt Pathway.
Lu D, Zhang X, Ye H, Wang J, Han D
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22092-22104
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22092-22104
SMYD1 modulates the proliferation of multipotent cardiac progenitor cells derived from human pluripotent stem cells during myocardial differentiation through GSK3β/β-catenin&ERK signaling.
Chang Y, Bai R, Zhang Y, Lu WJ, Ma S, Zhu M, Lan F, Jiang Y
Stem cell research & therapy 2024 Oct 8;15(1):350
Stem cell research & therapy 2024 Oct 8;15(1):350
SMYD2 Promotes Calcium Oxalate-Induced Glycolysis in Renal Tubular Epithelial Cells via PTEN Methylation.
Pan S, Yuan T, Xia Y, Yu W, Li H, Rao T, Ye Z, Li L, Zhou X, Cheng F
Biomedicines 2024 Oct 8;12(10)
Biomedicines 2024 Oct 8;12(10)
Aldo-keto reductase family 1 member C3 mediates radioresistance of esophageal cancer cells through suppressing MAPK and AKT signaling.
Xiong W, Xie Y, Wang D, Huang X, Hao X, Liu J, Liu X, Gu X, Sun S, Li Y, Li J
BMC cancer 2024 Oct 7;24(1):1236
BMC cancer 2024 Oct 7;24(1):1236
Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway.
Yang J, Cong N, Shi D, Chen S, Zhang Z, Zhao P
Journal of ethnopharmacology 2024 Oct 5;332:118366
Journal of ethnopharmacology 2024 Oct 5;332:118366
CD74(+) fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloids.
Zhang J, Li S, Kuang C, Shen Y, Yu H, Chen F, Tang R, Mao S, Lv L, Qi M, Zhang J, Yuan K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70103
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70103
Exploring the anti-inflammatory and immune regulatory effects of Taohe Chengqi decoction in sepsis-induced lung injury.
Deng M, Chen S, Wu J, Su L, Xu Z, Jiang C, Sheng L, Yang X, Zeng L, Wang J, Dai W
Journal of ethnopharmacology 2024 Oct 28;333:118404
Journal of ethnopharmacology 2024 Oct 28;333:118404
Colon Cancer-Derived Exosomal LncRNA-XIST Promotes M2-like Macrophage Polarization by Regulating PDGFRA.
Gao B, Wang L, Wen T, Xie X, Rui X, Chen Q
International journal of molecular sciences 2024 Oct 24;25(21)
International journal of molecular sciences 2024 Oct 24;25(21)
[Aumolertinib combined with anlotinib inhibits proliferation of non-small cell lung cancer cells by down-regulating the PI3K/AKT pathway].
Yang Y, Liu X, Liu W, Zhou X, Zhang Z, Hu Y, Liu P, Li X, Liu H, Li S
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Oct 20;44(10):1965-1975
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Oct 20;44(10):1965-1975
Ouabain Ameliorates Alzheimer's Disease-Associated Neuropathology and Cognitive Impairment in FAD(4T) Mice.
Wang D, Liu J, Zhu Q, Wei X, Zhang X, Chen Q, Zhao Y, Tang H, Xu W
Nutrients 2024 Oct 20;16(20)
Nutrients 2024 Oct 20;16(20)
Exploring the Mechanism of Sempervirine Inhibiting Glioblastoma Invasion Based on Network Pharmacology and Bioinformatics.
Zhang B, Wang W, Song Y, Chen H, Lin X, Chen J, Chen Y, Huang J, Li D, Wu S
Pharmaceuticals (Basel, Switzerland) 2024 Oct 2;17(10)
Pharmaceuticals (Basel, Switzerland) 2024 Oct 2;17(10)
A novel role for WZ3146 in the inhibition of cell proliferation via ERK and AKT pathway in the rare EGFR G719X mutant cells.
Li L, Liu C, Wang R, Yang X, Wei X, Chu C, Zhang G, Liu C, Cui W, Xu H, Wang K, An L, Li X
Scientific reports 2024 Oct 2;14(1):22895
Scientific reports 2024 Oct 2;14(1):22895
The Inhibition of Reactive Oxygen Species Modulator 1 Attenuates Sevoflurane-Induced Neural Injury via Reducing Apoptosis and Oxidative Stress.
Gu L, Wang X, Wu Z, Chen J
Journal of molecular neuroscience : MN 2024 Oct 16;74(4):97
Journal of molecular neuroscience : MN 2024 Oct 16;74(4):97
Ginsenoside Re Regulates Oxidative Stress through the PI3K/Akt/Nrf2 Signaling Pathway in Mice with Scopolamine-Induced Memory Impairments.
Li X, Zheng K, Chen H, Li W
Current issues in molecular biology 2024 Oct 13;46(10):11359-11374
Current issues in molecular biology 2024 Oct 13;46(10):11359-11374
Mechanisms of neural infiltration-mediated tumor metabolic reprogramming impacting immunotherapy efficacy in non-small cell lung cancer.
Zheng Y, Li L, Shen Z, Wang L, Niu X, Wei Y, Sun S, Zhao J
Journal of experimental & clinical cancer research : CR 2024 Oct 10;43(1):284
Journal of experimental & clinical cancer research : CR 2024 Oct 10;43(1):284
GL-V9 Promotes Autophagy-Mediated YAP1 Degradation and Activates Mitochondrial Apoptosis in PDAC Cells.
Liu H, Lin Z, Guo Y, Zhou Y, Li W
Pharmaceuticals (Basel, Switzerland) 2024 Oct 10;17(10)
Pharmaceuticals (Basel, Switzerland) 2024 Oct 10;17(10)
Vitexin Inhibits TNBC Progression and Metastasis by Modulating Macrophage Polarization Through EGFR Signaling.
Lin Y, Li L, Huang H, Wen X, Zhang Y, Zhang R, Huang W
Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Oct 1;47(8):303-312
Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Oct 1;47(8):303-312
NONRATT000538.2 promotes vascular smooth muscle cell phenotypic switch and in-stent restenosis.
Zhao J, Cheng Y, Zhou M
Experimental cell research 2024 Oct 1;442(2):114260
Experimental cell research 2024 Oct 1;442(2):114260
The role of ALDH1A1 in glioblastoma proliferation and invasion.
Huang YK, Wang TM, Chen CY, Li CY, Wang SC, Irshad K, Pan Y, Chang KC
Chemico-biological interactions 2024 Oct 1;402:111202
Chemico-biological interactions 2024 Oct 1;402:111202
STC2 knockdown inhibits cell proliferation and glycolysis in hepatocellular carcinoma through promoting autophagy by PI3K/Akt/mTOR pathway.
Li D, Xiong Y, Li M, Long L, Zhang Y, Yan H, Xiang H
Archives of biochemistry and biophysics 2024 Nov;761:110149
Archives of biochemistry and biophysics 2024 Nov;761:110149
Calcium-sensing receptor regulates the angiogenic differentiation of LPS-treated human dental pulp cells via the phosphoinositide 3-kinase/Akt pathway in vitro.
Yang T, Liu P, Qiu Z, Zhang Y, An S
International endodontic journal 2024 Nov;57(11):1655-1668
International endodontic journal 2024 Nov;57(11):1655-1668
CypA/TAF15/STAT5A/miR-514a-3p feedback loop drives ovarian cancer metastasis.
Li Y, Yang H, Li A, Chen B, Wang Y, Song Z, Tan H, Li H, Feng Q, Zhou Y, Li S, Zeng L, Lan T
Oncogene 2024 Nov;43(49):3570-3585
Oncogene 2024 Nov;43(49):3570-3585
SPAG4 enhances mitochondrial respiration and aerobic glycolysis in colorectal cancer cells by activating the PI3K/Akt signaling pathway.
Zhou J, Sun H, Zhou H, Liu Y
Journal of biochemical and molecular toxicology 2024 Nov;38(11):e70009
Journal of biochemical and molecular toxicology 2024 Nov;38(11):e70009
Long non-coding RNA AC010457.1 promotes the growth and EMT of gastric cancer via the PI3K/AKT axis.
Qian C, Chen Y, Zhao Z, Hu Y, Yi J, Chen S, He J, Chen J, Xue W
Pathology, research and practice 2024 Nov;263:155646
Pathology, research and practice 2024 Nov;263:155646
Mechanism of Gastrodin against neurotoxicity based on network pharmacology, molecular docking and experimental verification.
Guo H, Li C, Zhao J, Guo T, Chen S, Qin X, Zhu K, Zhang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117611
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117611
Human placental mesenchymal stromal cells alleviate intestinal oxidative damage in mice with graft-versus-host disease via CD73/adenosine/PI3K/Akt/GSK-3β axis.
Han K, Wang F, Ma X, Wu Y, Zhang H, Zhao Y, Wang H, Ma J, Luan X
Cellular signalling 2024 Nov;123:111372
Cellular signalling 2024 Nov;123:111372
MTFR2 accelerates hepatocellular carcinoma mediated by metabolic reprogramming via the Akt signaling pathway.
Bao Z, Yang M, Guo Y, Ge Q, Zhang H
Cellular signalling 2024 Nov;123:111366
Cellular signalling 2024 Nov;123:111366
Overexpression of microRNA-611 inhibits TGF-β-induced epithelial-mesenchymal transition and migration in lung cancer cells through MAPKAP1.
Ke B, Huang Y, Gong Y, Zhong H, Shi L
Cellular signalling 2024 Nov;123:111357
Cellular signalling 2024 Nov;123:111357
Taurine Inhibits Lung Metastasis in Triple-Negative Breast Cancer by Modulating Macrophage Polarization Through PTEN-PI3K/Akt/mTOR Pathway.
Lin Y, Huang Y, Zheng Y, Chen W, Zhang Y, Yang Y, Huang W
Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Nov-Dec 01;47(9):369-377
Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Nov-Dec 01;47(9):369-377
DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis.
Wang J, Xia Z, Qing B, Chen Y, Gu L, Chen H, Ge Z, Yuan Y
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):228
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):228
Predicting the therapeutic role and potential mechanisms of Indole-3-acetic acid in diminished ovarian reserve based on network pharmacology and molecular docking.
Zheng J, Wang L, Liu A, Shen H, Wang B, Jiang Y, Jing P, Guan D, Yu L, Zhang X
Hereditas 2024 Nov 21;161(1):47
Hereditas 2024 Nov 21;161(1):47
Exploring the role of iNOS in HFpEF-Related myocardial fibrosis: Involvement of PTEN-PI3K/AKT signaling pathway.
You H, Gou Q, Dong M, Chang F, Xiu J
Biochemical and biophysical research communications 2024 Nov 19;734:150589
Biochemical and biophysical research communications 2024 Nov 19;734:150589
EHD1 promotes breast cancer metastasis through upregulating HIF2a expression via activating mTOR pathway.
Gao X, Li J, Feng X, Xie Y, Zhang J, Liu J, Wang B, Liu P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70168
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70168
LINC00470 promotes malignant progression of testicular germ cell tumors.
Liu Z, Lv S, Qin Z, Shu J, Zhu F, Luo Y, Fan L, Chen M, Bo H, Liu L
Molecular biology reports 2024 Nov 14;51(1):1152
Molecular biology reports 2024 Nov 14;51(1):1152
Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway.
Huang G, Yang X, Yu Q, Luo Q, Ju C, Zhang B, Chen Y, Liang Z, Xia S, Wang X, Xiang D, Zhong N, Tang XX
Signal transduction and targeted therapy 2024 Nov 11;9(1):306
Signal transduction and targeted therapy 2024 Nov 11;9(1):306
PRMT1-mediated methylation of ME2 promotes hepatocellular carcinoma growth by inhibiting ubiquitination.
Zhang S, Zhang S, Xia B, Li X, Jiang H, Feng S, Xiang Y, Qiu Y, Zhou S, Luo P
Cell death & disease 2024 Nov 11;15(11):814
Cell death & disease 2024 Nov 11;15(11):814
Lanostane triterpenoids from Ganoderma calidophilum exhibit potent anti-tumor activity by inhibiting PTP1B.
Chen C, Xu R, Guo C, Li X, Zhao Y, Luo D
Chemico-biological interactions 2024 Nov 1;403:111253
Chemico-biological interactions 2024 Nov 1;403:111253
Neuronostatin regulates neuronal function and energetic metabolism in Alzheimer's disease in a GPR107-dependent manner.
Yang S, Tang Q, Zhang Y, Du Y, Zhao X, Mei F, Li Y
Neuropharmacology 2024 Nov 1;258:110090
Neuropharmacology 2024 Nov 1;258:110090
Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells.
Zhou Z, Sicairos B, Zhou J, Du Y
Journal of proteome research 2024 Nov 1;23(11):4835-4848
Journal of proteome research 2024 Nov 1;23(11):4835-4848
Interleukin-22 Alleviates Caerulein-Induced Acute Pancreatitis by Activating AKT/mTOR Pathway.
Fu X, Xiu Z, Xu Q, Yue R, Xu H
Digestive diseases and sciences 2024 May;69(5):1691-1700
Digestive diseases and sciences 2024 May;69(5):1691-1700
The promoting effects of Grin2d expression in tumorigenesis and the aggressiveness of esophageal cancer.
Wang LL, Li J, Xue H, Zhang L, Yu DY, Yang N, Yun WJ, Zhao MZ, Zheng HC
Histology and histopathology 2024 May;39(5):659-670
Histology and histopathology 2024 May;39(5):659-670
Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.
Liu L, Xiao W, Yang Z, Wang Q, Yi J
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 May;33(5):499-510
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 May;33(5):499-510
Shengmaisan combined with Liuwei Dihuang Decoction alleviates chronic intermittent hypoxia-induced cognitive impairment by activating the EPO/EPOR/JAK2 signaling pathway.
Si J, Chen X, Qi K, Li D, Liu B, Zheng Y, Ji E, Yang S
Chinese journal of natural medicines 2024 May;22(5):426-440
Chinese journal of natural medicines 2024 May;22(5):426-440
Gallic acid ameliorates endometrial hyperplasia through the inhibition of the PI3K/AKT pathway and the down-regulation of cyclin D1 expression.
Zheng C, Wang Y, Bi B, Zhou W, Cao X, Zhang C, Lu W, Sun Y, Qu J, Lv W
Journal of pharmacological sciences 2024 May;155(1):1-13
Journal of pharmacological sciences 2024 May;155(1):1-13
Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation.
Zhu Y, Ye X, Wu Y, Shen H, Cai Z, Xia F, Min W, Hou Y, Wang L, Wang X, Xiao Y, Yang P
Journal of medicinal chemistry 2024 May 9;67(9):7283-7300
Journal of medicinal chemistry 2024 May 9;67(9):7283-7300
Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer.
Zheng L, Zhang Y, Mei S, Xie T, Zou Y, Wang Y, Jing H, Xu S, Dramou P, Xu Z, Li J, Zhou Y, Niu MM
Journal of medicinal chemistry 2024 May 9;67(9):7130-7145
Journal of medicinal chemistry 2024 May 9;67(9):7130-7145
Tetramethylpyrazine-loaded electroconductive hydrogels promote tissue repair after spinal cord injury by protecting the blood-spinal cord barrier and neurons.
Deng B, Jiang S, Liu G, Li X, Zhao Y, Fan X, Ren J, Ning C, Xu L, Ji L, Mu X
Journal of materials chemistry. B 2024 May 8;12(18):4409-4426
Journal of materials chemistry. B 2024 May 8;12(18):4409-4426
Dual roles of HK3 in regulating the network between tumor cells and tumor-associated macrophages in neuroblastoma.
Wu X, Mi T, Jin L, Ren C, Wang J, Zhang Z, Liu J, Wang Z, Guo P, He D
Cancer immunology, immunotherapy : CII 2024 May 7;73(7):122
Cancer immunology, immunotherapy : CII 2024 May 7;73(7):122
Polymorphism rs2327430 in TCF21 predicts the risk and prognosis of gastric cancer by affecting the binding between TFAP2A and TCF21.
Zhou X, Shen K, Cao S, Li P, Xiao J, Dong J, Cheng Q, Hu L, Xu Z, Yang L
Cancer cell international 2024 May 7;24(1):159
Cancer cell international 2024 May 7;24(1):159
AGR2-mediated unconventional secretion of 14-3-3ε and α-actinin-4, responsive to ER stress and autophagy, drives chemotaxis in canine mammary tumor cells.
Yuan SH, Wu CC, Wang YC, Chan XY, Chu HW, Yang Y, Liu HP
Cellular & molecular biology letters 2024 May 31;29(1):84
Cellular & molecular biology letters 2024 May 31;29(1):84
SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE(-/-) mice.
Guo L, Yuan H, Zhu H, Zhou J, Wan Z, Zhou Y
BMC cardiovascular disorders 2024 May 28;24(1):275
BMC cardiovascular disorders 2024 May 28;24(1):275
miR-122-5p Promotes Cowshed Particulate Matter2.5-Induced Apoptosis in NR8383 by Targeting COL4A1.
Sun Y, Sun K, Ma Z, Zhang X, Du X, Jia Y, Zhu Y, Inam M, Gao Y, Basang W
Toxics 2024 May 25;12(6)
Toxics 2024 May 25;12(6)
Si-Ni-San promotes liver regeneration by maintaining hepatic oxidative equilibrium and glucose/lipid metabolism homeostasis.
Yang X, Zhang J, Li Y, Hu H, Li X, Ma T, Zhang B
Journal of ethnopharmacology 2024 May 23;326:117918
Journal of ethnopharmacology 2024 May 23;326:117918
Anti-papillary thyroid carcinoma effects of dioscorea bulbifera L. through ferroptosis and the PI3K/AKT pathway based on network pharmacology and experimental validation.
Gao Y, Yang Z, Ji T, Zhou P, Geng L, Gao X
Journal of ethnopharmacology 2024 May 23;326:117912
Journal of ethnopharmacology 2024 May 23;326:117912
An integrated network pharmacology, molecular docking and experiment validation study to investigate the potential mechanism of Isobavachalcone in the treatment of osteoarthritis.
Fan Y, Yin L, Zhong X, He Z, Meng X, Chai F, Kong M, Zhang Q, Xia C, Tong Y, Bi Q
Journal of ethnopharmacology 2024 May 23;326:117827
Journal of ethnopharmacology 2024 May 23;326:117827
Methionine and Leucine Promote mTOR Gene Transcription and Milk Synthesis in Mammary Epithelial Cells through the eEF1Bα-UBR5-ARID1A Signaling.
Qi H, Yu M, Fan X, Zhou Y, Zhang M, Gao X
Journal of agricultural and food chemistry 2024 May 22;72(20):11733-11745
Journal of agricultural and food chemistry 2024 May 22;72(20):11733-11745
Methylation-regulated tumor suppressor gene PDE7B promotes HCC invasion and metastasis through the PI3K/AKT signaling pathway.
Du Y, Xu Y, Guo X, Tan C, Zhu X, Liu G, Lyu X, Bei C
BMC cancer 2024 May 22;24(1):624
BMC cancer 2024 May 22;24(1):624
Inhibition of Nogo-B reduces the progression of pancreatic cancer by regulation NF-κB/GLUT1 and SREBP1 pathways.
Wang T, Zhang M, Gong X, Chen W, Peng Y, Liao C, Xu H, Li Q, Shen G, Ren H, Zhu Y, Zhang B, Mao J, Wei L, Chen Y, Yang X
iScience 2024 May 17;27(5):109741
iScience 2024 May 17;27(5):109741
Curdepsidone A Induces Intrinsic Apoptosis and Inhibits Protective Autophagy via the ROS/PI3K/AKT Signaling Pathway in HeLa Cells.
Xu S, Li Z, Xin X, An F
Marine drugs 2024 May 17;22(5)
Marine drugs 2024 May 17;22(5)
The Effects of Resveratrol and Apigenin on Jejunal Oxidative Injury in Ducks and on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Zhou N, Cao Y, Luo Y, Wang L, Li R, Di H, Gu T, Cao Y, Zeng T, Zhu J, Chen L, An D, Ma Y, Xu W, Tian Y, Lu L
Antioxidants (Basel, Switzerland) 2024 May 17;13(5)
Antioxidants (Basel, Switzerland) 2024 May 17;13(5)
The polysaccharides from Balanophora polyandra enhanced neuronal autophagy to ameliorate brain function decline in natural aging mice through the PI3K/AKT/mTOR signaling pathway.
Zhong W, Chen J, He Y, Xiao L, Yuan C
Neuroreport 2024 May 15;35(8):509-517
Neuroreport 2024 May 15;35(8):509-517
Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies.
Zhang M, Liu H, Xu L, Zhang X, Chen W, Wang C
Foods (Basel, Switzerland) 2024 May 14;13(10)
Foods (Basel, Switzerland) 2024 May 14;13(10)
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Wang FR, Peng ML, Zhu QF, Yu LL, Zhang LJ, Xu SY, Wang Q, Li J, He X, Liao SG, Ao JL, Xu GB
Journal of ethnopharmacology 2024 May 10;325:117830
Journal of ethnopharmacology 2024 May 10;325:117830
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Zhou ZX, Ma XF, Xiong WH, Ren Z, Jiang M, Deng NH, Zhou BB, Liu HT, Zhou K, Hu HJ, Tang HF, Zheng H, Jiang ZS
Atherosclerosis 2024 Mar;390:117430
Atherosclerosis 2024 Mar;390:117430
CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells.
Xu X, Li Y, Xu R, Meng Y, Li Z, Zuo D, Wu Y
The FEBS journal 2024 Mar;291(6):1199-1219
The FEBS journal 2024 Mar;291(6):1199-1219
β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer.
Wang H, Liu J, Zhang Z, Peng J, Wang Z, Yang L, Wang X, Hu S, Hong L
Free radical biology & medicine 2024 Mar;214:137-157
Free radical biology & medicine 2024 Mar;214:137-157
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation.
Zhang Y, Wang X, Liu W, Lei T, Qiao T, Feng W, Song W
Journal of translational medicine 2024 Mar 8;22(1):251
Journal of translational medicine 2024 Mar 8;22(1):251
Macrophage-derived exosomal HMGB3 regulates silica-induced pulmonary inflammation by promoting M1 macrophage polarization and recruitment.
Qin X, Niu Z, Chen H, Hu Y
Particle and fibre toxicology 2024 Mar 7;21(1):12
Particle and fibre toxicology 2024 Mar 7;21(1):12
MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer.
Jiang W, Miao Y, Xing X, Liu S, Xing W, Qian F
Heliyon 2024 Mar 30;10(6):e28172
Heliyon 2024 Mar 30;10(6):e28172
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Li J, Ma Z, Yang Z, Yang M, Li C, Li M, Li X, Chen X, Ma H, Chen W, Ye X, Li X
Journal of ethnopharmacology 2024 Mar 25;322:117600
Journal of ethnopharmacology 2024 Mar 25;322:117600
Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling.
Huang Y, Wu Z, Peng Z, Liu A, Yuan W, Han D, Peng J
BMC cancer 2024 Mar 18;24(1):345
BMC cancer 2024 Mar 18;24(1):345
The Chinese herbal prescription JZ-1 promotes extracellular vesicle production and protects against herpes simplex virus type 2 infection in vitro.
Wang W, Jin X, Shao Q, Liu T, Liu T, Zhao X, Xu L, Gao W, Hu L, Chen Z
Heliyon 2024 Mar 15;10(5):e27019
Heliyon 2024 Mar 15;10(5):e27019
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Li Y, Wang HB, Cao JL, Zhang WJ, Wang HL, Xu CH, Li KP, Liu Y, Wang JR, Ha HL, Fu SJ, Yang L
Journal of translational medicine 2024 Mar 10;22(1):261
Journal of translational medicine 2024 Mar 10;22(1):261
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
Huang LK, Zeng XS, Jiang ZW, Peng H, Sun F
Chemico-biological interactions 2024 Mar 1;391:110893
Chemico-biological interactions 2024 Mar 1;391:110893
Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.
Gao M, Shen H, Li Q, Gu X, Jia T, Wang Y
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333
An oxidized dextran-composite self-healing coated magnesium scaffold reduces apoptosis to induce bone regeneration.
Shi Z, Yang F, Hu Y, Pang Q, Shi L, Du T, Cao Y, Song B, Yu X, Cao Z, Ye Z, Liu C, Yu R, Chen X, Zhu Y, Pang Q
Carbohydrate polymers 2024 Mar 1;327:121666
Carbohydrate polymers 2024 Mar 1;327:121666
Baiheqingjin formula reduces inflammation in mice with asthma by inhibiting the PI3K/AKT/NF-κb signaling pathway.
Yan X, Tong X, Jia Y, Zhao Y, Zhang Q, Hu M, Li X, Li B, Ming X, Xie Y, Wu X, Yu X, Qu L, Xiong L, Huang F, Nie J
Journal of ethnopharmacology 2024 Mar 1;321:117565
Journal of ethnopharmacology 2024 Mar 1;321:117565
Exploring the potential mechanism of Heng-Gu-Gu-Shang-Yu-He-Ji therapy for osteoporosis based on network pharmacology and transcriptomics.
Xie L, Song X, Lei L, Chen C, Zhao H, Hu J, Yu Y, Bai X, Wu X, Li X, Yang X, Yuan B, Li D, Zhu X, Zhang X
Journal of ethnopharmacology 2024 Mar 1;321:117480
Journal of ethnopharmacology 2024 Mar 1;321:117480
Lentinan mitigates pemetrexed chemoresistance by the PI3K/Akt pathway in non-small cell lung cancer.
Tian P, Du D, Yang L, Zhou N, Tao L
Cell biochemistry and biophysics 2024 Jun;82(2):1421-1431
Cell biochemistry and biophysics 2024 Jun;82(2):1421-1431
PHPB ameliorates memory deficits and reduces oxidative injury in Alzheimer's disease mouse model by activating Nrf2 signaling pathway.
Shang NY, Huang LJ, Lan JQ, Kang YY, Tang JS, Wang HY, Li XN, Sun Z, Chen QY, Liu MY, Wen ZP, Feng XH, Wu L, Peng Y
Acta pharmacologica Sinica 2024 Jun;45(6):1142-1159
Acta pharmacologica Sinica 2024 Jun;45(6):1142-1159
Investigation of the active ingredients and mechanism of Shuangling extract in dextran sulfate sodium salt induced ulcerative colitis mice based on network pharmacology and experimental verification.
Mengzhen C, Yu W, Zhijian L, Jintao L, Xiaomeng Z, Bing Z
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Jun;44(3):478-488
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Jun;44(3):478-488
cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity.
Ma D, Yang M, Sun C, Cui X, Xiong G, Wang Q, Jing W, Chen H, Lv X, Liu S, Li T, Zhao Y, Han L
Cell death and differentiation 2024 Jun;31(6):722-737
Cell death and differentiation 2024 Jun;31(6):722-737
Pan-cancer analysis of DCTN2 and its tumour-promoting role in HCC by modulating the AKT pathway.
Xu S, Xing J, Li K, Qiao L, Zhang C, Ren Y, Liu Y
Journal of cellular and molecular medicine 2024 Jun;28(11):e18450
Journal of cellular and molecular medicine 2024 Jun;28(11):e18450
Porcine TLR8 signaling and its anti-infection function are disturbed by immune checkpoint receptor TIM-3 via inhibition of P13K-AKT pathway.
Zheng W, Ao D, Cao Q, Liu A, Lv M, Sun Z, Zhang H, Zheng W, Chen N, Zhu J
International journal of biological macromolecules 2024 Jun;269(Pt 1):132018
International journal of biological macromolecules 2024 Jun;269(Pt 1):132018
Eosinophil peroxidase promotes bronchial epithelial cells to secrete asthma-related factors and induces the early stage of airway remodeling.
Xu L, Huang X, Chen Z, Yang M, Deng J
Clinical immunology (Orlando, Fla.) 2024 Jun;263:110228
Clinical immunology (Orlando, Fla.) 2024 Jun;263:110228
A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.
Liu C, Sun Y, Li D, Wang F, Wang H, An S, Sun S
Materials today. Bio 2024 Jun;26:101034
Materials today. Bio 2024 Jun;26:101034
Scutellarin alleviates microglia-mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3β signaling pathway.
Duan Z, Chen H, Miao W, He J, Xu D, Qi Z, Yang L, Jia W, Wu C
Journal of cell communication and signaling 2024 Jun;18(2):e12023
Journal of cell communication and signaling 2024 Jun;18(2):e12023
Ginsenoside Rh4 alleviates gastrointestinal mucositis and enhances chemotherapy efficacy through modulating gut microbiota.
Bai X, Deng J, Duan Z, Fu R, Zhu C, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155577
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155577
CYP2E1 deficit mediates cholic acid-induced malignant growth in hepatocellular carcinoma cells.
Hao Z, Liu X, He H, Wei Z, Shu X, Wang J, Sun B, Zhou H, Wang J, Niu Y, Hu Z, Hu S, Liu Y, Fu Z
Molecular medicine (Cambridge, Mass.) 2024 Jun 7;30(1):79
Molecular medicine (Cambridge, Mass.) 2024 Jun 7;30(1):79
Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
Li T, Wei L, Zhang X, Fu B, Zhou Y, Yang M, Cao M, Chen Y, Tan Y, Shi Y, Wu L, Xuan C, Du Q, Hu R
Molecular cancer research : MCR 2024 Jun 4;22(6):538-554
Molecular cancer research : MCR 2024 Jun 4;22(6):538-554
lncRNA JPX Promotes Tumor Progression by Interacting with and Destabilizing YTHDF2 in Cutaneous Melanoma.
Luo D, Tang H, Tan L, Zhang L, Wang L, Cheng Q, Lei X, Wu J
Molecular cancer research : MCR 2024 Jun 4;22(6):524-537
Molecular cancer research : MCR 2024 Jun 4;22(6):524-537
Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury.
Gu N, Yan J, Tang W, Zhang Z, Wang L, Li Z, Wang Y, Zhu Y, Tang S, Zhong J, Cheng C, Sun X, Huang Z
Journal of neuroinflammation 2024 Jun 4;21(1):147
Journal of neuroinflammation 2024 Jun 4;21(1):147
CSF3 aggravates acute exacerbation of pulmonary fibrosis by disrupting alveolar epithelial barrier integrity.
Guo B, Liu W, Ji X, Xi B, Meng X, Xie W, Sun Y, Zhang M, Liu P, Zhang W, Yan X, Chen B
International immunopharmacology 2024 Jun 30;135:112322
International immunopharmacology 2024 Jun 30;135:112322
Anemoside B4 attenuates necrotic enteritis of laying hens induced by Clostridium perfringens via inhibiting NF-κB and PI3K/Akt/mTOR signalling pathways.
Tian X, Li J, Liu S, Dong Q, Fu Y, Luo R, Sun Y, Guo L, Lu Q, Ye C, Liu J, Fu S, Qiu Y
Heliyon 2024 Jun 30;10(12):e33161
Heliyon 2024 Jun 30;10(12):e33161
IFI16 promotes the progression of clear cell renal cell carcinoma through the IL6/PI3K/AKT axis.
Lu K, Zhao Y, Li Y, Fu Z, Chen Y, Kong Y, Li G
Journal of translational medicine 2024 Jun 3;22(1):533
Journal of translational medicine 2024 Jun 3;22(1):533
YY1 mediated DCUN1D5 transcriptional activation promotes triple-negative breast cancer progression by targeting FN1/PI3K/AKT pathway.
Lin Y, Li Y, Chen X, Jin X, Jiang M, Xiao H, Chen L, Chen M, Zhang W, Chen H, Nie Q, Guo R, Guo W, Fu F, Wang C
Biology direct 2024 Jun 3;19(1):42
Biology direct 2024 Jun 3;19(1):42
CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer.
Zhong C, Jiang WJ, Yao Y, Li Z, Li Y, Wang S, Wang X, Zhu W, Wu S, Wang J, Fan S, Ma S, Liu Y, Zhang H, Zhao W, Zhao L, Feng Y, Li Z, Guo R, Yu L, Pei F, Hu J, Feng X, Yang Z, Yang Z, Yang X, Hou Y, Zhang D, Xu D, Sheng R, Li Y, Liu L, Wu HJ, Huang J, Fei T
Nature communications 2024 Jun 29;15(1):5502
Nature communications 2024 Jun 29;15(1):5502
NFIC mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to represses malignant phenotype of non-small cell lung cancer cells.
Shi K, Chen Y, Liu R, Fu X, Guo H, Gao T, Wang S, Dou L, Wang J, Wu Y, Yu J, Yu H
Cancer cell international 2024 Jun 28;24(1):223
Cancer cell international 2024 Jun 28;24(1):223
Calpain 8 as a potential biomarker regulates the progression of pancreatic cancer via EMT and AKT/ERK pathway.
Song N, Cui K, Zeng L, Fan Y, Wang Z, Shi P, Su W, Wang H
Journal of proteomics 2024 Jun 15;301:105182
Journal of proteomics 2024 Jun 15;301:105182
Integrated component identification, network pharmacology, and experimental verification revealed mechanism of Dendrobium officinale Kimura et Migo against lung cancer.
Zhao Y, Zhu S, Li Y, Niu X, Shang G, Zhou X, Yin J, Bao B, Cao Y, Cheng F, Li Z, Wang R, Yao W
Journal of pharmaceutical and biomedical analysis 2024 Jun 15;243:116077
Journal of pharmaceutical and biomedical analysis 2024 Jun 15;243:116077
Design, synthesis and biological evaluation of indoline-maleimide conjugates as potential antitumor agents for the treatment of colorectal cancer.
Tang J, Zhang Y, Zhou L, Song X, Wei Y, Qi J, Wu J, Song Z, Zhan L
Bioorganic & medicinal chemistry 2024 Jun 15;108:117786
Bioorganic & medicinal chemistry 2024 Jun 15;108:117786
Direct contact between tumor cells and platelets initiates a FAK-dependent F3/TGF-β positive feedback loop that promotes tumor progression and EMT in osteosarcoma.
Shi Q, Xu J, Chen C, Hu X, Wang B, Zeng F, Ren T, Huang Y, Guo W, Tang X, Ji T
Cancer letters 2024 Jun 1;591:216902
Cancer letters 2024 Jun 1;591:216902
Ebselen improves fungal keratitis through exerting anti-inflammation, anti-oxidative stress, and antifungal effects.
Yu B, Wang Q, Zhang L, Lin J, Feng Z, Wang Z, Gu L, Tian X, Luan S, Li C, Zhao G
Redox biology 2024 Jul;73:103206
Redox biology 2024 Jul;73:103206
Anthrahydroquinone‑2,6‑disulfonate attenuates PQ‑induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of the PI3K/AKT/eNOS pathway.
Li N, Yi Y, Chen J, Huang Y, Peng J, Li Z, Wang Y, Zhang J, Xu C, Liu H, Li J, Liu X
International journal of molecular medicine 2024 Jul;54(1)
International journal of molecular medicine 2024 Jul;54(1)
Influence of METTL3 knockdown on PDLSC osteogenesis in E. coli LPS-induced inflammation.
Chen H, Peng L, Wang Z, He Y, Zhang X
Oral diseases 2024 Jul;30(5):3225-3238
Oral diseases 2024 Jul;30(5):3225-3238
Fibroblast growth factor 21 alleviates idiopathic pulmonary fibrosis by inhibiting PI3K-AKT-mTOR signaling and stimulating autophagy.
Qi J, Wu Y, Guo Z, Zhu S, Xiong J, Hu F, Liang X, Ye X
International journal of biological macromolecules 2024 Jul;273(Pt 1):132896
International journal of biological macromolecules 2024 Jul;273(Pt 1):132896
Silibinin attenuates TGF-β2-induced fibrogenic changes in human trabecular meshwork cells by targeting JAK2/STAT3 and PI3K/AKT signaling pathways.
Wu X, Liang J, Liu J, Huang Y, Zhang L, Liu X, Guo J, Zhang M, Chen Y, Wang J
Experimental eye research 2024 Jul;244:109939
Experimental eye research 2024 Jul;244:109939
MICAL-L2, as an estrogen-responsive gene, is involved in ER-positive breast cancer cell progression and tamoxifen sensitivity via the AKT/mTOR pathway.
Wen P, Li J, Wen Z, Guo X, Ma G, Hu S, Xu J, Zhao H, Li R, Liu Y, Wang Y, Gao J
Biochemical pharmacology 2024 Jul;225:116256
Biochemical pharmacology 2024 Jul;225:116256
Grifolin Induces Cell Death of Human Lung Cancer A549 Cell Line via Inhibiting KRAS-Mediated Multiple Signaling Pathways.
Zhao XC, Ma RF, Liu H, Shan P, Bao J, Zhang H
Chemistry & biodiversity 2024 Jul;21(7):e202400792
Chemistry & biodiversity 2024 Jul;21(7):e202400792
LGR5 Modulates Differentiated Phenotypes of Chondrocytes Through PI3K/AKT Signaling Pathway.
Wu X, Fu Y, Ma J, Li C, He A, Zhang T
Tissue engineering and regenerative medicine 2024 Jul;21(5):791-807
Tissue engineering and regenerative medicine 2024 Jul;21(5):791-807
Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis.
Chen Y, Gialeli C, Shen J, Dunér P, Walse B, Duelli A, Caing-Carlsson R, Blom AM, Zibert JR, Nilsson AH, Alenfall J, Liang C, Nilsson J
Pharmacological research 2024 Jul;205:107259
Pharmacological research 2024 Jul;205:107259
The combination of temozolomide and perifosine synergistically inhibit glioblastoma by impeding DNA repair and inducing apoptosis.
Zhao W, Zhou L, Zhao W, Yang H, Lu Z, Zhang L, Zhang Y, Xie Y, Lu H, Han W, He J, Qiu X, Jia F, Zhao W, Zhang B, Wang Z
Cell death discovery 2024 Jul 8;10(1):315
Cell death discovery 2024 Jul 8;10(1):315
GPR30 selective agonist G-1 induced insulin resistance in ovariectomized mice on high fat diet and its mechanism.
Lu C, Liu D, Li M, Shi X, Guan J, Song G, Yin Y, Zheng M, Ma F, Liu G
Biochemical and biophysical research communications 2024 Jul 5;716:150026
Biochemical and biophysical research communications 2024 Jul 5;716:150026
Leveraging a rationally designed veliparib-based anilide eliciting anti-leukemic effects for the design of pH-responsive polymer nanoformulation.
Thakur A, Chu YH, Rao NV, Mathew J, Grewal AS, Prabakaran P, Guru S, Liou JP, Pan CH, Nepali K
European journal of medicinal chemistry 2024 Jul 5;273:116507
European journal of medicinal chemistry 2024 Jul 5;273:116507
A black phosphorus nanosheet-based RNA delivery system for prostate cancer therapy by increasing the expression level of tumor suppressor gene PTEN via CeRNA mechanism.
Su S, Liu L, Fu Q, Ma M, Yang N, Pan T, Geng S, Yu XF, Zhu J
Journal of nanobiotechnology 2024 Jul 4;22(1):391
Journal of nanobiotechnology 2024 Jul 4;22(1):391
Echistatin/BYL-719 impedes epithelial-mesenchymal transition in pulmonary fibrosis induced by silica through modulation of the Integrin β1/ILK/PI3K signaling pathway.
Li H, Wang P, Hu M, Xu S, Li X, Xu D, Feng K, Zhou Q, Chang M, Yao S
International immunopharmacology 2024 Jul 30;136:112368
International immunopharmacology 2024 Jul 30;136:112368
Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/Akt/mTOR and RAS/MEK/ERK signalling pathways.
Fu S, Li J, You J, Liu S, Dong Q, Fu Y, Luo R, Sun Y, Tian X, Liu W, Zhang J, Ding Y, Zhang Y, Wang W, Guo L, Qiu Y
Veterinary research 2024 Jul 29;55(1):95
Veterinary research 2024 Jul 29;55(1):95
PHF12 regulates HDAC1 to promote tumorigenesis via EGFR/AKT signaling pathway in non-small cell lung cancer.
Kong Y, Jiang R, Zhou H, Ge M, Lin H, Wang Y, Yao R, Wang Q, Liang X, Li J, Zhou X
Journal of translational medicine 2024 Jul 29;22(1):689
Journal of translational medicine 2024 Jul 29;22(1):689
HMGB1/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4/Akt signaling.
Qiu H, Shao Z, Wen X, Qu D, Liu Z, Chen Z, Zhang X, Ding X, Zhang L
Journal of translational medicine 2024 Jul 29;22(1):688
Journal of translational medicine 2024 Jul 29;22(1):688
Icariside II modulates pulmonary fibrosis via PI3K/Akt/β-catenin pathway inhibition of M2 macrophage program.
Deng L, Ouyang B, Tang W, Wang N, Yang F, Shi H, Zhang Z, Yu H, Chen M, Wei Y, Dong J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155687
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155687
Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression.
Zhu Q, Han Y, He Y, Meng P, Fu Y, Yang H, He G, Long M, Shi Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155560
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155560
RABV induces biphasic actin cytoskeletal rearrangement through Rac1 activity modulation.
Liu X, Xu J, Zhang M, Wang H, Guo X, Zhao M, Duan M, Guan Z, Guo Y
Journal of virology 2024 Jul 23;98(7):e0060624
Journal of virology 2024 Jul 23;98(7):e0060624
Follicular Atresia in Buffalo: Cocaine- and Amphetamine-Regulated Transcript (CART) and the Underlying Mechanisms.
Yang C, Zheng H, Amin A, Faheem MS, Duan A, Li L, Xiao P, Li M, Shang J
Animals : an open access journal from MDPI 2024 Jul 23;14(15)
Animals : an open access journal from MDPI 2024 Jul 23;14(15)
Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues.
Wu J, Wang C, Sun S, Ren T, Pan L, Liu H, Hou S, Wu S, Yan X, Zhang J, Zhao X, Liu W, Zhu S, Wei S, Zhang C, Jia X, Zhang Q, Yu Z, Zhuo Y, Zhao Q, Yang C, Wang N
Protein & cell 2024 Jul 20;15(8):594-611
Protein & cell 2024 Jul 20;15(8):594-611
Insulin receptor isoform B is required for efficient proinsulin processing in pancreatic β cells.
Jiang M, Wang N, Zhang Y, Zhang J, Li Y, Yan X, Zhang H, Li C, Guan Y, Liang B, Zhang W, Wu Y
iScience 2024 Jul 19;27(7):110017
iScience 2024 Jul 19;27(7):110017
Glutamate rescues heat stress-induced apoptosis of Sertoli cells by enhancing the activity of antioxidant enzymes and activating the Trx1-Akt pathway in vitro.
Cai XQ, Yang H, Liang BQ, Deng CC, Xue HY, Zhang JJ, Wang XZ
Theriogenology 2024 Jul 15;223:1-10
Theriogenology 2024 Jul 15;223:1-10
The protective effects of aqueous extract of Schisandra sphenanthera against alcoholic liver disease partly through the PI3K-AKT-IKK signaling pathway.
Liu D, Yang K, Li T, Tang T, Wang Y, Wang W, Li J, Zhou P, Wang X, Zhao C, Guo D, Xie Y, Cheng J, Wang M, Sun J, Zhang X
Heliyon 2024 Jul 15;10(13):e34214
Heliyon 2024 Jul 15;10(13):e34214
CHRDL2 activates the PI3K/AKT pathway to ameliorate glucocorticoid-induced damages to bone microvascular endothelial cells (BMECs).
Huang X, Jie S, Li W, Liu C
Heliyon 2024 Jul 15;10(13):e33867
Heliyon 2024 Jul 15;10(13):e33867
Maternal high fat diet programs spatial learning and central leptin signaling in mouse offspring in a sex-specific manner.
Li Y, Yang Y, Ye B, Lin Y
Physiology & behavior 2024 Jul 1;281:114580
Physiology & behavior 2024 Jul 1;281:114580
SLC7A11 promotes EMT and metastasis in invasive pituitary neuroendocrine tumors by activating the PI3K/AKT signaling pathway.
Gui S, Yu W, Xie J, Peng L, Xiong Y, Song Z, Luo H, Xiao J, Yuan S, Cheng Z
Endocrine connections 2024 Jul 1;13(7)
Endocrine connections 2024 Jul 1;13(7)
Multi-omics analyses reveal bacteria and catalase associated with keloid disease.
Shan M, Xiao M, Xu J, Sun W, Wang Z, Du W, Liu X, Nie M, Wang X, Liang Z, Liu H, Hao Y, Xia Y, Zhu L, Song K, Feng C, Meng T, Wang Z, Cao W, Wang L, Zheng Z, Wang Y, Huang Y
EBioMedicine 2024 Jan;99:104904
EBioMedicine 2024 Jan;99:104904
Circadian misalignment impairs oligodendrocyte myelination via Bmal1 overexpression leading to anxiety and depression-like behaviors.
Zuo Y, Hou Y, Wang Y, Yuan L, Cheng L, Zhang T
Journal of pineal research 2024 Jan;76(1):e12935
Journal of pineal research 2024 Jan;76(1):e12935
Amplifying T cell-mediated antitumor immune responses in nonsmall cell lung cancer through photodynamic therapy and anti-PD1.
Gong B, Wang L, Zhang H, Wang Q, Li W
Cell biochemistry and function 2024 Jan;42(1):e3925
Cell biochemistry and function 2024 Jan;42(1):e3925
IGF-I protects porcine granulosa cells from hypoxia-induced apoptosis by promoting homologous recombination repair through the PI3K/AKT/E2F8/RAD51 pathway.
Liu Z, Feng C, Li C, He T, Wu G, Fu C, Li H, Shen M, Liu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23332
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23332
Berberine alleviates contrast-induced nephropathy by activating Akt/Foxo3a/Nrf2 signalling pathway.
Wang W, Yu R, Wu C, Li Q, Chen J, Xiao Y, Chen H, Song J, Ji M, Zuo Z
Journal of cellular and molecular medicine 2024 Jan;28(1):e18016
Journal of cellular and molecular medicine 2024 Jan;28(1):e18016
Yi-qi-hua-yu-jie-du decoction induces ferroptosis in cisplatin-resistant gastric cancer via the AKT/GSK3β/NRF2/GPX4 axis.
Huang W, Wen F, Yang P, Li Y, Li Q, Shu P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155220
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155220
Modified Guo-Min decoction ameliorates PM2.5-induced lung injury by inhibition of PI3K-AKT and MAPK signaling pathways.
Wang H, Wang G, Meng Y, Liu Y, Yao X, Feng C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155211
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155211
Radix Astragali decoction improves liver regeneration by upregulating hepatic expression of aquaporin-9.
Li Y, Yang X, Bao T, Sun X, Li X, Zhu H, Zhang B, Ma T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155166
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155166
Curcumin suppresses metastasis, invasion, and proliferation in osteosarcoma cells by regulating the EGFR/Src signaling axis.
Liu H, Li Z, Xu B, Li Z, Yang X, Luo J
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241308082
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241308082
Lactate accumulation induced by Akt2-PDK1 signaling promotes pulmonary fibrosis.
Sun Z, Ji Z, He W, Duan R, Qu J, Yu G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23426
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23426
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca(2+) antagonism and maintaining mitochondrial function.
Shen G, Zhou Z, Guo Y, Li L, Zeng J, Wang J, Zhao J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117192
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117192
Zearalenone triggers programmed cell death and impairs milk fat synthesis via the AKT-mTOR-PPARγ-ACSL4 pathway in bovine mammary epithelial cells.
Ma Z, Li Q, Xu H, Li Y, Wang S, Xiong Y, Lan D, Li J, Xiong X, Fu W
Journal of animal science 2024 Jan 3;102
Journal of animal science 2024 Jan 3;102
RUNX1 targeting AKT3 promotes alveolar hypercoagulation and fibrinolytic inhibition in LPS induced ARDS.
