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- Antibody Data
- Antigen structure
- References [404]
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- Western blot [1]
- Immunoprecipitation [1]
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- Product number
- 10176-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10176-2-AP, RRID:AB_2224574
- Product name
- AKT antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated AKT antibody (Cat. #10176-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer.
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Postnatal overfeeding induces hepatic microRNA-221 expression and impairs the PI3K/AKT pathway in adult male rats.
Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.
Blocking VRK2 suppresses pulmonary adenocarcinoma progression via ERK1/2/AKT signal pathway by targeting miR-145-5p.
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats.
Peptide OM-LV20 exerts neuroprotective effects against cerebral ischemia/reperfusion injury in rats.
Typical phthalic acid esters induce apoptosis by regulating the PI3K/Akt/Bcl-2 signaling pathway in rat insulinoma cells.
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer.
RAB31 marks and controls an ESCRT-independent exosome pathway.
MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
ACTL6A knockdown inhibits cell migration by suppressing the AKT signaling pathway and enhances the sensitivity of glioma cells to temozolomide.
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes.
Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer.
G-Rh4 improves pancreatic β-cells dysfunction in vivo and in vitro by increased expression of Nrf2 and its target genes.
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
SPANXN2 functions a cell migration inhibitor in testicular germ cell tumor cells.
miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism.
Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.
Bta-miR-223 Targeting CBLB Contributes to Resistance to Staphylococcus aureus Mastitis Through the PI3K/AKT/NF-κB Pathway.
PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1R/VEGFR2 Pathway in Papillary Thyroid Carcinoma.
Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling.
Tianma Gouteng Decoction Exerts Cardiovascular Protection by Upregulating OPG and TRAIL in Spontaneously Hypertensive Rats.
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma.
miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway.
Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40.
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
Apatinib suppresses tumor progression and enhances cisplatin sensitivity in esophageal cancer via the Akt/β-catenin pathway.
Effects of Kindlin-2 on proliferation and migration of VSMC and integrinβ1 andβ3 activity via FAK-PI3K signaling pathway.
TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
Insulin-Like Growth Factor-1 Down-Regulates the Phosphorylation of FXYD1 and Rescues Behavioral Deficits in a Mouse Model of Rett Syndrome.
RPL38 Regulates the Proliferation and Apoptosis of Gastric Cancer via miR-374b-5p/VEGF Signal Pathway.
Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-β/Smad3 signaling and promoting angiogenesis.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Rutaecarpine Ameliorates Ethanol-Induced Gastric Mucosal Injury in Mice by Modulating Genes Related to Inflammation, Oxidative Stress and Apoptosis.
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
Facilitating Granule Cell Survival and Maturation in Dentate Gyrus With Baicalin for Antidepressant Therapeutics.
Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling.
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
HPV16 E6/E7 promote the translocation and glucose uptake of GLUT1 by PI3K/AKT pathway via relieving miR-451 inhibitory effect on CAB39 in lung cancer cells.
Metformin activates the STING/IRF3/IFN-β pathway by inhibiting AKT phosphorylation in pancreatic cancer.
Precise and efficient silencing of mutant KrasG12D by CRISPR-CasRx controls pancreatic cancer progression.
LRRC4 Suppresses E-Cadherin-Dependent Collective Cell Invasion and Metastasis in Epithelial Ovarian Cancer.
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
Targeting CPT1B as a potential therapeutic strategy in castration-resistant and enzalutamide-resistant prostate cancer.
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway.
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
RNA-binding protein CUGBP1 controls the differential INSR splicing in molecular subtypes of breast cancer cells and affects cell aggressiveness.
Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop.
FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis.
Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.
Sphingomyelin Synthase 2 Participate in the Regulation of Sperm Motility and Apoptosis.
Neuronostatin Promotion Soluble Aβ1-42 Oligomers: Induced Dysfunctional Brain Glucose Metabolism in Mice.
Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.
LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene.
Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway.
Protective effect of astaxanthin against La2O3 nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Paired like homeodomain 1 and SAM and SH3 domain-containing 1 in the progression and prognosis of head and neck squamous cell carcinoma.
Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors.
Myostatin-1 Inhibits Cell Proliferation by Inhibiting the mTOR Signal Pathway and MRFs, and Activating the Ubiquitin-Proteasomal System in Skeletal Muscle Cells of Japanese Flounder Paralichthys olivaceus.
Phosphatidylinositol 4-kinase β is required for the ciliogenesis of zebrafish otic vesicle.
Bazedoxifene inhibits PDGF-BB induced VSMC phenotypic switch via regulating the autophagy level.
Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway.
Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma.
Pea-derived peptides, VLP, LLP, VA, and LL, improve insulin resistance in HepG2 cells via activating IRS-1/PI3K/