Xiao C, Liu J, Cheng Y, Wu Y, Li Q, Chen X, Yuan J, Dong Q, Li L, Liu Y, Shen F
Respiratory research 2024 Jan 24;25(1):54
Respiratory research 2024 Jan 24;25(1):54
Increased Circulating IL-32 Is Associated With Placenta Macrophage-derived IL-32 and Gestational Diabetes Mellitus.
Huang X, Li Y, Tong X, Wu Y, Zhang R, Sheng L, Xu J, Yu Z, Chen Z, Sun T, Wang F, Yang Q, Li Z, Gao C, Ma L, Ding H, Zang S, Yang N, Zhang TN, Liu J
The Journal of clinical endocrinology and metabolism 2024 Jan 18;109(2):333-343
The Journal of clinical endocrinology and metabolism 2024 Jan 18;109(2):333-343
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Li Y, Li L, Xiong W, Duan X, Xi H
Theriogenology 2024 Jan 15;214:192-200
Theriogenology 2024 Jan 15;214:192-200
SLFN11 promotes clear cell renal cell carcinoma progression via the PI3K/AKT signaling pathway.
Wang HX, Zhao ZP, Du XY, Peng SL, Xu HY, Tang W, Yang L
Medical oncology (Northwood, London, England) 2024 Jan 11;41(2):54
Medical oncology (Northwood, London, England) 2024 Jan 11;41(2):54
Combining transcriptomics and network pharmacology to reveal the mechanism of Zuojin capsule improving spasmolytic polypeptide-expressing metaplasia.
Xiong M, Chen X, Wang H, Tang X, Wang Q, Li X, Ma H, Ye X
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117075
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117075
Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K/AKT1/FOXO1 pathway.
Hu W, Xie N, Pan M, Zhang Q, Zhang H, Wang F, Qu F
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117025
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117025
Decreased AKAP4/PKA signaling pathway in high DFI sperm affects sperm capacitation.
Zhang K, Xu XH, Wu J, Wang N, Li G, Hao GM, Cao JF
Asian journal of andrology 2024 Jan 1;26(1):25-33
Asian journal of andrology 2024 Jan 1;26(1):25-33
Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway.
Li XN, Shang NY, Kang YY, Sheng N, Lan JQ, Tang JS, Wu L, Zhang JL, Peng Y
Acta pharmacologica Sinica 2024 Feb;45(2):248-267
Acta pharmacologica Sinica 2024 Feb;45(2):248-267
Efficacy of Ganshuang granules on non-alcoholic fatty liver and underlying mechanism: a network pharmacology and experimental verification.
Guoguo Z, Bingjie S, Tianyan Z, Shaoxiu JI, Jingwei LI, Yanni D, Feng L, Dong W
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Feb;44(1):122-130
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Feb;44(1):122-130
4-octyl itaconate protects against oxidative stress-induced liver injury by activating the Nrf2/Sirt3 pathway through AKT and ERK1/2 phosphorylation.
Hu Z, Xu D, Meng H, Liu W, Zheng Q, Wang J
Biochemical pharmacology 2024 Feb;220:115992
Biochemical pharmacology 2024 Feb;220:115992
Attenuation of pro-tumorigenic senescent secretory phenotype by StN, a novel derivative of stevioside, potentiates its inhibitory activity on hepatocellular carcinoma.
Guo Y, Wang S, Dong Y, Liu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114371
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114371
Tanshinone IIA ameliorates energy metabolism dysfunction of pulmonary fibrosis using (13)C metabolic flux analysis.
Shan B, Zhou H, Guo C, Liu X, Wu M, Zhai R, Chen J
Journal of pharmaceutical analysis 2024 Feb;14(2):244-258
Journal of pharmaceutical analysis 2024 Feb;14(2):244-258
Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways.
Xia ZY, Liu L, Kuok CF, Wang XL, Shi D, Ma Q, Cheng XY, Wang GL, Li MJ, Zheng QS, Liu XN, Li DF, Li BH
Biological & pharmaceutical bulletin 2024 Feb 22;47(2):486-498
Biological & pharmaceutical bulletin 2024 Feb 22;47(2):486-498
Exploring the chemical components of Kuanchang-Shu granule and its protective effects of postoperative ileus in rats by regulating AKT/HSP90AA1/eNOS pathway.
Duan WQ, Cai MC, Ma QQ, Huang P, Zhang JH, Wei TF, Shang D, Leng AJ, Qu JL
Chinese medicine 2024 Feb 21;19(1):29
Chinese medicine 2024 Feb 21;19(1):29
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
Lou J, Jin M, Zhou C, Fan Y, Ni L, Mao Y, Shen H, Li J, Zhang H, Fu C, Mao X, Chen Y, Zhong J, Zhou K, Wang L, Wu J
Free radical biology & medicine 2024 Feb 20;212:133-148
Free radical biology & medicine 2024 Feb 20;212:133-148
HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion.
Zhao X, Liu D, Zhao Y, Wang Z, Wang Y, Chen Z, Ning S, Wang G, Meng L, Yao J, Tian X
Cell death & disease 2024 Feb 20;15(2):154
Cell death & disease 2024 Feb 20;15(2):154
5'-Cytimidine Monophosphate Ameliorates H(2)O(2)-Induced Muscular Atrophy in C2C12 Myotubes by Activating IRS-1/Akt/S6K Pathway.
Wu X, Zhu N, He L, Xu M, Li Y
Antioxidants (Basel, Switzerland) 2024 Feb 19;13(2)
Antioxidants (Basel, Switzerland) 2024 Feb 19;13(2)
Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice.
Liu R, Shang W, Liu Y, Xie Y, Luan J, Zhang T, Ma Y, Wang Z, Sun Y, Song X, Han F
Cell death discovery 2024 Feb 19;10(1):89
Cell death discovery 2024 Feb 19;10(1):89
Integrated network pharmacology and metabolomics reveal the action mechanisms of vincristine combined with celastrol against colon cancer.
Ning JY, Ma B, Huang JY, Han L, Shao YH, Wang FY
Journal of pharmaceutical and biomedical analysis 2024 Feb 15;239:115883
Journal of pharmaceutical and biomedical analysis 2024 Feb 15;239:115883
High expression of TBRG4 in relation to unfavorable outcome and cell ferroptosis in hepatocellular carcinoma.
Tao S, Cui D, Cheng H, Liu X, Jiang Z, Chen H, Gao Y
BMC cancer 2024 Feb 12;24(1):194
BMC cancer 2024 Feb 12;24(1):194
Self-Healing Micro Arc Oxidation and Dicalcium Phosphate Dihydrate Double-Passivated Coating on Magnesium Membrane for Enhanced Bone Integration Repair.
Wu J, Shen Y, Wang P, Guo Z, Bai J, Wang X, Chen D, Lin X, Tang C
ACS biomaterials science & engineering 2024 Feb 12;10(2):1062-1076
ACS biomaterials science & engineering 2024 Feb 12;10(2):1062-1076
Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells.
Xia L, Liu JY, Yang MY, Zhang XH, Jiang Y, Yin QQ, Luo CH, Liu HC, Kang ZJ, Zhang CT, Gao BB, Zhou AW, Cai HY, Waller EK, Yan JS, Lu Y
Cancer research 2024 Feb 1;84(3):479-492
Cancer research 2024 Feb 1;84(3):479-492
Erxian decoction ameliorates myocardial tissue damage through activating PI3K/AKT signaling pathway in ovariectomized rats.
Yang Y, Liu H, Hu J, Ma Y, Li P, Zhang Z, Chen Y
Annals of medicine 2024 Dec;56(1):2411013
Annals of medicine 2024 Dec;56(1):2411013
TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis.
Wei W, Qu ZL, Lei L, Zhang P
Current medical science 2024 Dec;44(6):1280-1292
Current medical science 2024 Dec;44(6):1280-1292
Cell Sheets Formation Enhances Therapeutic Effects of Human Umbilical Cord Mesenchymal Stem Cells on Spinal Cord Injury.
Zhao Y, Wu Z, Zhou Y, Chen C, Lu Y, Wang H, Xu T, Yang C, Chen X
CNS neuroscience & therapeutics 2024 Dec;30(12):e70163
CNS neuroscience & therapeutics 2024 Dec;30(12):e70163
Taxifolin-loaded cellulose/l-arginine-chitosan hydrogel promoting bone defect repair through osteogenesis and angiogenesis.
Yang J, Han Y, Zhang L, Ding Q, Sun S, Zhang S, Wang Y, Wang N, Wei H, Yu T, Liu W, Ding C
International journal of biological macromolecules 2024 Dec;283(Pt 3):137843
International journal of biological macromolecules 2024 Dec;283(Pt 3):137843
Porcine reproductive and respiratory syndrome virus activates lipid synthesis through a ROS-dependent AKT/PCK1/INSIG/SREBPs axis.
Ma YX, Han YQ, Wang PZ, Wang MY, Yang GY, Li JL, Wang J, Chu BB
International journal of biological macromolecules 2024 Dec;282(Pt 1):136720
International journal of biological macromolecules 2024 Dec;282(Pt 1):136720
Spatial dimension cues derived from fibrous scaffolds trigger mechanical activation to potentiate the paracrine and regenerative functions of MSCs via the FAK-PI3K/AKT axis.
Xu S, Zhang M, Wang R, Zhang J, Wang C, Xie L, Zhao W
Acta biomaterialia 2024 Dec;190:273-292
Acta biomaterialia 2024 Dec;190:273-292
New benzophenone analogs from Nigrospora sphaerica and their inhibitory activity against PD-1/PD-L1 interactions.
Kuang QX, Huang YQ, Ruan YQ, Lai HZ, Long J, Yan CY, Lei HR, Guo DL, Deng Y, You FM, Jiang YF
Bioorganic chemistry 2024 Dec;153:107899
Bioorganic chemistry 2024 Dec;153:107899
20(R)-ginsenoside Rg3 alleviates diabetic retinal injury in T2DM mice by attenuating ROS-mediated ER stress through the activation of the Nrf2/HO-1 axis.
Li WL, Li K, Chang WG, Shi H, Zhang WX, Wang Z, Li W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156202
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156202
Astragaloside IV and cycloastragenol promote liver regeneration through regulation of hepatic oxidative homeostasis and glucose/lipid metabolism.
Li Y, Yang X, Li X, Wang S, Chen P, Ma T, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156165
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156165
Dang-Gui-Bu-Xue decoction against diabetic nephropathy via modulating the carbonyl compounds metabolic profile and AGEs/RAGE pathway.
Zhang ZT, Qi Y, Chen P, Chen L, Jiang Y, Fan Z, Guan H, Bai L, Liu J, Zhao D, Yan G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156104
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156104
Inhibiting TRIM8 alleviates adipocyte inflammation and insulin resistance by regulating the DUSP14/MAPKs pathway.
Zhu M, Pu J, Zhang T, Shao H, Su R, Tang C
Adipocyte 2024 Dec;13(1):2381262
Adipocyte 2024 Dec;13(1):2381262
HNRNPD/MAD2L2 axis facilitates lung adenocarcinoma progression and is a potential prognostic biomarker.
Gu Z, Ding W, Yuan S, Peng Y, Dong B, Gu Y, Li J, Chen Y, Wang K, Liu T, Han X, Li Y
Cellular signalling 2024 Dec;124:111443
Cellular signalling 2024 Dec;124:111443
LAMTOR1/mTORC1 promotes CD276 to induce immunosuppression via PI3K/Akt/MMP signaling pathway in Clostridium perfringens-induced necrotic enteritis of laying hens.
Dong Q, Sun Y, Li J, Tian X, Liu S, Fu Y, Luo R, Guo L, Zong B, Lu Q, Ye C, Fu S, Qiu Y
Poultry science 2024 Dec;103(12):104216
Poultry science 2024 Dec;103(12):104216
Identification and analysis of microplastic aggregation in CAR-T cells.
Yin Z, Huang Y, Zhu Y, Zhong Q, Shen H, Mahati S, Huang J, Li G, Ou R, Liu Z, Zhang Q, Liu S
Journal of hazardous materials 2024 Dec 5;480:136351
Journal of hazardous materials 2024 Dec 5;480:136351
Cyberpharmacology uncover the mechanism of the total Rhizoma Coptidis extracts ameliorate chronic atrophic gastritis.
Ma Z, Chen X, Xiong M, Wang H, Sun C, Tang W, Li J, Li X, Ma H, Ye X
Journal of ethnopharmacology 2024 Dec 5;335:118644
Journal of ethnopharmacology 2024 Dec 5;335:118644
Albiflorin inhibits osteoclastogenesis and titanium particles-induced osteolysis via inhibition of ROS accumulation and the PI3K/AKT signaling pathway.
Wang Q, Tao H, Wang H, Chen K, Zhu P, Chen W, Shi F, Gu Y, Xu Y, Geng D
International immunopharmacology 2024 Dec 5;142(Pt B):113245
International immunopharmacology 2024 Dec 5;142(Pt B):113245
The role of the PI3K/AKT/mTOR pathway in mediating PD-L1 upregulation during fibroblast transdifferentiation.
Zhao Y, Qi Y, Xia J, Duan M, Hao C, Yao W
International immunopharmacology 2024 Dec 5;142(Pt B):113186
International immunopharmacology 2024 Dec 5;142(Pt B):113186
Nuciferine ameliorates osteoarthritis: An in vitro and in vivo study.
Peng M, Shen G, Tu Q, Zhang W, Wang J
International immunopharmacology 2024 Dec 5;142(Pt B):113098
International immunopharmacology 2024 Dec 5;142(Pt B):113098
Schisandrin C inhibits AKT1-regulated cell proliferation in A549 cells.
Wang Z, Xie S, Li L, Liu Z, Zhou W
International immunopharmacology 2024 Dec 5;142(Pt A):113110
International immunopharmacology 2024 Dec 5;142(Pt A):113110
Liu-Shen-Wan inhibits PI3K/Akt and TRPV1 signaling alleviating bone cancer pain in rats.
Zhang H, Jiang J, Chen X, Zhu F, Fu F, Chen A, Fu L, Mao D
Cancer biology & therapy 2024 Dec 31;25(1):2432098
Cancer biology & therapy 2024 Dec 31;25(1):2432098
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
Yun WJ, Li J, Yin NC, Zhang CY, Cui ZG, Zhang L, Zheng HC
Cancer biology & therapy 2024 Dec 31;25(1):2302162
Cancer biology & therapy 2024 Dec 31;25(1):2302162
EIF2S2 transcriptionally upregulates HIF1α to promote gastric cancer progression via activating PI3K/AKT/mTOR pathway.
Wang Z, Zhang Y, Xue Y, Huang W, Zhang H
Carcinogenesis 2024 Dec 30;45(12):916-927
Carcinogenesis 2024 Dec 30;45(12):916-927
Annexin A5 knockdown inhibits cardiomyocyte apoptosis and alleviates cardiac hypertrophy via activating the PI3K/AKT/Bcl-2 signaling pathway.
Zhao L, Cao H, Yuan Y, Liao C, Huang D, Li X, Zhao Y, Huang Q, Li S, Zhang B
Scientific reports 2024 Dec 30;14(1):31915
Scientific reports 2024 Dec 30;14(1):31915
The Mitochondrial Fusion Promoter M1 Mitigates Cigarette Smoke-Induced Airway Inflammation and Oxidative Stress via the PI3K-AKT Signaling Pathway.
Zeng T, Liu L, Xu D, Wang T, Wu Y, Qin J, Gao L, Chen M, Li X, Li D, Chen J, Shen Y, Wen F
Lung 2024 Dec 3;203(1):12
Lung 2024 Dec 3;203(1):12
Resolvin D1 combined with exercise rehabilitation alleviates neurological injury in mice with intracranial hemorrhage via the BDNF/TrkB/PI3K/AKT pathway.
Xiaoyu L, Dandan L, Tianzhao O, Ziyou Z, Zhenlin L, Zhuang L, Mingrui L, Yusong H, Yangyang Z, Yanjiao L, Chun S, Siqi W, Tong L, Bensi Z
Scientific reports 2024 Dec 28;14(1):31447
Scientific reports 2024 Dec 28;14(1):31447
GPR37-enhanced ubiquitination of ATP1A1 inhibits tumor progression and radiation resistance in esophageal squamous cell carcinoma.
Hu J, Meng F, Lv L, Hong F, He Q, Zhu Q, Tian T, Chang N, Zhang S, Yi Q, Qian L
Cell death & disease 2024 Dec 27;15(12):933
Cell death & disease 2024 Dec 27;15(12):933
Discovery of SILA-123 as a Highly Potent FLT3 Inhibitor for the Treatment of Acute Myeloid Leukemia with Various FLT3 Mutations.
Wei TH, Wang ZX, Lu MY, Xu YJ, Yang J, Ni XF, Cheng Y, Zhang MY, Liu JC, Li QQ, Cai J, Chen ZJ, Kang JB, Li N, Dai WC, Ding N, Yu YC, Leng XJ, Xue X, Wang XL, Sun SL, Yang Y, Li NG, Shi ZH
Journal of medicinal chemistry 2024 Dec 26;67(24):21752-21780
Journal of medicinal chemistry 2024 Dec 26;67(24):21752-21780
FERMT1 contributes to the epithelial-mesenchymal transition of chronic rhinosinusitis with nasal polyps via PI3K/Akt signaling.
Dong Z, Jiang Y, Zhang J, Zheng C, Chen H, Tang W, Yan X, Yu L, Han L, Wang L
International immunopharmacology 2024 Dec 25;143(Pt 3):113545
International immunopharmacology 2024 Dec 25;143(Pt 3):113545
CARD9 promotes cholangiocarcinoma by regulating the IL-17A/Hedgehog and the THEM4/AKT/mTOR signaling pathways.
Zhang T, Zhu LX, Sun QK, Chen LJ, Qian YB
International immunopharmacology 2024 Dec 25;143(Pt 2):113399
International immunopharmacology 2024 Dec 25;143(Pt 2):113399
Functional omics of ORP7 in primary endothelial cells.
Taskinen JH, Holopainen M, Ruhanen H, van der Stoel M, Käkelä R, Ikonen E, Keskitalo S, Varjosalo M, Olkkonen VM
BMC biology 2024 Dec 18;22(1):292
BMC biology 2024 Dec 18;22(1):292
Revealing the Mechanism of Hemerocallis citrina Baroni in Depression Treatment Through Integrated Network Pharmacology and Transcriptomic Analysis.
Gao S, Lu J, Gu Y, Zhang Y, Wang C, Gao F, Dai Z, Xu S, Zhang J, Yang Y, Lei H
Pharmaceuticals (Basel, Switzerland) 2024 Dec 17;17(12)
Pharmaceuticals (Basel, Switzerland) 2024 Dec 17;17(12)
Phosphocholine inhibits proliferation and reduces stemness of endometrial cancer cells by downregulating mTOR-c-Myc signaling.
Gong K, Zheng Y, Liu Y, Zhang T, Song Y, Chen W, Guo L, Zhou J, Liu W, Fang T, Chen Y, Wang J, Pan F, Shi K
Cellular and molecular life sciences : CMLS 2024 Dec 16;82(1):3
Cellular and molecular life sciences : CMLS 2024 Dec 16;82(1):3
Elaiophylin targets EIF4B to suppress the growth of esophageal squamous cell carcinoma via the PI3K/AKT signaling pathway.
Qiu H, Gao L, Shi W, Wang J, Li B, Ke S, Chen J, Gong Y, Wu Y, Zhao W, Chen Y
Cancer letters 2024 Dec 16;611:217401
Cancer letters 2024 Dec 16;611:217401
Dihydromyricetin-loaded oxidized polysaccharide/L-arginine chitosan adhesive hydrogel promotes bone regeneration by regulating PI3K/AKT signaling pathway and MAPK signaling pathway.
Yang J, Zhang L, Wang Y, Wang N, Wei H, Zhang S, Ding Q, Sun S, Ding C, Liu W
Carbohydrate polymers 2024 Dec 15;346:122614
Carbohydrate polymers 2024 Dec 15;346:122614
The involvement of lidocaine in amyloid-β1-42-dependent mitochondrial dysfunction and apoptosis in hippocampal neurons via nerve growth factor-protein kinase B pathway.
Guo J, Xu Y, Liu J, Hou X
Neuroreport 2024 Dec 11;35(18):1123-1132
Neuroreport 2024 Dec 11;35(18):1123-1132
Ectopic endometrial stromal cell-derived extracellular vesicles encapsulating microRNA-25-3p induce endometrial collagen I deposition impairing decidualization in endometriosis.
Zhu Y, Zheng B, Zhang Y, Li M, Jiang Y, Zhou J, Zhang Y, Kang N, Wu M, Yan Y, Xing J, Zhou J
Molecular human reproduction 2024 Dec 11;30(12)
Molecular human reproduction 2024 Dec 11;30(12)
F13B regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway.
Jiang D, Qi Z, Xu ZY, Li YR
Biomolecules & biomedicine 2024 Dec 11;25(1):189-209
Biomolecules & biomedicine 2024 Dec 11;25(1):189-209
SNX14 inhibits autophagy via the PI3K/AKT/mTOR signaling cascade in breast cancer cells.
Lv S, Jiang H, Yu L, Zhang Y, Sun L, Xu J
Journal of molecular histology 2024 Aug;55(4):391-401
Journal of molecular histology 2024 Aug;55(4):391-401
MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway.
Pu Y, Yang J, Pan Q, Li C, Wang L, Xie X, Chen X, Xiao F, Chen G
The Journal of biological chemistry 2024 Aug;300(8):107530
The Journal of biological chemistry 2024 Aug;300(8):107530
A p38 MAP kinase inhibitor suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss through the inhibition of bone turnover.
Xu C, Wei Z, Dong X, Xing J, Meng X, Qiu Y, Zhou H, Zheng W, Xu Z, Huang S, Xia W, Lv L, Jiang H, Wang W, Zhao X, Liu Z, Akimoto Y, Zhao B, Wang S, Hu Z
Biochemical pharmacology 2024 Aug;226:116391
Biochemical pharmacology 2024 Aug;226:116391
Targeting FTO suppresses hepatocellular carcinoma by inhibiting ERBB3 and TUBB4A expression.
Jiang L, Liang R, Luo Q, Chen Z, Song G
Biochemical pharmacology 2024 Aug;226:116375
Biochemical pharmacology 2024 Aug;226:116375
Changes in PI3K/AKT and NRF2/HO-1 signaling expression and intestinal microbiota in bleomycin-induced pulmonary fibrosis.
Li C, Cao Y, Peng Y, Ma T, Wu F, Hua Y, Wang X, Bai T, Wei Y, Ji P
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Aug;190:114796
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Aug;190:114796
Digirseophene A promotes recovery in injured developing cerebellum via AMPK/AKT/GSK3β pathway-mediated neural stem cell proliferation.
Tang X, Huang Y, Fu W, Wang P, Feng L, Yang J, Zhu H, Huang X, Ming Q, Li P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117046
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117046
Isorhamnetin improves diabetes-induced erectile dysfunction in rats through activation of the PI3K/AKT/eNOS signaling pathway.
Mao Y, Zha Y, Zang Y, Gao Y, Sun J, Liu Y, Wang Z, Wei Z, Wang M, Yang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116987
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116987
Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.
Zhou S, Guo L, Cui X, Zhang X, Yang Y, Zhang M, Zhang P
Cellular signalling 2024 Aug;120:111217
Cellular signalling 2024 Aug;120:111217
A Lipid-Sensitive Spider Peptide Toxin Exhibits Selective Anti-Leukemia Efficacy through Multimodal Mechanisms.
Zhang P, Luo W, Zhang Z, Lv M, Sang L, Wen Y, Wang L, Ding C, Wu K, Li F, Nie Y, Zhu J, Liu X, Yi Y, Ding X, Zeng Y, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2404937
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2404937
mRNA-Lipid Nanoparticle-Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple-Negative Breast Cancer.
Li W, Huang M, Wu Z, Zhang Y, Cai Y, Su J, Xia J, Yang F, Xiao D, Yang W, Xu Y, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2309988
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2309988
Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo.
Hao EJ, Zhao Y, Yu M, Li XJ, Wang KX, Su FY, Liang YR, Wang Y, Guo HM
Journal of medicinal chemistry 2024 Aug 8;67(15):12553-12570
Journal of medicinal chemistry 2024 Aug 8;67(15):12553-12570
Network Pharmacological Analysis Combined with Experimental Verification to Explore the Effect of Ginseng Polypeptide on the Improvement of Diabetes Symptoms in db/db Mice.
Liu T, Zhu C, Duan Z, Ma P, Ma X, Fan D
Journal of agricultural and food chemistry 2024 Aug 21;72(33):18537-18551
Journal of agricultural and food chemistry 2024 Aug 21;72(33):18537-18551
Extract of Phyllanthus emblica L. fruit stimulates basal glucose uptake and ameliorates palmitate-induced insulin resistance through AMPK activation in C2C12 myotubes.
Li HY, Li CF, Liu CH, Chen SC, Liu YF, Lv QH, Zhang W
BMC complementary medicine and therapies 2024 Aug 2;24(1):296
BMC complementary medicine and therapies 2024 Aug 2;24(1):296
ITGB6 modulates resistance to anti-CD276 therapy in head and neck cancer by promoting PF4(+) macrophage infiltration.
Zhang C, Li K, Zhu H, Cheng M, Chen S, Ling R, Wang C, Chen D
Nature communications 2024 Aug 16;15(1):7077
Nature communications 2024 Aug 16;15(1):7077
Leptin protects chondrocytes by inhibiting autophagy via phosphoinositide 3 kinase/protein kinase B/mammalian target of rapamycin signaling pathway.
Li P, Jiang W, Yang Q, Lu Y, Zhang J
Heliyon 2024 Aug 15;10(15):e35665
Heliyon 2024 Aug 15;10(15):e35665
Does rAj-Tspin, a novel peptide from A. japonicus, exert antihepatocellular carcinoma effects via the ITGB1/ZYX/FAK/AKT signaling pathway?
Che Y, Lu X, Wang X, Liu Z, Guan L, Li X, Du Z, Ren H, Wang J, Zhou Z, Lv L
Cancer cell international 2024 Aug 14;24(1):290
Cancer cell international 2024 Aug 14;24(1):290
The mechanism of extracellular CypB promotes glioblastoma adaptation to glutamine deprivation microenvironment.
Yin H, Liu Y, Dong Q, Wang H, Yan Y, Wang X, Wan X, Yuan G, Pan Y
Cancer letters 2024 Aug 10;597:216862
Cancer letters 2024 Aug 10;597:216862
CUDC-907 exhibits potent antitumor effects against ovarian cancer through multiple in vivo and in vitro mechanisms.
Wang Y, Wen J, Sun X, Sun Y, Liu Y, Cheng X, Wu W, Liu Q, Ren F
Cancer chemotherapy and pharmacology 2024 Apr;93(4):295-306
Cancer chemotherapy and pharmacology 2024 Apr;93(4):295-306
YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
Yin G, Jia S, Zhang Y, Xian Y, Guo Y, Liu Q
Archives of biochemistry and biophysics 2024 Apr;754:109921
Archives of biochemistry and biophysics 2024 Apr;754:109921
DNAJC12 causes breast cancer chemotherapy resistance by repressing doxorubicin-induced ferroptosis and apoptosis via activation of AKT.
Shen M, Cao S, Long X, Xiao L, Yang L, Zhang P, Li L, Chen F, Lei T, Gao H, Ye F, Bu H
Redox biology 2024 Apr;70:103035
Redox biology 2024 Apr;70:103035
Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway.
Xueying Z, Liang G, Siyi L, Fengyue LI, Mingli L, Wanting L, Chun M, Guanghui L
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Apr;44(2):268-276
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Apr;44(2):268-276
Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3K/Akt/GSK3β pathway in stroke-prone renovascular hypertensive rats.
Wang N, Guo W, Liu T, Chen X, Lin M
Biotechnology & genetic engineering reviews 2024 Apr;40(1):519-539
Biotechnology & genetic engineering reviews 2024 Apr;40(1):519-539
M2 macrophage-derived paracrine factor TNFSF13 affects the fibrogenic alterations in endothelial cells and cardiac fibroblasts by mediating the NF-κB and Akt pathway.
Tan X, Wang J, Liu X, Xie G, Ouyang F
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23707
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23707
APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy.
Du Y, Zhou Y, Yan X, Pan F, He L, Guo Z, Hu Z
Cell death and differentiation 2024 Apr;31(4):431-446
Cell death and differentiation 2024 Apr;31(4):431-446
PI3K/AKT mediated De novo fatty acid synthesis regulates RIG-1/MDA-5-dependent type I IFN responses in BVDV-infected CD8(+)T cells.
Liu SS, Bai TT, Que TL, Luo A, Liang YX, Song YX, Liu TY, Chen JW, Li J, Li N, Zhang ZC, Chen NN, Liu Y, Zhang ZC, Zhou YL, Wang X, Zhu ZB
Veterinary microbiology 2024 Apr;291:110034
Veterinary microbiology 2024 Apr;291:110034
Retinoic acid induced specific changes in the phosphoproteome of C17.2 neural stem cells.
Zhang C, Ge L, Xie H, Liu X, Xun C, Chen Y, Chen H, Lu M, Chen P
Journal of cellular and molecular medicine 2024 Apr;28(7):e18205
Journal of cellular and molecular medicine 2024 Apr;28(7):e18205
Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.
Hou G, Hu W, Sang Y, Gan X, Xu H, Hu Q, Cao X
Biochemical pharmacology 2024 Apr;222:116110
Biochemical pharmacology 2024 Apr;222:116110
Arsenic disturbs neural tube closure involving AMPK/PKB-mTORC1-mediated autophagy in mice.
Li X, Li G, Cui S, Hou Y, Li Z, Yan Z, Huang T, Zhao T, Su H, Zhou B, Zhang J, Ao R, Zhao H, Qiu Y, Liu Z, Xie J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114538
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114538
Ginsenoside Rg3 suppresses vasculogenic mimicry by impairing DVL3-maintained stemness via PAAD cell-derived exosomal miR-204 in pancreatic adenocarcinoma.
Cai X, Wang Z, Lin S, Chen H, Bu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155402
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155402
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.
Chen L, Wang J, Ren Y, Ma Y, Liu J, Jiang H, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155382
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155382
Neonatal resveratrol administration promotes skeletal muscle growth and insulin sensitivity in intrauterine growth-retarded suckling piglets associated with activation of FGF21-AMPKα pathway.
Bai G, Chen J, Liu Y, Chen J, Yan H, You J, Zou T
Journal of the science of food and agriculture 2024 Apr;104(6):3719-3728
Journal of the science of food and agriculture 2024 Apr;104(6):3719-3728
Uncovering the key pharmacodynamic material basis and possible molecular mechanism of Xiaoke formulation improve insulin resistant through a comprehensive investigation.
Ma W, Long J, Dong L, Zhang J, Wang A, Zhang Y, Yan D
Journal of ethnopharmacology 2024 Apr 6;323:117752
Journal of ethnopharmacology 2024 Apr 6;323:117752
Integration of network pharmacology and serum medicinal chemistry to investigate the pharmacological mechanisms of QiZhuYangGan Decoction in the treatment of hepatic fibrosis.
Deng JW, Yuan S, Shi LP, Chen X, Liu J, Chen ZW, Tan KY, Yang Q, Cao WF
Journal of ethnopharmacology 2024 Apr 6;323:117730
Journal of ethnopharmacology 2024 Apr 6;323:117730
Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling.
Zhang ZT, Liang QF, Wang X, Wang RS, Duan TT, Wang SM, Tang D
Journal of ethnopharmacology 2024 Apr 6;323:117647
Journal of ethnopharmacology 2024 Apr 6;323:117647
KIF15 promotes the development and progression of chordoma via activating PI3K-AKT signalling pathway.
Yang J, Liu L, Xu X, Zeng H
Heliyon 2024 Apr 30;10(8):e29386
Heliyon 2024 Apr 30;10(8):e29386
Diterpenoid tanshinones inhibit gastric cancer angiogenesis through the PI3K/Akt/mTOR signaling pathway.
Yu JR, Liu YY, Gao YY, Qian LH, Qiu JL, Wang PP, Zhang GJ
Journal of ethnopharmacology 2024 Apr 24;324:117791
Journal of ethnopharmacology 2024 Apr 24;324:117791
Anti-hepatocellular carcinoma activity of Sorbaria sorbifolia by regulating VEGFR and c-Met/apoptotic pathway.
Xu ZH, Dang Y, Dong Y, Dong CY, Liu Y, Chen X, Yao Z, Shi JP
Journal of ethnopharmacology 2024 Apr 24;324:117758
Journal of ethnopharmacology 2024 Apr 24;324:117758
BMSCs attenuate radiation-induced brain injury induced hippocampal neuronal apoptosis through a PI3K/Akt/Bax/Bcl-2 signaling pathway.
Xu K, Liu Z, Pan S, Zhang N, Wu S, Yang G, Song X, Teng Y, Tong X
Brain research 2024 Apr 15;1829:148795
Brain research 2024 Apr 15;1829:148795
Hepatic LGR4 aggravates cholestasis-induced liver injury in mice.
Gao Y, Zhai W, Sun L, Du X, Wang X, Mulholland MW, Yin Y, Zhang W
American journal of physiology. Gastrointestinal and liver physiology 2024 Apr 1;326(4):G460-G472
American journal of physiology. Gastrointestinal and liver physiology 2024 Apr 1;326(4):G460-G472
The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats.
Cao T, Wang L, Jiao S, Chen H, Lin C, Zhang B, Cai H
Neuropsychobiology 2023;82(6):346-358
Neuropsychobiology 2023;82(6):346-358
Trimethylamine N-oxide Promotes Atherosclerosis by Regulating Low-Density Lipoprotein-Induced Autophagy in Vascular Smooth Muscle Cells Through PI3K/AKT/mTOR Pathway.
Shi G, Zeng L, Shi J, Chen Y
International heart journal 2023;64(3):462-469
International heart journal 2023;64(3):462-469
MiR-328-3p promotes TGF-β1-induced proliferation, migration, and inflammation of airway smooth muscle cells by regulating the PTEN/Akt pathway.
Gao J, Wu XL
Allergologia et immunopathologia 2023;51(2):151-159
Allergologia et immunopathologia 2023;51(2):151-159
YWHAH activates the HMGA1/PI3K/AKT/mTOR signaling pathway by positively regulating Fra-1 to affect the proliferation of gastric cancer cells.
He J, Zeng F, Jin XI, Liang L, Gao M, Li W, Li G, Zhou Y
Oncology research 2023;31(4):615-630
Oncology research 2023;31(4):615-630
Resveratrol inhibits TGF-β1-induced fibrotic effects in human pterygium fibroblasts.
Fan J, Wei S, Zhang X, Chen L, Zhang X, Jiang Y, Sheng M, Chen Y
Environmental health and preventive medicine 2023;28:59
Environmental health and preventive medicine 2023;28:59
Penehyclidine Hydrochloride Protects Rat Cardiomyocytes from Ischemia- Reperfusion Injury by Platelet-derived Growth Factor-B.
Lu Y, Zi C, Zhang L, Cui B, Li L, Ma J
Combinatorial chemistry & high throughput screening 2023;26(6):1204-1213
Combinatorial chemistry & high throughput screening 2023;26(6):1204-1213
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells.
Ning J, Ding J, Wang S, Jiang Y, Wang D, Jiang S
Journal of immunology research 2023;2023:5532617
Journal of immunology research 2023;2023:5532617
Low Expression of GIGYF1 Inhibits Metastasis, Proliferation, and Promotes Apoptosis and Autophagy of Gastric Cancer Cells.
Zhu L, Yao Z, Luo Q, Liu Y, Zhao W, Shao C, Shao S, Cui F
International journal of medical sciences 2023;20(8):1038-1045
International journal of medical sciences 2023;20(8):1038-1045
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy.
Huang Y, Zhang Y, Wu Y, Xiang Q, Yu R
Drug design, development and therapy 2023;17:237-260
Drug design, development and therapy 2023;17:237-260
Network pharmacology reveals that Berberine may function against Alzheimer's disease via the AKT signaling pathway.
Wei W, Yao JX, Zhang TT, Wen JY, Zhang Z, Luo YM, Cao Y, Li H
Frontiers in neuroscience 2023;17:1059496
Frontiers in neuroscience 2023;17:1059496
Molecular mechanism of miRNA-23a in sepsis-induced lung injury.
Zhang P, Huang Q, Liao P, Sun S, Yang J
American journal of translational research 2023;15(6):3900-3911
American journal of translational research 2023;15(6):3900-3911
TREM2 as an independent predictor of poor prognosis promotes the migration via the PI3K/AKT axis in prostate cancer.
Gao HT, Yang Z, Sun H, Zhang Y, Wang Z, Liu WY, Wen HZ, Qu CB, Wang XL
American journal of translational research 2023;15(2):779-798
American journal of translational research 2023;15(2):779-798
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
Zhang T, Liu MQ, Xie GS, Wu DM, Luo PW, Liu T, Deng SH, Wang YY, He S, Zhou Y, Zhou J, Xu Y
Journal of Cancer 2023;14(8):1350-1361
Journal of Cancer 2023;14(8):1350-1361
PLEKHG2 Promotes NSCLC Cell Growth by Increasing Glycolysis via Activated PI3K/AKT Pathway.
Xia Y, Feng X, Ning Y, Zhang W, Hu Z, Chen Q, Wang J, Qin H, Lu Y, Dong Y
Journal of Cancer 2023;14(18):3550-3560
Journal of Cancer 2023;14(18):3550-3560
CSNK1G2-AS1 promotes metastasis, colony formation and serves as a biomarker in testicular germ cell tumor cells.
Li R, Zhou Q, Liu G, Zhu F, Liu Z, Bo H, Fan L
Journal of Cancer 2023;14(15):2771-2783
Journal of Cancer 2023;14(15):2771-2783
Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer.
Yang HW, Lan Y, Li A, Wu H, Song ZW, Wan AL, Wang Y, Li SB, Ji S, Wang ZC, Wu XY, Lan T
Frontiers in pharmacology 2023;14:1288883
Frontiers in pharmacology 2023;14:1288883
Onvansertib inhibits the proliferation and improves the cisplatin-resistance of lung adenocarcinoma via β-catenin/c-Myc signaling pathway.
Wang R, Hou Y, Geng G, Zhu X, Wang Z, Cai W, Ye J, Zhao S, Mi Y, Jiang J
American journal of cancer research 2023;13(2):623-637
American journal of cancer research 2023;13(2):623-637
Characteristics of the immune microenvironment associated with RRM2 expression and its application to PD-L1/PD-1 inhibitors in lung adenocarcinoma.
Lee SK, Hwang Y, Han JH, Haam S, Lee HW, Koh YW
American journal of cancer research 2023;13(11):5443-5454
American journal of cancer research 2023;13(11):5443-5454
S-Nitrosylation-mediated coupling of DJ-1 with PTEN induces PI3K/AKT/mTOR pathway-dependent keloid formation.
Lv D, Xu Z, Cheng P, Hu Z, Dong Y, Rong Y, Xu H, Wang Z, Cao X, Deng W, Tang B
Burns & trauma 2023;11:tkad024
Burns & trauma 2023;11:tkad024
Daidzein alleviates osteoporosis by promoting osteogenesis and angiogenesis coupling.
Jia J, He R, Yao Z, Su J, Deng S, Chen K, Yu B
PeerJ 2023;11:e16121
PeerJ 2023;11:e16121
Investigation of anti-diabetic effect of a novel coenzyme Q10 derivative.
Tan X, Yang X, Xu X, Peng Y, Li X, Deng Y, Zhang X, Qiu W, Wu D, Ruan Y, Zhi C
Frontiers in chemistry 2023;11:1280999
Frontiers in chemistry 2023;11:1280999
Blockade of C5aR1 alleviates liver inflammation and fibrosis in a mouse model of NASH by regulating TLR4 signaling and macrophage polarization.
Jiang K, Lu S, Li D, Liu M, Jin H, Lei B, Wang S, Long K, He S, Zhong F
Journal of gastroenterology 2023 Sep;58(9):894-907
Journal of gastroenterology 2023 Sep;58(9):894-907
An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma.
Oyelakin A, Sosa J, Nayak KB, Glathar A, Gluck C, Sethi I, Tsompana M, Nowak N, Buck M, Romano RA, Sinha S
NAR cancer 2023 Sep;5(3):zcad038
NAR cancer 2023 Sep;5(3):zcad038
Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression.
Wu T, Zhang Y, Han Q, Lu X, Cheng Y, Chen J, Sha J, Xia W
Oncogene 2023 Sep;42(38):2801-2815
Oncogene 2023 Sep;42(38):2801-2815
miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb the Proliferation and Functions of Chondrocytes.
Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z, Yang W, Yang H, Zhou Z
The American journal of pathology 2023 Sep;193(9):1234-1247
The American journal of pathology 2023 Sep;193(9):1234-1247
Cinnamaldehyde protects donor heart from cold ischemia-reperfusion injury via the PI3K/AKT/mTOR pathway.
Lan H, Zheng Q, Wang K, Li C, Xiong T, Shi J, Dong N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:114867
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:114867
Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC.
Zhao X, Guo B, Sun W, Yu J, Cui L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2206878
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2206878
Targeting of AKT1 by miR-143-3p Suppresses Epithelial-to-Mesenchymal Transition in Prostate Cancer.
Armstrong L, Willoughby CE, McKenna DJ
Cells 2023 Sep 5;12(18)
Cells 2023 Sep 5;12(18)
Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.
Guo H, Wu H, Hou Y, Hu P, Du J, Cao L, Yang R, Dong X, Li Z
International journal of biological macromolecules 2023 Sep 30;249:126039
International journal of biological macromolecules 2023 Sep 30;249:126039
Gastrodin relieves cognitive impairment by regulating autophagy via PI3K/AKT signaling pathway in vascular dementia.
Chen YX, Yang H, Wang DS, Yao YT, Chen TT, Tao L, Chen Y, Shen XC
Biochemical and biophysical research communications 2023 Sep 3;671:246-254
Biochemical and biophysical research communications 2023 Sep 3;671:246-254
Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer.
Mao D, Zhou Z, Chen H, Liu X, Li D, Chen X, He Y, Liu M, Zhang C
Cancer letters 2023 Sep 28;572:216351
Cancer letters 2023 Sep 28;572:216351
Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk.
Ying P, Chen C, Lu Z, Chen S, Zhang M, Cai Y, Zhang F, Huang J, Fan L, Ning C, Li Y, Wang W, Geng H, Liu Y, Tian W, Yang Z, Liu J, Huang C, Yang X, Xu B, Li H, Zhu X, Li N, Li B, Wei Y, Zhu Y, Tian J, Miao X
Nature communications 2023 Sep 25;14(1):5958
Nature communications 2023 Sep 25;14(1):5958
METTL3 exerts synergistic effects on m6A methylation and histone modification to regulate the function of VGF in lung adenocarcinoma.
Shi K, Sa R, Dou L, Wu Y, Dong Z, Fu X, Yu H
Clinical epigenetics 2023 Sep 23;15(1):153
Clinical epigenetics 2023 Sep 23;15(1):153
δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis.
He X, Wang D, Yi Y, Tan Y, Wu M, Wang H, Hu W, Chen H, Zhang Q, Wu Y
Cell death discovery 2023 Sep 22;9(1):349
Cell death discovery 2023 Sep 22;9(1):349
Fagopyrum tataricum ethanol extract ameliorates symptoms of hyperglycemia by regulating gut microbiota in type 2 diabetes mellitus mice.
Ge X, Liu T, Chen Z, Zhang J, Yin X, Huang Z, Chen L, Zhao C, Shao R, Xu W
Food & function 2023 Sep 19;14(18):8487-8503
Food & function 2023 Sep 19;14(18):8487-8503
TIMELESS promotes the proliferation and migration of lung adenocarcinoma cells by activating EGFR through AMPK and SPHK1 regulation.
Yin H, Wang Z, Wang D, Nuer M, Han M, Ren P, Ma S, Lin C, Chen J, Xian H, Ai D, Li X, Ma S, Lin Z, Pan Y
European journal of pharmacology 2023 Sep 15;955:175883
European journal of pharmacology 2023 Sep 15;955:175883
Proteomic analysis of uterine lavage fluid of dairy cows at different time after delivery by mass spectrometry.
Jiang X, Li Z, Chang X, Huang C, Qiu R, Wang A, Lin P, Tang K, Chen H, Zhou D, Jin Y
Theriogenology 2023 Sep 1;207:31-48
Theriogenology 2023 Sep 1;207:31-48
TRIM11 regulated by m6A modification promotes the progression of cervical cancer by PHLPP1 ubiquitination.
Zhang P, Tang Y, Zhao J, Yang J, Chen Y, Gong Y, Meng S, Shu C
Neoplasma 2023 Oct;70(5):659-669
Neoplasma 2023 Oct;70(5):659-669
Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis.
Li T, Yang S, Liu X, Li Y, Gu Z, Jiang Z
Journal of advanced research 2023 Oct;52:119-134
Journal of advanced research 2023 Oct;52:119-134
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Deng H, Jiang J, Shu J, Huang M, Zhang QL, Wu LJ, Sun WK
Inflammation 2023 Oct;46(5):1981-1996
Inflammation 2023 Oct;46(5):1981-1996
Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway.
Wang X, Yang J, Wang W, Li Y, Yang Y
Immunopharmacology and immunotoxicology 2023 Oct;45(5):527-538
Immunopharmacology and immunotoxicology 2023 Oct;45(5):527-538
PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression.
Ma Z, Mo R, Yang P, Ding Y, Zhang H, Dong Z, Chen Y, Tan Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23215
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23215
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.
Fan R, Wang S, Wu Y, Feng Y, Gao M, Cao Y, Ma X, Xie S, Wang C, Gao L, Wang Y, Dai F
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Ma Y, Zhang J, Li Y, Hu H, Ye Q, Yang C, Yang L, Zhang B, Ma T
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
A new peptide, VD11, promotes structural and functional recovery after spinal cord injury.
Li SS, Zhang BY, Yin SG, Wei ZQ, Liu NX, Li YL, Wang SY, Shi YH, Zhao J, Wang LJ, Zhang Y, Sun J, Wang Y, Yang XW
Neural regeneration research 2023 Oct;18(10):2260-2267
Neural regeneration research 2023 Oct;18(10):2260-2267
Equine β-defensin 1 regulates cytokine expression and phagocytosis in S. aureus-infected mouse monocyte macrophages via the Paxillin-FAK-PI3K pathway.
Pei L, Hou Y, Feng Y, Li F, Su H, Zhang Y, Song Y, Liu K, Cao G
International immunopharmacology 2023 Oct;123:110793
International immunopharmacology 2023 Oct;123:110793
A network pharmacology approach to investigate dehydrocostus lactone inhibits the proliferation and epithelial-mesenchymal transition of human gastric cancer cells via regulating the PI3K/Akt and extracellular signal-regulated kinases/mitogen-activated protein kinase signalling pathways.
Wan M, Dai J, Gan A, Wang J, Lin F, Zhang X, Lv X, Wu B, Yan T, Jia Y
The Journal of pharmacy and pharmacology 2023 Oct 5;75(10):1344-1356
The Journal of pharmacy and pharmacology 2023 Oct 5;75(10):1344-1356
Network pharmacology integrated with experimental validation revealed potential molecular mechanisms of Camellia nitidissima C. W. Chi in the treatment of lung cancer.
Zhou A, Zhou C, Wang D, Qian M, Huang L
Journal of ethnopharmacology 2023 Oct 5;314:116576
Journal of ethnopharmacology 2023 Oct 5;314:116576
Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus.
Zhao Y, Liu Y, Deng J, Zhu C, Ma X, Jiang M, Fan D
Journal of agricultural and food chemistry 2023 Oct 4;71(39):14263-14275
Journal of agricultural and food chemistry 2023 Oct 4;71(39):14263-14275
N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.
Jing YX, Li HX, Yue F, Li YM, Yu X, He JJ, Zhang XH
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2023 Oct 26;39(1):2276167
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2023 Oct 26;39(1):2276167
Effects of Gestational Diabetes Mellitus and Selenium Deficiency on the Offspring Growth and Blood Glucose Mechanisms of C57BL/6J Mice.
Xu W, Gong J, Chen Y, Chen Y, Chen S, Wu Y, He Y, Li C, Yu H, Xie L
Nutrients 2023 Oct 25;15(21)
Nutrients 2023 Oct 25;15(21)
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer.
Zhao S, Li Y, Li G, Ye J, Wang R, Zhang X, Li F, Gao C, Li J, Jiang J, Mi Y
European journal of pharmacology 2023 Oct 15;957:176004
European journal of pharmacology 2023 Oct 15;957:176004
Scutellarin attenuates oxidative stress and neuroinflammation in cerebral ischemia/reperfusion injury through PI3K/Akt-mediated Nrf2 signaling pathways.
Xie X, Wang F, Ge W, Meng X, Fan L, Zhang W, Wang Z, Ding M, Gu S, Xing X, Sun X
European journal of pharmacology 2023 Oct 15;957:175979
European journal of pharmacology 2023 Oct 15;957:175979
Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway.
Lei M, Guo X, Yao Y, Shu T, Ren Z, Yang X, Ouyang C, Chen Q, Liu C, Liu X
Experimental gerontology 2023 Oct 15;182:112307
Experimental gerontology 2023 Oct 15;182:112307
RFC2 promotes aerobic glycolysis and progression of colorectal cancer.
Lou F, Zhang M
BMC gastroenterology 2023 Oct 11;23(1):353
BMC gastroenterology 2023 Oct 11;23(1):353
FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
Zhang W, Lin W, Zeng X, Zhang M, Chen Q, Tang Y, Sun J, Liang B, Zha L, Yu Z
Aging and disease 2023 Oct 1;14(5):1927-1944
Aging and disease 2023 Oct 1;14(5):1927-1944
Paternal lipopolysaccharide exposure induced intrauterine growth restriction via the inactivation of placental MEST/PI3K/AKT pathway in mice.
Jiang PY, Lin S, Liu JR, Liu Y, Zheng LM, Hong Q, Fan YJ, Xu DX, Chen YH
Archives of toxicology 2023 Nov;97(11):2929-2941
Archives of toxicology 2023 Nov;97(11):2929-2941
Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study.
Qiu K, Xia Q, Chen H, Ye Q, Mao H, Tian M, Gan Y, Huang Q, Wang H, Duan S
Heliyon 2023 Nov;9(11):e21851
Heliyon 2023 Nov;9(11):e21851
Catalpol Alleviates Ischemic Stroke Through Promoting Angiogenesis and Facilitating Proliferation and Differentiation of Neural Stem Cells via the VEGF-A/KDR Pathway.
Sun S, Xu Y, Yu N, Zhang M, Wang J, Wan D, Tian Z, Zhu H
Molecular neurobiology 2023 Nov;60(11):6227-6247
Molecular neurobiology 2023 Nov;60(11):6227-6247
6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice.
Gong K, Zhang Z, Chen SS, Zhu XR, Wang MY, Yang XY, Ding C, Han JH, Li QS, Duan YJ
Acta pharmacologica Sinica 2023 Nov;44(11):2216-2229
Acta pharmacologica Sinica 2023 Nov;44(11):2216-2229
Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
Huang X, Liu X, Lin J
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2361-2380
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2361-2380
Design and synthesis of 3,4-seco-lupane triterpene derivatives to resist myocardial ischemia-reperfusion injury by inhibiting oxidative stress-mediated mitochondrial dysfunction via the PI3K/AKT/HIF-1α axis.
Teng H, Wu D, Lu L, Gao C, Wang H, Zhao Y, Wang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115452
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115452
Discovery of Novel Fourth-Generation EGFR Inhibitors to Overcome C797S-Mediated Resistance.
Zhu Y, Ye X, Shen H, Li J, Cai Z, Min W, Hou Y, Dong H, Wu Y, Wang L, Wang X, Xiao Y, Yang P
Journal of medicinal chemistry 2023 Nov 9;66(21):14633-14652
Journal of medicinal chemistry 2023 Nov 9;66(21):14633-14652
GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3‑ITD acute myeloid leukemia.
Xiao X, Wang P, Zhang W, Wang J, Cai M, Jiang H, Wu Y, Shan H
Cancer cell international 2023 Nov 30;23(1):302
Cancer cell international 2023 Nov 30;23(1):302
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
Liu W, Li F, Guo D, Du C, Zhao S, Li J, Yan Z, Hao J
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3β/GLI1 pathway.
Yin L, Cao R, Liu Z, Luo G, Li Y, Zhou X, Chen X, Wu Y, He J, Zu X, Shen Y
Acta biochimica et biophysica Sinica 2023 Nov 25;55(11):1770-1783
Acta biochimica et biophysica Sinica 2023 Nov 25;55(11):1770-1783
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway.
Fu Y, Jia Q, Ren M, Bie H, Zhang X, Zhang Q, He S, Li C, Zhou H, Wang Y, Gan X, Tao Z, Chen X, Jia E
Immunity & ageing : I & A 2023 Nov 21;20(1):66
Immunity & ageing : I & A 2023 Nov 21;20(1):66
Leucine Supplementation Improves Diastolic Function in HFpEF by HDAC4 Inhibition.
Alves PKN, Schauer A, Augstein A, Männel A, Barthel P, Joachim D, Friedrich J, Prieto ME, Moriscot AS, Linke A, Adams V
Cells 2023 Nov 2;12(21)
Cells 2023 Nov 2;12(21)
Fibromodulin overexpression drives oral squamous cell carcinoma via activating downstream EGFR signaling.
Xia L, Zhang T, Yao J, Lu K, Hu Z, Gu X, Chen Y, Qin S, Leng W
iScience 2023 Nov 17;26(11):108201
iScience 2023 Nov 17;26(11):108201
Accelerating Wound Closure With Metrnl in Normal and Diabetic Mouse Skin.
Song L, Chang X, Hu L, Liu L, Wang G, Huang Y, Xu L, Jin B, Song J, Hu L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Chen Q, Guo B, Zhou Y
Diabetes 2023 Nov 1;72(11):1692-1706
Diabetes 2023 Nov 1;72(11):1692-1706
Spermidine suppresses oxidative stress and ferroptosis by Nrf2/HO-1/GPX4 and Akt/FHC/ACSL4 pathway to alleviate ovarian damage.
Niu C, Jiang D, Guo Y, Wang Z, Sun Q, Wang X, Ling W, An X, Ji C, Li S, Zhao H, Kang B
Life sciences 2023 Nov 1;332:122109
Life sciences 2023 Nov 1;332:122109
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
Ji X, Hong J, Yang W, Yao M, Wang J, Jiang G, Wang Y, Li C, Lin J, Mou H, Li C, Li S, Chen Y, Shi M, Wang W, Lu F, Wu H, Zhao X, Qi Y, Yan S
Redox biology 2023 May;61:102635
Redox biology 2023 May;61:102635
MSC-EXO and tempol ameliorate bronchopulmonary dysplasia in newborn rats by activating HIF-1α.
Wang J, Zhang A, Huang F, Xu J, Zhao M
Pediatric pulmonology 2023 May;58(5):1367-1379
Pediatric pulmonology 2023 May;58(5):1367-1379
IL1RAP Knockdown in LPS-Stimulated Normal Human Astrocytes Suppresses LPS-Induced Reactive Astrogliosis and Promotes Neuronal Cell Proliferation.
Zhou J, Xiang W, Zhang K, Zhao Q, Xu Z, Li Z
Neurochemical research 2023 May;48(5):1468-1479
Neurochemical research 2023 May;48(5):1468-1479
ZD6474 attenuates TGF-β1-induced fibrosis in human Tenon fibroblasts and inhibits neovascularization via AKT-mTOR signaling pathway.
Liu W, Chen Y, Song X, Xue Y, Zhang Y
International ophthalmology 2023 May;43(5):1523-1536
International ophthalmology 2023 May;43(5):1523-1536
Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.
Li L, Cao X, Huang L, Huang X, Gu J, Yu X, Zhu Y, Zhou Y, Song Y, Zhu M
Journal of cellular and molecular medicine 2023 May;27(10):1327-1340
Journal of cellular and molecular medicine 2023 May;27(10):1327-1340
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway.
Sun X, Huang LY, Pan HX, Li LJ, Wang L, Pei GQ, Wang Y, Zhang Q, Cheng HX, He CQ, Wei Q
Neural regeneration research 2023 May;18(5):1067-1075
Neural regeneration research 2023 May;18(5):1067-1075
A low-salt diet with candesartan administration is associated with acute kidney injury in nephritis by increasing nitric oxide.
Yu Y, Wang P, Ren Z, Xue Y, Jia Y, Wang W, Liu M, Pan K, Xiao L, Ji D, Wang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114484
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114484
Integrating HPLC-Q-TOF-MS/MS, network pharmacology and experimental validation to decipher the chemical substances and mechanism of modified Gui-shao-liu-jun-zi decoction against gastric cancer.
Huang W, Wen F, Ruan S, Gu P, Gu S, Song S, Zhou J, Li Y, Liu J, Shu P
Journal of traditional and complementary medicine 2023 May;13(3):245-262
Journal of traditional and complementary medicine 2023 May;13(3):245-262
Extracellular vesicles derived from Akkermansia muciniphila promote placentation and mitigate preeclampsia in a mouse model.
Chen Y, Ou Z, Pang M, Tao Z, Zheng X, Huang Z, Wen D, Li Q, Zhou R, Chen P, Situ B, Sheng C, Huang Y, Yue X, Zheng L, Huang L
Journal of extracellular vesicles 2023 May;12(5):e12328
Journal of extracellular vesicles 2023 May;12(5):e12328
MAPK4 predicts poor prognosis and facilitates the proliferation and migration of glioma through the AKT/mTOR pathway.
Ren J, Zheng S, Zhang L, Liu J, Cao H, Wu S, Xu Y, Sun J
Cancer medicine 2023 May;12(10):11624-11640
Cancer medicine 2023 May;12(10):11624-11640
Venlafaxine antagonizes the noradrenaline-promoted colon cancer progression by inhibiting the norepinephrine transporter.
Zhang H, Han J, Zhang J, Miao J, Li F, Tang K, Zhou K, Duan B, Li W, Cheng J, Sun Y, Hou N, Huang C
Cell death discovery 2023 May 8;9(1):152
Cell death discovery 2023 May 8;9(1):152
Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC.
Dong H, Ye X, Zhu Y, Shen H, Shen H, Chen W, Ji M, Zheng M, Wang K, Cai Z, Sun H, Xiao Y, Yang P
Journal of medicinal chemistry 2023 May 25;66(10):6849-6868
Journal of medicinal chemistry 2023 May 25;66(10):6849-6868
Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway.
Fu C, Zhang Y, Xi WJ, Xu K, Meng F, Ma T, Li W, Wu L, Chen Z
Journal of ethnopharmacology 2023 May 23;308:116191
Journal of ethnopharmacology 2023 May 23;308:116191
Role of Protein Tyrosine Phosphatase 1B Inhibitor in Early Brain Injury of Subarachnoid Hemorrhage in Mice.
Zhang ZH, Zhou XM, Zhang X
Brain sciences 2023 May 18;13(5)
Brain sciences 2023 May 18;13(5)
Cysteamine and N-Acetyl-cysteine Alleviate Placental Oxidative Stress and Barrier Function Damage Induced by Deoxynivalenol.
Huang S, Zhang L, Luo J, Wu D, Ma K, Chen Y, Ma S, Feng L, Li F, Liu D, Deng J, Tan C
Journal of agricultural and food chemistry 2023 May 10;71(18):6846-6858
Journal of agricultural and food chemistry 2023 May 10;71(18):6846-6858
Antitumor mechanism of kangliu pill on gliomas in mice through PI3K-Akt signaling pathway.
Chen F, Cui JJ, Jiang DC, Wang HZ, Zhuang W, Feng YN, Lin XL, Xi SY
Journal of ethnopharmacology 2023 May 10;307:116252
Journal of ethnopharmacology 2023 May 10;307:116252
Toxicity mechanism of peri-implantation pesticide beta-cypermethrin exposure on endometrial remodeling in early pregnant mice.
Zhou YJ, Qiao QF, Wang LQ, Sheng TY, Cui MX, Chen QD, Wang CY, Zhang YX
Toxicology 2023 May 1;489:153497
Toxicology 2023 May 1;489:153497
KIFC3 regulates progression of hepatocellular carcinoma via EMT and the AKT/mTOR pathway.
Lu S, Liu Y, Tian S, He Y, Dong W
Experimental cell research 2023 May 1;426(1):113564
Experimental cell research 2023 May 1;426(1):113564
PD-1(+) mast cell enhanced by PD-1 blocking therapy associated with resistance to immunotherapy.
Li J, Peng G, Zhu K, Jie X, Xu Y, Rao X, Xu Y, Chen Y, Xing B, Wu G, Shi L
Cancer immunology, immunotherapy : CII 2023 Mar;72(3):633-645
Cancer immunology, immunotherapy : CII 2023 Mar;72(3):633-645
ZD6474 Attenuates Fibrosis and Inhibits Neovascularization in Human Pterygium by Suppressing AKT-mTOR Signaling Pathway.
Liu W, Lin T, Gong L
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2023 Mar;39(2):128-138
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2023 Mar;39(2):128-138
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Chen D, Jiang X, Zou H
Journal of orthopaedic translation 2023 Mar;39:163-176
Journal of orthopaedic translation 2023 Mar;39:163-176
Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica.
Liu Z, Hong LL, Zheng JS, Ling ZN, Zhang ZL, Qi YN, Zhang XY, Zhu TY, Wang JL, Han J, Chen XL, Yu QM, Wang S, Li P, Ling ZQ
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2023 Mar;26(2):203-219
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2023 Mar;26(2):203-219
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
Yang J, Hasenbilige, Bao S, Luo S, Jiang L, Li Q, Kong Y, Cao J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Mar;173:113609
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Mar;173:113609
hsa-mir-133a-2 promotes the proliferation and invasion of cervical cancer cells by targeting the LAMB3-mediated PI3K/ATK pathway.
Sui X, Sun Y, Zhang G, Chi N, Guan Y, Wang D, Li X
Cancer medicine 2023 Mar;12(5):5874-5888
Cancer medicine 2023 Mar;12(5):5874-5888
Sustainably released nanoparticle-based rhynchophylline limits pulmonary fibrosis by inhibiting the TEK-PI3K/AKT signaling pathway.
Wang S, Huang Z, Liu Y, Sun H, Zhou Y, Shi J
Translational lung cancer research 2023 Mar 31;12(3):427-445
Translational lung cancer research 2023 Mar 31;12(3):427-445
Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.
Zhu Y, Yang J, Li Y, Xu J, Fang Z
Medical oncology (Northwood, London, England) 2023 Mar 27;40(5):130
Medical oncology (Northwood, London, England) 2023 Mar 27;40(5):130
The short isoform of MS4A7 is a novel player in glioblastoma microenvironment, M2 macrophage polarization, and tumor progression.
Ni B, Huang G, Yang R, Wang Z, Song H, Li K, Zhang Y, Wu K, Shi G, Wang X, Shen J, Liu Y
Journal of neuroinflammation 2023 Mar 21;20(1):80
Journal of neuroinflammation 2023 Mar 21;20(1):80
Chemical Constituents and Hypoglycemic Mechanisms of Dendrobium nobile in Treatment of Type 2 Diabetic Rats by UPLC-ESI-Q-Orbitrap, Network Pharmacology and In Vivo Experimental Verification.
Li Z, Zeng M, Geng K, Lai D, Xu Z, Zhou W
Molecules (Basel, Switzerland) 2023 Mar 16;28(6)
Molecules (Basel, Switzerland) 2023 Mar 16;28(6)
AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer.
Li Y, She W, Xu X, Liu Y, Wang X, Tian S, Li S, Wang M, Yu C, Liu P, Huang T, Wei Y
Journal of Zhejiang University. Science. B 2023 Mar 15;24(3):232-247
Journal of Zhejiang University. Science. B 2023 Mar 15;24(3):232-247
P53 Deficiency Accelerates Esophageal Epithelium Intestinal Metaplasia Malignancy.
Qiu Q, Guo G, Guo X, Hu X, Yu T, Liu G, Zhang H, Chen Y, She J
Biomedicines 2023 Mar 13;11(3)
Biomedicines 2023 Mar 13;11(3)
The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways.
Wang Z, Jian G, Chen T, Chen Y, Li J, Wang N
European journal of histochemistry : EJH 2023 Mar 1;67(1)
European journal of histochemistry : EJH 2023 Mar 1;67(1)
Harmine suppresses the malignant phenotypes and PI3K activity in breast cancer.
Yao P, Yao P, Ku X, Yang J
Anti-cancer drugs 2023 Mar 1;34(3):373-383
Anti-cancer drugs 2023 Mar 1;34(3):373-383
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Liu X, Xi H, Han S, Zhang H, Hu J
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Effect of isorhamnetin on carbonic anhydrase IX expression and tumorigenesis of bladder cancer by activating PPARγ/PTEN/AKT pathway.
Zhang P, Sun Y, Shi L, Sun D, Wang L, Feng D, Ding C
Tissue & cell 2023 Jun;82:102048
Tissue & cell 2023 Jun;82:102048
LncRNA SLC7A11-AS1 promotes the progression of hepatocellular carcinoma by mediating KLF9 ubiquitination.
Zeng FL, Lin J, Xie X, Xie YK, Zhang JH, Xu D, He X, Liu FE, Xie BH
Neoplasma 2023 Jun;70(3):361-374
Neoplasma 2023 Jun;70(3):361-374
FAM83A promotes the progression and metastasis of human pancreatic neuroendocrine tumors by inducing the epithelial-mesenchymal transition via the PI3K/AKT and ERK pathways.
Zhou B, Zhou X, Zhan C, Jin M, Yan S
Journal of endocrinological investigation 2023 Jun;46(6):1115-1130
Journal of endocrinological investigation 2023 Jun;46(6):1115-1130
Glycoside combinations of Buyang Huanwu decoction ameliorate atherosclerosis via STAT3, HIF-1, and VEGF.
Yan F, Ding H, Sun Z, Liu J, Li J, Zhou D, Zhang W
Naunyn-Schmiedeberg's archives of pharmacology 2023 Jun;396(6):1187-1203
Naunyn-Schmiedeberg's archives of pharmacology 2023 Jun;396(6):1187-1203
Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
Wang F, Fan X, Kong J, Wang C, Ma B, Sun W, Ye Z, Liu P, Wen J
Vascular 2023 Jun;31(3):533-543
Vascular 2023 Jun;31(3):533-543
Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signalling pathway.
Liu Z, Xiang H, Deng Q, Fu W, Li Y, Yu Z, Qiu Y, Mei Z, Xu L
Nephrology (Carlton, Vic.) 2023 Jun;28(6):315-327
Nephrology (Carlton, Vic.) 2023 Jun;28(6):315-327
DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway.
Liu H, Xu L, Zhou L, Han W, Li Z, Liu C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113782
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113782
Characterizing the specific mechanism of series processed Coptidis Rhizoma by multi-organ metabolomics combined with network pharmacology and molecular docking.
Zhou N, Wang Y, Zhang Z, Feng W, Liu T, Cao Y, Zhang J, Zhang B, Zheng X, Li K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154804
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154804
TWEAK Signaling-Induced ID1 Expression Drives Malignant Transformation of Hepatic Progenitor Cells During Hepatocarcinogenesis.
Liu W, Gao L, Hou X, Feng S, Yan H, Pan H, Zhang S, Yang X, Jiang J, Ye F, Zhao Q, Wei L, Han Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(18):e2300350
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(18):e2300350
CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP-43 and Encoding A Novel TMEFF1-339aa Protein.
Chen R, Yang T, Jin B, Xu W, Yan Y, Wood N, Lehmann HI, Wang S, Zhu X, Yuan W, Chen H, Liu Z, Li G, Bowen TS, Li J, Xiao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(17):e2206732
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(17):e2206732
PTEN Inhibitor Treatment Lowers Muscle Plasma Membrane Damage and Enhances Muscle ECM Homeostasis after High-Intensity Eccentric Exercise in Mice.
Wu B, Shi L, Wu Y
International journal of molecular sciences 2023 Jun 9;24(12)
International journal of molecular sciences 2023 Jun 9;24(12)
Risk signature identification and NPRL2 affects sunitinib sensitivity in clear cell renal cell carcinoma.
Du X, Zhao Z, Zhao X, Wang H, Jiang L, Tang W
Biochemical and biophysical research communications 2023 Jun 30;663:122-131
Biochemical and biophysical research communications 2023 Jun 30;663:122-131
Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production.
Yan Y, Yang X, Han N, Liu Y, Liang Q, Li LG, Hu J, Li TF, Xu Z
Journal of nanobiotechnology 2023 Jun 29;21(1):204
Journal of nanobiotechnology 2023 Jun 29;21(1):204
Patrinia villosa treat colorectal cancer by activating PI3K/Akt signaling pathway.
Li XC, Wang S, Yang XX, Li TJ, Gu JX, Zhao L, Bao YR, Meng XS
Journal of ethnopharmacology 2023 Jun 12;309:116264
Journal of ethnopharmacology 2023 Jun 12;309:116264
HNRNPA2B1-mediated m(6)A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis.
Li K, Gong Q, Xiang XD, Guo G, Liu J, Zhao L, Li J, Chen N, Li H, Zhang LJ, Zhou CY, Wang ZY, Zhuang L
Journal of translational medicine 2023 Jun 12;21(1):382
Journal of translational medicine 2023 Jun 12;21(1):382
Arsenic interferes with spermatogenesis involving Rictor/mTORC2-mediated blood-testis barrier disruption in mice.
Li X, Wang W, Hou Y, Li G, Yi H, Cui S, Zhang J, He X, Zhao H, Yang Z, Qiu Y, Liu Z, Xie J
Ecotoxicology and environmental safety 2023 Jun 1;257:114914
Ecotoxicology and environmental safety 2023 Jun 1;257:114914
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
Cai Z, Li Y, Ma M, Wang L, Wang H, Liu M, Jiang C
Oncology reports 2023 Jul;50(1)
Oncology reports 2023 Jul;50(1)
Autophagy-related gene PXN as a prognostic marker: Promotion of ovarian cancer progression by suppressing the p110β/Vps34/Beclin1 pathway.
Wu Q, Cui Z, Jiang S, Xia H, Liu L, You Y, Sun Y
Cell biochemistry and function 2023 Jul;41(5):599-608
Cell biochemistry and function 2023 Jul;41(5):599-608
TANGO1 interacts with NRTN to promote hepatocellular carcinoma progression by regulating the PI3K/AKT/mTOR signaling pathway.
Man J, Zhou W, Zuo S, Zhao X, Wang Q, Ma H, Li HY
Biochemical pharmacology 2023 Jul;213:115615
Biochemical pharmacology 2023 Jul;213:115615
Low Pi stress enhances the sensitivity of hepatocellular carcinoma to sorafenib.
Bi QC, Deng ZQ, Lv YF, Liu Y, Xie CS, He YQ, Tang Q
Biochemical pharmacology 2023 Jul;213:115593
Biochemical pharmacology 2023 Jul;213:115593
Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma.
Yin Z, Lv Y, Deng L, Li G, Ou R, Chen L, Zhu Y, Zhong Q, Liu Z, Huang J, Wu H, Zhang Q, Fei J, Liu S
Free radical biology & medicine 2023 Jul;203:86-101
Free radical biology & medicine 2023 Jul;203:86-101
miR-221/222 Promote Endothelial Differentiation of Adipose-Derived Stem Cells by Regulation of PTEN/PI3K/AKT/mTOR Pathway.
Gao W, Yuan L, Zhang Y, Si Y, Wang X, Lv T, Wang YS
Applied biochemistry and biotechnology 2023 Jul;195(7):4196-4214
Applied biochemistry and biotechnology 2023 Jul;195(7):4196-4214
A novel organic arsenic derivative MZ2 remodels metabolism and triggers mtROS-mediated apoptosis in acute myeloid leukemia.
Chen G, She W, Yu C, Rouzi T, Li X, Ma L, Zhang N, Jiang H, Liu X, Wu J, Wang Q, Shen H, Zhou F
Journal of cancer research and clinical oncology 2023 Jul;149(8):4225-4242
Journal of cancer research and clinical oncology 2023 Jul;149(8):4225-4242
Oral nano-formulation improves pancreatic islets dysfunction via lymphatic transport for antidiabetic treatment.
Hou L, Peng X, Wang R, Wang Y, Li H, Zhang H, Zhang Y, Zhang Z
Acta pharmaceutica Sinica. B 2023 Jul;13(7):3137-3152
Acta pharmaceutica Sinica. B 2023 Jul;13(7):3137-3152
Inhibition of TREM-1 ameliorates Lipopolysaccharide-induced depressive-like behaviors by alleviating neuroinflammation in the PFC via PI3K/Akt signaling pathway.
Fu A, Qiao F, Feng H, Luo Q
Behavioural brain research 2023 Jul 9;449:114464
Behavioural brain research 2023 Jul 9;449:114464
Atractylenolide III Ameliorates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting the PI3K/AKT Pathway and Regulating Glutamine Metabolism.
Wang Y, Shi K, Tu J, Ke C, Chen N, Wang B, Liu Y, Zhou Z
Molecules (Basel, Switzerland) 2023 Jul 19;28(14)
Molecules (Basel, Switzerland) 2023 Jul 19;28(14)
Gypenosides suppress fibrosis of the renal NRK-49F cells by targeting miR-378a-5p through the PI3K/AKT signaling pathway.
Zhang L, Wang X, He S, Zhang F, Li Y
Journal of ethnopharmacology 2023 Jul 15;311:116466
Journal of ethnopharmacology 2023 Jul 15;311:116466
Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model.
Liu Y, Chen LJ, Li XW, Yang JZ, Liu JL, Zhang KK, Li JH, Wang Q, Xu JT, Zhi X
Chemico-biological interactions 2023 Jul 1;379:110512
Chemico-biological interactions 2023 Jul 1;379:110512
Periplocin inhibits hepatocellular carcinoma progression and reduces the recruitment of MDSCs through AKT/NF-κB pathway.
Lin JP, Huang MH, Sun ZT, Chen L, Lei YH, Huang YQ, Qi M, Fan SR, Chen SG, Chung CW, Chan MC, Liu JS, Hu M, Chen MF, Ye WC, Chen YY, Deng LJ
Life sciences 2023 Jul 1;324:121715
Life sciences 2023 Jul 1;324:121715
SFTS bunyavirus NSs protein sequestrates mTOR into inclusion bodies and deregulates mTOR-ULK1 signaling, provoking pro-viral autophagy.
Feng K, Zhang H, Jiang Z, Zhou M, Min YQ, Deng F, Li P, Wang H, Ning YJ
Journal of medical virology 2023 Jan;95(1):e28371
Journal of medical virology 2023 Jan;95(1):e28371
Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co-expression network analysis.
Liu Q, Dong Y, Escames G, Wu X, Ren J, Yang W, Zhang S, Zhu Y, Tian Y, Acuña-Castroviejo D, Yang Y
Bioengineering & translational medicine 2023 Jan;8(1):e10384
Bioengineering & translational medicine 2023 Jan;8(1):e10384
HYOU1 promotes cell proliferation, migration, and invasion via the PI3K/AKT/FOXO1 feedback loop in bladder cancer.
Wang W, Jiang X, Xia F, Chen X, Li G, Liu L, Xu Q, Zhu M, Chen C
Molecular biology reports 2023 Jan;50(1):453-464
Molecular biology reports 2023 Jan;50(1):453-464
Prefoldin 6 promotes glioma progression via the AKT signalling pathway.
Jiang L, Liu J
Cell biology international 2023 Jan;47(1):52-62
Cell biology international 2023 Jan;47(1):52-62
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Li M, Zhang Y, Han T, Guan L, Fan D, Wu Q, Liu J, Xu Y, Fan Y
Phytochemistry 2023 Jan;205:113487
Phytochemistry 2023 Jan;205:113487
Triptolide inhibits intrahepatic cholangiocarcinoma growth by suppressing glycolysis via the AKT/mTOR pathway.
Li L, Wang C, Qiu Z, Deng D, Chen X, Wang Q, Meng Y, Zhang B, Zheng G, Hu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154575
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154575
Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia.
Liu H, Yu L, Ding Y, Peng M, Deng Y
Cell transplantation 2023 Jan-Dec;32:9636897221145682
Cell transplantation 2023 Jan-Dec;32:9636897221145682
Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1.
Liu Y, She W, Li Y, Wang M, Liu Y, Ning B, Xu T, Huang T, Wei Y
Journal of translational medicine 2023 Jan 7;21(1):7
Journal of translational medicine 2023 Jan 7;21(1):7
Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis.
Zheng ZG, Xu YY, Liu WP, Zhang Y, Zhang C, Liu HL, Zhang XY, Liu RZ, Zhang YP, Shi MY, Yang H, Li P
Cell metabolism 2023 Jan 3;35(1):101-117.e11
Cell metabolism 2023 Jan 3;35(1):101-117.e11
Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion.
Yang L, Du H, Zhang X, Gao B, Zhang D, Qiao Z, Su X, Bao T, Han S
BMC neuroscience 2023 Jan 27;24(1):8
BMC neuroscience 2023 Jan 27;24(1):8
Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer.
Han L, Dai W, Luo W, Ye L, Fang H, Mo S, Li Q, Xu Y, Wang R, Cai G
Cancers 2023 Jan 17;15(3)
Cancers 2023 Jan 17;15(3)
Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice.
Xia Y, Hao L, Li Y, Li Y, Chen J, Li L, Han X, Liu Y, Wang X, Li D
Ecotoxicology and environmental safety 2023 Jan 15;250:114497
Ecotoxicology and environmental safety 2023 Jan 15;250:114497
Betulinaldehyde exhibits effective anti-tumor effects in A549 cells by regulating intracellular autophagy.
Huang PH, Duan XB, Tang ZZ, Zou ZX, Song WM, Gao G, Li D, Nie FQ, Yan X, Fu YX, Guo R, Xu YY
Scientific reports 2023 Jan 13;13(1):743
Scientific reports 2023 Jan 13;13(1):743
Monotropein attenuates doxorubicin-induced oxidative stress, inflammation, and arrhythmia via the AKT signal pathway.
Fang Z, Wei W, Jiang X
Biochemical and biophysical research communications 2023 Jan 1;638:14-22
Biochemical and biophysical research communications 2023 Jan 1;638:14-22
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Xi H, Hu Z, Han S, Liu X, Wang L, Hu J
Theriogenology 2023 Jan 1;195:103-114
Theriogenology 2023 Jan 1;195:103-114
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting.
Wang L, Chen X, Meng F, Huang T, Wang S, Zheng Z, Zheng G, Li W, Zhang J, Liu Y
Journal of physiology and biochemistry 2023 Feb;79(1):19-34
Journal of physiology and biochemistry 2023 Feb;79(1):19-34
Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma.
Zhu XF, Sun ZL, Ma J, Hu B, Yu MC, Liu XJ, Yang P, Xu Y, Ju D, Mu Q
Phytotherapy research : PTR 2023 Feb;37(2):592-610
Phytotherapy research : PTR 2023 Feb;37(2):592-610
S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.
Chen B, Zheng D, Liu C, Bhandari A, Hirachan S, Shen C, Mainali S, Li H, Jiang W, Xu J, Zhang X, Tang K, Zhang W
Pathology, research and practice 2023 Feb;242:154325
Pathology, research and practice 2023 Feb;242:154325
LncRNA NR2F1-AS1 was involved in azacitidine resistance of THP-1 cells by targeting IGF1 with miR-483-3p.
Hu C, Li S, Fu X, Zhao X, Peng J
Cytokine 2023 Feb;162:156105
Cytokine 2023 Feb;162:156105
Single-cell transcriptome analysis identifies Versican(+) myofibroblast as a hallmark for thoracic aortic aneurysm marked by activation of PI3K-AKT signaling pathway.
Song W, Qin L, Chen Y, Chen J, Wei L
Biochemical and biophysical research communications 2023 Feb 5;643:175-185
Biochemical and biophysical research communications 2023 Feb 5;643:175-185
Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia.
Chang N, Feng J, Liao P, Hu Y, Li M, He Y, Li Y
Translational cancer research 2023 Feb 28;12(2):287-300
Translational cancer research 2023 Feb 28;12(2):287-300
Synergistic effects of L-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation.
Xu W, Song X, Qu Q, Gong Z, Xiao W
Food & function 2023 Feb 21;14(4):2059-2073
Food & function 2023 Feb 21;14(4):2059-2073
Onchidium struma polysaccharides exhibit hypoglycemic activity and modulate the gut microbiota in mice with type 2 diabetes mellitus.
Zhao Y, Song P, Yin S, Fan T, Li F, Ge X, Liu T, Xu W, Xu S, Chen L
Food & function 2023 Feb 21;14(4):1937-1951
Food & function 2023 Feb 21;14(4):1937-1951
RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4.
Fang J, Wu X, He J, Zhang H, Chen X, Zhang H, Novakovic B, Qi H, Yu X
Molecular medicine (Cambridge, Mass.) 2023 Feb 20;29(1):23
Molecular medicine (Cambridge, Mass.) 2023 Feb 20;29(1):23
Silk-Inorganic Nanoparticle Hybrid Hydrogel as an Injectable Bone Repairing Biomaterial.
Sun L, Lu M, Chen L, Zhao B, Yao J, Shao Z, Chen X, Liu Y
Journal of functional biomaterials 2023 Feb 2;14(2)
Journal of functional biomaterials 2023 Feb 2;14(2)
Activation of long-non-coding RNA NEAT1 sponging microRNA-147 inhibits radiation damage by targeting PDPK1 in troxerutin radioprotection.
Hu YJ, Song GY, Zhang F, Zhang N, Wang F, Wang JL, Wang X, Wang TY, Li YF, Yan YD, Dou WT, Cheng CY, Xu P
iScience 2023 Feb 17;26(2):105932
iScience 2023 Feb 17;26(2):105932
Cytosolic Release of Mitochondrial DNA and Associated cGAS Signaling Mediates Radiation-Induced Hematopoietic Injury of Mice.
Guan H, Zhang W, Xie D, Nie Y, Chen S, Sun X, Zhao H, Liu X, Wang H, Huang X, Bai C, Huang B, Zhou P, Gao S
International journal of molecular sciences 2023 Feb 16;24(4)
International journal of molecular sciences 2023 Feb 16;24(4)
Metformin regulates autophagy via LGMN to inhibit choriocarcinoma.
Tu W, Qin M, Li Y, Wu W, Tong X
Gene 2023 Feb 15;853:147090
Gene 2023 Feb 15;853:147090
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
Wang Y, Liu Q, Chu C, Li L, Wang Z, Liu Q, Wu G, Wei X, An L, Ma J
Toxicology and applied pharmacology 2023 Feb 15;461:116385
Toxicology and applied pharmacology 2023 Feb 15;461:116385
Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK.
He Y, Luo M, Lei S, Zeng Z, Chen T, Wu Y, Wang D, Wang L, Wang L
Molecules (Basel, Switzerland) 2023 Feb 12;28(4)
Molecules (Basel, Switzerland) 2023 Feb 12;28(4)
The role of PDIA3 in oral squamous cell carcinoma and its value as A diagnostic and prognostic biomarker.
Wang L, Wang X, Zhang J, Duan J, Tang C, Zhang L, Zeng H, Li H, Li Y, Zhou Y
Heliyon 2023 Dec;9(12):e22596
Heliyon 2023 Dec;9(12):e22596
AKAP12 inhibits esophageal squamous carcinoma cell proliferation, migration, and cell cycle via the PI3K/AKT signaling pathway.
Li X, Dong H, Zheng Y, Ding S, Li Y, Li H, Huang H, Zhong C, Xie T, Xu Y
Molecular and cellular probes 2023 Dec;72:101939
Molecular and cellular probes 2023 Dec;72:101939
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Wang Z, Li L, Chu C, Wei X, Liu Q, Wang R, Zhang G, Wu G, Wang Y, An L, Li X
International journal of oncology 2023 Dec;63(6)
International journal of oncology 2023 Dec;63(6)
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
Chen T, Bao S, Chen J, Zhang J, Wei H, Hu X, Liang Y, Li J, Yan S
Pharmaceutical biology 2023 Dec;61(1):1234-1248
Pharmaceutical biology 2023 Dec;61(1):1234-1248
ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway.
Wu M, Li R, Qin J, Wang Z, Guo J, Lv F, Wang G, Huang Y
Journal of molecular histology 2023 Dec;54(6):621-631
Journal of molecular histology 2023 Dec;54(6):621-631
Human Dental Pulp Stem Cells Are Subjected to Metabolic Reprogramming and Repressed Proliferation and Migration by the Sympathetic Nervous System via α1B-Adrenergic Receptor.
Yang C, Gao Q, Xu N, Yang K, Bian Z
Journal of endodontics 2023 Dec;49(12):1641-1651.e6
Journal of endodontics 2023 Dec;49(12):1641-1651.e6
Acteoside Derived from Cistanche Improves Glucocorticoid-Induced Osteoporosis by Activating PI3K/AKT/mTOR Pathway.
Li S, Cui Y, Li M, Zhang W, Sun X, Xin Z, Li J
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2023 Dec;36(1):2154578
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2023 Dec;36(1):2154578
Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes.
Liu Y, Wu K, Fu Y, Li W, Zhao XY
Redox report : communications in free radical research 2023 Dec;28(1):2260646
Redox report : communications in free radical research 2023 Dec;28(1):2260646
Integrated analysis of murine cornea identifies JAK/STAT signaling pathway upregulated specifically in female Vitamin A Deficient mice.
Yu H, Wu J, Li K, Huang Y, Wu T, Wang L, Huang Y
Experimental eye research 2023 Dec;237:109714
Experimental eye research 2023 Dec;237:109714
BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment.
Gu R, Dai F, Xiang C, Chen J, Yang D, Tan W, Wang Z, Liu H, Cheng Y
The Journal of steroid biochemistry and molecular biology 2023 Dec;235:106410
The Journal of steroid biochemistry and molecular biology 2023 Dec;235:106410
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator.
Wang R, Li J, Fu Y, Li Y, Qi Y, Li C, Gao F, Li C
Biochemical pharmacology 2023 Dec;218:115874
Biochemical pharmacology 2023 Dec;218:115874
Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells.
Guo X, Fan A, Qi X, Liu D, Huang J, Lin W
Bioorganic chemistry 2023 Dec;141:106873
Bioorganic chemistry 2023 Dec;141:106873
TPN10475 alleviates concanavalin A-induced autoimmune hepatitis by limiting T cell development and function through inhibition of PI3K-AKT pathway.
Wang C, Han M, Li X, Lv J, Zhuang W, Xie L, Liu G, Saimaier K, Han S, Shi C, Hua Q, Zhang R, Jiang X, Wang G, Du C
International immunopharmacology 2023 Dec;125(Pt A):111110
International immunopharmacology 2023 Dec;125(Pt A):111110
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics.
Huang Y, Luo W, Chen S, Su H, Zhu W, Wei Y, Qiu Y, Long Y, Shi Y, Wei J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155117
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155117
Combinational application of the natural products 1-deoxynojirimycin and morin ameliorates insulin resistance and lipid accumulation in prediabetic mice.
Ren X, Guo Q, Jiang H, Han X, He X, Liu H, Xiu Z, Dong Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155106
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155106
Comprehensive analysis of clinical prognosis and biological significance of CNIH4 in cervical cancer.
Wang J, Wang S, Wang J, Huang J, Lu H, Pan B, Pan H, Song Y, Deng Q, Jin X, Shi G
Cancer medicine 2023 Dec;12(24):22381-22394
Cancer medicine 2023 Dec;12(24):22381-22394
ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.
Cui L, Lu Y, Zheng J, Guo B, Zhao X
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335
Phenolic Constituents from Black Quinoa Alleviate Insulin Resistance in HepG2 Cells via Regulating IRS1/PI3K/Akt/GLUTs Signaling Pathways.
Cao M, Wang J, Jiang X, Sun Z, Zhao L, Chen G
Journal of agricultural and food chemistry 2023 Dec 6;71(48):18780-18791
Journal of agricultural and food chemistry 2023 Dec 6;71(48):18780-18791
RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells.
Chen Y, He Z, Yang S, Chen C, Xiong W, He Y, Liu S
Journal of translational medicine 2023 Dec 6;21(1):886
Journal of translational medicine 2023 Dec 6;21(1):886
Nodakenin alleviates ovariectomy-induced osteoporosis by modulating osteoblastogenesis and osteoclastogenesis.
Liu C, Zhao M, Chen J, Xu L, Wang K, Li G
European journal of pharmacology 2023 Dec 5;960:176121
European journal of pharmacology 2023 Dec 5;960:176121
RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma.
Yang Q, Meng X, Chen J, Li X, Huang Y, Xiao X, Li R, Wu X
Cell death discovery 2023 Dec 5;9(1):440
Cell death discovery 2023 Dec 5;9(1):440
FGFR2 modulates the Akt/Nrf2/ARE signaling pathway to improve angiotensin II-induced hypertension-related endothelial dysfunction.
Jiao K, Su P, Li Y
Clinical and experimental hypertension (New York, N.Y. : 1993) 2023 Dec 31;45(1):2208777
Clinical and experimental hypertension (New York, N.Y. : 1993) 2023 Dec 31;45(1):2208777
Preclinical characterization of danatinib as a novel FLT3 inhibitor with excellent efficacy against resistant acute myeloid leukemia.
Sun SL, Wu JZ, Wang JJ, Zhou H, Zhang CQ, Tong ZJ, Wang YB, Sha JK, Wang QX, Liu JC, Zheng XR, Li QQ, Zhang MY, Yang J, Wei TH, Wang ZX, Yu YC, Ding N, Leng XJ, Xue X, Li HM, Dai WC, Yin XY, Yang Y, Duan JA, Li NG, Shi ZH
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115905
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115905
Tetrahydropalmatine: Orchestrating survival - Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps.
Chen X, Fu K, Lai Y, Dong C, Chen Z, Huang Y, Li G, Jiang R, Wu H, Wang A, Huang S, Shen L, Gao W, Li S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115887
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115887
Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway.
Luo F, Tang Y, Zheng L, Yang Y, Gao H, Tian S, Chen H, Tang C, Tang S, Man Q, Wu Y
Pharmaceuticals (Basel, Switzerland) 2023 Dec 27;17(1)
Pharmaceuticals (Basel, Switzerland) 2023 Dec 27;17(1)
A homozygous variant in INTS11 links mitosis and neurogenesis defects to a severe neurodevelopmental disorder.
Kuang H, Li Y, Wang Y, Shi M, Duan R, Xiao Q, She H, Liu Y, Liang Q, Teng Y, Zhou M, Liang D, Li Z, Wu L
Cell reports 2023 Dec 26;42(12):113445
Cell reports 2023 Dec 26;42(12):113445
Metabolites-Based Network Pharmacology to Preliminarily Verify In Vitro Anti-Inflammatory Effect of Ardisiacrispin B.
Zhou W, Yang G, Wen Y, Xiao Q, Sun L, Li Y, Gong Z, Wang Y
International journal of molecular sciences 2023 Dec 2;24(23)
International journal of molecular sciences 2023 Dec 2;24(23)
Ultrasound-targeted microbubble destruction promotes PDGF-primed bone mesenchymal stem cell transplantation for myocardial protection in acute Myocardial Infarction in rats.
Sun Z, Cai Y, Chen Y, Jin Q, Zhang Z, Zhang L, Li Y, Huang L, Wang J, Yang Y, Lv Q, Han Z, Xie M, Zhu X
Journal of nanobiotechnology 2023 Dec 15;21(1):481
Journal of nanobiotechnology 2023 Dec 15;21(1):481
Regulatory and Interacting Partners of PDLIM7 in Thyroid Cancer.
Rood K, Yamauchi CR, Sharma U, Laxa RT, Robins C, Lanza G, Sánchez-Ruiz K, Khan A, Kim HS, Shields A, Kennedy K, Mirshahidi S, Perez MC, Firek A, Munir I, Simental AA, Khan S
Current oncology (Toronto, Ont.) 2023 Dec 13;30(12):10450-10462
Current oncology (Toronto, Ont.) 2023 Dec 13;30(12):10450-10462
Cirsiliol induces autophagy and mitochondrial apoptosis through the AKT/FOXO1 axis and influences methotrexate resistance in osteosarcoma.
Luo M, Su Z, Gao H, Tan J, Liao R, Yang J, Lin L
Journal of translational medicine 2023 Dec 12;21(1):907
Journal of translational medicine 2023 Dec 12;21(1):907
Blockade of CXCR4 promotes macrophage autophagy through the PI3K/AKT/mTOR pathway to alleviate coronary heart disease.
Li F, Peng J, Lu Y, Zhou M, Liang J, Le C, Ding J, Wang J, Dai J, Wan C, Wang J, Luo P, Xia B
International journal of cardiology 2023 Dec 1;392:131303
International journal of cardiology 2023 Dec 1;392:131303
Pectolinarigenin attenuates hepatic ischemia/reperfusion injury via activation of the PI3K/AKT/Nrf2 signaling pathway.
Li H, Chen Y, Ding M, Yan Z, Guo W, Guo R
Chemico-biological interactions 2023 Dec 1;386:110763
Chemico-biological interactions 2023 Dec 1;386:110763
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery.
Li P, Dai S, Gao X, Li W
Journal of physiology and biochemistry 2023 Aug;79(3):569-582
Journal of physiology and biochemistry 2023 Aug;79(3):569-582
NOX2 inhibition stabilizes vulnerable plaques by enhancing macrophage efferocytosis via MertK/PI3K/AKT pathway.
Wang Y, Liu XY, Wang Y, Zhao WX, Li FD, Guo PR, Fan Q, Wu XF
Redox biology 2023 Aug;64:102763
Redox biology 2023 Aug;64:102763
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
He Y, Zhang B, Han D, Du Y, Zhang X, Wang H, Yue Z, Shang P
Biochemical genetics 2023 Aug;61(4):1265-1281
Biochemical genetics 2023 Aug;61(4):1265-1281
Exposure to MoS2 nanosheets or bulk activated Kruppel-like factor 4 in 3D Caco-2 spheroids in vitro and mouse intestines in vivo.
Xiao Y, He Y, Xu C, Li M, Hu F, Wang W, Wang Z, Cao Y
Environmental toxicology 2023 Aug;38(8):1925-1938
Environmental toxicology 2023 Aug;38(8):1925-1938
Danlou Tablet Protects Against Cardiac Remodeling and Dysfunction after Myocardial Ischemia/Reperfusion Injury through Activating AKT/FoxO3a Pathway.
Li L, Qi W, Zhu Y, Yin M, Chen C, Wei M, Huang Z, Su Z, Jiang J, Zhang M, Bei Y
Journal of cardiovascular translational research 2023 Aug;16(4):803-815
Journal of cardiovascular translational research 2023 Aug;16(4):803-815
Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B.
Liu H, Huang Q, Fan Y, Li B, Liu X, Hu C
Acta pharmaceutica Sinica. B 2023 Aug;13(8):3400-3413
Acta pharmaceutica Sinica. B 2023 Aug;13(8):3400-3413
Immunosensitivity mediated by downregulated AKT1-SKP2 induces anti-PD-1-associated thyroid immune injury.
Wu Y, Li J, Yang X, Hou B, Qiao H
International immunopharmacology 2023 Aug;121:110452
International immunopharmacology 2023 Aug;121:110452
YY1 regulates the proliferation and invasion of triple-negative breast cancer via activating PLAUR.
Zhang C, Chen S, Wang W, Gao Y
Functional & integrative genomics 2023 Aug 8;23(3):269
Functional & integrative genomics 2023 Aug 8;23(3):269
Alteration of the N(6)-methyladenosine methylation landscape in a mouse model of polycystic ovary syndrome.
Zou L, Li W, Xu D, Zhu S, Jiang B
Journal of ovarian research 2023 Aug 8;16(1):157
Journal of ovarian research 2023 Aug 8;16(1):157
Sodium Butyrate Induces Mitophagy and Apoptosis of Bovine Skeletal Muscle Satellite Cells through the Mammalian Target of Rapamycin Signaling Pathway.
Ding Y, Wang P, Li C, Zhang Y, Yang C, Zhou X, Wang X, Su Z, Ming W, Zeng L, Shi Y, Li CJ, Kang X
International journal of molecular sciences 2023 Aug 30;24(17)
International journal of molecular sciences 2023 Aug 30;24(17)
Exploring the Therapeutic Potential of Ethyl 3-Hydroxybutyrate in Alleviating Skeletal Muscle Wasting in Cancer Cachexia.
Zhou Y, Lu R, Lin F, Chen S, He QQ, Wu G, Huang C, Lin D
Biomolecules 2023 Aug 30;13(9)
Biomolecules 2023 Aug 30;13(9)
MicroRNA-144-3p protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles by targeting MAP3K9.
Liu M, Xiao B, Zhu Y, Chen M, Huang J, Guo H, Wang F
European journal of medical research 2023 Aug 3;28(1):264
European journal of medical research 2023 Aug 3;28(1):264
METTL3 regulatory TROAP can regulate the progression of non-small cell lung cancer through PI3K/AKT and EMT signaling pathway.
Xu M, Yu J, Liu X, Jia W, Duan Y, Ma D, Ma J, Lei W, Tai W
Medical oncology (Northwood, London, England) 2023 Aug 22;40(9):274
Medical oncology (Northwood, London, England) 2023 Aug 22;40(9):274
Analyzing roles of small nucleolar RNA host gene 25 from clinical, molecular target and tumor formation in prostate cancer.
Liu Z, Ke S, Wang Q, Gu X, Zhai G, Shao H, He M, Guo J
Experimental cell research 2023 Aug 15;429(2):113686
Experimental cell research 2023 Aug 15;429(2):113686
The effect of PINK1/Parkin pathway on glucose homeostasis imbalance induced by tacrolimus in mouse livers.
Li Z, Xiang J, Mei S, Wu Y, Xu Y
Heliyon 2023 Apr;9(4):e15536
Heliyon 2023 Apr;9(4):e15536
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
Chang T, Lian Z, Ma S, Liang Z, Ma X, Wen X, Wang Y, Liu R
The Prostate 2023 Apr;83(5):470-486
The Prostate 2023 Apr;83(5):470-486
SNORD60 promotes the tumorigenesis and progression of endometrial cancer through binding PIK3CA and regulating PI3K/AKT/mTOR signaling pathway.
Wu W, Chen X, Liu X, Bao HJ, Li QH, Xian JY, Lu BF, Zhao Y, Chen S
Molecular carcinogenesis 2023 Apr;62(4):413-426
Molecular carcinogenesis 2023 Apr;62(4):413-426
Metformin alleviates ethanol-induced cardiomyocyte injury by activating AKT/Nrf2 signaling in an ErbB2-dependent manner.
Chen Y, Zhu S, Lin Z, Zhang Y, Jin C, He S, Chen X, Zhou X
Molecular biology reports 2023 Apr;50(4):3469-3478
Molecular biology reports 2023 Apr;50(4):3469-3478
The potential mechanism of Neu5Gc inducing colorectal cancer based on network pharmacology and experimental validation.
Zhang LC, Liu YN, La XQ, Yan SN, Chen Y, Liang JY, Li ZY
Naunyn-Schmiedeberg's archives of pharmacology 2023 Apr;396(4):705-718
Naunyn-Schmiedeberg's archives of pharmacology 2023 Apr;396(4):705-718
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
Liang X, Yang Y, Huang C, Ye Z, Lai W, Luo J, Li X, Yi X, Fan JB, Wang Y, Wang Y
Journal of controlled release : official journal of the Controlled Release Society 2023 Apr;356:691-701
Journal of controlled release : official journal of the Controlled Release Society 2023 Apr;356:691-701
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.
Zhou G, Wu H, Yang J, Ye M, Liu D, Li Y, Zhang D, Zhang J, Yang Q, Liu Y
Cardiovascular toxicology 2023 Apr;23(3-4):161-175
Cardiovascular toxicology 2023 Apr;23(3-4):161-175
Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling.
Zhang L, Xue K, Fan P, Chen C, Hu J, Huang J, Lu W, Xu J, Xu S, Ran J, Zhu S, Gan S
Experimental eye research 2023 Apr;229:109416
Experimental eye research 2023 Apr;229:109416
Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling.
Wang H, Zhou HC, Ren RL, Du SX, Guo ZK, Shen XH
Hepatobiliary & pancreatic diseases international : HBPD INT 2023 Apr;22(2):179-189
Hepatobiliary & pancreatic diseases international : HBPD INT 2023 Apr;22(2):179-189
Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities.
Wang J, Wang D, Feng L, Li X, Gong Y, Wang Z, Tan N, Han J
Phytochemistry 2023 Apr;208:113603
Phytochemistry 2023 Apr;208:113603
Budding uninhibited by benzimidazoles 1 overexpression is associated with poor prognosis and malignant phenotype: A promising therapeutic target for lung adenocarcinoma.
Chen R, Wang Z, Lu T, Liu Y, Ji Y, Yu Y, Tou F, Guo S
Thoracic cancer 2023 Apr;14(10):893-912
Thoracic cancer 2023 Apr;14(10):893-912
Acinetobacter baumannii outer membrane protein A induces autophagy in bone marrow-derived dendritic cells involving the PI3K/mTOR pathway.
Tan H, Cao L
Immunity, inflammation and disease 2023 Apr;11(4):e830
Immunity, inflammation and disease 2023 Apr;11(4):e830
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
Li J, Sun Y, Zhao X, Ma Y, Xie Y, Liu S, Hui B, Shi X, Sun X, Zhang X
Cell death & disease 2023 Apr 8;14(4):259
Cell death & disease 2023 Apr 8;14(4):259
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
Zheng Z, Cao F, Ding YX, Lu JD, Fu YQ, Liu L, Guo YL, Liu S, Sun HC, Cui YQ, Li F
World journal of gastrointestinal surgery 2023 Apr 27;15(4):600-620
World journal of gastrointestinal surgery 2023 Apr 27;15(4):600-620
An AKT1-and TRIM21-mediated phosphodegron controls proteasomal degradation of HuR enabling cell survival under heat shock.
Nag S, Rahaman S, Guha A, Ray PS
iScience 2023 Apr 21;26(4):106307
iScience 2023 Apr 21;26(4):106307
[High expression of MYH9 inhibits apoptosis of non-small cell lung cancer cells through activating the AKT/c-Myc pathway].
Liu F, Peng L, Xi J
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Apr 20;43(4):527-536
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Apr 20;43(4):527-536
Diluent pH affects sperm motility via GSK3 α/β-hexokinase pathway for the efficient enrichment of X-sperm to increase the female kids rate of dairy goats.
He Q, Wu S, Gao F, Xu X, Wang S, Xu Z, Huang M, Zhang K, Zhang Y, Quan F
Theriogenology 2023 Apr 15;201:1-11
Theriogenology 2023 Apr 15;201:1-11
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
Li TY, Du Y, Wang MC, Liu K, Liu Y, Cao Y, Wang YY, Chen WW, Qian XY, Qiu PC, Tang HF, Lu YY
International journal of molecular sciences 2023 Apr 12;24(8)
International journal of molecular sciences 2023 Apr 12;24(8)
S-Equol enhances osteoblastic bone formation and prevents bone loss through OPG/RANKL via the PI3K/Akt pathway in streptozotocin-induced diabetic rats.
Xu Z, Xu J, Li S, Cui H, Zhang G, Ni X, Wang J
Frontiers in nutrition 2022;9:986192
Frontiers in nutrition 2022;9:986192
Suppression of SMOC2 alleviates myocardial fibrosis via the ILK/p38 pathway.
Rui H, Zhao F, Yuhua L, Hong J
Frontiers in cardiovascular medicine 2022;9:951704
Frontiers in cardiovascular medicine 2022;9:951704
Beneficial effects of whey protein peptides on muscle loss in aging mice models.
Wu X, Yu X, Zhu N, Xu M, Li Y
Frontiers in nutrition 2022;9:897821
Frontiers in nutrition 2022;9:897821
ADAMTS8 Promotes Cardiac Fibrosis Partly Through Activating EGFR Dependent Pathway.
Zha Y, Li Y, Ge Z, Wang J, Jiao Y, Zhang J, Zhang S
Frontiers in cardiovascular medicine 2022;9:797137
Frontiers in cardiovascular medicine 2022;9:797137
Exosomes derived from M2 macrophages induce angiogenesis to promote wound healing.
Lyu L, Cai Y, Zhang G, Jing Z, Liang J, Zhang R, Dang X, Zhang C
Frontiers in molecular biosciences 2022;9:1008802
Frontiers in molecular biosciences 2022;9:1008802
Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis.
Xiong W, Huang XL, Li CY, Wang XL, Lan HW, Wang TT, Chen ZL, Yang QP, Hu AL, Xia YF, Zhu FR, Zhou ZZ
Folia histochemica et cytobiologica 2022;60(4):323-334
Folia histochemica et cytobiologica 2022;60(4):323-334
Potential role of gut microbiota-LCA-INSR axis in high fat-diet-induced non-alcoholic fatty liver dysfunction: From perspective of radiation variation.
Pan H, Zhou M, Ju Z, Luo J, Jin J, Shen L, Zhou P, Huang R
Current research in food science 2022;5:1685-1700
Current research in food science 2022;5:1685-1700
Huangqi-Honghua Combination Prevents Cerebral Infarction with Qi Deficiency and Blood Stasis Syndrome in Rats by the Autophagy Pathway.
Chen Y, Lei L, Wang K, Liang R, Qiao Y, Feng Z, Zhang J, Bai M, Chen H, Zhao J, Xiong X, Cao J, Shen X, Yang Z
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9496926
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9496926
Transcriptional Patterns of Lower-Grade Glioma Patients with Distinct Ferroptosis Levels, Immunotherapy Response, and Temozolomide Sensitivity.
Tu Z, Li J, Long X, Wu L, Zhu X, Huang K
Oxidative medicine and cellular longevity 2022;2022:9408886
Oxidative medicine and cellular longevity 2022;2022:9408886
Artesunate Suppresses the Growth of Lung Cancer Cells by Downregulating the AKT/Survivin Signaling Pathway.
Zhang W, Ning N, Huang J
BioMed research international 2022;2022:9170053
BioMed research international 2022;2022:9170053
Protective Effects of Herba Houttuyniae Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice.
Yang Y, Lai Q, Wang C, Zhou G
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7609785
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7609785
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
Lei Y, Chan M, Liu H, Lyu W, Chen L, Zhong Y, Gan H, Wang M, Qi M, Guo Y, Liu J, Zhang E
Disease markers 2022;2022:4399334
Disease markers 2022;2022:4399334
MicroRNA-325-3p Targets Human Epididymis Protein 4 to Relieve Right Ventricular Fibrosis in Rats with Pulmonary Arterial Hypertension.
Tang Y, Huo X, Liu J, Tang Y, Zhang M, Xie W, Zheng Z, He J, Lian J
Cardiovascular therapeutics 2022;2022:4382999
Cardiovascular therapeutics 2022;2022:4382999
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Chen J, Cui Z, Wang Y, Lyu L, Feng C, Feng D, Cheng Y, Li Z, Sun S
Oxidative medicine and cellular longevity 2022;2022:3182368
Oxidative medicine and cellular longevity 2022;2022:3182368
Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice.
Zhang B, Huang R, Yang D, Chen G, Chen Y, Han J, Zhang S, Ma L, Yang X
Oxidative medicine and cellular longevity 2022;2022:3087198
Oxidative medicine and cellular longevity 2022;2022:3087198
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
Wang S, Tan J, Chen L, Wang J
Journal of oncology 2022;2022:2956888
Journal of oncology 2022;2022:2956888
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Xu G, Ma T, Zhou C, Zhao F, Peng K, Li B
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2502263
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2502263
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
Zuo X, Shi X, Zhang X, Chen Z, Yang Z, Pan X, Lai R, Zhao Z
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2347419
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2347419
Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells.
Lin L, Wang X, Zhao W, Chen Y
Genetics research 2022;2022:1500768
Genetics research 2022;2022:1500768
GNAI2 Is a Risk Factor for Gastric Cancer: Study of Tumor Microenvironment (TME) and Establishment of Immune Risk Score (IRS).
Yu H, Liu S, Wu Z, Gao F
Oxidative medicine and cellular longevity 2022;2022:1254367
Oxidative medicine and cellular longevity 2022;2022:1254367
Celastrol inhibits the proliferation and migration of MCF-7 cells through the leptin-triggered PI3K/AKT pathway.
Chen P, Wang B, Li M, Cui C, Liu F, Gao Y
Computational and structural biotechnology journal 2022;20:3173-3181
Computational and structural biotechnology journal 2022;20:3173-3181
High-mobility Group Box 1 Contributes to Hypoxic-Ischemic Brain Damage by Facilitating Imbalance of Microglial Polarization through RAGE-PI3K/Akt Pathway in Neonatal Rats.
Sun Y, Zhu X, Zhu K, Yu J, Cheng L, Hei M
International journal of medical sciences 2022;19(14):2093-2103
International journal of medical sciences 2022;19(14):2093-2103
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
Li J, Yang T, Wang Q, Li Y, Wu H, Zhang M, Qi H, Zhang H, Li J
International journal of biological sciences 2022;18(9):3576-3591
International journal of biological sciences 2022;18(9):3576-3591
HNRNPK/CLCN3 axis facilitates the progression of LUAD through CAF-tumor interaction.
Li Y, Yang Y, Ma Q, Cheng H, Wang H, Ma C, Li F, Zhao S, Li X, Qi Y, Gu Z
International journal of biological sciences 2022;18(16):6084-6101
International journal of biological sciences 2022;18(16):6084-6101
Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis.
Li J, Cen W, Tong C, Wang L, Zhang W, Deng S, Yu J, Lu B
PloS one 2022;17(4):e0266738
PloS one 2022;17(4):e0266738
Long non-coding RNA NEAT1 promotes angiogenesis in hepatoma carcinoma via the miR-125a-5p/VEGF pathway.
Guo J, Yuan Q, Fang Y, Liao J, Zhang Z
Open life sciences 2022;17(1):1229-1239
Open life sciences 2022;17(1):1229-1239
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression.
Li Y, Wang ML, Zhang B, Fan XX, Tang Q, Yu X, Li LN, Fan AR, Chang HS, Zhang LZ
Drug design, development and therapy 2022;16:843-861
Drug design, development and therapy 2022;16:843-861
Network Pharmacology Integrated with Transcriptomics Analysis Reveals Ermiao Wan Alleviates Atopic Dermatitis via Suppressing MAPK and Activating the EGFR/AKT Signaling.
Xia T, Liang X, Liu CS, Hu YN, Luo ZY, Tan XM
Drug design, development and therapy 2022;16:4325-4341
Drug design, development and therapy 2022;16:4325-4341
Effects of Lycium barbarum polysaccharide on the photoinduced autophagy of retinal pigment epithelium cells.
Gao YY, Li J, Huang J, Li WJ, Yu Y
International journal of ophthalmology 2022;15(1):23-30
International journal of ophthalmology 2022;15(1):23-30
FGL2-MCOLN3-Autophagy Axis-Triggered Neutrophil Extracellular Traps Exacerbate Liver Injury in Fulminant Viral Hepatitis.
Li X, Gao Q, Wu W, Hai S, Hu J, You J, Huang D, Wang H, Wu D, Han M, Xi D, Yan W, Chen T, Luo X, Ning Q, Wang X
Cellular and molecular gastroenterology and hepatology 2022;14(5):1077-1101
Cellular and molecular gastroenterology and hepatology 2022;14(5):1077-1101
LncRNA LINC00460 facilitates the proliferation and metastasis of renal cell carcinoma via PI3K/AKT signaling pathway.
Zhou FJ, Meng S, Wu XF, Hou PF, Li ML, Chu SF, Bai J, Zheng JN
Journal of Cancer 2022;13(9):2844-2854
Journal of Cancer 2022;13(9):2844-2854
LHPP suppresses gastric cancer progression via the PI3K/AKT/mTOR signaling pathway.
Wang D, Li J, Li W
Journal of Cancer 2022;13(14):3584-3592
Journal of Cancer 2022;13(14):3584-3592
Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma.
Wang S, Yang XX, Li TJ, Zhao L, Bao YR, Meng XS
Frontiers in pharmacology 2022;13:999935
Frontiers in pharmacology 2022;13:999935
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
Liu M, Hu T, Gou W, Chang H, Li Y, Li Y, Zuo D, Hou W, Jiao S
Frontiers in pharmacology 2022;13:993022
Frontiers in pharmacology 2022;13:993022
Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome.
Jiang XL, Tai H, Xiao XS, Zhang SY, Cui SC, Qi SB, Hu DD, Zhang LN, Kuang JS, Meng XS, Li SM
Frontiers in endocrinology 2022;13:962154
Frontiers in endocrinology 2022;13:962154
SMO mutation predicts the effect of immune checkpoint inhibitor: From NSCLC to multiple cancers.
Ji W, Niu X, Yu Y, Li Z, Gu L, Lu S
Frontiers in immunology 2022;13:955800
Frontiers in immunology 2022;13:955800
D-tagatose protects against oleic acid-induced acute respiratory distress syndrome in rats by activating PTEN/PI3K/AKT pathway.
Huang J, Wang B, Tao S, Hu Y, Wang N, Zhang Q, Wang C, Chen C, Gao B, Cheng X, Li Y
Frontiers in immunology 2022;13:928312
Frontiers in immunology 2022;13:928312
Azoxystrobin induces apoptosis via PI3K/AKT and MAPK signal pathways in oral leukoplakia progression.
Li L, Li J, Chen H, Shen Y, Lu Y, Zhang M, Tang X
Frontiers in pharmacology 2022;13:912084
Frontiers in pharmacology 2022;13:912084
Astragalus-Scorpion Drug Pair Inhibits the Development of Prostate Cancer by Regulating GDPD4-2/PI3K/AKT/mTOR Pathway and Autophagy.
You X, Wu Y, Li Q, Sheng W, Zhou Q, Fu W
Frontiers in pharmacology 2022;13:895696
Frontiers in pharmacology 2022;13:895696
Hydrogen Repairs LPS-Induced Endothelial Progenitor Cells Injury via PI3K/AKT/eNOS Pathway.
Mu Q, Lv K, Yu J, Chu S, Zhang L, Kong L, Zhang L, Tian Y, Jia X, Liu B, Wei Y, Yang N
Frontiers in pharmacology 2022;13:894812
Frontiers in pharmacology 2022;13:894812
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
Xin M, Gao Q, Xiang X, Xu J, Jiao Y, Li X, Zhang X, Jia X
Frontiers in pharmacology 2022;13:890974
Frontiers in pharmacology 2022;13:890974
Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway.
Zhou L, Xie Y, Li Y
Frontiers in immunology 2022;13:871705
Frontiers in immunology 2022;13:871705
Rosmarinic Acid Ameliorates Pulmonary Ischemia/Reperfusion Injury by Activating the PI3K/Akt Signaling Pathway.
Luo W, Tao Y, Chen S, Luo H, Li X, Qu S, Chen K, Zeng C
Frontiers in pharmacology 2022;13:860944
Frontiers in pharmacology 2022;13:860944
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
Chen R, Zeng J, Li C, Xiao H, Li S, Lin Z, Huang K, Shen J, Huang H
Frontiers in pharmacology 2022;13:853383
Frontiers in pharmacology 2022;13:853383
H(2)S Protects Against Immobilization-Induced Muscle Atrophy via Reducing Oxidative Stress and Inflammation.
Xu M, Liu X, Bao P, Wang YJ, Lu J, Liu YJ
Frontiers in physiology 2022;13:844539
Frontiers in physiology 2022;13:844539
ALG-bFGF Hydrogel Inhibiting Autophagy Contributes to Protection of Blood-Spinal Cord Barrier Integrity via PI3K/Akt/FOXO1/KLF4 Pathway After SCI.
Zhang R, Xie L, Wu F, Xu J, Lu L, Cao L, Li L, Meng W, Zhang H, Shao C, Li X, Chen D
Frontiers in pharmacology 2022;13:828896
Frontiers in pharmacology 2022;13:828896
Exploring the Anti-Pulmonary Fibrosis Mechanism of Jingyin Granule by Network Pharmacology Strategy.
Zhu DW, Yu Q, Jiang MF, Wang DD, Shen YH
Frontiers in pharmacology 2022;13:825667
Frontiers in pharmacology 2022;13:825667
Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy.
Sun J, Wei J, Zhang Y, Li J, Li J, Yan J, Guo M, Han J, Qiao H
Frontiers in immunology 2022;13:819680
Frontiers in immunology 2022;13:819680
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
Dong C, Chen Z, Zhu L, Bsoul N, Wu H, Jiang J, Chen X, Lai Y, Yu G, Gu Y, Guo X, Gao W
Frontiers in pharmacology 2022;13:809034
Frontiers in pharmacology 2022;13:809034
LYPD3, a New Biomarker and Therapeutic Target for Acute Myelogenous Leukemia.
Hu T, Zhang Y, Yang T, He Q, Zhao M
Frontiers in genetics 2022;13:795820
Frontiers in genetics 2022;13:795820
Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells.
Yu PC, Liu D, Han ZX, Liang F, Hao CY, Lei YT, Guo CR, Wang WH, Li XH, Yang XN, Li CZ, Yu Y, Fan YZ
Frontiers in pharmacology 2022;13:779715
Frontiers in pharmacology 2022;13:779715
Farrerol prevents Angiotensin II-induced cardiac remodeling in vivo and in vitro.
He J, Xu D, Wang L, Yu X
Frontiers in pharmacology 2022;13:1079251
Frontiers in pharmacology 2022;13:1079251
Dynamic changes in human THP-1-derived M1-to-M2 macrophage polarization during Thelazia callipaeda MIF induction.
Yin C, Cai J, Gou Y, Li D, Tang H, Wang L, Liu H, Luo B
Frontiers in immunology 2022;13:1078880
Frontiers in immunology 2022;13:1078880
Platelet-rich plasma ameliorates lipopolysaccharide-induced cardiac injury by inflammation and ferroptosis regulation.
Jiao Y, Zhang Q, Zhang J, Zha Y, Wang J, Li Y, Zhang S
Frontiers in pharmacology 2022;13:1026641
Frontiers in pharmacology 2022;13:1026641
Identification of NLE1/CDK1 axis as key regulator in the development and progression of non-small cell lung cancer.
Xu P, Wang L, Mo B, Xie X, Hu R, Jiang L, Hu F, Ding F, Xiao H
Frontiers in oncology 2022;12:985827
Frontiers in oncology 2022;12:985827
S645C Point Mutation Suppresses Degradation of EGFR to Promote Progression of Glioblastoma.
Huang W, Zou L, Hao Z, Wang B, Mao F, Duan Q, Guo D
Frontiers in oncology 2022;12:904383
Frontiers in oncology 2022;12:904383
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma.
Glathar AR, Oyelakin A, Gluck C, Bard J, Sinha S
Frontiers in oncology 2022;12:879054
Frontiers in oncology 2022;12:879054
Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim-Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer.
Hu S, Ge M, Zhang S, Jiang M, Hu K, Gao L
Frontiers in oncology 2022;12:854596
Frontiers in oncology 2022;12:854596
Syntenin Regulated by miR-216b Promotes Cancer Progression in Pancreatic Cancer.
Zu F, Chen H, Liu Q, Zang H, Li Z, Tan X
Frontiers in oncology 2022;12:790788
Frontiers in oncology 2022;12:790788
NUF2 overexpression contributes to epithelial ovarian cancer progression via ERBB3-mediated PI3K-AKT and MAPK signaling axes.
Leng R, Meng Y, Sun X, Zhao Y
Frontiers in oncology 2022;12:1057198
Frontiers in oncology 2022;12:1057198
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Sun F, Zhou JL, Wei SX, Jiang ZW, Peng H
PeerJ 2022;10:e13319
PeerJ 2022;10:e13319
The Role of Syncytin in Placental Angiogenesis and Fetal Growth.
Wang YN, Ye Y, Zhou D, Guo ZW, Xiong Z, Gong XX, Jiang SW, Chen H
Frontiers in cell and developmental biology 2022;10:852561
Frontiers in cell and developmental biology 2022;10:852561
HIF-1α Regulates Osteogenesis of Periosteum-Derived Stem Cells Under Hypoxia Conditions via Modulating POSTN Expression.
Zhuang Y, Zhao Z, Cheng M, Li M, Si J, Lin K, Yu H
Frontiers in cell and developmental biology 2022;10:836285
Frontiers in cell and developmental biology 2022;10:836285
HSPA6 is Correlated With the Malignant Progression and Immune Microenvironment of Gliomas.
Zhou X, Ji Q, Li Q, Wang P, Hu G, Xiao F, Ye M, Lin L, Luo M, Guo Y, Wu W, Huang K, Guo H
Frontiers in cell and developmental biology 2022;10:833938
Frontiers in cell and developmental biology 2022;10:833938
Poloxamer 407 and Hyaluronic Acid Thermosensitive Hydrogel-Encapsulated Ginsenoside Rg3 to Promote Skin Wound Healing.
Peng X, Ding C, Zhao Y, Hao M, Liu W, Yang M, Xiao F, Zheng Y
Frontiers in bioengineering and biotechnology 2022;10:831007
Frontiers in bioengineering and biotechnology 2022;10:831007
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
Guo W, Long X, Lv M, Deng S, Liu D, Yang Q
The Journal of international medical research 2022 Sep;50(9):3000605221118680
The Journal of international medical research 2022 Sep;50(9):3000605221118680
RNA-seq and ATAC-seq analyses of multilineage differentiating stress enduring cells: Comparison with dermal fibroblasts.
Mao XQ, Cheng Y, Zhang RZ, Liu YB, Li Y, Ge K, Jin HL
Cell biology international 2022 Sep;46(9):1480-1494
Cell biology international 2022 Sep;46(9):1480-1494
Calycosin suppresses colorectal cancer progression by targeting ERβ, upregulating PTEN, and inhibiting PI3K/Akt signal pathway.
Zhu L, Liu S, Liao YF, Sheng YM, He JC, Cai ZX, Man Q, Wu YY
Cell biology international 2022 Sep;46(9):1367-1377
Cell biology international 2022 Sep;46(9):1367-1377
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
Overexpression of SFXN1 indicates poor prognosis and promotes tumor progression in lung adenocarcinoma.
Chen L, Kang Y, Jiang Y, You J, Huang C, Xu X, Chen F
Pathology, research and practice 2022 Sep;237:154031
Pathology, research and practice 2022 Sep;237:154031
Trichodermin inhibits the growth of oral cancer through apoptosis-induced mitochondrial dysfunction and HDAC-2-mediated signaling.
Chen HL, Lo YH, Lin CL, Lee TH, Leung W, Wang SW, Lin IP, Lin MY, Lee CH
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113351
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113351
Grass Carp Reovirus triggers autophagy enhancing virus replication via the Akt/mTOR pathway.
Zhu M, Zhang Y, Pan J, Tong X, Zhang X, Hu X, Gong C
Fish & shellfish immunology 2022 Sep;128:148-156
Fish & shellfish immunology 2022 Sep;128:148-156
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Zhang C, Li Z, Li L, Li S, Yang L, Chen L, Zhang X, Yang S, Guo Y
Journal of orthopaedic surgery (Hong Kong) 2022 Sep-Dec;30(3):10225536221135474
Journal of orthopaedic surgery (Hong Kong) 2022 Sep-Dec;30(3):10225536221135474
Comprehensive analysis of the prognostic implications and functional exploration of PAK gene family in human cancer.
Lei K, Luo M, Tu Z, Lv S, Liu J, Gong C, Ye M, Wu M, Sheng Y, Long X, Li J, Zhu X, Huang K
Cancer cell international 2022 Sep 5;22(1):275
Cancer cell international 2022 Sep 5;22(1):275
Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer.
Yu F, Tan W, Chen Z, Shen X, Mo X, Mo X, He J, Deng Z, Wang J, Luo Z, Yang J
Chinese medicine 2022 Sep 29;17(1):115
Chinese medicine 2022 Sep 29;17(1):115
Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation.
Luo W, Xu Y, Liu R, Liao Y, Wang S, Zhang H, Li X, Wang H
Cell death & disease 2022 Sep 29;13(9):838
Cell death & disease 2022 Sep 29;13(9):838
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Adediran S, Wang L, Khan MA, Guang W, Fan X, Dan H, Qi J, Jay SM, Carrier F, Hussain A
Cancers 2022 Sep 23;14(19)
Cancers 2022 Sep 23;14(19)
Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism.
Li P, Lin Q, Sun S, Yang N, Xia Y, Cao S, Zhang W, Li Q, Guo H, Zhu M, Wang Y, Zheng Z, Li S
Cell death & disease 2022 Sep 21;13(9):808
Cell death & disease 2022 Sep 21;13(9):808
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
He D, Liu Y, Li J, Wang H, Ye B, He Y, Li Z, Gao X, Fu S, Liu D
Cells 2022 Sep 19;11(18)
Cells 2022 Sep 19;11(18)
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.
Wang X, Jian W, Luo Q, Fang L
Cell death & disease 2022 Sep 17;13(9):794
Cell death & disease 2022 Sep 17;13(9):794
Synthesis and biological evaluation of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine covalent inhibitors as potential agents for the treatment of acute myeloid leukemia.
Kang JB, Chen L, Leng XJ, Wang JJ, Cheng Y, Wu SH, Ma YY, Yang LJ, Cao YH, Yang X, Tong ZJ, Wu JZ, Wang YB, Zhou H, Liu JC, Ding N, Dai WC, Yu YC, Xue X, Sun SL, Dai XB, Chang L, Wang XL, Li NG, Shi ZH
Bioorganic & medicinal chemistry 2022 Sep 15;70:116937
Bioorganic & medicinal chemistry 2022 Sep 15;70:116937
Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway.
Zhuang Y, Cheng M, Li M, Cui J, Huang J, Zhang C, Si J, Lin K, Yu H
Acta biomaterialia 2022 Sep 15;150:413-426
Acta biomaterialia 2022 Sep 15;150:413-426
Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth.
Gu C, Zhang W, Yang E, Gu C, Zhang Z, Ke J, Wang X, Wu S, Li S, Wu F
Oncogenesis 2022 Sep 15;11(1):55
Oncogenesis 2022 Sep 15;11(1):55
Heterozygous LRP1 deficiency causes developmental dysplasia of the hip by impairing triradiate chondrocytes differentiation due to inhibition of autophagy.
Yan W, Zheng L, Xu X, Hao Z, Zhang Y, Lu J, Sun Z, Dai J, Shi D, Guo B, Jiang Q
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 13;119(37):e2203557119
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 13;119(37):e2203557119
Low-dose radiation exaggerates HFD-induced metabolic dysfunction by gut microbiota through PA-PYCR1 axis.
Ju Z, Guo P, Xiang J, Lei R, Ren G, Zhou M, Yang X, Zhou P, Huang R
Communications biology 2022 Sep 10;5(1):945
Communications biology 2022 Sep 10;5(1):945
Network pharmacology and molecular docking study on the effect of Kaempferol in treatment of metabolic associated fatty liver disease.
Kaixuan Z, Dong Z, Huiwei B, Lijing LI
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):788-794
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):788-794
3-Nitrobenzanthrone promotes malignant transformation in human lung epithelial cells through the epiregulin-signaling pathway.
Chen KY, Tseng CH, Feng PH, Sun WL, Ho SC, Lin CW, Van Hiep N, Luo CS, Tseng YH, Chen TT, Liu WT, Lee KY, Wu SM
Cell biology and toxicology 2022 Oct;38(5):865-887
Cell biology and toxicology 2022 Oct;38(5):865-887
A peptide translated from circPPP1R12A promotes the malignancy of non-small cell lung cancer cells through AKT signaling pathway.
Zhao W, Xue Y, Zhang Y, Zhu Y, Chen Z, Zhao X
Journal of clinical laboratory analysis 2022 Oct;36(10):e24644
Journal of clinical laboratory analysis 2022 Oct;36(10):e24644
The prognostic value and mechanisms of centromere protein M in patients with lung adenocarcinoma.
Qi N, Niu Y, Li Z, Xiao L, Tang D, Gao W
Translational cancer research 2022 Oct;11(10):3471-3490
Translational cancer research 2022 Oct;11(10):3471-3490
DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism.
Li Z, Tan Y, Li X, Quan J, Bode AM, Cao Y, Luo X
Cell death & disease 2022 Oct 3;13(10):845
Cell death & disease 2022 Oct 3;13(10):845
Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.
Jiang XL, Tai H, Kuang JS, Zhang JY, Cui SC, Lu YX, Qi SB, Zhang SY, Li SM, Chen JP, Meng XS
Aging 2022 Oct 27;14(20):8321-8345
Aging 2022 Oct 27;14(20):8321-8345
Equus β-Defensin-1 Regulates Innate IMMUNE Response in S. aureus-Infected Mouse Monocyte Macrophage.
Pei L, Liu K, Wei W, Su H, Li F, Feng Y, Wang D, Li X, Hou Y, Cao G
Animals : an open access journal from MDPI 2022 Oct 27;12(21)
Animals : an open access journal from MDPI 2022 Oct 27;12(21)
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Tai H, Cui XZ, He J, Lan ZM, Li SM, Li LB, Yao SC, Jiang XL, Meng XS, Kuang JS
Aging 2022 Oct 20;14(20):8302-8320
Aging 2022 Oct 20;14(20):8302-8320
Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages.
Yang T, Zhao Q, Hu M, Pan S, Zhang L, Zhu R, Zhou B, Feng X, Gao Z, Zhu Z, Zhang Y, Hu L, Liu F, Shan Z
Antioxidants (Basel, Switzerland) 2022 Oct 18;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 18;11(10)
Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system.
Guo H, Wang J, Ren S, Zheng LF, Zhuang YX, Li DL, Sun HH, Liu LY, Xie C, Wu YY, Wang HR, Deng X, Li P, Zhao TJ
Nature communications 2022 Oct 12;13(1):6004
Nature communications 2022 Oct 12;13(1):6004
Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma.
Chen X, Liu Q, Chen Y, Wang L, Yang R, Zhang W, Pan X, Zhang S, Chen C, Wu T, Xia J, Cheng B, Chen X, Ren X
Molecular metabolism 2022 Nov;65:101600
Molecular metabolism 2022 Nov;65:101600
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Wang T, Liu J, Huang X, Zhang C, Shangguan M, Chen J, Wu S, Chen M, Yang Z, Zhao S
Oncology reports 2022 Nov;48(5)
Oncology reports 2022 Nov;48(5)
Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis.
Yang J, Miao RR, Li YN, Pan T, Wu SH, Qu XJ, Cui SX
Acta pharmacologica Sinica 2022 Nov;43(11):2967-2976
Acta pharmacologica Sinica 2022 Nov;43(11):2967-2976
SIRT3 Promotes the Development of Esophageal Squamous Cell Carcinoma by Regulating Hexokinase 2 through the AKT Signaling Pathway.
Yuan ML, Ren LH, Yu XC, Dong JW, Shi RH
Bulletin of experimental biology and medicine 2022 Nov;174(1):81-88
Bulletin of experimental biology and medicine 2022 Nov;174(1):81-88
Protective effect of 3-n-butylphthalide against intrastriatal injection of malonic acid-induced neurotoxicity and biochemical alteration in rats.
Yuan C, Zheng L, Zhao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113664
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113664
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Deng X, Hao C, Li Y, Guo Y, Si H, He J, Deng M, Niu Z, Wang C, Xu X, Dai K, Yao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
PSMB5 overexpression is correlated with tumor proliferation and poor prognosis in hepatocellular carcinoma.
Liu J, Mi J, Liu S, Chen H, Jiang L
FEBS open bio 2022 Nov;12(11):2025-2041
FEBS open bio 2022 Nov;12(11):2025-2041
Exercise attenuates angiotensinⅡ-induced muscle atrophy by targeting PPARγ/miR-29b.
Liu Q, Chen L, Liang X, Cao Y, Zhu X, Wang S, Li J, Gao J, Xiao J
Journal of sport and health science 2022 Nov;11(6):696-707
Journal of sport and health science 2022 Nov;11(6):696-707
Identification of FDFT1 as a potential biomarker associated with ferroptosis in ccRCC.
Huang R, Zhang C, Wang X, Zou X, Xiang Z, Wang Z, Gui B, Lin T, Hu H
Cancer medicine 2022 Nov;11(21):3993-4004
Cancer medicine 2022 Nov;11(21):3993-4004
Lysine stimulates the development of the murine mammary gland at puberty via PI3K/AKT/mTOR signalling axis.
Li W, Long X, Li F, Cao Y, Liu J, Fu S, Guo W, Hu G
Journal of animal physiology and animal nutrition 2022 Nov;106(6):1420-1430
Journal of animal physiology and animal nutrition 2022 Nov;106(6):1420-1430
L-arginine stimulates the proliferation of mouse mammary epithelial cells and the development of mammary gland in pubertal mice by activating the GPRC6A/PI3K/AKT/mTOR signalling pathway.
Ge Y, Li F, He Y, Cao Y, Guo W, Hu G, Liu J, Fu S
Journal of animal physiology and animal nutrition 2022 Nov;106(6):1383-1395
Journal of animal physiology and animal nutrition 2022 Nov;106(6):1383-1395
A dynamic fluorescence probed glycolysis suppression process in HeLa cells treated with trichostatin A.
Zhang F, Shao C, Wu Y, Zhao W, Jing X, Fang C, Huang Q
The Analyst 2022 Nov 7;147(22):5082-5090
The Analyst 2022 Nov 7;147(22):5082-5090
Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury.
Xu H, Xu S, Li L, Wu Y, Mai S, Xie Y, Tan Y, Li A, Xue F, He X, Li Y
Chinese medicine 2022 Nov 24;17(1):131
Chinese medicine 2022 Nov 24;17(1):131
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
He H, Deng J, Yang M, An L, Ye X, Li X
Journal of ethnopharmacology 2022 Nov 15;298:115529
Journal of ethnopharmacology 2022 Nov 15;298:115529
Dietary N(ε)-(carboxymethyl) lysine affects cardiac glucose metabolism and myocardial remodeling in mice.
Wang ZQ, Sun Z
World journal of diabetes 2022 Nov 15;13(11):972-985
World journal of diabetes 2022 Nov 15;13(11):972-985
Lactate Activates AMPK Remodeling of the Cellular Metabolic Profile and Promotes the Proliferation and Differentiation of C2C12 Myoblasts.
Zhou Y, Liu X, Huang C, Lin D
International journal of molecular sciences 2022 Nov 13;23(22)
International journal of molecular sciences 2022 Nov 13;23(22)
NAP1L5 targeting combined with MYH9 Inhibit HCC progression through PI3K/AKT/mTOR signaling pathway.
Zhao R, Ge Y, Gong Y, Li B, Xiao B, Zuo S
Aging 2022 Nov 11;14(22):9000-9019
Aging 2022 Nov 11;14(22):9000-9019
Effects of apolipoprotein E on regulating insulin sensitivity via regulating insulin receptor signalosome in caveolae.
Liu M, Chen MY, An L, Ma SQ, Mei J, Huang WH, Zhang W
Life sciences 2022 Nov 1;308:120929
Life sciences 2022 Nov 1;308:120929
Gaseous signal molecule SO(2) regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes.
Zhao J, Wu Q, Yang T, Nie L, Liu S, Zhou J, Chen J, Jiang Z, Xiao T, Yang J, Chu C
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):541-556
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):541-556
Collagen peptides from Acaudina molpadioides prevent CCl(4) -induced liver injury via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways.
Li J, Li Y, Lin S, Zhao W, Chen Y, Jin H
Journal of food science 2022 May;87(5):2185-2196
Journal of food science 2022 May;87(5):2185-2196
Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of the AKT/Gsk-3β signal pathway.
Huang Z, Chen H, Tan P, Huang M, Shi H, Sun B, Cheng Y, Li T, Mou Z, Li Q, Fu W
Drug development research 2022 May;83(3):721-734
Drug development research 2022 May;83(3):721-734
Dictamnine inhibits pancreatic cancer cell growth and epithelial-mesenchymal transition by blocking the PI3K/AKT signaling pathway.
Zhang ZQ, Xuan WL, Huang Y, Ren S, Wulan TY, Song Y, Xue DB, Zhang WH
Neoplasma 2022 May;69(3):603-619
Neoplasma 2022 May;69(3):603-619
Macamide B Pretreatment Attenuates Neonatal Hypoxic-Ischemic Brain Damage of Mice Induced Apoptosis and Regulates Autophagy via the PI3K/AKT Signaling Pathway.
Yang X, Wang M, Zhou Q, Bai Y, Liu J, Yang J, Li L, Li G, Luo L
Molecular neurobiology 2022 May;59(5):2776-2798
Molecular neurobiology 2022 May;59(5):2776-2798
MMP-9 secreted by M2-type macrophages promotes Wilms' tumour metastasis through the PI3K/AKT pathway.
Tian K, Du G, Wang X, Wu X, Li L, Liu W, Wu R
Molecular biology reports 2022 May;49(5):3469-3480
Molecular biology reports 2022 May;49(5):3469-3480
Platelet-rich plasma pretreatment protects anterior cruciate ligament fibroblasts correlated with PI3K-Akt-mTOR pathway under hypoxia condition.
Cao Y, Li Y, Fu SC, Shen J, Zhang H, Jiang C, Shu-Hang Yung P
Journal of orthopaedic translation 2022 May;34:102-112
Journal of orthopaedic translation 2022 May;34:102-112
Angiotensin-(1-7) improves diabetes mellitus-induced erectile dysfunction in rats by regulating nitric oxide synthase levels.
Xu Y, Zhang F, Li C, Hao H, Hao Y
Peptides 2022 May;151:170765
Peptides 2022 May;151:170765
Anti-fatigue effects of fermented soybean protein peptides in mice.
Fang L, Zhang RX, Wei Y, Ling K, Lu L, Wang J, Pan XC, Cai MY
Journal of the science of food and agriculture 2022 May;102(7):2693-2703
Journal of the science of food and agriculture 2022 May;102(7):2693-2703
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
Zhang JJ, Cao CX, Wan LL, Zhang W, Liu ZJ, Wang JL, Guo Q, Tang H
World journal of gastroenterology 2022 May 7;28(17):1781-1797
World journal of gastroenterology 2022 May 7;28(17):1781-1797
Brasilterpenes A-E, Bergamotane Sesquiterpenoid Derivatives with Hypoglycemic Activity from the Deep Sea-Derived Fungus Paraconiothyrium brasiliense HDN15-135.
Wang W, Shi Y, Liu Y, Zhang Y, Wu J, Zhang G, Che Q, Zhu T, Li M, Li D
Marine drugs 2022 May 23;20(5)
Marine drugs 2022 May 23;20(5)
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Zhang W, Ho CT, Lu M
International journal of molecular sciences 2022 May 17;23(10)
International journal of molecular sciences 2022 May 17;23(10)
VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
Pu Z, Duda DG, Zhu Y, Pei S, Wang X, Huang Y, Yi P, Huang Z, Peng F, Hu X, Fan X
Journal of translational medicine 2022 May 13;20(1):212
Journal of translational medicine 2022 May 13;20(1):212
Xiao-Luo-Wan treats propylthiouracil-induced goiter with hypothyroidism in rats through the PI3K-AKT/RAS pathways based on UPLC/MS and network pharmacology.
Dong S, Liu Q, Jiang M, Ma Q, Huang Q, Liu T, Li Y, Ni L, Shi Y
Journal of ethnopharmacology 2022 May 10;289:115045
Journal of ethnopharmacology 2022 May 10;289:115045
Autophagy protects against high uric acid-induced hepatic insulin resistance.
He F, Wang M, Zhao H, Xie D, Lv J, Liu W, Yu W, Wang Q, Chen B, Xu C, Yamamoto T, Koyama H, Cheng J
Molecular and cellular endocrinology 2022 May 1;547:111599
Molecular and cellular endocrinology 2022 May 1;547:111599
Construction and a preliminary study of paracrine effect of bone marrow-derived endothelial progenitor cell sheet.
Xue F, Bai Y, Jiang Y, Liu J, Jian K
Cell and tissue banking 2022 Mar;23(1):185-197
Cell and tissue banking 2022 Mar;23(1):185-197
Azithromycin alleviates the severity of rheumatoid arthritis by targeting the unfolded protein response component of glucose-regulated protein 78 (GRP78).
Zhang Y, Ge L, Song G, Zhang R, Li S, Shi H, Zhang H, Li Y, Pan J, Wang L, Han J
British journal of pharmacology 2022 Mar;179(6):1201-1219
British journal of pharmacology 2022 Mar;179(6):1201-1219
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Zhang J, Shang L, Jiang W, Wu W
Bioengineered 2022 Mar;13(3):7904-7918
Bioengineered 2022 Mar;13(3):7904-7918
Cyclin D1 mediated by the nuclear translocation of nuclear factor kappa B exerts an oncogenic role in lung cancer.
Wang X, Liu X, Yang Y, Yang D
Bioengineered 2022 Mar;13(3):6866-6879
Bioengineered 2022 Mar;13(3):6866-6879
Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification.
Jiang G, Sun C, Wang X, Mei J, Li C, Zhan H, Liao Y, Zhu Y, Mao J
Bioengineered 2022 Mar;13(3):5216-5235
Bioengineered 2022 Mar;13(3):5216-5235
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
Tian H, Wang G, Wang Q, Zhang B, Jiang G, Li H, Chai D, Fang L, Wang M, Zheng J
Cancer science 2022 Mar;113(3):875-890
Cancer science 2022 Mar;113(3):875-890
Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling.
Zhang W, Dun Y, You B, Qiu L, Ripley-Gonzalez JW, Cheng J, Fu S, Li C, Liu S
BMJ open diabetes research & care 2022 Mar;10(2)
BMJ open diabetes research & care 2022 Mar;10(2)
Network Pharmacology-Based Analysis on the Effects and Mechanism of the Wang-Bi Capsule for Rheumatoid Arthritis and Osteoarthritis.
Wu SS, Hao LJ, Shi YY, Lu ZJ, Yu JL, Jiang SQ, Liu QL, Wang T, Guo SY, Li P, Li F
ACS omega 2022 Mar 8;7(9):7825-7836
ACS omega 2022 Mar 8;7(9):7825-7836
Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.
Huang H, Chen J, Hu X, Chen Y, Xie J, Ao T, Wang H, Xie J, Yu Q
Food & function 2022 Mar 7;13(5):2710-2728
Food & function 2022 Mar 7;13(5):2710-2728
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
Wang L, Chen J, Hu Y, Liao A, Zheng W, Wang X, Lan J, Shen J, Wang S, Yang F, Wang Y, Li Y, Chen D
Translational psychiatry 2022 Mar 22;12(1):114
Translational psychiatry 2022 Mar 22;12(1):114
EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway.
Wang X, Song H, Fang L, Wu T
Cell death discovery 2022 Mar 2;8(1):92
Cell death discovery 2022 Mar 2;8(1):92
SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway.
Liu Z, Wang Q, Zhai G, Ke S, Yu X, Guo J
Cancer cell international 2022 Mar 19;22(1):127
Cancer cell international 2022 Mar 19;22(1):127
Continuous wave irradiation at 0.1 terahertz facilitates transmembrane transport of small molecules.
Hu E, Zhang Q, Shang S, Jiang Y, Lu X
iScience 2022 Mar 18;25(3):103966
iScience 2022 Mar 18;25(3):103966
Chelerythrine inhibits the progression of glioblastoma by suppressing the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway.
Zhu M, Niu J, Jiang J, Dong T, Chen Y, Yang X, Liu P
Life sciences 2022 Mar 15;293:120358
Life sciences 2022 Mar 15;293:120358
Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer.
Zhang Y, Sun L, Li H, Ai L, Ma Q, Qiao X, Yang J, Zhang H, Ou X, Wang Y, Chen G, Xue J, Zhu X, Zhao Y, Yang Y, Liu C
eLife 2022 Mar 14;11
eLife 2022 Mar 14;11
CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases.
Xue B, Wang P, Yu W, Feng J, Li J, Zhao R, Yang Z, Yan X, Duan H
Science China. Life sciences 2022 Jun;65(6):1157-1170
Science China. Life sciences 2022 Jun;65(6):1157-1170
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
Chen Z, Tian L, Wang L, Ma X, Lei F, Chen X, Fu R
Inflammation 2022 Jun;45(3):992-1006
Inflammation 2022 Jun;45(3):992-1006
Restraint of FAM60A has a cancer-inhibiting role in pancreatic carcinoma via the effects on the Akt/GSK-3β/β-catenin signaling pathway.
Zhang Y, Li JH, Yuan QG, Yang WB
Environmental toxicology 2022 Jun;37(6):1432-1444
Environmental toxicology 2022 Jun;37(6):1432-1444
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Tai H, Tong YJ, Yu R, Yu Y, Yao SC, Li LB, Liu Y, Cui XZ, Kuang JS, Meng XS, Jiang XL
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway.
Shi XY, Zhang XL, Shi QY, Qiu X, Wu XB, Zheng BL, Jiang HX, Qin SY
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2022 Jun;24(6):1073-1085
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2022 Jun;24(6):1073-1085
Berberine attenuates sepsis-induced cardiac dysfunction by upregulating the Akt/eNOS pathway in mice.
Zhang H, Wu X, Tao Y, Lu G
Experimental and therapeutic medicine 2022 Jun;23(6):371
Experimental and therapeutic medicine 2022 Jun;23(6):371
MicroRNA-221-5p Promotes Ricin Toxin-induced Inflammation via PI3K/Akt signaling pathway by targeting COL4a5.
Zhao N, Yu H, Xi Y, Dong M, Wang Y, Sun C, Zhang J, Xu N, Liu W
Toxicon : official journal of the International Society on Toxinology 2022 Jun;212:11-18
Toxicon : official journal of the International Society on Toxinology 2022 Jun;212:11-18
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
Wu L, Yang FR, Xing ML, Lu SF, Chen HL, Yang QW, Zhang YT, Lu Y, Huang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154055
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154055
The molecular mechanism of baicalein repressing progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway.
Qiao D, Xing J, Duan Y, Wang S, Yao G, Zhang S, Jin J, Lin Z, Chen L, Piao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154046
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154046
Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.
Zhong T, Li M, Wu H, Wang D, Liu J, Xu Y, Fan Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041
PI3K inhibitor impairs tumor progression and enhances sensitivity to anlotinib in anlotinib-resistant osteosarcoma.
Chen C, Guo Y, Huang Q, Wang B, Wang W, Niu J, Lou J, Xu J, Ren T, Huang Y, Guo W
Cancer letters 2022 Jun 28;536:215660
Cancer letters 2022 Jun 28;536:215660
Delivery of engineered extracellular vesicles with miR-29b editing system for muscle atrophy therapy.
Chen R, Yuan W, Zheng Y, Zhu X, Jin B, Yang T, Yan Y, Xu W, Chen H, Gao J, Li G, Gokulnath P, Vulugundam G, Li J, Xiao J
Journal of nanobiotechnology 2022 Jun 27;20(1):304
Journal of nanobiotechnology 2022 Jun 27;20(1):304
Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway.
Ma Y, Li S, Tang S, Ye S, Liang N, Liang Y, Xiao F
Environmental science and pollution research international 2022 Jul;29(34):52289-52301
Environmental science and pollution research international 2022 Jul;29(34):52289-52301
Transcriptional landscape of human neuroblastoma cells in response to SARS-CoV-2.
Yang RC, Huang K, Zhang HP, Li L, Tan C, Chen HC, Jin ML, Wang XR
BMC neuroscience 2022 Jul 6;23(1):43
BMC neuroscience 2022 Jul 6;23(1):43
Discovery of Novel Phosphoinositide-3-Kinase α Inhibitors with High Selectivity, Excellent Bioavailability, and Long-Acting Efficacy for Gastric Cancer.
Hou Y, Zhang F, Min W, Yuan K, Kuang W, Wang X, Zhu Y, Sun C, Xia F, Wang Y, Zhang H, Wang L, Yang P
Journal of medicinal chemistry 2022 Jul 28;65(14):9873-9892
Journal of medicinal chemistry 2022 Jul 28;65(14):9873-9892
Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis.
Zhdanov AV, Golubeva AV, Yordanova MM, Andreev DE, Ventura-Silva AP, Schellekens H, Baranov PV, Cryan JF, Papkovsky DB
Cellular and molecular life sciences : CMLS 2022 Jul 16;79(8):426
Cellular and molecular life sciences : CMLS 2022 Jul 16;79(8):426
Remodeling on adipocytic physiology of organophosphorus esters in mature adipocytes.
Liu Y, Le Y, Xu M, Wang W, Chen H, Zhang Q, Wang C
Environmental pollution (Barking, Essex : 1987) 2022 Jul 15;305:119287
Environmental pollution (Barking, Essex : 1987) 2022 Jul 15;305:119287
The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats.
Yao Z, Lin M, Lin T, Gong X, Qin P, Li H, Kang T, Ye J, Zhu Y, Hong Q, Liu Y, Li Y, Wang J, Fang F
Reproductive biology and endocrinology : RB&E 2022 Jul 12;20(1):100
Reproductive biology and endocrinology : RB&E 2022 Jul 12;20(1):100
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Liu R, Cai D, Li X, Liu B, Chen J, Jiang X, Li H, Li Z, Teerds K, Sun J, Bai W, Jin Y
Ecotoxicology and environmental safety 2022 Jul 1;239:113623
Ecotoxicology and environmental safety 2022 Jul 1;239:113623
Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway.
Zhou YH, Tang YZ, Guo LY, Zheng LL, Zhang D, Yang CY, Wang W
Microvascular research 2022 Jan;139:104252
Microvascular research 2022 Jan;139:104252
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Liu X, Yang Y, Song J, Li D, Liu X, Li C, Ma Z, Zhong J, Wang L
Bioengineered 2022 Jan;13(1):1320-1334
Bioengineered 2022 Jan;13(1):1320-1334
Leptin relieves ischemia/reperfusion induced acute kidney injury through inhibiting apoptosis and autophagy.
Li S, Zhuang K, He Y, Deng Y, Xi J, Chen J
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2022 Jan 28;47(1):8-17
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2022 Jan 28;47(1):8-17
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Li R, Xiao J, Cao Y, Huang Q, Ho CT, Lu M
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
A novel FBW7/NFAT1 axis regulates cancer immunity in sunitinib-resistant renal cancer by inducing PD-L1 expression.
Liu W, Ren D, Xiong W, Jin X, Zhu L
Journal of experimental & clinical cancer research : CR 2022 Jan 26;41(1):38
Journal of experimental & clinical cancer research : CR 2022 Jan 26;41(1):38
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Li W, Huang BS, Xiong YY, Yang LJ, Wu LX
Cancer cell international 2022 Jan 18;22(1):32
Cancer cell international 2022 Jan 18;22(1):32
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
Ji R, Jia FY, Chen X, Wang ZH, Jin WY, Yang J
Archives of biochemistry and biophysics 2022 Jan 15;715:109094
Archives of biochemistry and biophysics 2022 Jan 15;715:109094
C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy.
Cang X, Wang Y, Zeng J, Gao J, Yu Q, Lu C, Xu F, Lin J, Zhu J, Wang X
Biochemical and biophysical research communications 2022 Jan 15;588:15-22
Biochemical and biophysical research communications 2022 Jan 15;588:15-22
FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.
Xi H, Ren F, Li Y, Xian M, Wang L, Hu J
Molecular and cellular endocrinology 2022 Jan 15;540:111505
Molecular and cellular endocrinology 2022 Jan 15;540:111505
Short-term starvation synergistically enhances cytotoxicity of Niraparib via Akt/mTOR signaling pathway in ovarian cancer therapy.
Zhi W, Li S, Wan Y, Wu F, Hong L
Cancer cell international 2022 Jan 11;22(1):18
Cancer cell international 2022 Jan 11;22(1):18
Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma.
Shen Y, Yang F, Peng H, Zhang G, Zhu F, Xu H, Shi L
Journal of ethnopharmacology 2022 Jan 10;282:114601
Journal of ethnopharmacology 2022 Jan 10;282:114601
Estrogen receptor-α36 is involved in diallyl sulfide-induced inhibition of malignant growth of HepG2 and Huh7 hepatocellular carcinoma cells.
Wu W, Chen H, Wang R, Chen J, Yu H, Wei Z, Liu X, Xue M, Chen Q, Zhou H, Fu Z
Environmental toxicology 2022 Feb;37(2):270-281
Environmental toxicology 2022 Feb;37(2):270-281
MiR-195 promotes pancreatic β-cell dedifferentiation by targeting Mfn2 and impairing Pi3k/Akt signaling in type 2 diabetes.
Xu Y, Tang Z, Dai H, Hou J, Li F, Tang Z, Zhang D
Obesity (Silver Spring, Md.) 2022 Feb;30(2):447-459
Obesity (Silver Spring, Md.) 2022 Feb;30(2):447-459
SDF-1 inhibits the dedifferentiation of islet β cells in hyperglycaemia by up-regulating FoxO1 via binding to CXCR4.
Chen XY, Shi YX, Huang YP, Ding M, Shen QL, Li CJ, Lin JN
Journal of cellular and molecular medicine 2022 Feb;26(3):750-763
Journal of cellular and molecular medicine 2022 Feb;26(3):750-763
Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis.
Wen C, Lin L, Zou R, Lin F, Liu Y
Cell cycle (Georgetown, Tex.) 2022 Feb;21(3):289-303
Cell cycle (Georgetown, Tex.) 2022 Feb;21(3):289-303
Therapeutic effect of adipose stromal vascular fraction spheroids for partial bladder outlet obstruction induced underactive bladder.
Liu J, Zhou L, Zhao F, Zhou C, Yang T, Xu Z, Wang X, Xu L, Xu Z, Ge Y, Wu R, Jia R
Stem cell research & therapy 2022 Feb 9;13(1):68
Stem cell research & therapy 2022 Feb 9;13(1):68
Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury through the PI3K/Akt/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression.
Liu XM, Zhang Z, Zhong J, Li N, Wang T, Wang L, Zhang Q
European journal of pharmacology 2022 Feb 5;916:174719
European journal of pharmacology 2022 Feb 5;916:174719
OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer.
Ouyang S, Zeng Z, Liu Z, Zhang Z, Sun J, Wang X, Ma M, Ye X, Yu J, Kang W
Cell death discovery 2022 Feb 2;8(1):45
Cell death discovery 2022 Feb 2;8(1):45
Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation.
Li Y, Li YC, Liu XT, Zhang L, Chen YH, Zhao Q, Gao W, Liu B, Yang H, Li P
Cell reports 2022 Feb 15;38(7):110391
Cell reports 2022 Feb 15;38(7):110391
RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway.
Jiao Y, Li Y, Zhang J, Zhang S, Zha Y, Wang J
Biomolecules 2022 Feb 12;12(2)
Biomolecules 2022 Feb 12;12(2)
Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.
Song JX, Zhao YS, Zhen YQ, Yang XY, Chen Q, An JR, Ji ES
Pharmaceutical biology 2022 Dec;60(1):609-620
Pharmaceutical biology 2022 Dec;60(1):609-620
The protective effect of proanthocyanidins on the psoriasis-like cell models via PI3K/AKT and HO-1.
Zhao Y, Xie Y, Li X, Song J, Guo M, Xian D, Zhong J
Redox report : communications in free radical research 2022 Dec;27(1):200-211
Redox report : communications in free radical research 2022 Dec;27(1):200-211
Daidzein Activates Akt Pathway to Promote the Proliferation of Female Germline Stem Cells through Upregulating Clec11a.
Li F, Hu X, Wu J
Stem cell reviews and reports 2022 Dec;18(8):3021-3032
Stem cell reviews and reports 2022 Dec;18(8):3021-3032
IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
Ma Y, Bao Y, Wu L, Ke Y, Tan L, Ren H, Song J, Zhang Q, Jin Y
Molecular immunology 2022 Dec;152:111-122
Molecular immunology 2022 Dec;152:111-122
TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice.
Yan J, Zhang Y, Wang L, Li Z, Tang S, Wang Y, Gu N, Sun X, Li L
Journal of neuroinflammation 2022 Dec 3;19(1):289
Journal of neuroinflammation 2022 Dec 3;19(1):289
Deletion of large-conductance calcium-activated potassium channels promotes vascular remodelling through the CTRP7-mediated PI3K/Akt signaling pathway.
Bi J, Duan Y, Wang M, He C, Li X, Zhang X, Tao Y, Du Y, Liu H
Acta biochimica et biophysica Sinica 2022 Dec 25;54(12):1-11
Acta biochimica et biophysica Sinica 2022 Dec 25;54(12):1-11
The Nrf2 inhibitor brusatol synergistically enhances the cytotoxic effect of lapatinib in HER2-positive cancers.
Tian Z, Yang Y, Wu H, Chen Y, Jia H, Zhu L, He R, Jin Y, Zhou B, Ge C, Sun Y, Yang Y
Heliyon 2022 Aug;8(8):e10410
Heliyon 2022 Aug;8(8):e10410
Corn oligopeptides inhibit Akt/NF-κB signaling pathway and inflammatory factors to ameliorate CCl(4) -induced hepatic fibrosis in mice.
Feng XW, Cheng QL, Fang L, Liu WY, Liu LW, Sun CQ, Lu ZH, Li GM, Gu RZ
Journal of food biochemistry 2022 Aug;46(8):e14162
Journal of food biochemistry 2022 Aug;46(8):e14162
Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway.
Wu X, Hu Z, Zhou J, Liu J, Ren P, Huang X
Journal of cardiovascular translational research 2022 Aug;15(4):865-875
Journal of cardiovascular translational research 2022 Aug;15(4):865-875
Growth arrest-specific transcript 5 represses endometrial cancer development by promoting antitumor function of tumor-associated macrophages.
Tu J, Tan X, Chen Y, Chen Y, Li Z, Zhang Y, Chen X, Yang H, Chen H, Yu Z
Cancer science 2022 Aug;113(8):2496-2512
Cancer science 2022 Aug;113(8):2496-2512
Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity.
Zhou C, Dong X, Wang M, Qian X, Hu M, Liang K, Liang Y, Zhang R, Huang Y, Lyu H, Xiao S, Tang Y, Ali DW, Michalak M, Chen XZ, Tang J
Cell insight 2022 Aug;1(4):100045
Cell insight 2022 Aug;1(4):100045
Discovery of highly potent and selective CRBN-recruiting EGFR(L858R/T790M) degraders in vivo.
Zhang W, Li P, Sun S, Jia C, Yang N, Zhuang X, Zheng Z, Li S
European journal of medicinal chemistry 2022 Aug 5;238:114509
European journal of medicinal chemistry 2022 Aug 5;238:114509
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Jia X, Xin M, Xu J, Xiang X, Li X, Jiao Y, Wang L, Jiang J, Pang F, Zhang X, Zhang J
Cell death & disease 2022 Aug 30;13(8):750
Cell death & disease 2022 Aug 30;13(8):750
Investigation of the effects of high cervical spinal cord electrical stimulation on improving neurological dysfunction and its potential mechanism in rats with traumatic brain injury.
Zhao PC, Huang ZS, Xu SN, Deng PC, Qian F, Shi J, Zhang YM
Neuroreport 2022 Aug 2;33(12):509-517
Neuroreport 2022 Aug 2;33(12):509-517
LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2.
Wang J, He Z, Liu X, Xu J, Jiang X, Quan G, Jiang J
Cell death & disease 2022 Aug 18;13(8):718
Cell death & disease 2022 Aug 18;13(8):718
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Zhao X, Sun W, Guo B, Cui L
Stem cell research & therapy 2022 Aug 13;13(1):417
Stem cell research & therapy 2022 Aug 13;13(1):417
Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.
Wang Z, Liang M, Li H, Liu B, Yang L
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Aug 1;47(8):826-838
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Aug 1;47(8):826-838
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
Wu J, Chen Y, Li X, Ran L, Liu X, Wang X, Zhen M, Shao S, Zeng L, Wang C, Liang B, Zhao J, Wu Y
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376
miR-141-3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1.
Xin X, Duan L, Yang H, Yu H, Bao Y, Jia D, Wu N, Qiao Y
Environmental toxicology 2022 Apr;37(4):741-753
Environmental toxicology 2022 Apr;37(4):741-753
FAM83A has a pro-tumor function in ovarian cancer by affecting the Akt/Wnt/β-catenin pathway.
Zhao J, Zhao F, Yang T, Tian S, Zhao M, Wang S, Yang X
Environmental toxicology 2022 Apr;37(4):695-707
Environmental toxicology 2022 Apr;37(4):695-707
Downregulating MFN2 Promotes the Differentiation of Induced Pluripotent Stem Cells into Mesenchymal Stem Cells through the PI3K/Akt/GSK-3β/Wnt Signaling Pathway.
Deng L, Yi S, Yin X, Li Y, Luan Q
Stem cells and development 2022 Apr;31(7-8):181-194
Stem cells and development 2022 Apr;31(7-8):181-194
Dietary intake of diosgenin delays aging of male fish Nothobranchius guentheri through modulation of multiple pathways that play prominent roles in ROS production.
Song L, Li C, Wu F, Zhang S
Biogerontology 2022 Apr;23(2):201-213
Biogerontology 2022 Apr;23(2):201-213
GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSGL-1 in atherosclerosis.
Ye Z, Guo H, Wang L, Li Y, Xu M, Zhao X, Song X, Chen Z, Huang R
Journal of molecular and cellular cardiology 2022 Apr;165:54-63
Journal of molecular and cellular cardiology 2022 Apr;165:54-63
Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway.
Liu W, Feng Y, Wang X, Ding J, Li H, Guan H, Chen Z
Bioengineered 2022 Apr;13(4):8850-8865
Bioengineered 2022 Apr;13(4):8850-8865
Structure-based discovery of a specific SHP2 inhibitor with enhanced blood-brain barrier penetration from PubChem database.
Ma Y, Li WY, Sun T, Zhang L, Lu XH, Yang B, Wang RL
Bioorganic chemistry 2022 Apr;121:105648
Bioorganic chemistry 2022 Apr;121:105648
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Lin F, Li X, Wang X, Sun H, Wang Z, Wang X
Journal of experimental & clinical cancer research : CR 2022 Apr 7;41(1):129
Journal of experimental & clinical cancer research : CR 2022 Apr 7;41(1):129
miR-486 attenuates cardiac ischemia/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection.
Bei Y, Lu D, Bär C, Chatterjee S, Costa A, Riedel I, Mooren FC, Zhu Y, Huang Z, Wei M, Hu M, Liu S, Yu P, Wang K, Thum T, Xiao J
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1675-1691
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1675-1691
Bolbostemma paniculatum (Maxim.) Franquet extract suppresses the development of colorectal cancer through downregulation of PI3K/Akt pathway.
Li Y, Sun Y, Zhang Q, Liu Y, Niu Y, Li X, Cai D
Journal of ethnopharmacology 2022 Apr 6;287:114937
Journal of ethnopharmacology 2022 Apr 6;287:114937
Mechanism exploration of ancient pharmaceutic processing (Paozhi) improving the gastroprotective efficacy of Aucklandiae Radix.
Song S, Qiu R, Jin X, Zhou Z, Yan J, Ou Q, Liu X, Li W, Mao Y, Yao W, Lu T
Journal of ethnopharmacology 2022 Apr 6;287:114911
Journal of ethnopharmacology 2022 Apr 6;287:114911
Brusatol inhibits the growth of renal cell carcinoma by regulating the PTEN/PI3K/AKT pathway.
Wang T, Chen Z, Chen H, Yu X, Wang L, Liu X
Journal of ethnopharmacology 2022 Apr 24;288:115020
Journal of ethnopharmacology 2022 Apr 24;288:115020
GALNT8 suppresses breast cancer cell metastasis potential by regulating EGFR O-GalNAcylation.
Huang T, Meng F, Huang H, Wang L, Wang L, Liu Y, Liu Y, Wang J, Li W, Zhang J, Liu Y
Biochemical and biophysical research communications 2022 Apr 23;601:16-23
Biochemical and biophysical research communications 2022 Apr 23;601:16-23
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
Fu NJ, Xi RY, Shi XK, Li RZ, Zhang ZH, Li LY, Zhang GL, Wang F
Toxicology and applied pharmacology 2022 Apr 15;441:115988
Toxicology and applied pharmacology 2022 Apr 15;441:115988
Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration via the miR-205-5p/PTEN/AKT pathway.
Shen K, Duan A, Cheng J, Yuan T, Zhou J, Song H, Chen Z, Wan B, Liu J, Zhang X, Zhang Y, Xie R, Liu F, Fan W, Zuo Q
Acta biomaterialia 2022 Apr 15;143:173-188
Acta biomaterialia 2022 Apr 15;143:173-188
Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
Xi X, Li Z, Liu H, Chen S, Liu D
Frontiers in cell and developmental biology 2021;9:816000
Frontiers in cell and developmental biology 2021;9:816000
The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance.
Deng C, Hu F, Zhao Z, Zhou Y, Liu Y, Zhang T, Li S, Zheng W, Zhang W, Wang T, Ma X
Frontiers in cell and developmental biology 2021;9:797005
Frontiers in cell and developmental biology 2021;9:797005
Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways.
Li H, Zhang Y, Lan X, Yu J, Yang C, Sun Z, Kang P, Han Y, Yu D
Frontiers in cell and developmental biology 2021;9:773048
Frontiers in cell and developmental biology 2021;9:773048
Increased Nuclear Transporter Importin 7 Contributes to the Tumor Growth and Correlates With CD8 T Cell Infiltration in Cervical Cancer.
Chen J, Hu Y, Teng Y, Yang B
Frontiers in cell and developmental biology 2021;9:732786
Frontiers in cell and developmental biology 2021;9:732786
NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.
Dang NN, Li XB, Zhang M, Han C, Fan XY, Huang SH
Frontiers in cell and developmental biology 2021;9:662763
Frontiers in cell and developmental biology 2021;9:662763
Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.
Wang X, Li Z, Cui Y, Cui X, Chen C, Wang Z
Frontiers in cell and developmental biology 2021;9:644380
Frontiers in cell and developmental biology 2021;9:644380
lncRNA Gm16410 Mediates PM(2).(5)-Induced Macrophage Activation via PI3K/AKT Pathway.
Xu J, Xu H, Ma K, Wang Y, Niu B, Zhang L, Li F
Frontiers in cell and developmental biology 2021;9:618045
Frontiers in cell and developmental biology 2021;9:618045
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Hua L, Zhou Y, Hou C, Chen J, Wang Y, Zhang S, Zhou H, He S, Jia E
Frontiers in cardiovascular medicine 2021;8:700630
Frontiers in cardiovascular medicine 2021;8:700630
Taurine Protects C2C12 Myoblasts From Impaired Cell Proliferation and Myotube Differentiation Under Cisplatin-Induced ROS Exposure.
Zhou L, Lu R, Huang C, Lin D
Frontiers in molecular biosciences 2021;8:685362
Frontiers in molecular biosciences 2021;8:685362
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Yao M, Zhang J, Li Z, Bai X, Ma J, Li Y
Frontiers in medicine 2021;8:630962
Frontiers in medicine 2021;8:630962
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Tai H, Jiang XL, Song N, Xiao HH, Li Y, Cheng MJ, Yin XM, Chen YR, Yang GL, Jiang XY, Kuang JS, Lan ZM, Jia LQ
Frontiers in medicine 2021;8:617393
Frontiers in medicine 2021;8:617393
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J
Nutrition and cancer 2021;73(8):1459-1470
Nutrition and cancer 2021;73(8):1459-1470
Pentadecanoic acid promotes basal and insulin-stimulated glucose uptake in C2C12 myotubes.
Fu WC, Li HY, Li TT, Yang K, Chen JX, Wang SJ, Liu CH, Zhang W
Food & nutrition research 2021;65
Food & nutrition research 2021;65
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
Qiao D, Jin J, Xing J, Zhang Y, Jia N, Ren X, Lin Z, Jin N, Chen L, Piao Y
The American journal of Chinese medicine 2021;49(2):525-541
The American journal of Chinese medicine 2021;49(2):525-541
Qingjie Fuzheng Granule Inhibits EMT and Induces Autophagy in Colorectal Cancer via mTOR Signaling Pathways.
Zhu X, Chen Y, Lin M, Huang B, Lin J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9950499
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9950499
Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G(0)/G(1) Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation.
Zhang Y, Chen G, Zhuang X, Guo M
Oxidative medicine and cellular longevity 2021;2021:8807676
Oxidative medicine and cellular longevity 2021;2021:8807676
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway.
Liu H, Xu X, Wu R, Bi L, Zhang C, Chen H, Yang Y
BioMed research international 2021;2021:6616547
BioMed research international 2021;2021:6616547
A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke.
Wang C, Chen H, Ma ST, Mao BB, Chen Y, Xu HN, Yu H
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5582782
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5582782
Evodiamine Inhibits Gastric Cancer Cell Proliferation via PTEN-Mediated EGF/PI3K Signaling Pathway.
Yang R, Wen J, Yang T, Dai C, Zhao Y
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5570831
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5570831
Manual Acupuncture at ST37 Modulates TRPV1 in Rats with Acute Visceral Hyperalgesia via Phosphatidylinositol 3-Kinase/Akt Pathway.
Chen C, Yu Z, Lin D, Wang X, Zhang X, Ji F, He L, Xu B
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5561999
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5561999
Therapeutic Potential of RTA 404 in Human Brain Malignant Glioma Cell Lines via Cell Cycle Arrest via p21/AKT Signaling.
Tsai TH, Lieu AS, Wang YW, Yang SF, Hsu YC, Lin CL
BioMed research international 2021;2021:5552226
BioMed research international 2021;2021:5552226
The Key Ingredient Acacetin in Weishu Decoction Alleviates Gastrointestinal Motility Disorder Based on Network Pharmacology Analysis.
Guo X, Xu Y, Tan HL, Wang XJ, Xiao L
Mediators of inflammation 2021;2021:5265444
Mediators of inflammation 2021;2021:5265444
The Effect of miR-520b on Macrophage Polarization and T Cell Immunity by Targeting PTEN in Breast Cancer.
Zhu Q, Yuan J, He Y, Hu Y
Journal of oncology 2021;2021:5170496
Journal of oncology 2021;2021:5170496
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
Du P, Luo K, Li G, Zhu J, Xiao Q, Li Y, Zhang X
International journal of medical sciences 2021;18(15):3588-3598
International journal of medical sciences 2021;18(15):3588-3598
Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.
Wang CM, Li HF, Wang XK, Li WG, Su Q, Xiao X, Hao TF, Chen W, Zhang YW, Zhang HY, Wu W, Hu ZR, Zhao GY, Huo MY, He YL, Zhang CH
International journal of biological sciences 2021;17(11):2811-2825
International journal of biological sciences 2021;17(11):2811-2825
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer.
Chen YQ, Zhu WT, Lin CY, Yuan ZW, Li ZH, Yan PK
International journal of nanomedicine 2021;16:269-281
International journal of nanomedicine 2021;16:269-281
Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.
Wang C, Chen H, Jiang HH, Mao BB, Yu H
Frontiers in neuroscience 2021;15:772401
Frontiers in neuroscience 2021;15:772401
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Yang Y, Yi J, Pan M, Hu B, Duan H
Drug design, development and therapy 2021;15:1409-1422
Drug design, development and therapy 2021;15:1409-1422
Fatty Acid-Binding Protein 4 (FABP4) Suppresses Proliferation and Migration of Endometrial Cancer Cells via PI3K/Akt Pathway.
Wu Z, Jeong JH, Ren C, Yang L, Ding L, Li F, Jiang D, Zhu Y, Lu J
OncoTargets and therapy 2021;14:3929-3942
OncoTargets and therapy 2021;14:3929-3942
Downregulation of TAF9B by miR-7-5p Inhibits the Progression of Osteosarcoma.
Gu W, Chen P, Ren P, Wang Y, Li X, Gong M
OncoTargets and therapy 2021;14:2917-2927
OncoTargets and therapy 2021;14:2917-2927
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
Deng L, Wu X, Zhu X, Yu Z, Liu Z, Wang J, Zheng Y
American journal of translational research 2021;13(1):57-72
American journal of translational research 2021;13(1):57-72
Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice.
Yang XB, Zu HB, Zhao YF, Yao K
Frontiers in aging neuroscience 2021;13:766410
Frontiers in aging neuroscience 2021;13:766410
GTW inhibits the Epithelial to Mesenchymal Transition of Epithelial Ovarian Cancer via ILK/AKT/GSK3β/Slug Signalling Pathway.
Feng Y, Le F, Tian P, Zhong Y, Zhan F, Huang G, Hu H, Chen T, Tan B
Journal of Cancer 2021;12(5):1386-1397
Journal of Cancer 2021;12(5):1386-1397
MRPS17 promotes invasion and metastasis through PI3K/AKT signal pathway and could be potential prognostic marker for gastric cancer.
Zhou W, Ouyang J, Li J, Liu F, An T, Cheng L, Kuo ZC, Zhang C, He Y
Journal of Cancer 2021;12(16):4849-4861
Journal of Cancer 2021;12(16):4849-4861
Peroxisome Proliferator-Activated Receptor-Gamma Reduces ER Stress and Inflammation via Targeting NGBR Expression.
Ma J, Zeng P, Liu L, Zhu M, Zheng J, Wang C, Zhao X, Hu W, Yang X, Duan Y, Han J, Miao QR, Chen Y
Frontiers in pharmacology 2021;12:817784
Frontiers in pharmacology 2021;12:817784
Diosgenin From Dioscorea Nipponica Rhizoma Against Graves' Disease-On Network Pharmacology and Experimental Evaluation.
Xin J, Cheng W, Yu Y, Chen J, Zhang X, Shao S
Frontiers in pharmacology 2021;12:806829
Frontiers in pharmacology 2021;12:806829
ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway.
Zhang Q, Xie T, Mo G, Zhang Z, Lin L, Zhang X
Frontiers in immunology 2021;12:774323
Frontiers in immunology 2021;12:774323
PARP Inhibitor Upregulates PD-L1 Expression and Provides a New Combination Therapy in Pancreatic Cancer.
Wang Y, Zheng K, Xiong H, Huang Y, Chen X, Zhou Y, Qin W, Su J, Chen R, Qiu H, Yuan X, Wang Y, Zou Y
Frontiers in immunology 2021;12:762989
Frontiers in immunology 2021;12:762989
Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.
Cao T, Chen Q, Zhang B, Wu X, Zeng C, Zhang S, Cai H
Frontiers in endocrinology 2021;12:727371
Frontiers in endocrinology 2021;12:727371
Exploring the Critical Components and Therapeutic Mechanisms of Perilla frutescens L. in the Treatment of Chronic Kidney Disease via Network Pharmacology.
Yong C, Zhang Z, Huang G, Yang Y, Zhu Y, Qian L, Tian F, Liu L, Wu Q, Xu Z, Chen C, Zhao J, Gao K, Zhou E
Frontiers in pharmacology 2021;12:717744
Frontiers in pharmacology 2021;12:717744
Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Pathway.
Zeng T, Cao Y, Gu T, Chen L, Tian Y, Li G, Shen J, Tao Z, Lu L
Frontiers in genetics 2021;12:693780
Frontiers in genetics 2021;12:693780
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Luo LF, Qin LY, Wang JX, Guan P, Wang N, Ji ES
Frontiers in pharmacology 2021;12:669782
Frontiers in pharmacology 2021;12:669782
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Zheng T, Yang J, Zhang J, Yang C, Fan Z, Li Q, Zhai Y, Liu H, Yang J
Frontiers in pharmacology 2021;12:669146
Frontiers in pharmacology 2021;12:669146
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Wang T, Dong J, Yuan X, Wen H, Wu L, Liu J, Sui H, Deng W
Frontiers in pharmacology 2021;12:653306
Frontiers in pharmacology 2021;12:653306
Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.
Zhang KK, Wang H, Qu D, Chen LJ, Wang LB, Li JH, Liu JL, Xu LL, Yoshida JS, Xu JT, Xie XL, Li DR
Frontiers in pharmacology 2021;12:641917
Frontiers in pharmacology 2021;12:641917
Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice.
Adu-Nti F, Gao X, Wu JM, Li J, Iqbal J, Ahmad R, Ma XM
Frontiers in pharmacology 2021;12:641909
Frontiers in pharmacology 2021;12:641909
Rapamycin Modulates the Proinflammatory Memory-Like Response of Microglia Induced by BAFF.
Wang J, Yang C, Hou X, Xu J, Yun Y, Qin L, Yang P
Frontiers in immunology 2021;12:639049
Frontiers in immunology 2021;12:639049
Isovitexin Inhibits Ginkgolic Acids-Induced Inflammation Through Downregulating SHP2 Activation.
Zhang Y, Qi Z, Wang W, Wang L, Cao F, Zhao L, Fang X
Frontiers in pharmacology 2021;12:630320
Frontiers in pharmacology 2021;12:630320
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.
Cao T, Tang M, Jiang P, Zhang B, Wu X, Chen Q, Zeng C, Li N, Zhang S, Cai H
Frontiers in pharmacology 2021;12:612083
Frontiers in pharmacology 2021;12:612083
Human Mesenchymal Stem Cell-Derived Exosomal microRNA-143 Promotes Apoptosis and Suppresses Cell Growth in Pancreatic Cancer via Target Gene Regulation.
Wang B, Xu Y, Wei Y, Lv L, Liu N, Lin R, Wang X, Shi B
Frontiers in genetics 2021;12:581694
Frontiers in genetics 2021;12:581694
ADORA2A-AS1 Restricts Hepatocellular Carcinoma Progression via Binding HuR and Repressing FSCN1/AKT Axis.
Pu J, Zhang Y, Wang A, Qin Z, Zhuo C, Li W, Xu Z, Tang Q, Wang J, Wei H
Frontiers in oncology 2021;11:754835
Frontiers in oncology 2021;11:754835
TPL Inhibits the Invasion and Migration of Drug-Resistant Ovarian Cancer by Targeting the PI3K/AKT/NF-κB-Signaling Pathway to Inhibit the Polarization of M2 TAMs.
Le F, Yang L, Han Y, Zhong Y, Zhan F, Feng Y, Hu H, Chen T, Tan B
Frontiers in oncology 2021;11:704001
Frontiers in oncology 2021;11:704001
The EIF4A3/CASC2/RORA Feedback Loop Regulates the Aggressive Phenotype in Glioblastomas.
Zhao J, Jiang Y, Chen L, Ma Y, Zhang H, Zhou J, Li H, Jing Z
Frontiers in oncology 2021;11:699933
Frontiers in oncology 2021;11:699933
Transcriptomic Analyses Reveal B-Cell Translocation Gene 2 as a Potential Therapeutic Target in Ovarian Cancer.
Wang J, Li H, Wang L, Zhang J, Li M, Qiao L, Zhang J, Liu L, Zhang C, Gao J, Li W
Frontiers in oncology 2021;11:681250
Frontiers in oncology 2021;11:681250
A Novel Small Molecular Antibody, HER2-Nanobody, Inhibits Tumor Proliferation in HER2-Positive Breast Cancer Cells In Vitro and In Vivo.
Yan Y, Cheng X, Li L, Zhang R, Zhu Y, Wu Z, Ding K
Frontiers in oncology 2021;11:669393
Frontiers in oncology 2021;11:669393
The LncRNA CASC11 Promotes Colorectal Cancer Cell Proliferation and Migration by Adsorbing miR-646 and miR-381-3p to Upregulate Their Target RAB11FIP2.
Zhang W, Li X, Zhang W, Lu Y, Lin W, Yang L, Zhang Z, Li X
Frontiers in oncology 2021;11:657650
Frontiers in oncology 2021;11:657650
Down-Regulating the Expression of miRNA-21 Inhibits the Glucose Metabolism of A549/DDP Cells and Promotes Cell Death Through the PI3K/AKT/mTOR/HIF-1α Pathway.
Sun Y, Liu W, Zhao Q, Zhang R, Wang J, Pan P, Shang H, Liu C, Wang C
Frontiers in oncology 2021;11:653596
Frontiers in oncology 2021;11:653596
MiR-454-3p Promotes Oxaliplatin Resistance by Targeting PTEN in Colorectal Cancer.
Qian XL, Zhou F, Xu S, Jiang J, Chen ZP, Wang SK, Zuo Y, Ni C
Frontiers in oncology 2021;11:638537
Frontiers in oncology 2021;11:638537
MiR-338-5p Inhibits EGF-Induced EMT in Pancreatic Cancer Cells by Targeting EGFR/ERK Signaling.
Sun J, Chen L, Dong M
Frontiers in oncology 2021;11:616481
Frontiers in oncology 2021;11:616481
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
Ding F, Yang S
Canadian journal of physiology and pharmacology 2021 Sep;99(9):910-920
Canadian journal of physiology and pharmacology 2021 Sep;99(9):910-920
Triclosan regulates the Nrf2/HO-1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons.
Wang D, Liu J, Jiang H
Environmental toxicology 2021 Sep;36(9):1953-1964
Environmental toxicology 2021 Sep;36(9):1953-1964
Low-dose repeated exposure to chemical surfactant impairs corneal epithelium: When personal cleaning products entering the eye.
Wu J, Wu T, Zheng S, Huang Y, Wang L
Experimental eye research 2021 Sep;210:108696
Experimental eye research 2021 Sep;210:108696
A novel delivery nanobiotechnology: engineered miR-181b exosomes improved osteointegration by regulating macrophage polarization.
Liu W, Yu M, Chen F, Wang L, Ye C, Chen Q, Zhu Q, Xie D, Shao M, Yang L
Journal of nanobiotechnology 2021 Sep 7;19(1):269
Journal of nanobiotechnology 2021 Sep 7;19(1):269
Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction.
Van Lent J, Verstraelen P, Asselbergh B, Adriaenssens E, Mateiu L, Verbist C, De Winter V, Eggermont K, Van Den Bosch L, De Vos WH, Timmerman V
Brain : a journal of neurology 2021 Sep 4;144(8):2471-2485
Brain : a journal of neurology 2021 Sep 4;144(8):2471-2485
miR-497 defect contributes to gastric cancer tumorigenesis and progression via regulating CDC42/ITGB1/FAK/PXN/AKT signaling.
Zhang L, Yao L, Zhou W, Tian J, Ruan B, Lu Z, Deng Y, Li Q, Zeng Z, Yang D, Shang R, Xu M, Zhang M, Cheng D, Yang Y, Ding Q, Yu H
Molecular therapy. Nucleic acids 2021 Sep 3;25:567-577
Molecular therapy. Nucleic acids 2021 Sep 3;25:567-577
Tanshinone IIA affects the malignant growth of Cholangiocarcinoma cells by inhibiting the PI3K-Akt-mTOR pathway.
Liu H, Liu C, Wang M, Sun D, Zhu P, Zhang P, Tan X, Shi G
Scientific reports 2021 Sep 29;11(1):19268
Scientific reports 2021 Sep 29;11(1):19268
PHLDA3 exerts an antitumor function in prostate cancer by down-regulating Wnt/β-catenin pathway via inhibition of Akt.
Ma S, Quan P, Yu C, Fan X, Yang S, Jia W, Zhang L, Wang F, Liu F, Yang L, Qin W, Yang X
Biochemical and biophysical research communications 2021 Sep 24;571:66-73
Biochemical and biophysical research communications 2021 Sep 24;571:66-73
Midkine promotes glioblastoma progression via PI3K-Akt signaling.
Hu B, Qin C, Li L, Wei L, Mo X, Fan H, Lei Y, Wei F, Zou D
Cancer cell international 2021 Sep 23;21(1):509
Cancer cell international 2021 Sep 23;21(1):509
Latcripin-7A from Lentinula edodes C(91-3) induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling.
Din SRU, Nisar MA, Ramzan MN, Saleem MZ, Ghayas H, Ahmad B, Batool S, Kifayat K, Guo X, Huang M, Zhong M
European journal of pharmacology 2021 Sep 15;907:174305
European journal of pharmacology 2021 Sep 15;907:174305
Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.
Li L, Wang J, Feng L, Fan J, Wang J, Tan N, Wang Z
Journal of ethnopharmacology 2021 Sep 15;277:114184
Journal of ethnopharmacology 2021 Sep 15;277:114184
Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes.
Liang N, Li S, Liang Y, Ma Y, Tang S, Ye S, Xiao F
Ecotoxicology and environmental safety 2021 Sep 15;221:112447
Ecotoxicology and environmental safety 2021 Sep 15;221:112447
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Lan J, Hu Y, Wang X, Zheng W, Liao A, Wang S, Li Y, Wang Y, Yang F, Chen D
Neuropharmacology 2021 Sep 15;196:108689
Neuropharmacology 2021 Sep 15;196:108689
Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway.
Li N, Yang F, Liu DY, Guo JT, Ge N, Sun SY
World journal of gastrointestinal oncology 2021 Sep 15;13(9):1164-1183
World journal of gastrointestinal oncology 2021 Sep 15;13(9):1164-1183
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
Liu L, Liu M, Zhao W, Zhao YL, Wang Y
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386
Methyl eugenol attenuates liver ischemia reperfusion injury via activating PI3K/Akt signaling.
Wang M, Zhang J, Zhang J, Sun K, Li Q, Kuang B, Wang MMZ, Hou S, Gong N
International immunopharmacology 2021 Oct;99:108023
International immunopharmacology 2021 Oct;99:108023
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Wen L, Yang QH, Ma XL, Li T, Xiao S, Sun CF
International immunopharmacology 2021 Oct;99:107993
International immunopharmacology 2021 Oct;99:107993
SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pathway.
Luo Z, Wang J, Zhu Y, Sun X, He C, Cai M, Ma J, Wang Y, Han S
Neoplasia (New York, N.Y.) 2021 Oct;23(10):1037-1047
Neoplasia (New York, N.Y.) 2021 Oct;23(10):1037-1047
miR-19a-3p downregulates tissue factor and functions as a potential therapeutic target for sepsis-induced disseminated intravascular coagulation.
Zhang R, Lu S, Yang X, Li M, Jia H, Liao J, Jing Q, Wu Y, Wang H, Xiao F, Bai X, Na X, Kang Y, Wan L, Yang J
Biochemical pharmacology 2021 Oct;192:114671
Biochemical pharmacology 2021 Oct;192:114671
Study on the potential nephrotoxicity and mutagenicity of aristolochic acid IVa and its mechanism.
Xian Z, Tian J, Zhang Y, Meng J, Zhao Y, Li C, Yi Y, Han J, Liu S, Wang L, Pan C, Wang D, Wang F, Liang A
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:112081
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:112081
Cathepsin B Regulates Mice Granulosa Cells' Apoptosis and Proliferation In Vitro.
Chen C, Ahmad MJ, Ye T, Du C, Zhang X, Liang A, Yang L
International journal of molecular sciences 2021 Oct 31;22(21)
International journal of molecular sciences 2021 Oct 31;22(21)
A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties.
Liu S, Sun Y, Hou Y, Yang L, Wan X, Qin Y, Liu Y, Wang R, Zhu P, Teng Y, Liu M
Journal of hematology & oncology 2021 Oct 29;14(1):178
Journal of hematology & oncology 2021 Oct 29;14(1):178
SUMO1 modification of IGF-1R combining with SNAI2 inhibited osteogenic differentiation of PDLSCs stimulated by high glucose.
Jiang R, Wang M, Shen X, Huang S, Han J, Li L, Xu Z, Jiang C, Zhou Q, Feng X
Stem cell research & therapy 2021 Oct 18;12(1):543
Stem cell research & therapy 2021 Oct 18;12(1):543
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
Wang S, Zhang RH, Zhang H, Wang YC, Yang D, Zhao YL, Yan GY, Xu GB, Guan HY, Zhou YH, Cui DB, Liu T, Li YJ, Liao SG, Zhou M
European journal of medicinal chemistry 2021 Oct 15;222:113573
European journal of medicinal chemistry 2021 Oct 15;222:113573
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
Tan X, Cai D, Chen N, Du S, Qiao D, Yue X, Wang T, Li J, Xie W, Wang H
Toxicology letters 2021 Oct 10;350:98-110
Toxicology letters 2021 Oct 10;350:98-110
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X, Wu C
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Abnormally elevated ubiquilin‑1 expression in breast cancer regulates metastasis and stemness via AKT signaling.
Feng X, Cao A, Qin T, Zhang Q, Fan S, Wang B, Song B, Yu X, Li L
Oncology reports 2021 Nov;46(5)
Oncology reports 2021 Nov;46(5)
Protective effect of carvacrol on liver injury in type 2 diabetic db/db mice.
Zhao W, Chen L, Zhou H, Deng C, Han Q, Chen Y, Wu Q, Li S
Molecular medicine reports 2021 Nov;24(5)
Molecular medicine reports 2021 Nov;24(5)
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Fan Y, Lu J, Liu J, Zhang R, Yu Z, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression.
Li L, Zheng B, Zhang F, Luo X, Li F, Xu T, Zhao H, Shi G, Guo Y, Shi J, Sun J
Archives of gerontology and geriatrics 2021 Nov-Dec;97:104505
Archives of gerontology and geriatrics 2021 Nov-Dec;97:104505
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Liu XL, Zhao YC, Zhu HY, Wu M, Zheng YN, Yang M, Cheng ZQ, Ding CB, Liu WC
Food & function 2021 Nov 29;12(23):12142-12158
Food & function 2021 Nov 29;12(23):12142-12158
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Liu X, Yang J, Yang C, Huang X, Han M, Kang F, Li J
Cancer cell international 2021 Nov 25;21(1):622
Cancer cell international 2021 Nov 25;21(1):622
miR-30b-5p inhibits proliferation, invasion, and migration of papillary thyroid cancer by targeting GALNT7 via the EGFR/PI3K/AKT pathway.
Wang Y, Wang C, Fu Z, Zhang S, Chen J
Cancer cell international 2021 Nov 24;21(1):618
Cancer cell international 2021 Nov 24;21(1):618
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Lin L, Zeng L, Liu A, Yuan D, Peng Y, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Nutrients 2021 Nov 17;13(11)
Nutrients 2021 Nov 17;13(11)
Long non-coding RNA SMASR inhibits the EMT by negatively regulating TGF-β/Smad signaling pathway in lung cancer.
Xu L, Liu W, Li T, Hu Y, Wang Y, Huang L, Wang Y, Shao S, Liu X, Zhan Q
Oncogene 2021 May;40(20):3578-3592
Oncogene 2021 May;40(20):3578-3592
Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT/mTOR and ERK1/2 signaling pathways.
Cao Y, Zhang Y, Ma L, Wang J, Guo W, Cheng J, Hu G, Fu S, Liu J
Cell and tissue research 2021 May;384(2):313-324
Cell and tissue research 2021 May;384(2):313-324
Role of epigenetic m(6) A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling.
Parial R, Li H, Li J, Archacki S, Yang Z, Wang IZ, Chen Q, Xu C, Wang QK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21465
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21465
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Li J, Chen H, Lou J, Bao G, Wu C, Lou Z, Wang X, Ding J, Li Z, Xiao J, Xu H, Gao W, Zhou K
Journal of cellular physiology 2021 May;236(5):3641-3659
Journal of cellular physiology 2021 May;236(5):3641-3659
Knockdown of CLN5 inhibits the tumorigenic properties of glioblastoma cells via the Akt/mTOR signaling pathway.
Xing J, Li Y, Zhao H
Oncology letters 2021 May;21(5):387
Oncology letters 2021 May;21(5):387
αKlotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy.
Zhu X, Li S, Lin Q, Shao X, Wu J, Zhang W, Cai H, Zhou W, Jiang N, Zhang Z, Shen J, Wang Q, Ni Z
Pharmacological research 2021 May;167:105531
Pharmacological research 2021 May;167:105531
Bioactive glass activates VEGF paracrine signaling of cardiomyocytes to promote cardiac angiogenesis.
Shi M, Zhao F, Sun L, Tang F, Gao W, Xie W, Cao X, Zhuang J, Chen X
Materials science & engineering. C, Materials for biological applications 2021 May;124:112077
Materials science & engineering. C, Materials for biological applications 2021 May;124:112077
2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.
Wu X, Li J, Wang S, Jiang L, Sun X, Liu X, Yao X, Zhang C, Wang N, Yang G
Journal of agricultural and food chemistry 2021 May 5;69(17):5206-5215
Journal of agricultural and food chemistry 2021 May 5;69(17):5206-5215
Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
Chen Z, Huo D, Li L, Liu Z, Li Z, Xu S, Huang Y, Wu W, Zhou C, Liu Y, Kuang M, Wu F, Li H, Qian P, Song G, Wu X, Chen J, Hou Y
The Journal of experimental medicine 2021 May 3;218(5)
The Journal of experimental medicine 2021 May 3;218(5)
The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.
Qi R, Sun J, Qiu X, Zhang Y, Wang J, Wang Q, Huang J, Ge L, Liu Z
Scientific reports 2021 May 27;11(1):11237
Scientific reports 2021 May 27;11(1):11237
LRRC4 functions as a neuron-protective role in experimental autoimmune encephalomyelitis.
Zhang Y, Li D, Zeng Q, Feng J, Fu H, Luo Z, Xiao B, Yang H, Wu M
Molecular medicine (Cambridge, Mass.) 2021 May 1;27(1):44
Molecular medicine (Cambridge, Mass.) 2021 May 1;27(1):44
CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP-9/PI3K/AKT pathway.
Chen H, Pan R, Li H, Zhang W, Ren C, Lu Q, Chen H, Zhang X, Nie Y
Cell biology international 2021 Mar;45(3):623-632
Cell biology international 2021 Mar;45(3):623-632
Hypoxia-induced SPOP attenuates the mobility of trophoblast cells through inhibition of the PI3K/AKT/GSK3β pathway.
Yuan D, Yang Z, Chen Y, Li S, Tan B, Yu Q
Cell biology international 2021 Mar;45(3):599-611
Cell biology international 2021 Mar;45(3):599-611
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Zhang Y, Sun J, Dong Y, Shen X, Zhang Z
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22680
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22680
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Han B, Jiang P, Jiang L, Li X, Ye X
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Radiotherapy programs neutrophils to an antitumor phenotype by inducing mesenchymal-epithelial transition.
Liu Q, Hao Y, Du R, Hu D, Xie J, Zhang J, Deng G, Liang N, Tian T, Käsmann L, Rades D, Rim CH, Hu P, Zhang J
Translational lung cancer research 2021 Mar;10(3):1424-1443
Translational lung cancer research 2021 Mar;10(3):1424-1443
Angiotensin II-induced muscle atrophy via PPARγ suppression is mediated by miR-29b.
Li J, Yang T, Sha Z, Tang H, Hua X, Wang L, Wang Z, Gao Z, Sluijter JPG, Rowe GC, Das S, Yang L, Xiao J
Molecular therapy. Nucleic acids 2021 Mar 5;23:743-756
Molecular therapy. Nucleic acids 2021 Mar 5;23:743-756
Inhibition of lncRNA MAAT Controls Multiple Types of Muscle Atrophy by cis- and trans-Regulatory Actions.
Li J, Yang T, Tang H, Sha Z, Chen R, Chen L, Yu Y, Rowe GC, Das S, Xiao J
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Mar 3;29(3):1102-1119
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Mar 3;29(3):1102-1119
mTOR pathway regulates the differentiation of peripheral blood Th2/Treg cell subsets in patients with pemphigus vulgaris.
Lai K, Zhang W, Li S, Zhang Z, Xie S, Xu M, Li C, Zeng K
Acta biochimica et biophysica Sinica 2021 Mar 26;53(4):438-445
Acta biochimica et biophysica Sinica 2021 Mar 26;53(4):438-445
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway.
Chen Y, Xu T, Li M, Li C, Ma Y, Chen G, Sun Y, Zheng H, Wu G, Liao W, Liao Y, Chen Y, Bin J
Clinical science (London, England : 1979) 2021 Mar 26;135(6):811-828
Clinical science (London, England : 1979) 2021 Mar 26;135(6):811-828
Iridoids from Gardeniae fructus ameliorates depression by enhancing synaptic plasticity via AMPA receptor-mTOR signaling.
Xia B, Huang X, Sun G, Tao W
Journal of ethnopharmacology 2021 Mar 25;268:113665
Journal of ethnopharmacology 2021 Mar 25;268:113665
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Tai H, Jiang XL, Lan ZM, Li Y, Kong L, Yao SC, Song N, Lv MJ, Wu J, Yang P, Xiao XS, Yang GL, Kuang JS, Jia LQ
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
ACTG1 regulates intervertebral disc degeneration via the NF-κB-p65 and Akt pathways.
Wu T, Jia X, Feng H, Wu D
Biochemical and biophysical research communications 2021 Mar 19;545:54-61
Biochemical and biophysical research communications 2021 Mar 19;545:54-61
FoxP3-miR-150-5p/3p suppresses ovarian tumorigenesis via an IGF1R/IRS1 pathway feedback loop.
Zhang Q, Zhou X, Wan M, Zeng X, Luo J, Xu Y, Ji L, Zhang JA, Fan P, Zhong J, Wu J
Cell death & disease 2021 Mar 15;12(3):275
Cell death & disease 2021 Mar 15;12(3):275
The Effect of Hispidulin, a Flavonoid from Salvia plebeia, on Human Nasopharyngeal Carcinoma CNE-2Z Cell Proliferation, Migration, Invasion, and Apoptosis.
Dai Y, Sun X, Li B, Ma H, Wu P, Zhang Y, Zhu M, Li HM, Qin M, Wu CZ
Molecules (Basel, Switzerland) 2021 Mar 14;26(6)
Molecules (Basel, Switzerland) 2021 Mar 14;26(6)
Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.
Feng J, Xie L, Yu X, Liu C, Dong H, Lu W, Kong R
Biochemical and biophysical research communications 2021 Mar 12;544:22-30
Biochemical and biophysical research communications 2021 Mar 12;544:22-30
miR-20b and miR-125a promote tumorigenesis in radioresistant esophageal carcinoma cells.
Chen D, Su H, Li Y, Wu X, Li Y, Wei C, Shi D, Gao Y, Zhou Q, Wang Q, Jin X, Xie C
Aging 2021 Mar 10;13(7):9566-9581
Aging 2021 Mar 10;13(7):9566-9581
FAM122A promotes acute myeloid leukemia cell growth through inhibiting PP2A activity and sustaining MYC expression.
Liu MH, Chen J, Yang YS, Wang YQ, Chen GQ, Zhang Y, Huang Y
Haematologica 2021 Mar 1;106(3):903-907
Haematologica 2021 Mar 1;106(3):903-907
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Lu D, Le Y, Ding J, Dou X, Mao W, Zhu J
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Sparstolonin B exerts beneficial effects on prostate cancer by acting on the reactive oxygen species-mediated PI3K/AKT pathway.
Liu S, Hu J, Shi C, Sun L, Yan W, Song Y
Journal of cellular and molecular medicine 2021 Jun;25(12):5511-5524
Journal of cellular and molecular medicine 2021 Jun;25(12):5511-5524
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Zhang Z, Qin X, Wang Z, Li Y, Chen F, Chen R, Li C, Zhang W, Zhang M
Experimental and therapeutic medicine 2021 Jun;21(6):556
Experimental and therapeutic medicine 2021 Jun;21(6):556
Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway.
Liang Y, Chen G, Zhang F, Yang X, Chen Y, Duan Y, Yu M, Zhang S, Han J
Antioxidants (Basel, Switzerland) 2021 Jun 5;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 5;10(6)
Longdan Xiegan Tang attenuates liver injury and hepatic insulin resistance by regulating the angiotensin-converting enzyme 2/Ang (1-7)/Mas axis-mediated anti-inflammatory pathway in rats.
Wang C, Ren L, Chen S, Zheng H, Yang Y, Gu T, Li Y, Wang C
Journal of ethnopharmacology 2021 Jun 28;274:114072
Journal of ethnopharmacology 2021 Jun 28;274:114072
Protective effect of scorpion venom heat-resistant synthetic peptide against PM(2.5)-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway.
Xu X, Xu H, Ren F, Huang L, Xu J, Li F
Journal of neuroimmunology 2021 Jun 15;355:577567
Journal of neuroimmunology 2021 Jun 15;355:577567
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
Peng MF, Tian S, Song YG, Li CX, Miao MS, Ren Z, Li M
Journal of ethnopharmacology 2021 Jun 12;273:113947
Journal of ethnopharmacology 2021 Jun 12;273:113947
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Zhou Z, Li Y, Ma X, Cao B, Peng T, Sheng Y, Peng H, Li R, Cao Y, Xi R, Li F, Wang M, Sun H, Zhang G, Zhang H, Hu K, Xiao W, Wang F
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
Xin C, Zhao M, Wang J, Wang Z
Journal of food biochemistry 2021 Jul;45(7):e13771
Journal of food biochemistry 2021 Jul;45(7):e13771
Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells.
Wang Y, Wang Z, Lu J, Zhang H
Human cell 2021 Jul;34(4):1174-1184
Human cell 2021 Jul;34(4):1174-1184
MicroRNA-215-5p inhibits the proliferation of keratinocytes and alleviates psoriasis-like inflammation by negatively regulating DYRK1A and its downstream signalling pathways.
Liu A, Zhang B, Zhao W, Tu Y, Wang Q, Li J
Experimental dermatology 2021 Jul;30(7):932-942
Experimental dermatology 2021 Jul;30(7):932-942
Downregulation of HOXA11 enhances endometrial cancer malignancy and cisplatin resistance via activating PTEN/AKT signaling pathway.
Kong C, Zhu Z, Li Y, Xue P, Chen L
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Jul;23(7):1334-1341
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 Jul;23(7):1334-1341
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
Du W, Gao A, Herman JG, Wang L, Zhang L, Jiao S, Guo M
Cancer science 2021 Jul;112(7):2870-2883
Cancer science 2021 Jul;112(7):2870-2883
Enteric glial cells exert neuroprotection from hyperglycemia-induced damage via Akt/GSK3β pathway.
Luo P, He WX, Li C, Chang MJ
Neuroreport 2021 Jul 7;32(10):875-881
Neuroreport 2021 Jul 7;32(10):875-881
Identification and optimization of 3-bromo-N'-(4-hydroxybenzylidene)-4-methylbenzohydrazide derivatives as mTOR inhibitors that induce autophagic cell death and apoptosis in triple-negative breast cancer.
Xu T, Zhang J, Yang C, Pluta R, Wang G, Ye T, Ouyang L
European journal of medicinal chemistry 2021 Jul 5;219:113424
European journal of medicinal chemistry 2021 Jul 5;219:113424
A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.
Li P, Cao S, Huang Y, Zhang Y, Liu J, Cai X, Zhou L, Li J, Jiang Z, Ding L, Zheng Z, Li S, Ye Q
Cell death discovery 2021 Jul 29;7(1):198
Cell death discovery 2021 Jul 29;7(1):198
Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation.
Jing F, Zou Q, Wang Y, Cai Z, Tang Y
The journal of headache and pain 2021 Jul 29;22(1):86
The journal of headache and pain 2021 Jul 29;22(1):86
FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer.
Zhang Z, Qin Y, Ji S, Xu W, Liu M, Hu Q, Ye Z, Fan G, Yu X, Liu W, Xu X
Acta biochimica et biophysica Sinica 2021 Jul 28;53(8):997-1008
Acta biochimica et biophysica Sinica 2021 Jul 28;53(8):997-1008
The role of PKA/PP2B-mediated Drp1 phosphorylation and the subsequent EGFR inhibition in Cr(VI)-induced premature senescence.
Li S, Ma Y, Liang Y, Liang N, Ye S, Xiao F
Ecotoxicology and environmental safety 2021 Jul 15;218:112300
Ecotoxicology and environmental safety 2021 Jul 15;218:112300
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Zhou J, Zhao Y, Guo YJ, Zhao YS, Liu H, Ren J, Li JR, Ji ES
Life sciences 2021 Jul 1;276:119403
Life sciences 2021 Jul 1;276:119403
Postnatal overfeeding induces hepatic microRNA-221 expression and impairs the PI3K/AKT pathway in adult male rats.
Huang F, Zhu P, Wang J, Chen J, Lin W
Pediatric research 2021 Jan;89(1):143-149
Pediatric research 2021 Jan;89(1):143-149
Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.
Jiang F, Ren S, Chen Y, Zhang A, Zhu Y, Zhang Z, Li Z, Piao D
Oncology reports 2021 Jan;45(1):139-150
Oncology reports 2021 Jan;45(1):139-150
Blocking VRK2 suppresses pulmonary adenocarcinoma progression via ERK1/2/AKT signal pathway by targeting miR-145-5p.
Mu Y, Liu WJ, Bie LY, Mu XQ, Zhao YQ
European review for medical and pharmacological sciences 2021 Jan;25(1):145-153
European review for medical and pharmacological sciences 2021 Jan;25(1):145-153
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Qing Ju Han, Han G, Peng J, Tang Z
Free radical biology & medicine 2021 Jan;162:181-190
Free radical biology & medicine 2021 Jan;162:181-190
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats.
Tang C, Luo Y, Li S, Huang B, Xu S, Li L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111081
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111081
Peptide OM-LV20 exerts neuroprotective effects against cerebral ischemia/reperfusion injury in rats.
Yin S, Yang M, Li Y, Li S, Fu Z, Liu N, Wang Y, Hu Y, Xie C, Shu L, Pang A, Gu Y, Wang Y, Sun J, Yang X
Biochemical and biophysical research communications 2021 Jan 22;537:36-42
Biochemical and biophysical research communications 2021 Jan 22;537:36-42
Human Serum-derived Extracellular Vesicles Protect A549 from PM (2.5)-induced Cell Apoptosis.
Zhou QL, Bai YZ, Gao J, Duan Y, Lyu YC, Guan LF, Elkin K, Xie YL, Jiao Z, Wang HY
Biomedical and environmental sciences : BES 2021 Jan 20;34(1):40-49
Biomedical and environmental sciences : BES 2021 Jan 20;34(1):40-49
Typical phthalic acid esters induce apoptosis by regulating the PI3K/Akt/Bcl-2 signaling pathway in rat insulinoma cells.
Li L, Wang F, Zhang J, Wang K, De X, Li L, Zhang Y
Ecotoxicology and environmental safety 2021 Jan 15;208:111461
Ecotoxicology and environmental safety 2021 Jan 15;208:111461
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Sun Z, Zhang L, Li L, Shao C, Liu J, Zhou M, Wang Z
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
Canstatin represses glioma growth by inhibiting formation of VM-like structures.
Ma Y, Wu T, Zhou H, He G, Li Y, Wang B, Guo Q, Chen B, Li W
Translational neuroscience 2021 Jan 1;12(1):309-319
Translational neuroscience 2021 Jan 1;12(1):309-319
Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer.
Wang Z, Yang Y, Hu S, He J, Wu Z, Qi Z, Huang M, Liu R, Lin Y, Tan C, Xu M, Zhang Z
Cell biology and toxicology 2021 Feb;37(1):35-49
Cell biology and toxicology 2021 Feb;37(1):35-49
RAB31 marks and controls an ESCRT-independent exosome pathway.
Wei D, Zhan W, Gao Y, Huang L, Gong R, Wang W, Zhang R, Wu Y, Gao S, Kang T
Cell research 2021 Feb;31(2):157-177
Cell research 2021 Feb;31(2):157-177
Liver paraoxonase 3 expression and the effect of liraglutide treatment in a rat model of diabetes.
Liu Y, Zhu D, Dong G, Zeng Y, Jiang P, Xiao Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2021 Feb;30(2):157-163
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2021 Feb;30(2):157-163
Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2.
Zhang Y, Yan H, Jiang Y, Chen T, Ma Z, Li F, Lin M, Xu Y, Zhang X, Zhang J, He H
Experimental biology and medicine (Maywood, N.J.) 2021 Feb;246(4):371-379
Experimental biology and medicine (Maywood, N.J.) 2021 Feb;246(4):371-379
MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
Liu Z, Ma T, Duan J, Liu X, Liu L
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
ACTL6A knockdown inhibits cell migration by suppressing the AKT signaling pathway and enhances the sensitivity of glioma cells to temozolomide.
Chen X, Xiang Z, Li D, Zhu X, Peng X
Experimental and therapeutic medicine 2021 Feb;21(2):175
Experimental and therapeutic medicine 2021 Feb;21(2):175
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes.
Li J, Du S, Shi Y, Han J, Niu Z, Wei L, Yang P, Chen L, Tian H, Gao L
Experimental eye research 2021 Feb;203:108399
Experimental eye research 2021 Feb;203:108399
Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer.
Jhou AJ, Chang HC, Hung CC, Lin HC, Lee YC, Liu WT, Han KF, Lai YW, Lin MY, Lee CH
Biochemical pharmacology 2021 Feb;184:114403
Biochemical pharmacology 2021 Feb;184:114403
Loss of STAT5A promotes glucose metabolism and tumor growth through miRNA-23a-AKT signaling in hepatocellular carcinoma.
Jiang Y, Tao Y, Zhang X, Wei X, Li M, He X, Zhou B, Guo W, Yin H, Cheng S
Molecular oncology 2021 Feb;15(2):710-724
Molecular oncology 2021 Feb;15(2):710-724
G-Rh4 improves pancreatic β-cells dysfunction in vivo and in vitro by increased expression of Nrf2 and its target genes.
Liu Y, Deng J, Fan D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111925
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111925
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Wang Z, Li B, Jiang H, Ma Y, Bao Y, Zhu X, Xia H, Jin Y
Cytokine 2021 Feb;138:155402
Cytokine 2021 Feb;138:155402
Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1.
Labeit S, Hirner S, Bogomolovas J, Cruz A, Myrzabekova M, Moriscot A, Bowen TS, Adams V
International journal of molecular sciences 2021 Feb 23;22(4)
International journal of molecular sciences 2021 Feb 23;22(4)
Pterostilbene inhibits gallbladder cancer progression by suppressing the PI3K/Akt pathway.
Tong C, Wang Y, Li J, Cen W, Zhang W, Zhu Z, Yu J, Lu B
Scientific reports 2021 Feb 23;11(1):4391
Scientific reports 2021 Feb 23;11(1):4391
QiShenYiQi pill activates autophagy to attenuate reactive myocardial fibrosis via the PI3K/AKT/mTOR pathway.
Lv S, Yuan P, Lu C, Dong J, Li M, Qu F, Zhu Y, Zhang J
Aging 2021 Feb 11;13(4):5525-5538
Aging 2021 Feb 11;13(4):5525-5538
Social context-dependent singing alters molecular markers of synaptic plasticity signaling in finch basal ganglia Area X.
So LY, Miller JE
Behavioural brain research 2021 Feb 1;398:112955
Behavioural brain research 2021 Feb 1;398:112955
DNA damage promotes microtubule dynamics through a DNA-PK-AKT axis for enhanced repair.
Ma S, Rong Z, Liu C, Qin X, Zhang X, Chen Q
The Journal of cell biology 2021 Feb 1;220(2)
The Journal of cell biology 2021 Feb 1;220(2)
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Cui Y, Wang Y, Liu G
Pharmaceutical biology 2021 Dec;59(1):1305-1313
Pharmaceutical biology 2021 Dec;59(1):1305-1313
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Feng Z, Wang C, Yue, Jin, Meng Q, Wu J, Sun H
Pharmaceutical biology 2021 Dec;59(1):1106-1116
Pharmaceutical biology 2021 Dec;59(1):1106-1116
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation.
Lu C, Liu L, Chen S, Niu J, Li S, Xie W, Cheng X
Clinical and experimental pharmacology & physiology 2021 Dec;48(12):1621-1632
Clinical and experimental pharmacology & physiology 2021 Dec;48(12):1621-1632
Lobetyolin inhibits the proliferation of breast cancer cells via ASCT2 down-regulation-induced apoptosis.
Chen Y, Tian Y, Jin G, Cui Z, Guo W, Zhang X, Liu X
Human & experimental toxicology 2021 Dec;40(12):2074-2086
Human & experimental toxicology 2021 Dec;40(12):2074-2086
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice.
Xu Q, Fu Q, Li Z, Liu H, Wang Y, Lin X, He R, Zhang X, Ju Z, Campisi J, Kirkland JL, Sun Y
Nature metabolism 2021 Dec;3(12):1706-1726
Nature metabolism 2021 Dec;3(12):1706-1726
ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma.
Huang W, Chen K, Lu Y, Zhang D, Cheng Y, Li L, Huang W, He G, Liao H, Cai L, Tang Y, Zhao L, Pan M
Neoplasia (New York, N.Y.) 2021 Dec;23(12):1227-1239
Neoplasia (New York, N.Y.) 2021 Dec;23(12):1227-1239
Knockdown of METTL14 suppresses the malignant progression of non-small cell lung cancer by reducing Twist expression.
Yang F, Yuan WQ, Li J, Luo YQ
Oncology letters 2021 Dec;22(6):847
Oncology letters 2021 Dec;22(6):847
miR-199b-5p mediates adriamycin-induced podocyte apoptosis by inhibiting the expression of RGS10.
Qu G, He T, Dai A, Zhao Y, Guan D, Li S, Shi H, Gan W, Zhang A
Experimental and therapeutic medicine 2021 Dec;22(6):1469
Experimental and therapeutic medicine 2021 Dec;22(6):1469
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Chen X, Tang H, Liang Y, Wu P, Xie L, Ding Y, Yang P, Long B, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112288
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112288
Silencing FYVE, RhoGEF, and PH domain containing 1 (FGD1) suppresses melanoma progression by inhibiting PI3K/AKT signaling pathway.
Niu Z, Li Y, Xu Y, Jiang W, Tao R, Chen Y, Han Y
Bioengineered 2021 Dec;12(2):12193-12205
Bioengineered 2021 Dec;12(2):12193-12205
The effects of Omarigliptin on promoting osteoblastic differentiation.
Liao F, Hu X, Chen R
Bioengineered 2021 Dec;12(2):11837-11846
Bioengineered 2021 Dec;12(2):11837-11846
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
Zhao P, Cai Z, Tian Y, Li J, Li K, Li M, Bai Y, Li J
International immunopharmacology 2021 Dec;101(Pt B):108360
International immunopharmacology 2021 Dec;101(Pt B):108360
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.
Zhang L, Zhu T, He F, Li X
International immunopharmacology 2021 Dec;101(Pt B):108238
International immunopharmacology 2021 Dec;101(Pt B):108238
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
Zhu F, Shao J, Tian Y, Xu Z
International immunopharmacology 2021 Dec;101(Pt B):108221
International immunopharmacology 2021 Dec;101(Pt B):108221
Gsα deficiency facilitates cardiac remodeling via CREB/ Bmp10-mediated signaling.
Yin P, Li D, Zhao Q, Cai M, Wu Z, Shi Y, Su L
Cell death discovery 2021 Dec 14;7(1):391
Cell death discovery 2021 Dec 14;7(1):391
Nutrient metabolism in the liver and muscle of juvenile blunt snout bream (Megalobrama amblycephala) in response to dietary methionine levels.
Ji K, Liang H, Ren M, Ge X, Pan L, Yu H
Scientific reports 2021 Dec 13;11(1):23843
Scientific reports 2021 Dec 13;11(1):23843
A maternal high-fat/low-fiber diet impairs glucose tolerance and induces the formation of glycolytic muscle fibers in neonatal offspring.
Hu C, Yang Y, Chen M, Hao X, Wang S, Yang L, Yin Y, Tan C
European journal of nutrition 2021 Aug;60(5):2709-2718
European journal of nutrition 2021 Aug;60(5):2709-2718
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
Man S, Wu Z, Sun R, Guan Q, Li Z, Zuo D, Zhang W, Wu Y
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22831
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22831
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Ma L, Li C, Lian S, Xu B, Lv H, Liu Y, Lu J, Ji H, Li S, Guo J, Yang H
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
DNAJC2 is reversely regulated by miR‑627‑3p, promoting the proliferation of colorectal cancer.
Liu H, Li J, Zhao H, Liu X, Ye X
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
The active ingredients and mechanisms of Longchai Jiangxue Formula in treating PV, based on UPLC/Q-TOF-MS/MS, systematic pharmacology, and molecular biology validation.
Ming J, Liu W, Wu H, Li Y, Yang E, Wang Z, Xiao H, Quan R, Hu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug;140:111767
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug;140:111767
Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.
Wei N, Lu T, Yang L, Dong Y, Liu X
FEBS open bio 2021 Aug;11(8):2118-2126
FEBS open bio 2021 Aug;11(8):2118-2126
Yak milk-derived exosomes alleviate lipopolysaccharide-induced intestinal inflammation by inhibiting PI3K/AKT/C3 pathway activation.
Gao HN, Hu H, Wen PC, Lian S, Xie XL, Song HL, Yang ZN, Ren FZ
Journal of dairy science 2021 Aug;104(8):8411-8424
Journal of dairy science 2021 Aug;104(8):8411-8424
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
Chen X, Zhang W, Xu X
World journal of surgical oncology 2021 Aug 6;19(1):232
World journal of surgical oncology 2021 Aug 6;19(1):232
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Zhu Y, Yang H, Deng J, Fan D
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
TLR7/8 signalling affects X-sperm motility via the GSK3 α/β-hexokinase pathway for the efficient production of sexed dairy goat embryos.
Ren F, Xi H, Ren Y, Li Y, Wen F, Xian M, Zhao M, Zhu D, Wang L, Lei A, Hu J
Journal of animal science and biotechnology 2021 Aug 3;12(1):89
Journal of animal science and biotechnology 2021 Aug 3;12(1):89
Helicobacter urease suppresses cytotoxic CD8+ T-cell responses through activating Myh9-dependent induction of PD-L1.
Wu J, Zhu X, Guo X, Yang Z, Cai Q, Gu D, Luo W, Yuan C, Xiang Y
International immunology 2021 Aug 23;33(9):491-504
International immunology 2021 Aug 23;33(9):491-504
Advanced oxidation protein products impair autophagic flux in macrophage by inducing lysosomal dysfunction via activation of PI3K-Akt-mTOR pathway in Crohn's disease.
Liao Y, Xu J, Qin B, Shi J, Qin C, Xie F, Ou S, Tang J, Wang W, Wu F, Bai L
Free radical biology & medicine 2021 Aug 20;172:33-47
Free radical biology & medicine 2021 Aug 20;172:33-47
[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling.
Jiang X, Wang J, Chen P, He Z, Xu J, Chen Y, Liu X, Jiang J
Cancer cell international 2021 Aug 10;21(1):420
Cancer cell international 2021 Aug 10;21(1):420
Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study.
Wang Y, Zeng Z, Zhao S, Tang L, Yan J, Li N, Zou L, Fan X, Xu C, Huang J, Xia W, Zhu C, Rao M
Endocrinology 2021 Aug 1;162(8)
Endocrinology 2021 Aug 1;162(8)
NCX3 alleviates ethanol-induced apoptosis of SK-N-SH cells via the elimination of intracellular calcium ions.
Xia Z, Wang C, Wang X, Yu H, Yao H, Shen H, Lan X, Wu X, Zhang G
Toxicology in vitro : an international journal published in association with BIBRA 2021 Apr;72:105104
Toxicology in vitro : an international journal published in association with BIBRA 2021 Apr;72:105104
IARS2 regulates proliferation, migration, and angiogenesis of human umbilical vein endothelial cells.
Yu YM, Xu L, Li HR, Zhang TQ, Qian G, Li LF, Wang MH
Revista da Associacao Medica Brasileira (1992) 2021 Apr;67(4):555-560
Revista da Associacao Medica Brasileira (1992) 2021 Apr;67(4):555-560
Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect.
Zhu D, Li S, Chen C, Wang S, Zhu J, Kong L, Luo J
Pharmacological research 2021 Apr;166:105523
Pharmacological research 2021 Apr;166:105523
Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway.
Liu N, Yan L, Shan F, Wang X, Qu N, Handley MK, Ma M
Translational oncology 2021 Apr;14(4):101028
Translational oncology 2021 Apr;14(4):101028
KLF5-mediated Eppk1 expression promotes cell proliferation in cervical cancer via the p38 signaling pathway.
Ma D, Pan Z, Chang Q, Zhang JJ, Liu X, Hua N, Li GH
BMC cancer 2021 Apr 8;21(1):377
BMC cancer 2021 Apr 8;21(1):377
1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells.
Lu J, Fan Y, Liu M, Zhang Q, Guan S
Toxicology 2021 Apr 30;454:152716
Toxicology 2021 Apr 30;454:152716
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
Xiao Y, Liu Y, Lai Z, Huang J, Li C, Zhang Y, Gong X, Deng J, Ye X, Li X
Journal of ethnopharmacology 2021 Apr 24;270:113806
Journal of ethnopharmacology 2021 Apr 24;270:113806
LF-rTMS ameliorates social dysfunction of FMR1(-/-) mice via modulating Akt/GSK-3β signaling.
Hou Y, Zhao J, Yang D, Xuan R, Xie R, Wang M, Mo H, Liang L, Wang W, Wu S, Wang Y, Liu X
Biochemical and biophysical research communications 2021 Apr 23;550:22-29
Biochemical and biophysical research communications 2021 Apr 23;550:22-29
The anti-rotavirus effect of baicalin via the gluconeogenesis-related p-JNK-PDK1-AKT-SIK2 signaling pathway.
Song L, Zhong P, Zhu X, Zhou R, Gao M, Lan Q, Chen J, Chen Y, Zhao W
European journal of pharmacology 2021 Apr 15;897:173927
European journal of pharmacology 2021 Apr 15;897:173927
Biocompatible Chitin Hydrogel Incorporated with PEDOT Nanoparticles for Peripheral Nerve Repair.
Huang L, Yang X, Deng L, Ying D, Lu A, Zhang L, Yu A, Duan B
ACS applied materials & interfaces 2021 Apr 14;13(14):16106-16117
ACS applied materials & interfaces 2021 Apr 14;13(14):16106-16117
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
Wang F, Wang L, Qu C, Chen L, Geng Y, Cheng C, Yu S, Wang D, Yang L, Meng Z, Chen Z
BMC cancer 2021 Apr 12;21(1):396
BMC cancer 2021 Apr 12;21(1):396
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
Wang Y, Zhao H, Liu Y, Li J, Nie X, Huang P, Xing M
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:116597
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:116597
The protein kinase D1-mediated inflammatory pathway is involved in olanzapine-induced impairment of skeletal muscle insulin signaling in rats.
Wang C, Wang C, Ren L, Chen S, Chen WH, Li Y
Life sciences 2021 Apr 1;270:119037
Life sciences 2021 Apr 1;270:119037
SPANXN2 functions a cell migration inhibitor in testicular germ cell tumor cells.
Zhu F, Bo H, Liu G, Li R, Liu Z, Fan L
PeerJ 2020;8:e9358
PeerJ 2020;8:e9358
miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism.
Chen X, Deng S, Lei Q, He Q, Ren Y, Zhang Y, Nie J, Lu W
Frontiers in cell and developmental biology 2020;8:598020
Frontiers in cell and developmental biology 2020;8:598020
Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.
Ma D, Liu X, Zhang JJ, Zhao JJ, Xiong YJ, Chang Q, Wang HY, Su P, Meng J, Zhao YB
Frontiers in cardiovascular medicine 2020;7:592550
Frontiers in cardiovascular medicine 2020;7:592550
Bta-miR-223 Targeting CBLB Contributes to Resistance to Staphylococcus aureus Mastitis Through the PI3K/AKT/NF-κB Pathway.
Han S, Li X, Liu J, Zou Z, Luo L, Wu R, Zhao Z, Wang C, Shen B
Frontiers in veterinary science 2020;7:529
Frontiers in veterinary science 2020;7:529
PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1R/VEGFR2 Pathway in Papillary Thyroid Carcinoma.
Chen Q, Yu WY, Zhang HH, Zhang SZ, Fang J, Wu F, Ying HZ, Yu CH
BioMed research international 2020;2020:8954513
BioMed research international 2020;2020:8954513
Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling.
Xing J, Li P, Hong J, Wang M, Liu Y, Gao Y, Dong J, Gu H, Li L
Mediators of inflammation 2020;2020:4121750
Mediators of inflammation 2020;2020:4121750
Tianma Gouteng Decoction Exerts Cardiovascular Protection by Upregulating OPG and TRAIL in Spontaneously Hypertensive Rats.
Deng LH, Li L, Zhai Y, Michael S, Yang CY, Guo R, Chen SF, Fan GW, Zhao YQ, Liu W
Evidence-based complementary and alternative medicine : eCAM 2020;2020:3439191
Evidence-based complementary and alternative medicine : eCAM 2020;2020:3439191
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma.
Jiang H, Guo W, Yuan S, Song L
BioMed research international 2020;2020:3418398
BioMed research international 2020;2020:3418398
miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway.
Tian R, Jiang H, Shao L, Yu Y, Guo Q, Cao B, Guo S
BioMed research international 2020;2020:2863236
BioMed research international 2020;2020:2863236
Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40.
Song W, Lv Y, Tang Z, Nie F, Huang P, Pei Q, Guo R
Cardiovascular therapeutics 2020;2020:1795853
Cardiovascular therapeutics 2020;2020:1795853
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Jing X, Du L, Niu A, Wang Y, Wang Y, Wang C
BioMed research international 2020;2020:1276328
BioMed research international 2020;2020:1276328
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
An Y, Zhang J, Cheng X, Li B, Tian Y, Zhang X, Zhao F
Cancer cell international 2020;20:237
Cancer cell international 2020;20:237
Apatinib suppresses tumor progression and enhances cisplatin sensitivity in esophageal cancer via the Akt/β-catenin pathway.
Wei B, Wang Y, Wang J, Cai X, Xu L, Wu J, Wang Y, Liu W, Gu Y, Guo W, Xu Q
Cancer cell international 2020;20:198
Cancer cell international 2020;20:198
Effects of Kindlin-2 on proliferation and migration of VSMC and integrinβ1 andβ3 activity via FAK-PI3K signaling pathway.
Wu X, Bian F, Hu H, Zhu T, Li C, Zhou Q
PloS one 2020;15(6):e0225173
PloS one 2020;15(6):e0225173
TiO(2) Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.
Han B, Pei Z, Shi L, Wang Q, Li C, Zhang B, Su X, Zhang N, Zhou L, Zhao B, Niu Y, Zhang R
International journal of nanomedicine 2020;15:6279-6294
International journal of nanomedicine 2020;15:6279-6294
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
Lin HY, Han HW, Wang YS, He DL, Sun WX, Feng L, Wen ZL, Yang MK, Lu GH, Wang XM, Qi JL, Yang YH
Chinese medicine 2020;15:23
Chinese medicine 2020;15:23
Insulin-Like Growth Factor-1 Down-Regulates the Phosphorylation of FXYD1 and Rescues Behavioral Deficits in a Mouse Model of Rett Syndrome.
Yuan ZF, Mao SS, Shen J, Jiang LH, Xu L, Xu JL, Gao F
Frontiers in neuroscience 2020;14:20
Frontiers in neuroscience 2020;14:20
RPL38 Regulates the Proliferation and Apoptosis of Gastric Cancer via miR-374b-5p/VEGF Signal Pathway.
Ji H, Zhang X
OncoTargets and therapy 2020;13:6131-6141
OncoTargets and therapy 2020;13:6131-6141
Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-β/Smad3 signaling and promoting angiogenesis.
Zong J, Jiang J, Shi P, Liu J, Wang W, Li B, Zhao T, Pan T, Zhang Z, Bi L, Diao Y, Wang S
American journal of translational research 2020;12(2):478-492
American journal of translational research 2020;12(2):478-492
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446
American journal of translational research 2020;12(2):428-446
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Jing X, Chen Y, Chen Y, Shi G, Lv S, Cheng N, Feng C, Xin Z, Zhang L, Wu J
Cancer management and research 2020;12:2185-2194
Cancer management and research 2020;12:2185-2194
Rutaecarpine Ameliorates Ethanol-Induced Gastric Mucosal Injury in Mice by Modulating Genes Related to Inflammation, Oxidative Stress and Apoptosis.
Ren S, Wei Y, Wang R, Wei S, Wen J, Yang T, Chen X, Wu S, Jing M, Li H, Wang M, Zhao Y
Frontiers in pharmacology 2020;11:600295
Frontiers in pharmacology 2020;11:600295
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
Luo H, Peng F, Weng B, Tang X, Chen Y, Yang A, Chen B, Ran M
Frontiers in genetics 2020;11:581593
Frontiers in genetics 2020;11:581593
Facilitating Granule Cell Survival and Maturation in Dentate Gyrus With Baicalin for Antidepressant Therapeutics.
Zhao F, Tao W, Shang Z, Zhang W, Ruan J, Zhang C, Zhou L, Aiello H, Lai H, Qu R
Frontiers in pharmacology 2020;11:556845
Frontiers in pharmacology 2020;11:556845
Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling.
Liu C, Chen K, Wang H, Zhang Y, Duan X, Xue Y, He H, Huang Y, Chen Z, Ren H, Wang H, Zeng C
Frontiers in pharmacology 2020;11:540479
Frontiers in pharmacology 2020;11:540479
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
Xu HX, Lin SX, Gong Y, Huo ZX, Zhao CY, Zhu HM, Xi SY
Frontiers in pharmacology 2020;11:245
Frontiers in pharmacology 2020;11:245
HPV16 E6/E7 promote the translocation and glucose uptake of GLUT1 by PI3K/AKT pathway via relieving miR-451 inhibitory effect on CAB39 in lung cancer cells.
Wang HM, Lu YJ, He L, Gu NJ, Wang SY, Qiu XS, Wang EH, Wu GP
Therapeutic advances in chronic disease 2020;11:2040622320957143
Therapeutic advances in chronic disease 2020;11:2040622320957143
Metformin activates the STING/IRF3/IFN-β pathway by inhibiting AKT phosphorylation in pancreatic cancer.
Ren D, Qin G, Zhao J, Sun Y, Zhang B, Li D, Wang B, Jin X, Wu H
American journal of cancer research 2020;10(9):2851-2864
American journal of cancer research 2020;10(9):2851-2864
Precise and efficient silencing of mutant Kras(G12D) by CRISPR-CasRx controls pancreatic cancer progression.
Jiang W, Li H, Liu X, Zhang J, Zhang W, Li T, Liu L, Yu X
Theranostics 2020;10(25):11507-11519
Theranostics 2020;10(25):11507-11519
LRRC4 Suppresses E-Cadherin-Dependent Collective Cell Invasion and Metastasis in Epithelial Ovarian Cancer.
Zhao C, She X, Zhang Y, Liu C, Li P, Chen S, Sai B, Li Y, Feng J, Liu J, Sun Y, Xiao S, Li L, Wu M
Frontiers in oncology 2020;10:144
Frontiers in oncology 2020;10:144
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
Wu Y, Wang Z, Fu X, Lin Z, Yu K
International immunopharmacology 2020 Sep;86:106713
International immunopharmacology 2020 Sep;86:106713
Targeting CPT1B as a potential therapeutic strategy in castration-resistant and enzalutamide-resistant prostate cancer.
Abudurexiti M, Zhu W, Wang Y, Wang J, Xu W, Huang Y, Zhu Y, Shi G, Zhang H, Zhu Y, Shen Y, Dai B, Wan F, Lin G, Ye D
The Prostate 2020 Sep;80(12):950-961
The Prostate 2020 Sep;80(12):950-961
KLHL22 promotes malignant melanoma growth in vitro and in vivo by activating the PI3K/Akt/mTOR signaling pathway.
Liu XR, Wang W, Li HM
Neoplasma 2020 Sep;67(5):1106-1113
Neoplasma 2020 Sep;67(5):1106-1113
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway.
Zhang ZF, Huang TJ, Zhang XK, Xie YJ, Lin ST, Luo FF, Meng DF, Hu H, Wang J, Peng LX, Qian CN, Cheng C, Huang BJ
Journal of cellular and molecular medicine 2020 Sep;24(17):9999-10012
Journal of cellular and molecular medicine 2020 Sep;24(17):9999-10012
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
Liu Z, Ye S, Zhong X, Wang W, Lai CH, Yang W, Yue P, Luo J, Huang X, Zhong Z, Xiong Y, Fan X, Li L, Wang Y, Ye Q
Molecular medicine reports 2020 Sep;22(3):2373-2385
Molecular medicine reports 2020 Sep;22(3):2373-2385
FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.
Zhao L, Kong X, Zhong W, Wang Y, Li P
Pathology, research and practice 2020 Sep;216(9):153042
Pathology, research and practice 2020 Sep;216(9):153042
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
Yang F, Qu Q, Zhao C, Liu X, Yang P, Li Z, Han L, Shi X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Liu J, Shangguan Y, Sun J, Cong W, Xie Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.
Wu Q, Song Y, Liu R, Wang R, Mei W, Chen W, Yang H, Wang X
Bioorganic chemistry 2020 Sep;102:104074
Bioorganic chemistry 2020 Sep;102:104074
RNA-binding protein CUGBP1 controls the differential INSR splicing in molecular subtypes of breast cancer cells and affects cell aggressiveness.
Huang G, Song C, Wang N, Qin T, Sui S, Obr A, Zeng L, Wood TL, Leroith D, Li M, Wu Y
Carcinogenesis 2020 Sep 24;41(9):1294-1305
Carcinogenesis 2020 Sep 24;41(9):1294-1305
Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop.
Zhang X, Niu W, Mu M, Hu S, Niu C
Journal of experimental & clinical cancer research : CR 2020 Sep 22;39(1):196
Journal of experimental & clinical cancer research : CR 2020 Sep 22;39(1):196
FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis.
Gao W, Liang J, Ye Y, Lu J, Lin T, Wang N, Dong J, Pan J
BMC cancer 2020 Sep 18;20(1):895
BMC cancer 2020 Sep 18;20(1):895
Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.
Li P, Ding L, Cao S, Feng X, Zhang Q, Chen Y, Zhang N, Qiu F
Journal of ethnopharmacology 2020 Sep 15;259:113015
Journal of ethnopharmacology 2020 Sep 15;259:113015
Sphingomyelin Synthase 2 Participate in the Regulation of Sperm Motility and Apoptosis.
Li X, Luo T, Li H, Yan N
Molecules (Basel, Switzerland) 2020 Sep 15;25(18)
Molecules (Basel, Switzerland) 2020 Sep 15;25(18)
Neuronostatin Promotion Soluble Aβ1-42 Oligomers: Induced Dysfunctional Brain Glucose Metabolism in Mice.
Yang S, Zhou F, Ma M, Yuan Y, Zhao S, Yu P
Neurochemical research 2020 Oct;45(10):2474-2486
Neurochemical research 2020 Oct;45(10):2474-2486
Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.
Yang ZH, Li J, Chen WZ, Kong FS
Cell biochemistry and function 2020 Oct;38(7):943-954
Cell biochemistry and function 2020 Oct;38(7):943-954
LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.
Li Y, Zhang M, Li F
Histology and histopathology 2020 Oct;35(10):1171-1180
Histology and histopathology 2020 Oct;35(10):1171-1180
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Lv S, Yuan P, Dong J, Lu C, Li M, Qu F, Zhu Y, Yuan Z, Zhang J
Journal of cellular and molecular medicine 2020 Oct;24(19):11283-11293
Journal of cellular and molecular medicine 2020 Oct;24(19):11283-11293
Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene.
Wang X, Xu X, Jiang G, Zhang C, Liu L, Kang J, Wang J, Owusu L, Zhou L, Zhang L, Li W
Journal of cellular and molecular medicine 2020 Oct;24(19):11177-11187
Journal of cellular and molecular medicine 2020 Oct;24(19):11177-11187
Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway.
Gou Z, Su X, Hu X, Zhou Y, Huang L, Fan Y, Li J, Lu L
Brain research bulletin 2020 Oct;163:40-48
Brain research bulletin 2020 Oct;163:40-48
Protective effect of astaxanthin against La(2)O(3) nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Yuan L, Qu Y, Li Q, An T, Chen Z, Chen Y, Deng X, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Paired like homeodomain 1 and SAM and SH3 domain-containing 1 in the progression and prognosis of head and neck squamous cell carcinoma.
Jin Y, Qin X
The international journal of biochemistry & cell biology 2020 Oct;127:105846
The international journal of biochemistry & cell biology 2020 Oct;127:105846
Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors.
Ma Z, Liu K, Li XR, Wang C, Liu C, Yan DY, Deng Y, Liu W, Xu B
Cell death & disease 2020 Oct 8;11(10):834
Cell death & disease 2020 Oct 8;11(10):834
Myostatin-1 Inhibits Cell Proliferation by Inhibiting the mTOR Signal Pathway and MRFs, and Activating the Ubiquitin-Proteasomal System in Skeletal Muscle Cells of Japanese Flounder Paralichthys olivaceus.
Liu J, Pan M, Huang D, Guo Y, Yang M, Zhang W, Mai K
Cells 2020 Oct 29;9(11)
Cells 2020 Oct 29;9(11)
Phosphatidylinositol 4-kinase β is required for the ciliogenesis of zebrafish otic vesicle.
Feng Y, Yu P, Li J, Cao Y, Zhang J
Journal of genetics and genomics = Yi chuan xue bao 2020 Oct 20;47(10):627-636
Journal of genetics and genomics = Yi chuan xue bao 2020 Oct 20;47(10):627-636
Bazedoxifene inhibits PDGF-BB induced VSMC phenotypic switch via regulating the autophagy level.
Song W, Gao K, Huang P, Tang Z, Nie F, Jia S, Guo R
Life sciences 2020 Oct 15;259:118397
Life sciences 2020 Oct 15;259:118397
Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway.
Chen Y, Niu J, Li L, Li Z, Jiang J, Zhu M, Dong T, Zhang J, Shi C, Xu P, Lu Y, Jiang Y, Liu P, Chen W
Life sciences 2020 Oct 1;258:118158
Life sciences 2020 Oct 1;258:118158
Lamin B1 deficiency promotes malignancy and predicts poor prognosis in gastric cancer.
Yu ZY, Jiang XY, Zhao RR, Luo CJ, Ren YX, Ma ZJ, Ye HL, Shi WG, Wang C, Jiao ZY
Neoplasma 2020 Nov;67(6):1303-1313
Neoplasma 2020 Nov;67(6):1303-1313
Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma.
Li L, Huang K, Lu Z, Zhao H, Li H, Ye Q, Peng G
Oncology reports 2020 Nov;44(5):2185-2197
Oncology reports 2020 Nov;44(5):2185-2197
Pea-derived peptides, VLP, LLP, VA, and LL, improve insulin resistance in HepG2 cells via activating IRS-1/PI3K/AKT and blocking ROS-mediated p38MAPK signaling.
Zhu Y, Zhang H, Wei Y, Cai M, Gu R, Wang Y, Ma Y, Chen L
Journal of food biochemistry 2020 Nov;44(11):e13454
Journal of food biochemistry 2020 Nov;44(11):e13454
Hydroquinone inhibits PRV infection in neurons in vitro and in vivo.
Fang L, Gao Y, Lan M, Jiang P, Bai J, Li Y, Wang X
Veterinary microbiology 2020 Nov;250:108864
Veterinary microbiology 2020 Nov;250:108864
The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model.
Cui H, Cheng Y, He Y, Cheng W, Zhao W, Zhao H, Zhou FH, Wang L, Dong J, Cai S
Molecular medicine reports 2020 Nov;22(5):3723-3734
Molecular medicine reports 2020 Nov;22(5):3723-3734
Establishment and characterization of a docetaxel-resistant human prostate cancer cell line.
Liu J, Huang Y, Zhu D, Dai Y, Liu D, Zhai Y, Liang X, Wu L, Zhao Q
Oncology letters 2020 Nov;20(5):230
Oncology letters 2020 Nov;20(5):230
SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway.
Du Q, Chen J
Experimental and therapeutic medicine 2020 Nov;20(5):110
Experimental and therapeutic medicine 2020 Nov;20(5):110
Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate-induced colitis.
Liu M, Xie W, Wan X, Deng T
Experimental and therapeutic medicine 2020 Nov;20(5):10
Experimental and therapeutic medicine 2020 Nov;20(5):10
Extracellular ubiquitin protects cardiomyocytes during ischemia/hypoxia by inhibiting mitochondrial apoptosis pathway through CXCR4.
Ji Y, Yao J, He Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110787
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110787
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
Li T, Zhang L, Jin C, Xiong Y, Cheng YY, Chen K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110769
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110769
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Zhang H, Hui J, Yang J, Deng J, Fan D
European journal of pharmacology 2020 Nov 15;887:173557
European journal of pharmacology 2020 Nov 15;887:173557
Arsenic induces hepatic insulin resistance via mtROS-NLRP3 inflammasome pathway.
Jia X, Qiu T, Yao X, Jiang L, Wang N, Wei S, Tao Y, Pei P, Wang Z, Zhang J, Zhu Y, Yang G, Liu X, Liu S, Sun X
Journal of hazardous materials 2020 Nov 15;399:123034
Journal of hazardous materials 2020 Nov 15;399:123034
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
Zhang Y, Liu X, Yu M, Xu M, Xiao Y, Ma W, Huang L, Li X, Ye X
Life sciences 2020 Nov 1;260:118413
Life sciences 2020 Nov 1;260:118413
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Cai BB, Lu YN, Xu M
Acta pharmacologica Sinica 2020 May;41(5):650-660
Acta pharmacologica Sinica 2020 May;41(5):650-660
Kp-10 promotes bovine mammary epithelial cell proliferation by activating GPR54 and its downstream signaling pathways.
Li Y, Cao Y, Wang J, Fu S, Cheng J, Ma L, Zhang Q, Guo W, Kan X, Liu J
Journal of cellular physiology 2020 May;235(5):4481-4493
Journal of cellular physiology 2020 May;235(5):4481-4493
MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.
Zhang M, Li F, Wang X, Gong J, Xian Y, Wang G, Zheng Z, Shang C, Wang B, He Y, Wang W, Lin R
Histochemistry and cell biology 2020 May;153(5):357-366
Histochemistry and cell biology 2020 May;153(5):357-366
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
Yu YP, Cai LC, Wang XY, Cheng SY, Zhang DM, Jian WG, Wang TD, Yang JK, Yang KB, Zhang C
Cancer science 2020 May;111(5):1555-1566
Cancer science 2020 May;111(5):1555-1566
CRISPR/Cas9-Mediated miR-29b Editing as a Treatment of Different Types of Muscle Atrophy in Mice.
Li J, Wang L, Hua X, Tang H, Chen R, Yang T, Das S, Xiao J
Molecular therapy : the journal of the American Society of Gene Therapy 2020 May 6;28(5):1359-1372
Molecular therapy : the journal of the American Society of Gene Therapy 2020 May 6;28(5):1359-1372
MiR-193b-5p inhibits proliferation and enhances radio-sensitivity by downregulating the AKT/mTOR signaling pathway in tongue cancer.
Jiang L, He C, Zhang X, Chen Y, Li G
Translational cancer research 2020 Mar;9(3):1851-1860
Translational cancer research 2020 Mar;9(3):1851-1860
Silencing of DHX32 increases the proliferation of liver cancer cells.
Cai MJ, Zhu JH, He JQ, Zhang ZY, Liang XM
Translational cancer research 2020 Mar;9(3):1833-1842
Translational cancer research 2020 Mar;9(3):1833-1842
Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes.
Han P, Hanlon D, Arshad N, Lee JS, Tatsuno K, Robinson E, Filler R, Sobolev O, Cote C, Rivera-Molina F, Toomre D, Fahmy T, Edelson R
Science advances 2020 Mar;6(11):eaaz1580
Science advances 2020 Mar;6(11):eaaz1580
Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury.
Wang X, Liu M, Zhu MJ, Shi L, Liu L, Zhao YL, Cheng L, Gu YJ, Zhou MY, Chen L, Kumar A, Wang Y
Cell proliferation 2020 Mar;53(3):e12773
Cell proliferation 2020 Mar;53(3):e12773
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Xiao T, Sun J, Xing Z, Xie F, Yang L, Ding W
Cell biology international 2020 Mar;44(3):821-829
Cell biology international 2020 Mar;44(3):821-829
Do You Know the Details of Your PAX8 Antibody? Monoclonal PAX8 (MRQ-50) Is Not Expressed in a Series of 45 Medullary Thyroid Carcinomas.
Gucer H, Caliskan S, Kefeli M, Mete O
Endocrine pathology 2020 Mar;31(1):33-38
Endocrine pathology 2020 Mar;31(1):33-38
Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats.
Tan XH, Zhang KK, Xu JT, Qu D, Chen LJ, Li JH, Wang Q, Wang HJ, Xie XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111179
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111179
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
Tang W, Wang D, Shao L, Liu X, Zheng J, Xue Y, Ruan X, Yang C, Liu L, Ma J, Li Z, Liu Y
Molecular therapy. Nucleic acids 2020 Mar 6;19:905-921
Molecular therapy. Nucleic acids 2020 Mar 6;19:905-921
miR-552 Regulates Liver Tumor-Initiating Cell Expansion and Sorafenib Resistance.
Han T, Zhang Y, Yang X, Han L, Li H, Chen T, Zheng Z
Molecular therapy. Nucleic acids 2020 Mar 6;19:1073-1085
Molecular therapy. Nucleic acids 2020 Mar 6;19:1073-1085
Galectin-1 Overexpression Activates the FAK/PI3K/AKT/mTOR Pathway and Is Correlated with Upper Urinary Urothelial Carcinoma Progression and Survival.
Su YL, Luo HL, Huang CC, Liu TT, Huang EY, Sung MT, Lin JJ, Chiang PH, Chen YT, Kang CH, Cheng YT
Cells 2020 Mar 26;9(4)
Cells 2020 Mar 26;9(4)
LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway.
Zhang Y, Chen L, Cao Y, Chen S, Xu C, Xing J, Zhang K
Journal of gastric cancer 2020 Jun;20(2):139-151
Journal of gastric cancer 2020 Jun;20(2):139-151
Tolfenamic acid inhibits GSK-3β and PP2A mediated tau hyperphosphorylation in Alzheimer's disease models.
Zhang H, Wang X, Xu P, Ji X, Chi T, Liu P, Zou L
The journal of physiological sciences : JPS 2020 Jun 9;70(1):29
The journal of physiological sciences : JPS 2020 Jun 9;70(1):29
lncRNA PVT1 Promotes Tumorigenesis of Colorectal Cancer by Stabilizing miR-16-5p and Interacting with the VEGFA/VEGFR1/AKT Axis.
Wu H, Wei M, Jiang X, Tan J, Xu W, Fan X, Zhang R, Ding C, Zhao F, Shao X, Zhang Z, Shi R, Zhang W, Wu G
Molecular therapy. Nucleic acids 2020 Jun 5;20:438-450
Molecular therapy. Nucleic acids 2020 Jun 5;20:438-450
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Liu JZ, Hu YL, Feng Y, Jiang Y, Guo YB, Liu YF, Chen X, Yang JL, Chen YY, Mao QS, Xue WJ
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro.
Tan Y, Yin L, Sun Z, Shao S, Chen W, Man X, Du Y, Chen Y
International journal of biological macromolecules 2020 Jun 15;153:349-356
International journal of biological macromolecules 2020 Jun 15;153:349-356
TSPO ligand Ro5-4864 modulates microglia/macrophages polarization after subarachnoid hemorrhage in mice.
Zhou J, Zhang X, Peng J, Xie Y, Du F, Guo K, Feng Y, Zhang L, Chen L, Jiang Y
Neuroscience letters 2020 Jun 11;729:134977
Neuroscience letters 2020 Jun 11;729:134977
LAMC2 modulates the acidity of microenvironments to promote invasion and migration of pancreatic cancer cells via regulating AKT-dependent NHE1 activity.
Wang H, Cai J, Du S, Wei W, Shen X
Experimental cell research 2020 Jun 1;391(1):111984
Experimental cell research 2020 Jun 1;391(1):111984
Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway.
Han B, Jiang L, Jiang P, Zhou D, Jia X, Li X, Ye X
Planta medica 2020 Jul;86(11):767-775
Planta medica 2020 Jul;86(11):767-775
Prenatal High-Salt Diet-Induced Metabolic Disorders via Decreasing Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in Adult Male Rat Offspring.
Liu Y, Yang C, Feng X, Qi L, Guo J, Zhu D, Thai PN, Zhang Y, Zhang P, Sun M, Lv J, Zhang L, Xu Z, Lu X
Molecular nutrition & food research 2020 Jul;64(14):e2000196
Molecular nutrition & food research 2020 Jul;64(14):e2000196
Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.
Jiang F, Chen Y, Ren S, Li Z, Sun K, Xing Y, Zhu Y, Piao D
International journal of oncology 2020 Jul;57(1):183-196
International journal of oncology 2020 Jul;57(1):183-196
TGF‑β1 induces CREB1‑mediated miR‑1290 upregulation to antagonize lung fibrosis via Napsin A.
Guan S, Wu Y, Zhang Q, Zhou J
International journal of molecular medicine 2020 Jul;46(1):141-148
International journal of molecular medicine 2020 Jul;46(1):141-148
Fluid shear stress induces Runx-2 expression via upregulation of PIEZO1 in MC3T3-E1 cells.
Song J, Liu L, Lv L, Hu S, Tariq A, Wang W, Dang X
Cell biology international 2020 Jul;44(7):1491-1502
Cell biology international 2020 Jul;44(7):1491-1502
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, Qiu B, Tang B
Oncology reports 2020 Jul;44(1):103-114
Oncology reports 2020 Jul;44(1):103-114
AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway.
Chen Y, Cao W, Wang L, Zhong T
Journal of cellular and molecular medicine 2020 Jul;24(13):7652-7659
Journal of cellular and molecular medicine 2020 Jul;24(13):7652-7659
miR‑96 exerts an oncogenic role in the progression of cervical cancer by targeting CAV‑1.
Chen Y, Liu C, Xie B, Chen S, Zhuang Y, Zhang S
Molecular medicine reports 2020 Jul;22(1):543-550
Molecular medicine reports 2020 Jul;22(1):543-550
A novel antitumor dithiocarbamate compound inhibits the EGFR/AKT signaling pathway and induces apoptosis in esophageal cancer cells.
Yang Y, Tian Z, Zhao X, Li Y, Duan S
Oncology letters 2020 Jul;20(1):877-883
Oncology letters 2020 Jul;20(1):877-883
PRR11 and SKA2 promote the proliferation, migration and invasion of esophageal carcinoma cells.
Chen J, Yang HM, Zhou HC, Peng RR, Niu ZX, Kang CY
Oncology letters 2020 Jul;20(1):639-646
Oncology letters 2020 Jul;20(1):639-646
MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.
Wen X, Li H, Sun H, Zeng A, Lin R, Zhao J, Zhang Z
Life sciences 2020 Jul 15;253:117718
Life sciences 2020 Jul 15;253:117718
Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma.
Li D, Tang Z, Gao Z, Shen P, Liu Z, Dang X
Molecular and cellular biology 2020 Jul 14;40(15)
Molecular and cellular biology 2020 Jul 14;40(15)
Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.
Li T, Liu T, Chen X, Li L, Feng M, Zhang Y, Wan L, Zhang C, Yao W
Journal of neuroinflammation 2020 Jul 14;17(1):211
Journal of neuroinflammation 2020 Jul 14;17(1):211
Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy.
Xu D, Liu J, Ma H, Guo W, Wang J, Kan X, Li Y, Gong Q, Cao Y, Cheng J, Fu S
International immunopharmacology 2020 Jan;78:105983
International immunopharmacology 2020 Jan;78:105983
PCNA and GSK3β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis.
Liu XH, Tang DE, Dai Y, Gao XJ, Liu LX
Neoplasma 2020 Jan;67(1):15-26
Neoplasma 2020 Jan;67(1):15-26
Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway.
Wu P, Shi X, Luo M, Inam-U-Llah, Li K, Zhang M, Ma J, Li Y, Liu Y, Zhang C, Liu X, Li S, Li Q, Chen X, Che X, Piao F
Amino acids 2020 Jan;52(1):87-102
Amino acids 2020 Jan;52(1):87-102
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
Jiang ZH, Tang YZ, Song HN, Yang M, Li B, Ni CL
International journal of molecular medicine 2020 Jan;45(1):45-52
International journal of molecular medicine 2020 Jan;45(1):45-52
Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.
Li W, Jiang YH, Wang Y, Zhao M, Hou GJ, Hu HZ, Zhou L
Chinese journal of integrative medicine 2020 Jan;26(1):46-53
Chinese journal of integrative medicine 2020 Jan;26(1):46-53
Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
Zhu Y, Shi F, Wang M, Ding J
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820915958
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820915958
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway.
Meng Q, Xue H
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820905823
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820905823
Alisol A-24-acetate promotes glucose uptake via activation of AMPK in C2C12 myotubes.
Chen JX, Li HY, Li TT, Fu WC, Du X, Liu CH, Zhang W
BMC complementary medicine and therapies 2020 Jan 29;20(1):22
BMC complementary medicine and therapies 2020 Jan 29;20(1):22
FAM60A, increased by Helicobacter pylori, promotes proliferation and suppresses apoptosis of gastric cancer cells by targeting the PI3K/AKT pathway.
Yao X, Liu D, Zhou L, Xie Y, Li Y
Biochemical and biophysical research communications 2020 Jan 22;521(4):1003-1009
Biochemical and biophysical research communications 2020 Jan 22;521(4):1003-1009
MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury.
Yan Z, Zang B, Gong X, Ren J, Wang R
Life sciences 2020 Jan 15;241:117118
Life sciences 2020 Jan 15;241:117118
RETRACTED: Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis.
Guo SS, Liu R, Wen YF, Liu LT, Yuan L, Li YX, Li Y, Hao WW, Peng JY, Chen DN, Tang QN, Sun XS, Guo L, Mo HY, Qian CN, Zeng MS, Bei JX, Sun SY, Chen QY, Tang LQ, Mai HQ
Cancer letters 2020 Jan 1;468:27-40
Cancer letters 2020 Jan 1;468:27-40
Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.
Hua W, Li S, Luo R, Wu X, Zhang Y, Liao Z, Song Y, Wang K, Zhao K, Yang S, Yang C
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165575
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165575
Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis.
Tseng SH, Park ST, Lam B, Tsai YC, Cheng MA, Farmer E, Xing D, Hung CF
Journal for immunotherapy of cancer 2020 Feb;8(1)
Journal for immunotherapy of cancer 2020 Feb;8(1)
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
Hou B, Li W, Li J, Ma J, Xia P, Liu Z, Zeng Q, Zhang X, Chang D
Oncology reports 2020 Feb;43(2):536-548
Oncology reports 2020 Feb;43(2):536-548
Anti-insulin resistance effects of salidroside through mitochondrial quality control.
You B, Dun Y, Zhang W, Jiang L, Li H, Xie M, Liu Y, Liu S
The Journal of endocrinology 2020 Feb;244(2):383-393
The Journal of endocrinology 2020 Feb;244(2):383-393
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
He H, Xu C, Zheng L, Wang K, Jin M, Sun Y, Yue Z
Molecular medicine reports 2020 Feb;21(2):597-606
Molecular medicine reports 2020 Feb;21(2):597-606
Involvement of neurotrophic signaling in doxorubicin-induced cardiotoxicity.
Liao D, Zhang C, Liu N, Cao L, Wang C, Feng Q, Yao D, Long M, Jiang P
Experimental and therapeutic medicine 2020 Feb;19(2):1129-1135
Experimental and therapeutic medicine 2020 Feb;19(2):1129-1135
Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress.
Wang Y, Zhao H, Guo M, Fei D, Zhang L, Xing M
Journal of hazardous materials 2020 Feb 5;383:121217
Journal of hazardous materials 2020 Feb 5;383:121217
The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice.
Liu Q, Zhang S, Zhu D, Tang X, Che Y, Feng X
Behavioural brain research 2020 Feb 3;379:112337
Behavioural brain research 2020 Feb 3;379:112337
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.
Zeng Q, Zeng Y, Nie X, Guo Y, Zhan Y
Planta medica 2020 Dec;86(18):1401-1410
Planta medica 2020 Dec;86(18):1401-1410
Lycium barbarum polysaccharide protects against Homocysteine-induced Vascular smooth muscle cell proliferation and phenotypic transformation via PI3K/Akt pathway.
Zhang M, Li F, Pokharel S, Ma T, Wang X, Wang Y, Wang W, Lin R
Journal of molecular histology 2020 Dec;51(6):629-637
Journal of molecular histology 2020 Dec;51(6):629-637
Heat stress activates YAP/TAZ to induce the heat shock transcriptome.
Luo M, Meng Z, Moroishi T, Lin KC, Shen G, Mo F, Shao B, Wei X, Zhang P, Wei Y, Guan KL
Nature cell biology 2020 Dec;22(12):1447-1459
Nature cell biology 2020 Dec;22(12):1447-1459
Zinc application alleviates the adverse renal effects of arsenic stress in a protein quality control way in common carp.
Wang Y, Zhao H, Nie X, Guo M, Jiang G, Xing M
Environmental research 2020 Dec;191:110063
Environmental research 2020 Dec;191:110063
DHPAC, a novel microtubule depolymerizing agent, suppresses angiogenesis and vasculogenic mimicry formation of human non-small cell lung cancer.
Gong FL, Wang L, Yu LG, Dang YF, Jiang XN, Zhao L, Guo XL
Journal of cellular biochemistry 2020 Dec;121(12):4756-4771
Journal of cellular biochemistry 2020 Dec;121(12):4756-4771
Ssc-miR-21-5p regulates endometrial epithelial cell proliferation, apoptosis and migration via the PDCD4/AKT pathway.
Hua R, Zhang X, Li W, Lian W, Liu Q, Gao D, Wang Y, Lei M
Journal of cell science 2020 Dec 9;133(23)
Journal of cell science 2020 Dec 9;133(23)
Exploration of the Effects of Substrate Stiffness on Biological Responses of Neural Cells and Their Mechanisms.
Zhang C, Tan Y, Feng J, Huang C, Liu B, Fan Z, Xu B, Lu T
ACS omega 2020 Dec 8;5(48):31115-31125
ACS omega 2020 Dec 8;5(48):31115-31125
MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway.
Qiu C, Su W, Shen N, Qi X, Wu X, Wang K, Li L, Guo Z, Tao H, Wang G, Chen B, Xiang H
BMC cancer 2020 Dec 3;20(1):1187
BMC cancer 2020 Dec 3;20(1):1187
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Li Y, Liu M, Yi J, Song X, Zheng X, Liu D, Wang S, Chu C, Yang J
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Transplanting Rac1-silenced bone marrow mesenchymal stem cells promote neurological function recovery in TBI mice.
Huang D, Siaw-Debrah F, Wang H, Ye S, Wang K, Wu K, Zhang Y, Wang H, Yao C, Chen J, Yan L, Zhang CL, Zhuge Q, Yang J
Aging 2020 Dec 19;13(2):2822-2850
Aging 2020 Dec 19;13(2):2822-2850
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Xiao S, Li S, Yuan Z, Zhou L
Annals of translational medicine 2020 Aug;8(15):937
Annals of translational medicine 2020 Aug;8(15):937
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Zhou H, Yuan D, Gao W, Tian J, Sun H, Yu S, Wang J, Sun L
IUBMB life 2020 Aug;72(8):1659-1679
IUBMB life 2020 Aug;72(8):1659-1679
IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
Gao Y, Lu J, Zeng C, Yang J, Huang B, Zhang N, Li L, Fu X
Clinical and experimental medicine 2020 Aug;20(3):449-459
Clinical and experimental medicine 2020 Aug;20(3):449-459
Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.
Liu YC, Tsai JJ, Weng YS, Hsu FT
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110319
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110319
Liraglutide-loaded PLGA/gelatin electrospun nanofibrous mats promote angiogenesis to accelerate diabetic wound healing via the modulation of miR-29b-3p.
Yu M, Huang J, Zhu T, Lu J, Liu J, Li X, Yan X, Liu F
Biomaterials science 2020 Aug 7;8(15):4225-4238
Biomaterials science 2020 Aug 7;8(15):4225-4238
Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer.
Li JM, Yang F, Li J, Yuan WQ, Wang H, Luo YQ
Medical science monitor : international medical journal of experimental and clinical research 2020 Aug 7;26:e925298
Medical science monitor : international medical journal of experimental and clinical research 2020 Aug 7;26:e925298
NCOA5 is a master regulator of amino acid-induced mTOR activation and β-casein synthesis in bovine mammary epithelial cells.
Yuan X, Zhang L, Cui Y, Yu Y, Gao X, Ao J
Biochemical and biophysical research communications 2020 Aug 27;529(3):569-574
Biochemical and biophysical research communications 2020 Aug 27;529(3):569-574
Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway.
Yu M, Liu W, Li J, Lu J, Lu H, Jia W, Liu F
Stem cell research & therapy 2020 Aug 12;11(1):350
Stem cell research & therapy 2020 Aug 12;11(1):350
Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21(Waf1) signalling pathway.
Du S, Wang H, Cai J, Ren R, Zhang W, Wei W, Shen X
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):191-202
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):191-202
MicroRNA‑22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway.
Meng CY, Zhao ZQ, Bai R, Zhao W, Wang YX, Xue HQ, Sun L, Sun C, Feng W, Guo SB
Oncology reports 2020 Apr;43(4):1169-1186
Oncology reports 2020 Apr;43(4):1169-1186
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Zhan D, Zhang X, Li J, Ding X, Cui Y, Jia J
Cancer biotherapy & radiopharmaceuticals 2020 Apr;35(3):223-232
Cancer biotherapy & radiopharmaceuticals 2020 Apr;35(3):223-232
Suppression of CLEC3A inhibits osteosarcoma cell proliferation and promotes their chemosensitivity through the AKT1/mTOR/HIF1α signaling pathway.
Ren C, Pan R, Hou L, Wu H, Sun J, Zhang W, Tian X, Chen H
Molecular medicine reports 2020 Apr;21(4):1739-1748
Molecular medicine reports 2020 Apr;21(4):1739-1748
Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1.
Sun X, Yang S, Song W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109731
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109731
Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease.
Fang X, Zhou X, Miao Y, Han Y, Wei J, Chen T
AMB Express 2020 Apr 24;10(1):80
AMB Express 2020 Apr 24;10(1):80
Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice.
Wang C, Le Y, Lu D, Zhao M, Dou X, Zhang Q
Journal of hazardous materials 2020 Apr 15;388:121732
Journal of hazardous materials 2020 Apr 15;388:121732
Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs.
Li H, Liu S, Hu Y, Zhao B, Sun Y, Xu D
Ecotoxicology and environmental safety 2020 Apr 1;192:110267
Ecotoxicology and environmental safety 2020 Apr 1;192:110267
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
Chen Y, Liu P, Sun P, Jiang J, Zhu Y, Dong T, Cui Y, Tian Y, An T, Zhang J, Li Z, Yang X
Theranostics 2019;9(5):1453-1473
Theranostics 2019;9(5):1453-1473
CAPE-pNO(2) Inhibited the Growth and Metastasis of Triple-Negative Breast Cancer via the EGFR/STAT3/Akt/E-Cadherin Signaling Pathway.
Huang Q, Li S, Zhang L, Qiao X, Zhang Y, Zhao X, Xiao G, Li Z
Frontiers in oncology 2019;9:461
Frontiers in oncology 2019;9:461
Hsa_circ_001569 is an unfavorable prognostic factor and promotes cell proliferation and metastasis by modulating PI3K-AKT pathway in breast cancer.
Xu JH, Wang Y, Xu D
Cancer biomarkers : section A of Disease markers 2019;25(2):193-201
Cancer biomarkers : section A of Disease markers 2019;25(2):193-201
A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation.
Ye Z, Zhang S, Liu Y, Wang S, Zhang J, Huang R
Mediators of inflammation 2019;2019:8709583
Mediators of inflammation 2019;2019:8709583
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway.
Huang F, Chen J, Wang J, Zhu P, Lin W
BioMed research international 2019;2019:8171989
BioMed research international 2019;2019:8171989
Oleic Acid Protects against Hepatic Ischemia and Reperfusion Injury in Mice by Inhibiting AKT/mTOR Pathways.
Guo J, Zhang T, Gu J, Cai K, Deng X, Chen K, Huang K, Wang G, Li H, Wang J
Oxidative medicine and cellular longevity 2019;2019:4842592
Oxidative medicine and cellular longevity 2019;2019:4842592
VEGF Induce Vasculogenic Mimicry of Choroidal Melanoma through the PI3k Signal Pathway.
Xu X, Zong Y, Gao Y, Sun X, Zhao H, Luo W, Jia S
BioMed research international 2019;2019:3909102
BioMed research international 2019;2019:3909102
Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB).
Ma Q, Gao Y, Xu P, Li K, Xu X, Gao J, Qi Y, Xu J, Yang Y, Song W, He X, Liu S, Yuan X, Yin W, He Y, Pan W, Wei L, Zhang J
BioMed research international 2019;2019:3235021
BioMed research international 2019;2019:3235021
MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway.
Lin Z, Liu Z, Wang X, Qiu C, Zheng S
BioMed research international 2019;2019:2821731
BioMed research international 2019;2019:2821731
CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression.
Liu Y, Zhang S, Xue J, Wei Z, Ao P, Shen B, Ding L
Oxidative medicine and cellular longevity 2019;2019:2053149
Oxidative medicine and cellular longevity 2019;2019:2053149
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Zhang C, Wang B, Wang X, Sheng X, Cui Y
Cancer cell international 2019;19:339
Cancer cell international 2019;19:339
Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways.
Jin Y, Li Y, Wang X, Yang Y
Cancer cell international 2019;19:220
Cancer cell international 2019;19:220
Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K/Akt pathway.
Zeng J, Li X, Cheng Y, Ke B, Wang R
International journal of clinical and experimental pathology 2019;12(11):4096-4105
International journal of clinical and experimental pathology 2019;12(11):4096-4105
ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma.
Ye Z, Zeng Z, Shen Y, Yang Q, Chen D, Chen Z, Shen S
OncoTargets and therapy 2019;12:4081-4092
OncoTargets and therapy 2019;12:4081-4092
Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin.
Dong C, Liu X, Wang H, Li J, Dai L, Li J, Xu Z
OncoTargets and therapy 2019;12:1947-1956
OncoTargets and therapy 2019;12:1947-1956
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
Qu L, Chen C, He W, Chen Y, Li Y, Wen Y, Zhou S, Jiang Y, Yang X, Zhang R, Shen L
American journal of translational research 2019;11(4):2042-2055
American journal of translational research 2019;11(4):2042-2055
A combination of low-dose decitabine and chidamide resulted in synergistic effects on the proliferation and apoptosis of human myeloid leukemia cell lines.
Xu F, Guo H, Shi M, Liu S, Wei M, Sun K, Chen Y
American journal of translational research 2019;11(12):7644-7655
American journal of translational research 2019;11(12):7644-7655
Rutin suppresses FNDC1 expression in bone marrow mesenchymal stem cells to inhibit postmenopausal osteoporosis.
Xiao Y, Wei R, Yuan Z, Lan X, Kuang J, Hu D, Song Y, Luo J
American journal of translational research 2019;11(10):6680-6690
American journal of translational research 2019;11(10):6680-6690
HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells.
Pan C, Liu Q, Wu X
Cancer management and research 2019;11:10145-10156
Cancer management and research 2019;11:10145-10156
Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway.
Lin J, Jiao A, Lv W, Zhang C, Shi Y, Yang Z, Sun N, Li X, Zhang J
Frontiers in pharmacology 2019;10:896
Frontiers in pharmacology 2019;10:896
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Qiao X, Zhou ZC, Niu R, Su YT, Sun Y, Liu HL, Teng JL, Ye JN, Shi H, Yang CD, Cheng XB
Frontiers in pharmacology 2019;10:855
Frontiers in pharmacology 2019;10:855
Hydroxytyrosol Improves Obesity and Insulin Resistance by Modulating Gut Microbiota in High-Fat Diet-Induced Obese Mice.
Liu Z, Wang N, Ma Y, Wen D
Frontiers in microbiology 2019;10:390
Frontiers in microbiology 2019;10:390
The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.
Suo L, Chang X, Xu N, Ji H
Frontiers in endocrinology 2019;10:370
Frontiers in endocrinology 2019;10:370
Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt.
Xu F, Xiao H, Liu R, Yang Y, Zhang M, Chen L, Chen Z, Liu P, Huang H
Frontiers in pharmacology 2019;10:261
Frontiers in pharmacology 2019;10:261
RasGRP1 is a target for VEGF to induce angiogenesis and involved in the endothelial-protective effects of metformin under high glucose in HUVECs.
Xu J, Liu M, Yu M, Shen J, Zhou J, Hu J, Zhou Y, Zhang W
IUBMB life 2019 Sep;71(9):1391-1400
IUBMB life 2019 Sep;71(9):1391-1400
Catalpol ameliorates advanced glycation end product-induced dysfunction of glomerular endothelial cells via regulating nitric oxide synthesis by inducible nitric oxide synthase and endothelial nitric oxide synthase.
Sun W, Gao Y, Ding Y, Cao Y, Chen J, Lv G, Lu J, Yu B, Peng M, Xu H, Sun Y
IUBMB life 2019 Sep;71(9):1268-1283
IUBMB life 2019 Sep;71(9):1268-1283
Hedyotis diffusa Willd. inhibits VEGF‑C‑mediated lymphangiogenesis in colorectal cancer via multiple signaling pathways.
Li H, Lai Z, Yang H, Peng J, Chen Y, Lin J
Oncology reports 2019 Sep;42(3):1225-1236
Oncology reports 2019 Sep;42(3):1225-1236
DEPDC1 drives hepatocellular carcinoma cell proliferation, invasion and angiogenesis by regulating the CCL20/CCR6 signaling pathway.
Guo W, Li H, Liu H, Ma X, Yang S, Wang Z
Oncology reports 2019 Sep;42(3):1075-1089
Oncology reports 2019 Sep;42(3):1075-1089
Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8(+) T cell recruitment.
Diao W, Chen W, Cao W, Yuan H, Ji H, Wang T, Chen W, Zhu X, Zhou H, Guo H, Zhao X
Biochimica et biophysica acta. General subjects 2019 Sep;1863(9):1360-1370
Biochimica et biophysica acta. General subjects 2019 Sep;1863(9):1360-1370
Hydroxytyrosol prevents PM(2.5)-induced adiposity and insulin resistance by restraining oxidative stress related NF-κB pathway and modulation of gut microbiota in a murine model.
Wang N, Ma Y, Liu Z, Liu L, Yang K, Wei Y, Liu Y, Chen X, Sun X, Wen D
Free radical biology & medicine 2019 Sep;141:393-407
Free radical biology & medicine 2019 Sep;141:393-407
Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia.
Cui K, Luan Y, Tang Z, Li CC, Wang T, Wang SG, Chen Z, Liu JH
Asian journal of andrology 2019 Sep-Oct;21(5):508-515
Asian journal of andrology 2019 Sep-Oct;21(5):508-515
Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma.
Zhong B, Shi D, Wu F, Wang S, Hu H, Cheng C, Qing X, Huang X, Luo X, Zhang Z, Shao Z
Cell death & disease 2019 Sep 18;10(10):687
Cell death & disease 2019 Sep 18;10(10):687
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Jing L, Jiang JR, Liu DM, Sheng JW, Zhang WF, Li ZJ, Wei LY
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.
Guan P, Sun ZM, Wang N, Zhou J, Luo LF, Zhao YS, Ji ES
Life sciences 2019 Sep 15;233:116748
Life sciences 2019 Sep 15;233:116748
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
Wang X, Luo C, Mao XY, Li X, Yin JY, Zhang W, Zhou HH, Liu ZQ
Brain research 2019 Sep 15;1719:30-39
Brain research 2019 Sep 15;1719:30-39
The double inhibition of PDK1 and STAT3-Y705 prevents liver metastasis in colorectal cancer.
Qin W, Tian Y, Zhang J, Liu W, Zhou Q, Hu S, Yang F, Lu L, Lu H, Cui S, Wen L, Wei S
Scientific reports 2019 Sep 10;9(1):12973
Scientific reports 2019 Sep 10;9(1):12973
MiR-92a regulates endothelial progenitor cells (EPCs) by targeting GDF11 via activate SMAD2/3/FAK/Akt/eNOS pathway.
Huang HT, Liu ZC, Wu KQ, Gu SR, Lu TC, Zhong CJ, Zhou YX
Annals of translational medicine 2019 Oct;7(20):563
Annals of translational medicine 2019 Oct;7(20):563
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
Wen N, Guo B, Zheng H, Xu L, Liang H, Wang Q, Wang D, Chen X, Zhang S, Li Y, Zhang L
International journal of oncology 2019 Oct;55(4):879-895
International journal of oncology 2019 Oct;55(4):879-895
Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells.
Chen L, Cheng X, Tu W, Qi Z, Li H, Liu F, Yang Y, Zhang Z, Wang Z
Cellular oncology (Dordrecht, Netherlands) 2019 Oct;42(5):679-690
Cellular oncology (Dordrecht, Netherlands) 2019 Oct;42(5):679-690
TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.
Wu X, Li S, Wang K, Hua W, Li S, Song Y, Zhang Y, Yang S, Yang C
Inflammation 2019 Oct;42(5):1575-1584
Inflammation 2019 Oct;42(5):1575-1584
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
Dai B, Yu R, Fan M, Yang T, Wang B, Zhang Y
Oncology reports 2019 Oct;42(4):1451-1458
Oncology reports 2019 Oct;42(4):1451-1458
The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation.
Zhao H, Wang Y, Liu J, Guo M, Fei D, Yu H, Xing M
Environmental pollution (Barking, Essex : 1987) 2019 Oct;253:741-748
Environmental pollution (Barking, Essex : 1987) 2019 Oct;253:741-748
Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration.
Wang K, Zhu TN, Zhao RJ
Molecular medicine reports 2019 Oct;20(4):3671-3678
Molecular medicine reports 2019 Oct;20(4):3671-3678
CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK(½)/mTOR signaling pathways in oral squamous cell carcinomas.
Gao L, Dou ZC, Ren WH, Li SM, Liang X, Zhi KQ
Cell death & disease 2019 Oct 3;10(10):745
Cell death & disease 2019 Oct 3;10(10):745
The clinical characteristics and molecular mechanism of pituitary adenoma associated with meningioma.
Zhu H, Miao Y, Shen Y, Guo J, Xie W, Zhao S, Dong W, Zhang Y, Li C
Journal of translational medicine 2019 Oct 29;17(1):354
Journal of translational medicine 2019 Oct 29;17(1):354
NT3(P75-2) gene-modified bone mesenchymal stem cells improve neurological function recovery in mouse TBI model.
Wu K, Huang D, Zhu C, Kasanga EA, Zhang Y, Yu E, Zhang H, Ni Z, Ye S, Zhang C, Hu J, Zhuge Q, Yang J
Stem cell research & therapy 2019 Oct 24;10(1):311
Stem cell research & therapy 2019 Oct 24;10(1):311
12N-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells.
Bao Y, Pang Y, Tang S, Niu T, Guo Z, He H, Li Y, Song D
Molecules (Basel, Switzerland) 2019 Oct 17;24(20)
Molecules (Basel, Switzerland) 2019 Oct 17;24(20)
MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis.
Xu W, Li J, Tian H, Wang R, Feng Y, Tang J, Jia J
Molecular medicine reports 2019 Nov;20(5):4594-4602
Molecular medicine reports 2019 Nov;20(5):4594-4602
Brain-derived neurotrophic factor induces thioredoxin-1 expression through TrkB/Akt/CREB pathway in SH-SY5Y cells.
Bai L, Zhang S, Zhou X, Li Y, Bai J
Biochimie 2019 May;160:55-60
Biochimie 2019 May;160:55-60
Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.
Yang F, Lin ZW, Huang TY, Chen TT, Cui J, Li MY, Hua YQ
Scientific reports 2019 May 6;9(1):6991
Scientific reports 2019 May 6;9(1):6991
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Cao D, Qi Z, Pang Y, Li H, Xie H, Wu J, Huang Y, Zhu Y, Shen Y, Zhu Y, Dai B, Hu X, Ye D, Wang Z
Cancer research 2019 May 15;79(10):2604-2618
Cancer research 2019 May 15;79(10):2604-2618
Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways.
Yang H, Liu JX, Shang HX, Lin S, Zhao JY, Lin JM
World journal of gastrointestinal oncology 2019 May 15;11(5):377-392
World journal of gastrointestinal oncology 2019 May 15;11(5):377-392
Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.
Li Z, Chen Y, An T, Liu P, Zhu J, Yang H, Zhang W, Dong T, Jiang J, Zhang Y, Jiang M, Yang X
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139
Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells.
Zhou T, Sun Y, Wang Y, Chen X, Zhuo L, Bu L, Xu S, Han J, Li X, Shi J
Inflammation 2019 Jun;42(3):987-993
Inflammation 2019 Jun;42(3):987-993
MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte.
Wan GX, Cheng L, Qin HL, Zhang YZ, Wang LY, Zhang YG
Cardiovascular toxicology 2019 Jun;19(3):264-275
Cardiovascular toxicology 2019 Jun;19(3):264-275
Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN.
Lu Q, Liu T, Feng H, Yang R, Zhao X, Chen W, Jiang B, Qin H, Guo X, Liu M, Li L, Guo H
Molecular cancer 2019 Jun 22;18(1):111
Molecular cancer 2019 Jun 22;18(1):111
Knockdown of endothelin receptor B inhibits the progression of triple-negative breast cancer.
Gu X, Han S, Cui M, Xue J, Ai L, Sun L, Zhu X, Wang Y, Liu C
Annals of the New York Academy of Sciences 2019 Jul;1448(1):5-18
Annals of the New York Academy of Sciences 2019 Jul;1448(1):5-18
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Sun Z, Liu Y, Yu F, Xu Y, Yanli L, Liu N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Taurine protects against arsenic trioxide-induced insulin resistance via ROS-Autophagy pathway in skeletal muscle.
Yang L, Qiu T, Yao X, Jiang L, Wei S, Pei P, Wang Z, Bai J, Liu X, Yang G, Liu S, Sun X
The international journal of biochemistry & cell biology 2019 Jul;112:50-60
The international journal of biochemistry & cell biology 2019 Jul;112:50-60
Thyroid hormone (T(3)) is involved in inhibiting the proliferation of newborn calf Sertoli cells via the PI3K/Akt signaling pathway in vitro.
Wang C, Zheng P, Adeniran SO, Ma M, Huang F, Adegoke EO, Zhang G
Theriogenology 2019 Jul 15;133:1-9
Theriogenology 2019 Jul 15;133:1-9
Characterization, functional and signaling elucidation of pigeon (Columba livia) interferon-α: Knockdown p53 negatively modulates antiviral response.
Li S, Wang Y, Zhao H, Shao Y, Liu J, Xing M
Developmental and comparative immunology 2019 Jan;90:29-40
Developmental and comparative immunology 2019 Jan;90:29-40
Everolimus Reverses Palbociclib Resistance in ER+ Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase(PI3K)/Akt/Mammalian Target of Rapamycin (mTOR) Pathway.
Chen L, Yang G, Dong H
Medical science monitor : international medical journal of experimental and clinical research 2019 Jan 3;25:77-86
Medical science monitor : international medical journal of experimental and clinical research 2019 Jan 3;25:77-86
Involvement of Hepatic SHIP2 and PI3K/Akt Signalling in the Regulation of Plasma Insulin by Xiaoyaosan in Chronic Immobilization-Stressed Rats.
Pan Q, Wu J, Liu Y, Li X, Chen J
Molecules (Basel, Switzerland) 2019 Jan 29;24(3)
Molecules (Basel, Switzerland) 2019 Jan 29;24(3)
Long noncoding FOXD2-AS1 is activated by CREB1 and promotes cell proliferation and metastasis in glioma by sponging miR-185 through targeting AKT1.
Dong H, Cao W, Xue J
Biochemical and biophysical research communications 2019 Jan 22;508(4):1074-1081
Biochemical and biophysical research communications 2019 Jan 22;508(4):1074-1081
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Zhu BL, Long Y, Luo W, Yan Z, Lai YJ, Zhao LG, Zhou WH, Wang YJ, Shen LL, Liu L, Deng XJ, Wang XF, Sun F, Chen GJ
Brain : a journal of neurology 2019 Jan 1;142(1):176-192
Brain : a journal of neurology 2019 Jan 1;142(1):176-192
Testosterone preserves endothelial function through regulation of S1P1/Akt/FOXO3a signalling pathway in the rat corpus cavernosum.
Cui K, Li R, Liu K, Wang T, Liu J, Rao K
Andrologia 2019 Feb;51(1):e13173
Andrologia 2019 Feb;51(1):e13173
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Zhang X, Liu J, Gu Y, Sun C, Qu F
Cell biology international 2019 Feb;43(2):158-166
Cell biology international 2019 Feb;43(2):158-166
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Ma H, Yu Y, Wang M, Li Z, Xu H, Tian C, Zhang J, Ye X, Li X
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells.
Tan F, Huang Y, Pei Q, Liu H, Pei H, Zhu H
Journal of cellular biochemistry 2019 Feb;120(2):2213-2225
Journal of cellular biochemistry 2019 Feb;120(2):2213-2225
Low density lipoprotein mimics insulin action on autophagy and glucose uptake in endothelial cells.
Zhu L, Wu G, Yang X, Jia X, Li J, Bai X, Li W, Zhao Y, Li Y, Cheng W, Liu S, Jin S
Scientific reports 2019 Feb 28;9(1):3020
Scientific reports 2019 Feb 28;9(1):3020
Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury.
Bei Y, Pan LL, Zhou Q, Zhao C, Xie Y, Wu C, Meng X, Gu H, Xu J, Zhou L, Sluijter JPG, Das S, Agerberth B, Sun J, Xiao J
BMC medicine 2019 Feb 20;17(1):42
BMC medicine 2019 Feb 20;17(1):42
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Zhang Y, Li Q, Yu S, Zhu C, Zhang Z, Cao H, Xu J
Biochemical and biophysical research communications 2019 Feb 12;509(3):753-762
Biochemical and biophysical research communications 2019 Feb 12;509(3):753-762
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Zhang D, Zhang J, Zeng J, Li Z, Zuo H, Huang C, Zhao X
Journal of biomedical nanotechnology 2019 Feb 1;15(2):288-300
Journal of biomedical nanotechnology 2019 Feb 1;15(2):288-300
Indoxyl sulfate-induced calcification of vascular smooth muscle cells via the PI3K/Akt/NF-κB signaling pathway.
He X, Jiang H, Gao F, Liang S, Wei M, Chen L
Microscopy research and technique 2019 Dec;82(12):2000-2006
Microscopy research and technique 2019 Dec;82(12):2000-2006
Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model.
Wang J, Wan D, Wan G, Wang J, Zhang J, Zhu H
Annals of translational medicine 2019 Dec;7(23):756
Annals of translational medicine 2019 Dec;7(23):756
PP2Ac upregulates PI3K-Akt signaling and induces hepatocyte apoptosis in liver donor after brain death.
Xiong Y, Lan J, Huang K, Zhang Y, Zheng L, Wang Y, Ye Q
Apoptosis : an international journal on programmed cell death 2019 Dec;24(11-12):921-933
Apoptosis : an international journal on programmed cell death 2019 Dec;24(11-12):921-933
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin YE, Coppé JP, Lam EW, Campisi J, Sun Y
Aging cell 2019 Dec;18(6):e13027
Aging cell 2019 Dec;18(6):e13027
Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways.
Zhu B, Ren C, Du K, Zhu H, Ai Y, Kang F, Luo Y, Liu W, Wang L, Xu Y, Jiang X, Zhang Y
Biochemical pharmacology 2019 Dec;170:113642
Biochemical pharmacology 2019 Dec;170:113642
Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.
Tateyama H, Murase Y, Higuchi H, Inasaka Y, Kaneoka H, Iijima S, Nishijima KI
Immunology 2019 Dec;158(4):340-352
Immunology 2019 Dec;158(4):340-352
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
Wang J, Li L, Wang J, Song L, Tan N, Wang Z
Cells 2019 Dec 7;8(12)
Cells 2019 Dec 7;8(12)
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Wang Z, Liang M, Li H, Cai L, Yang L
International journal of molecular sciences 2019 Dec 6;20(24)
International journal of molecular sciences 2019 Dec 6;20(24)
PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling.
Gao H, Zhang J, Ren X
Bioscience reports 2019 Dec 20;39(12)
Bioscience reports 2019 Dec 20;39(12)
Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K /Akt/mTOR pathway.
Liu JZ, Hu YL, Feng Y, Guo YB, Liu YF, Yang JL, Mao QS, Xue WJ
Experimental cell research 2019 Dec 15;385(2):111691
Experimental cell research 2019 Dec 15;385(2):111691
Paper/polymer composited microfluidic platform for screening cell viability and protein expression under a chemical gradient environment.
Lei KF, Goh A, Huang CH
Talanta 2019 Dec 1;205:120124
Talanta 2019 Dec 1;205:120124
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Wu XT, Ansari AR, Pang XX, Li HZ, Zhang ZW, Luo Y, Arshad M, Song H
Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261
Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261
Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway.
Ming-Yan Y, Jing Z, Shu-Qin G, Xiao-Liang B, Zhi-Hong L, Xue Z
Bioscience reports 2019 Aug 30;39(8)
Bioscience reports 2019 Aug 30;39(8)
Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells.
Gao L, Wang Z, Lu D, Huang J, Liu J, Hong L
Cell death & disease 2019 Aug 13;10(8):609
Cell death & disease 2019 Aug 13;10(8):609
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2019 Aug 1;424:152236
Toxicology 2019 Aug 1;424:152236
Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3β pathway in lung adenocarcinoma.
Wang Y, Piao J, Wang Q, Cui X, Meng Z, Jin T, Lin Z
Human pathology 2019 Apr;86:233-242
Human pathology 2019 Apr;86:233-242
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Liang H, Mokrani A, Chisomo-Kasiya H, Ji K, Ge X, Ren M, Liu B, Xi B, Sun A
Fish physiology and biochemistry 2019 Apr;45(2):719-732
Fish physiology and biochemistry 2019 Apr;45(2):719-732
Taurine improves low-level inorganic arsenic-induced insulin resistance by activating PPARγ-mTORC2 signalling and inhibiting hepatic autophagy.
Gao N, Yao X, Jiang L, Yang L, Qiu T, Wang Z, Pei P, Yang G, Liu X, Sun X
Journal of cellular physiology 2019 Apr;234(4):5143-5152
Journal of cellular physiology 2019 Apr;234(4):5143-5152
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, Sun H, Qi Y, Fang L, Liu K, Peng J
British journal of pharmacology 2019 Apr;176(7):919-937
British journal of pharmacology 2019 Apr;176(7):919-937
TMEM30A deficiency in endothelial cells impairs cell proliferation and angiogenesis.
Zhang S, Liu W, Yang Y, Sun K, Li S, Xu H, Yang M, Zhang L, Zhu X
Journal of cell science 2019 Apr 3;132(7)
Journal of cell science 2019 Apr 3;132(7)
Immunomodulatory effects of an acidic polysaccharide fraction from herbal Gynostemma pentaphyllum tea in RAW264.7 cells.
Ren D, Zhao Y, Zheng Q, Alim A, Yang X
Food & function 2019 Apr 1;10(4):2186-2197
Food & function 2019 Apr 1;10(4):2186-2197
Protective Effect of Extract of Bletilla Striata on Isoflurane Induced Neuronal Injury By Altering PI3K/Akt Pathway.
Zhao G, Li K, Chen J, Li L
Translational neuroscience 2018;9:183-189
Translational neuroscience 2018;9:183-189
A somatic mutation of RasGRP3 decreases Na(+)/I(-) symporter expression in metastases of radioactive iodine-refractory thyroid cancer by stimulating the Akt signaling pathway.
Song J, Qiu W, Deng X, Qiu Z, Fan Y, Yang Z
American journal of cancer research 2018;8(9):1847-1855
American journal of cancer research 2018;8(9):1847-1855
Astragaloside IV Improves Vasodilatation Function by Regulating the PI3K/Akt/eNOS Signaling Pathway in Rat Aorta Endothelial Cells.
Lin XP, Cui HJ, Yang AL, Luo JK, Tang T
Journal of vascular research 2018;55(3):169-176
Journal of vascular research 2018;55(3):169-176
The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction.
Ye C, Zhang C, Huang H, Yang B, Xiao G, Kong D, Tian Q, Song Q, Song Y, Tan H, Wang Y, Zhou T, Zi X, Sun Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1230-1244
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1230-1244
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Gao Y, Yu H, Liu Y, Liu X, Zheng J, Ma J, Gong W, Chen J, Zhao L, Tian Y, Xue Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(1):131-147
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(1):131-147
Epithelial Cells Attenuate Toll-Like Receptor-Mediated Inflammatory Responses in Monocyte-Derived Macrophage-Like Cells to Mycobacterium tuberculosis by Modulating the PI3K/Akt/mTOR Signaling Pathway.
Yang Y, Sun Y, Xu J, Bao K, Luo M, Liu X, Wang Y
Mediators of inflammation 2018;2018:3685948
Mediators of inflammation 2018;2018:3685948
CD300A inhibits tumor cell growth by downregulating AKT phosphorylation in human glioblastoma multiforme.
Du X, Liu B, Ding Q, He D, Zhang R, Yang F, Fan H, Teng L, Xin T
International journal of clinical and experimental pathology 2018;11(7):3471-3478
International journal of clinical and experimental pathology 2018;11(7):3471-3478
BCAT1 promotes proliferation of endometrial cancer cells through reprogrammed BCAA metabolism.
Wang P, Wu S, Zeng X, Zhang Y, Zhou Y, Su L, Lin W
International journal of clinical and experimental pathology 2018;11(12):5536-5546
International journal of clinical and experimental pathology 2018;11(12):5536-5546
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
Jiang T, Zhou ML, Fan J
OncoTargets and therapy 2018;11:7865-7872
OncoTargets and therapy 2018;11:7865-7872
GPX3 suppresses tumor migration and invasion via the FAK/AKT pathway in esophageal squamous cell carcinoma.
Zhu X, Wang J, Li L, Deng L, Wang J, Liu L, Zeng R, Wang Q, Zheng Y
American journal of translational research 2018;10(6):1908-1920
American journal of translational research 2018;10(6):1908-1920
Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway.
Zhou W, Wang J, Qi Q, Feng Z, Huang B, Chen A, Zhang D, Li W, Zhang Q, Bjerkvig R, Li X, Wang J
Cancer medicine 2018 Sep;7(9):4729-4743
Cancer medicine 2018 Sep;7(9):4729-4743
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
Du Y, Wang L, Chen S, Liu Y, Zhao Y
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart.
Liu F, Wen Y, Kang J, Wei C, Wang M, Zheng Z, Peng J
International journal of molecular medicine 2018 Sep;42(3):1436-1444
International journal of molecular medicine 2018 Sep;42(3):1436-1444
UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT pathway in N2A cells.
Huang Y, Hu Z
Journal of cellular physiology 2018 Sep;233(9):7480-7496
Journal of cellular physiology 2018 Sep;233(9):7480-7496
Triptolide protects podocytes via autophagy in immunoglobulin A nephropathy.
Liang S, Jin J, Shen X, Jiang X, Li Y, He Q
Experimental and therapeutic medicine 2018 Sep;16(3):2275-2280
Experimental and therapeutic medicine 2018 Sep;16(3):2275-2280
miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN.
Nie X, Fan J, Li H, Yin Z, Zhao Y, Dai B, Dong N, Chen C, Wang DW
Molecular therapy. Nucleic acids 2018 Sep 7;12:254-266
Molecular therapy. Nucleic acids 2018 Sep 7;12:254-266
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Batool S, Joseph TP, Hussain M, Vuai MS, Khinsar KH, Din SRU, Padhiar AA, Zhong M, Ning A, Zhang W, Cao J, Huang M
International journal of molecular sciences 2018 Sep 30;19(10)
International journal of molecular sciences 2018 Sep 30;19(10)
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
Zou W, Ding F, Niu C, Fu Z, Liu S
Biochemical and biophysical research communications 2018 Sep 18;503(4):3212-3218
Biochemical and biophysical research communications 2018 Sep 18;503(4):3212-3218
DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway.
Xue Y, Jia X, Li L, Dong X, Ling J, Yuan J, Li Q
Biochemical and biophysical research communications 2018 Sep 18;503(4):2885-2891
Biochemical and biophysical research communications 2018 Sep 18;503(4):2885-2891
ZKSCAN3 promotes breast cancer cell proliferation, migration and invasion.
Chi Y, Xu H, Wang F, Chen X, Shan Z, Sun Y, Fan Q
Biochemical and biophysical research communications 2018 Sep 18;503(4):2583-2589
Biochemical and biophysical research communications 2018 Sep 18;503(4):2583-2589
Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor κB-Matrix Metalloproteinase Signaling.
Wang Y, Wang Y, Liu Z, Dong W, Yang B, Xia X, Song E, Song Y
Chemical research in toxicology 2018 Sep 17;31(9):954-963
Chemical research in toxicology 2018 Sep 17;31(9):954-963
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
Xu N, Fan W, Zhou X, Liu Y, Ma P, Qi S, Gu B
Metabolic brain disease 2018 Oct;33(5):1625-1633
Metabolic brain disease 2018 Oct;33(5):1625-1633
T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase(mTORC2/AKT) to Promote Ca(2+)Production.
Wang J, Yang C, Yuan Z, Yi J, Wu J
International journal of molecular sciences 2018 Oct 27;19(11)
International journal of molecular sciences 2018 Oct 27;19(11)
PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Yang T, Ren C, Qiao P, Han X, Wang L, Lv S, Sun Y, Liu Z, Du Y, Yu Z
Oncogene 2018 Nov;37(45):5997-6009
Oncogene 2018 Nov;37(45):5997-6009
Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells in vitro.
Huang C, Ji X, Peng Y, Wu M, Wu W, Luo Y, Cheng G, Zhu Y
Iranian journal of basic medical sciences 2018 Nov;21(11):1161-1166
Iranian journal of basic medical sciences 2018 Nov;21(11):1161-1166
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
Mu Z, Sun Q
Molecular medicine reports 2018 Nov;18(5):4603-4610
Molecular medicine reports 2018 Nov;18(5):4603-4610
Soluble epoxide hydrolase inhibition alleviated cognitive impairments via NRG1/ErbB4 signaling after chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis in mice.
Hao J, Chen Y, Yao E, Liu X
Brain research 2018 Nov 15;1699:89-99
Brain research 2018 Nov 15;1699:89-99
Saponins from Boussingaultia gracilis prevent obesity and related metabolic impairments in diet-induced obese mice.
Liu L, Wang N, Ma Y, Liu Y, Wen D
Food & function 2018 Nov 14;9(11):5660-5673
Food & function 2018 Nov 14;9(11):5660-5673
SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D
EMBO reports 2018 May;19(5)
EMBO reports 2018 May;19(5)
Patulin induced ROS-dependent autophagic cell death in Human Hepatoma G2 cells.
Yang G, Bai Y, Wu X, Sun X, Sun M, Liu X, Yao X, Zhang C, Chu Q, Jiang L, Wang S
Chemico-biological interactions 2018 May 25;288:24-31
Chemico-biological interactions 2018 May 25;288:24-31
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Knockdown of hnRNP A2/B1 inhibits cell proliferation, invasion and cell cycle triggering apoptosis in cervical cancer via PI3K/AKT signaling pathway.
Shi X, Ran L, Liu Y, Zhong SH, Zhou PP, Liao MX, Fang W
Oncology reports 2018 Mar;39(3):939-950
Oncology reports 2018 Mar;39(3):939-950
Marine Bacterial Polysaccharide EPS11 Inhibits Cancer Cell Growth via Blocking Cell Adhesion and Stimulating Anoikis.
Cao R, Jin W, Shan Y, Wang J, Liu G, Kuang S, Sun C
Marine drugs 2018 Mar 8;16(3)
Marine drugs 2018 Mar 8;16(3)
Increased ZNF84 expression in cervical cancer.
Li P, Guo H, Zhou G, Shi H, Li Z, Guan X, Deng Z, Li S, Zhou S, Wang Y, Wang S
Archives of gynecology and obstetrics 2018 Jun;297(6):1525-1532
Archives of gynecology and obstetrics 2018 Jun;297(6):1525-1532
Small interfering RNA-mediated silencing of G-protein-coupled receptor 137 inhibits growth of osteosarcoma cells.
Li H, Fu X, Gao Y, Li X, Shen Y, Wang W
Journal of bone oncology 2018 Jun;11:17-22
Journal of bone oncology 2018 Jun;11:17-22
A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy.
Liu C, Zhang Y, She X, Fan L, Li P, Feng J, Fu H, Liu Q, Liu Q, Zhao C, Sun Y, Wu M
Journal of hematology & oncology 2018 Jun 4;11(1):77
Journal of hematology & oncology 2018 Jun 4;11(1):77
Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic reticulum stress and prevents hepatic steatosis in diet-induced obesity mice.
Wang N, Liu Y, Ma Y, Wen D
The Journal of nutritional biochemistry 2018 Jul;57:180-188
The Journal of nutritional biochemistry 2018 Jul;57:180-188
Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression.
Li Y, Zeng C, Hu J, Pan Y, Shan Y, Liu B, Jia L
Journal of hematology & oncology 2018 Jul 3;11(1):89
Journal of hematology & oncology 2018 Jul 3;11(1):89
Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p.
Kong F, Ma J, Yang H, Yang D, Wang C, Ma X
Biochimica et biophysica acta. Molecular cell research 2018 Jul 19;
Biochimica et biophysica acta. Molecular cell research 2018 Jul 19;
Thioredoxin-interacting protein deficiency ameliorates diabetic retinal angiogenesis.
Duan J, Du C, Shi Y, Liu D, Ma J
The international journal of biochemistry & cell biology 2018 Jan;94:61-70
The international journal of biochemistry & cell biology 2018 Jan;94:61-70
UNBS5162 inhibits the proliferation of human A549 non-small-cell lung cancer cells by promoting apoptosis.
Liu C, Xing J, Gao Y
Thoracic cancer 2018 Jan;9(1):105-111
Thoracic cancer 2018 Jan;9(1):105-111
Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation.
Huang L, Chen C, Zhang X, Li X, Chen Z, Yang C, Liang X, Zhu G, Xu Z
Journal of molecular neuroscience : MN 2018 Jan;64(1):129-139
Journal of molecular neuroscience : MN 2018 Jan;64(1):129-139
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788
Journal of cellular physiology 2018 Jan;234(1):777-788
Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus.
Sun X, Li J, Zhao H, Wang Y, Liu J, Shao Y, Xue Y, Xing M
Journal of inorganic biochemistry 2018 Jan;178:54-62
Journal of inorganic biochemistry 2018 Jan;178:54-62
UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway.
He D, Zhang S
Molecular medicine reports 2018 Jan;17(1):549-555
Molecular medicine reports 2018 Jan;17(1):549-555
Pramlintide regulation of extracellular matrix (ECM) and apoptosis through mitochondrial-dependent pathways in human nucleus pulposus cells.
Wu X, Song Y, Li S, Liu X, Hua W, Wang K, Liu W, Li S, Zhang Y, Shao Z, Yang C
International journal of immunopathology and pharmacology 2018 Jan-Dec;31:394632017747500
International journal of immunopathology and pharmacology 2018 Jan-Dec;31:394632017747500
Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy.
Wei W, An XR, Jin SJ, Li XX, Xu M
Scientific reports 2018 Jan 8;8(1):9
Scientific reports 2018 Jan 8;8(1):9
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout.
Zhang J, Zhao J, Zheng X, Cai K, Mao Q, Xia H
Molecular medicine reports 2018 Feb;17(2):2169-2176
Molecular medicine reports 2018 Feb;17(2):2169-2176
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
Yin N, Wang Y, Lu X, Liu R, Zhang L, Zhao W, Yuan W, Luo Q, Wu H, Luan X, Zhang H
Stem cell research & therapy 2018 Feb 14;9(1):37
Stem cell research & therapy 2018 Feb 14;9(1):37
Interleukin‑10 promotes proliferation and migration, and inhibits tendon differentiation via the JAK/Stat3 pathway in tendon‑derived stem cells in vitro.
Deng G, Li K, Chen S, Chen P, Zheng H, Yu B, Zhang K
Molecular medicine reports 2018 Dec;18(6):5044-5052
Molecular medicine reports 2018 Dec;18(6):5044-5052
LASP1 promotes glioma cell proliferation and migration and is negatively regulated by miR-377-3p.
Liu Y, Gao Y, Li D, He L, Iw L, Hao B, Chen X, Cao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:845-851
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:845-851
4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling.
Sun D, Zhang F, Qian J, Shen W, Fan H, Tan J, Li L, Xu C, Yang Y, Cheng H
Chemico-biological interactions 2018 Dec 25;296:26-33
Chemico-biological interactions 2018 Dec 25;296:26-33
AAED1 modulates proliferation and glycolysis in gastric cancer.
Zhang B, Wu J, Cai Y, Luo M, Wang B, Gu Y
Oncology reports 2018 Aug;40(2):1156-1164
Oncology reports 2018 Aug;40(2):1156-1164
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells.
Ke M, Dong J, Wang Y, Zhang J, Zhang M, Wu Z, Lv Y, Wu R
The international journal of biochemistry & cell biology 2018 Aug;101:39-48
The international journal of biochemistry & cell biology 2018 Aug;101:39-48
Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Liu X, Tan X, Liu P, Wu Y, Qian S, Zhang X
Oncology research 2018 Aug 23;26(7):1123-1131
Oncology research 2018 Aug 23;26(7):1123-1131
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Sun H
Pharmacological research 2018 Apr;130:466-480
Pharmacological research 2018 Apr;130:466-480
Lactobacillus rhamnosus GG Affects Microbiota and Suppresses Autophagy in the Intestines of Pigs Challenged with Salmonella Infantis.
Zhang W, Zhu YH, Yang GY, Liu X, Xia B, Hu X, Su JH, Wang JF
Frontiers in microbiology 2017;8:2705
Frontiers in microbiology 2017;8:2705
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
Yao H, Sun Y, Song S, Qi Y, Tao X, Xu L, Yin L, Han X, Xu Y, Li H, Sun H, Peng J
Frontiers in pharmacology 2017;8:120
Frontiers in pharmacology 2017;8:120
IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells.
Wu X, Song Y, Liu W, Wang K, Gao Y, Li S, Duan Z, Shao Z, Yang S, Yang C
Cell death discovery 2017;3:16107
Cell death discovery 2017;3:16107
Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1-42)-Induced Rat Model of Alzheimer's Disease.
Sheng C, Xu P, Zhou K, Deng D, Zhang C, Wang Z
BioMed research international 2017;2017:7464872
BioMed research international 2017;2017:7464872
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.
Zhou W, Liu L, Xue Y, Zheng J, Liu X, Ma J, Li Z, Liu Y
Frontiers in molecular neuroscience 2017;10:68
Frontiers in molecular neuroscience 2017;10:68
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Zhao J, Zhu J, Lv X, Xing J, Liu S, Chen C, Xu Y
OncoTargets and therapy 2017;10:5471-5482
OncoTargets and therapy 2017;10:5471-5482
Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells.
Liang JX, Gao W, Cai L
OncoTargets and therapy 2017;10:3971-3978
OncoTargets and therapy 2017;10:3971-3978
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
Song Z, Shah SZA, Yang W, Dong H, Yang L, Zhou X, Zhao D
Frontiers in molecular neuroscience 2017;10:128
Frontiers in molecular neuroscience 2017;10:128
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Xu L, Yin L, Tao X, Qi Y, Han X, Xu Y, Song S, Li L, Sun P, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Lithium alleviates neurotoxic prion peptide-induced synaptic damage and neuronal death partially by the upregulation of nuclear target REST and the restoration of Wnt signaling.
Song Z, Yang W, Zhou X, Yang L, Zhao D
Neuropharmacology 2017 Sep 1;123:332-348
Neuropharmacology 2017 Sep 1;123:332-348
Mono-(2-ethylhexyl) phthalate induced ROS-dependent autophagic cell death in human vascular endothelial cells.
Liu N, Jiang L, Sun X, Yao X, Zhai X, Liu X, Wu X, Bai Y, Wang S, Yang G
Toxicology in vitro : an international journal published in association with BIBRA 2017 Oct;44:49-56
Toxicology in vitro : an international journal published in association with BIBRA 2017 Oct;44:49-56
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Liu J, Wang L, Du Y, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
RasGRP3 controls cell proliferation and migration in papillary thyroid cancer by regulating the Akt-MDM2 pathway.
Qiu W, Xia X, Qiu Z, Guo M, Yang Z
Gene 2017 Oct 30;633:35-41
Gene 2017 Oct 30;633:35-41
Maslinic acid inhibits impairment of endothelial functions induced by high glucose in HAEC cells through improving insulin signaling and oxidative stress.
Li F, Li Q, Shi X, Guo Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:904-913
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:904-913
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Song L, Wang Z, Wang Y, Guo D, Yang J, Chen L, Tan N
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs.
Ren K, Lu YJ, Mo ZC, -Liu X, Tang ZL, Jiang Y, Peng XS, Li L, Zhang QH, Yi GH
Journal of physiology and biochemistry 2017 May;73(2):287-296
Journal of physiology and biochemistry 2017 May;73(2):287-296
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
Liu W, Zhang B, Hu Q, Qin Y, Xu W, Shi S, Liang C, Meng Q, Xiang J, Liang D, Ji S, Liu J, Hu P, Liu L, Liu C, Long J, Ni Q, Yu X, Xu J
International journal of oncology 2017 May;50(5):1792-1800
International journal of oncology 2017 May;50(5):1792-1800
EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways.
Liu S, Sun Z, Chu P, Li H, Ahsan A, Zhou Z, Zhang Z, Sun B, Wu J, Xi Y, Han G, Lin Y, Peng J, Tang Z
Apoptosis : an international journal on programmed cell death 2017 May;22(5):672-680
Apoptosis : an international journal on programmed cell death 2017 May;22(5):672-680
miR-29b contributes to multiple types of muscle atrophy.
Li J, Chan MC, Yu Y, Bei Y, Chen P, Zhou Q, Cheng L, Chen L, Ziegler O, Rowe GC, Das S, Xiao J
Nature communications 2017 May 25;8:15201
Nature communications 2017 May 25;8:15201
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
Yin K, Zhu R, Wang S, Zhao RC
Stem cells and development 2017 May 15;26(10):762-775
Stem cells and development 2017 May 15;26(10):762-775
FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis.
Cui K, Ruan Y, Wang T, Rao K, Chen Z, Wang S, Liu J
The journal of sexual medicine 2017 Mar;14(3):323-335
The journal of sexual medicine 2017 Mar;14(3):323-335
Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-κB signaling pathways in RAW264.7 cells.
Ren D, Lin D, Alim A, Zheng Q, Yang X
Food & function 2017 Mar 22;8(3):1299-1312
Food & function 2017 Mar 22;8(3):1299-1312
PTEN/PI3k/AKT Regulates Macrophage Polarization in Emphysematous mice.
Lu J, Xie L, Liu C, Zhang Q, Sun S
Scandinavian journal of immunology 2017 Jun;85(6):395-405
Scandinavian journal of immunology 2017 Jun;85(6):395-405
Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway.
Xie XC, Zhao N, Xu QH, Yang X, Xia WK, Chen Q, Wang M, Fei X
Apoptosis : an international journal on programmed cell death 2017 Jun;22(6):769-776
Apoptosis : an international journal on programmed cell death 2017 Jun;22(6):769-776
Down-regulation of islet amyloid polypeptide expression induces death of human annulus fibrosus cells via mitochondrial and death receptor pathways.
Wu X, Wang K, Hua W, Li S, Liu X, Liu W, Song Y, Zhang Y, Shao Z, Yang C
Biochimica et biophysica acta. Molecular basis of disease 2017 Jun;1863(6):1479-1491
Biochimica et biophysica acta. Molecular basis of disease 2017 Jun;1863(6):1479-1491
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Xu J, Zhang S, Wang R, Wu X, Zeng L, Fu Z
Bioscience reports 2017 Jun 30;37(3)
Bioscience reports 2017 Jun 30;37(3)
Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice.
Zhuang S, Jian YM, Sun YN
World journal of gastroenterology 2017 Jun 21;23(23):4233-4242
World journal of gastroenterology 2017 Jun 21;23(23):4233-4242
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
Lu SY, Wang CY, Jin Y, Meng Q, Liu Q, Liu ZH, Liu KX, Sun HJ, Liu MZ
Scientific reports 2017 Jun 13;7(1):3331
Scientific reports 2017 Jun 13;7(1):3331
MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles.
He W, Wang C, Mu R, Liang P, Huang Z, Zhang J, Dong L
Oncogene 2017 Jul 20;36(29):4212-4223
Oncogene 2017 Jul 20;36(29):4212-4223
Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.
Ke Z, Wang G, Yang L, Qiu H, Wu H, Du M, Chen J, Song J, Jia X, Feng L
Journal of ethnopharmacology 2017 Jul 12;206:160-169
Journal of ethnopharmacology 2017 Jul 12;206:160-169
MicroRNA-302a enhances 5-fluorouracil-induced cell death in human colon cancer cells.
Liu N, Li J, Zhao Z, Han J, Jiang T, Chen Y, Hou N, Huang C
Oncology reports 2017 Jan;37(1):631-639
Oncology reports 2017 Jan;37(1):631-639
PRL-3 Is Involved in Estrogen- and IL-6-Induced Migration of Endometrial Stromal Cells From Ectopic Endometrium.
Ren S, Zhou Y, Fang X, She X, Wu Y, Wu X
Reproductive sciences (Thousand Oaks, Calif.) 2017 Jan;24(1):124-132
Reproductive sciences (Thousand Oaks, Calif.) 2017 Jan;24(1):124-132
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.
Zhang C, Li C, Chen S, Li Z, Ma L, Jia X, Wang K, Bao J, Liang Y, Chen M, Li P, Su H, Lee SM, Liu K, Wan JB, He C
Scientific reports 2017 Jan 23;7:41082
Scientific reports 2017 Jan 23;7:41082
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Huang T, Xiao Y, Yi L, Li L, Wang M, Tian C, Ma H, He K, Wang Y, Han B, Ye X, Li X
Scientific reports 2017 Feb 6;7:38524
Scientific reports 2017 Feb 6;7:38524
Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.
Li R, Yuan F, Fu W, Zhang L, Zhang N, Wang Y, Ma K, Li X, Wang L, Zhu WG, Zhao Y
The Journal of biological chemistry 2017 Feb 17;292(7):2830-2841
The Journal of biological chemistry 2017 Feb 17;292(7):2830-2841
TRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway.
Xu G, Guo Y, Xu D, Wang Y, Shen Y, Wang F, Lv Y, Song F, Jiang D, Zhang Y, Lou Y, Meng Y, Yang Y, Kang Y
Scientific reports 2017 Feb 16;7:42411
Scientific reports 2017 Feb 16;7:42411
miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway.
Jia L, Luo S, Ren X, Li Y, Hu J, Liu B, Zhao L, Shan Y, Zhou H
Digestive diseases and sciences 2017 Dec;62(12):3447-3459
Digestive diseases and sciences 2017 Dec;62(12):3447-3459
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Song Y, Kong L, Sun B, Gao L, Chu P, Ahsan A, Qaed E, Lin Y, Peng J, Ma X, Zhang J, Wang S, Tang Z
Cell biology international 2017 Dec;41(12):1367-1378
Cell biology international 2017 Dec;41(12):1367-1378
Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.
Yan Z, Feng J, Peng J, Lai Z, Zhang L, Jin Y, Yang H, Chen W, Lin J
Oncology letters 2017 Dec;14(6):7923-7930
Oncology letters 2017 Dec;14(6):7923-7930
Scutellaria barbata D. Don inhibits migration and invasion of colorectal cancer cells via suppression of PI3K/AKT and TGF-β/Smad signaling pathways.
Jin Y, Chen W, Yang H, Yan Z, Lai Z, Feng J, Peng J, Lin J
Experimental and therapeutic medicine 2017 Dec;14(6):5527-5534
Experimental and therapeutic medicine 2017 Dec;14(6):5527-5534
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525
Oncotarget 2017 Dec 29;8(70):114506-114525
High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice.
Wang N, Liu Y, Ma Y, Wen D
Life sciences 2017 Dec 15;191:122-131
Life sciences 2017 Dec 15;191:122-131
Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.
Wang H, Cai J, Du S, Guo Z, Xin B, Wang J, Wei W, Shen X
Cell biochemistry and function 2017 Aug;35(6):315-326
Cell biochemistry and function 2017 Aug;35(6):315-326
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Wu L, Zhang Q, Mo W, Feng J, Li S, Li J, Liu T, Xu S, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Xu L, Zhou Y, Fan X, Guo C
Scientific reports 2017 Aug 24;7(1):9289
Scientific reports 2017 Aug 24;7(1):9289
Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway.
Du C, Zhang T, Xiao X, Shi Y, Duan H, Ren Y
The Biochemical journal 2017 Aug 2;474(16):2733-2747
The Biochemical journal 2017 Aug 2;474(16):2733-2747
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Chu P, Han G, Ahsan A, Sun Z, Liu S, Zhang Z, Sun B, Song Y, Lin Y, Peng J, Tang Z
Vascular pharmacology 2017 Apr;91:26-35
Vascular pharmacology 2017 Apr;91:26-35
Gx-50 Inhibits Neuroinflammation via α7 nAChR Activation of the JAK2/STAT3 and PI3K/AKT Pathways.
Shi S, Liang D, Bao M, Xie Y, Xu W, Wang L, Wang Z, Qiao Z
Journal of Alzheimer's disease : JAD 2016;50(3):859-71
Journal of Alzheimer's disease : JAD 2016;50(3):859-71
siRNA knockdown validation 101: Incorporating negative controls in antibody research.
Olds W, Li J
F1000Research 2016;5:308
F1000Research 2016;5:308
Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.
Sun B, Bai Y, Zhang L, Gong L, Qi X, Li H, Wang F, Chi X, Jiang Y, Shao S
PloS one 2016;11(9):e0163622
PloS one 2016;11(9):e0163622
Dexmedetomidine Inhibits Maturation and Function of Human Cord Blood-Derived Dendritic Cells by Interfering with Synthesis and Secretion of IL-12 and IL-23.
Chen G, Le Y, Zhou L, Gong L, Li X, Li Y, Liao Q, Duan K, Tong J, Ouyang W
PloS one 2016;11(4):e0153288
PloS one 2016;11(4):e0153288
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
Wei WJ, Shen CT, Song HJ, Qiu ZL, Luo QY
Oncology reports 2016 Sep;36(3):1576-84
Oncology reports 2016 Sep;36(3):1576-84
Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma.
Song Y, Sun B, Hao L, Hu J, Du S, Zhou X, Zhang L, Liu L, Gong L, Chi X, Liu Q, Shao S
Oncotarget 2016 Sep 6;7(36):58470-58482
Oncotarget 2016 Sep 6;7(36):58470-58482
Oral kanglaite injection (KLTI) attenuates the lung cancer-promoting effect of high-fat diet (HFD)-induced obesity.
Cao N, Ma X, Guo Z, Zheng Y, Geng S, Meng M, Du Z, Lin H, Duan Y, Du G
Oncotarget 2016 Sep 20;7(38):61093-61106
Oncotarget 2016 Sep 20;7(38):61093-61106
Thioredoxin-interacting protein regulates lipid metabolism via Akt/mTOR pathway in diabetic kidney disease.
Du C, Wu M, Liu H, Ren Y, Du Y, Wu H, Wei J, Liu C, Yao F, Wang H, Zhu Y, Duan H, Shi Y
The international journal of biochemistry & cell biology 2016 Oct;79:1-13
The international journal of biochemistry & cell biology 2016 Oct;79:1-13
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
Sun B, Gao L, Ahsan A, Chu P, Song Y, Li H, Zhang Z, Lin Y, Peng J, Song Z, Wang S, Tang Z
International immunopharmacology 2016 Nov;40:400-409
International immunopharmacology 2016 Nov;40:400-409
The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis.
Wang X, Yuan W, Wang X, Qi J, Qin Y, Shi Y, Zhang J, Gong J, Dong Z, Liu X, Sun C, Chai R, Le Noble F, Liu D
Oncotarget 2016 Nov 22;7(47):77749-77763
Oncotarget 2016 Nov 22;7(47):77749-77763
17β-Estradiol Inhibites Tumor Necrosis Factor-α Induced Apoptosis of Human Nucleus Pulposus Cells via the PI3K/Akt Pathway.
Wang T, Yang SD, Liu S, Wang H, Liu H, Ding WY
Medical science monitor : international medical journal of experimental and clinical research 2016 Nov 12;22:4312-4322
Medical science monitor : international medical journal of experimental and clinical research 2016 Nov 12;22:4312-4322
The membrane complement regulatory protein CD59 promotes tumor growth and predicts poor prognosis in breast cancer.
Ouyang Q, Zhang L, Jiang Y, Ni X, Chen S, Ye F, Du Y, Huang L, Ding P, Wang N, Yang C, Huang T, Sun Y, Li S, Xia Y, Hu W, Luo R, Shao Z
International journal of oncology 2016 May;48(5):2015-24
International journal of oncology 2016 May;48(5):2015-24
AKT/TSC2/p70S6K signaling pathway is involved in quinocetone-induced death-promoting autophagy in HepG2 cells.
Zhang S, Zhang C, Tang S, Deng S, Zhou Y, Dai C, Yang X, Xiao X
Toxicology mechanisms and methods 2016 May;26(4):301-10
Toxicology mechanisms and methods 2016 May;26(4):301-10
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
Wang D, Wang M, Jiang N, Zhang Y, Bian X, Wang X, Roberts TM, Zhao JJ, Liu P, Cheng H
Oncotarget 2016 Mar 15;7(11):13153-66
Oncotarget 2016 Mar 15;7(11):13153-66
The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.
Zhao S, Cao Y, Liu SB, Wang XA, Bao RF, Shu YJ, Hu YP, Zhang YJ, Jiang L, Zhang F, Liang HB, Li HF, Ma Q, Xu Y, Wang Z, Zhang YC, Chen L, Zhou J, Liu YB
Journal of experimental & clinical cancer research : CR 2016 Jun 18;35(1):97
Journal of experimental & clinical cancer research : CR 2016 Jun 18;35(1):97
Apelin-13 Protects PC12 Cells from Corticosterone-Induced Apoptosis Through PI3K and ERKs Activation.
Zou Y, Wang B, Fu W, Zhou S, Nie Y, Tian S
Neurochemical research 2016 Jul;41(7):1635-44
Neurochemical research 2016 Jul;41(7):1635-44
Preventive Effects of a Novel Polysaccharide from Sepia esculenta Ink on Ovarian Failure and Its Action Mechanisms in Cyclophosphamide-Treated Mice.
Liu HZ, Tao YX, Luo P, Deng CM, Gu YP, Yang L, Zhong JP
Journal of agricultural and food chemistry 2016 Jul 20;64(28):5759-66
Journal of agricultural and food chemistry 2016 Jul 20;64(28):5759-66
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Wu J, Yang C, Guo C, Li X, Yang N, Zhao L, Hang H, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Chemico-biological interactions 2016 Jan 25;244:94-104
Chemico-biological interactions 2016 Jan 25;244:94-104
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Gao L, Xu Z, Wang Y, Sun B, Song Z, Yang B, Liu X, Lin Y, Peng J, Han G, Wang S, Tang Z
Oncology reports 2016 Feb;35(2):1101-8
Oncology reports 2016 Feb;35(2):1101-8
Dysregulation of Neuregulin-1/ErbB signaling in the prefrontal cortex and hippocampus of rats exposed to chronic unpredictable mild stress.
Dang R, Cai H, Zhang L, Liang D, Lv C, Guo Y, Yang R, Zhu Y, Jiang P
Physiology & behavior 2016 Feb 1;154:145-50
Physiology & behavior 2016 Feb 1;154:145-50
bFGF Protects Against Blood-Brain Barrier Damage Through Junction Protein Regulation via PI3K-Akt-Rac1 Pathway Following Traumatic Brain Injury.
Wang ZG, Cheng Y, Yu XC, Ye LB, Xia QH, Johnson NR, Wei X, Chen DQ, Cao G, Fu XB, Li XK, Zhang HY, Xiao J
Molecular neurobiology 2016 Dec;53(10):7298-7311
Molecular neurobiology 2016 Dec;53(10):7298-7311
Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.
Wang W, McKinnie SM, Farhan M, Paul M, McDonald T, McLean B, Llorens-Cortes C, Hazra S, Murray AG, Vederas JC, Oudit GY
Hypertension (Dallas, Tex. : 1979) 2016 Aug;68(2):365-77
Hypertension (Dallas, Tex. : 1979) 2016 Aug;68(2):365-77
miR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis.
Niu X, Fu N, Du J, Wang R, Wang Y, Zhao S, Du H, Wang B, Zhang Y, Sun D, Nan Y
FEBS letters 2016 Aug;590(16):2709-24
FEBS letters 2016 Aug;590(16):2709-24
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20
Lab on a chip 2016 Aug 7;16(15):2911-20
CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.
Zhang L, Liu L, He X, Shen Y, Liu X, Wei J, Yu F, Tian J
Biochemical and biophysical research communications 2016 Aug 26;477(3):356-62
Biochemical and biophysical research communications 2016 Aug 26;477(3):356-62
Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice.
Lv Y, Meng B, Dong H, Jing T, Wu N, Yang Y, Huang L, Moses RE, O'Malley BW, Mei B, Li X
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2016 Apr;41(5):1340-9
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2016 Apr;41(5):1340-9
Down-regulation of ribosomal protein S15A inhibits proliferation of human glioblastoma cells in vivo and in vitro via AKT pathway.
Yao Y, Liu Y, Lv X, Dong B, Wang F, Li J, Zhang Q, Xu R, Xu Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Apr;37(4):4979-90
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Apr;37(4):4979-90
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
DU Q, Hao C, Gou J, Li X, Zou K, He X, Li Z
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth.
Lu Y, Wang Y, Zhang M, Liu L, Li F, Zhang J, Ye M, Zhao H, Zhao J, Yan B, Yang A, Zhang R, Li X, Ren X
Oncotarget 2016 Apr 26;7(17):23594-607
Oncotarget 2016 Apr 26;7(17):23594-607
TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis.
Dong F, Ling Q, Ye D, Zhang Z, Shu J, Chen G, Fei Y, Li C
Scientific reports 2016 Apr 25;6:24859
Scientific reports 2016 Apr 25;6:24859
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Yao Z, Sun B, Hong Q, Yan J, Mu D, Li J, Sheng H, Guo H
Drug design, development and therapy 2015;9:5911-23
Drug design, development and therapy 2015;9:5911-23
Inhibitive effects of 15-deoxy-Δ(12),(14)-prostaglandin J2 on hepatoma-cell proliferation through reactive oxygen species-mediated apoptosis.
Chen K, Dai W, Wang F, Xia Y, Li J, Li S, Liu T, Zhang R, Wang J, Lu W, Zhou Y, Yin Q, Zheng Y, Abudumijiti H, Chen R, Lu J, Zhou Y, Guo C
OncoTargets and therapy 2015;8:3585-93
OncoTargets and therapy 2015;8:3585-93
NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/mTOR phosphorylation.
Sun Z, Li Q, Zhang S, Chen J, Huang L, Ren J, Chang Y, Liang Y, Wu G
OncoTargets and therapy 2015;8:269-77
OncoTargets and therapy 2015;8:269-77
Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis.
Farhan MA, Carmine-Simmen K, Lewis JD, Moore RB, Murray AG
PloS one 2015;10(8):e0135245
PloS one 2015;10(8):e0135245
Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway.
Xing SS, Yang XY, Zheng T, Li WJ, Wu D, Chi JY, Bian F, Bai XL, Wu GJ, Zhang YZ, Zhang CT, Zhang YH, Li YS, Jin S
Vascular pharmacology 2015 Sep;72:141-52
Vascular pharmacology 2015 Sep;72:141-52
Low dose photodynamic-therapy induce immune escape of tumor cells in a HIF-1α dependent manner through PI3K/Akt pathway.
Wan J, Wu W, Che Y, Kang N, Zhang R
International immunopharmacology 2015 Sep;28(1):44-51
International immunopharmacology 2015 Sep;28(1):44-51
Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas.
Hao L, Zhou X, Liu S, Sun M, Song Y, Du S, Sun B, Guo C, Gong L, Hu J, Guan H, Shao S
Proteomics 2015 Sep;15(17):3087-100
Proteomics 2015 Sep;15(17):3087-100
Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway.
Xie HX, Xu ZY, Tang JN, DU YA, Huang L, Yu PF, Cheng XD
Experimental and therapeutic medicine 2015 Sep;10(3):1212-1218
Experimental and therapeutic medicine 2015 Sep;10(3):1212-1218
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Zhang Q, Zhuang J, Deng Y, Zhao X, Tang B, Yao D, Zhao W, Chang C, Lu Q, Chen W, Zhang S, Ji C, Cao L, Guo H
Oncotarget 2015 Oct 13;6(31):32177-92
Oncotarget 2015 Oct 13;6(31):32177-92
Activated estrogen receptor-mitogen-activated protein kinases cross talk confer acquired resistance to lapatinib.
Li Z, Yang SS, Yin PH, Chang T, Shi LX, Fang L, Fang GE
Thoracic cancer 2015 Nov;6(6):695-703
Thoracic cancer 2015 Nov;6(6):695-703
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Li X, Zou K, Gou J, Du Q, Li D, He X, Li Z
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L, Zhang X
Cancer research 2015 Mar 1;75(5):846-57
Cancer research 2015 Mar 1;75(5):846-57
MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3.
Cao G, Dong W, Meng X, Liu H, Liao H, Liu S
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jun;36(6):4453-9
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jun;36(6):4453-9
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Dong D, Yin L, Qi Y, Xu L, Peng J
Nutrients 2015 Jun 15;7(6):4829-50
Nutrients 2015 Jun 15;7(6):4829-50
Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways.
Wu YJ, Neoh CA, Tsao CY, Su JH, Li HH
International journal of molecular sciences 2015 Jul 20;16(7):16469-82
International journal of molecular sciences 2015 Jul 20;16(7):16469-82
Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells.
Deng S, Tang S, Zhang S, Zhang C, Wang C, Zhou Y, Dai C, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jan;75:173-86
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jan;75:173-86
Quetiapine inhibits osteoclastogenesis and prevents human breast cancer-induced bone loss through suppression of the RANKL-mediated MAPK and NF-κB signaling pathways.
Wang H, Shen W, Hu X, Zhang Y, Zhuo Y, Li T, Mei F, Li X, Xiao L, Chu T
Breast cancer research and treatment 2015 Feb;149(3):705-14
Breast cancer research and treatment 2015 Feb;149(3):705-14
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
Gao L, Wang Y, Xu Z, Li X, Wu J, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1636-50
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1636-50
Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.
Ahsan A, Han G, Pan J, Liu S, Padhiar AA, Chu P, Sun Z, Zhang Z, Sun B, Wu J, Irshad A, Lin Y, Peng J, Tang Z
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1563-76
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1563-76
Salidroside stimulates mitochondrial biogenesis and protects against H₂O₂-induced endothelial dysfunction.
Xing S, Yang X, Li W, Bian F, Wu D, Chi J, Xu G, Zhang Y, Jin S
Oxidative medicine and cellular longevity 2014;2014:904834
Oxidative medicine and cellular longevity 2014;2014:904834
11-epi-Sinulariolide acetate reduces cell migration and invasion of human hepatocellular carcinoma by reducing the activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR signaling pathways.
Lin JJ, Su JH, Tsai CC, Chen YJ, Liao MH, Wu YJ
Marine drugs 2014 Sep 12;12(9):4783-98
Marine drugs 2014 Sep 12;12(9):4783-98
The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF.
Liu F, You X, Wang Y, Liu Q, Liu Y, Zhang S, Chen L, Zhang X, Ye L
Carcinogenesis 2014 May;35(5):1144-53
Carcinogenesis 2014 May;35(5):1144-53
Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.
Wu DM, Zhang P, Liu RY, Sang YX, Zhou C, Xu GC, Yang JL, Tong AP, Wang CT
FEBS letters 2014 May 21;588(10):1921-9
FEBS letters 2014 May 21;588(10):1921-9
ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21((CIP1/WAF1)) in human cancer cells.
Li J, Chen Y, Wan J, Liu X, Yu C, Li W
British journal of pharmacology 2014 Jul;171(13):3182-95
British journal of pharmacology 2014 Jul;171(13):3182-95
The mechanisms of EGFR in the regulation of axon regeneration.
Xu MF, Zhou H, Hu CY, Liang YQ, Hu L, Chen D
Cell biochemistry and function 2014 Jan;32(1):101-5
Cell biochemistry and function 2014 Jan;32(1):101-5
Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia.
Wu Q, He J, Mei W, Zhang Z, Wu X, Sun F
Metallomics : integrated biometal science 2014 Dec;6(12):2204-12
Metallomics : integrated biometal science 2014 Dec;6(12):2204-12
Ubiquitin‑specific protease 22‑induced autophagy is correlated with poor prognosis of pancreatic cancer.
Liang JX, Ning Z, Gao W, Ling J, Wang AM, Luo HF, Liang Y, Yan Q, Wang ZY
Oncology reports 2014 Dec;32(6):2726-34
Oncology reports 2014 Dec;32(6):2726-34
Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition.
Wang N, Zhang Y, Wu L, Wang Y, Cao Y, He L, Li X, Zhao J
Neuropharmacology 2014 Apr;79:282-9
Neuropharmacology 2014 Apr;79:282-9
MiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGF-VEGFR2 pathway.
Shi L, Zhang S, Wu H, Zhang L, Dai X, Hu J, Xue J, Liu T, Liang Y, Wu G
PloS one 2013;8(10):e78344
PloS one 2013;8(10):e78344
Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway.
Dai XF, Ding J, Zhang RG, Ren JH, Ma CM, Wu G
International journal of radiation biology 2013 Sep;89(9):724-31
International journal of radiation biology 2013 Sep;89(9):724-31
Effects of PI3K inhibitor NVP-BKM120 on acquired resistance to gefitinib of human lung adenocarcinoma H1975 cells.
Liang YC, Wu HG, Xue HJ, Liu Q, Shi LL, Liu T, Wu G
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2013 Dec;33(6):845-851
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2013 Dec;33(6):845-851
Facio-genital dysplasia-5 regulates matrix adhesion and survival of human endothelial cells.
Nakhaei-Nejad M, Haddad G, Zhang QX, Murray AG
Arteriosclerosis, thrombosis, and vascular biology 2012 Nov;32(11):2694-701
Arteriosclerosis, thrombosis, and vascular biology 2012 Nov;32(11):2694-701
Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma.
Gong K, Li W
Free radical biology & medicine 2011 Dec 15;51(12):2259-71
Free radical biology & medicine 2011 Dec 15;51(12):2259-71
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10176-2-AP(AKT antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-AKT (IP:10176-2-AP, 3ug; Detection:10176-2-AP 1:500) with HeLa cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 10176-2-AP(AKT antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AKT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AKT1. This antibody recognizes human,mouse,rat,zebrafish antigen. The AKT1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
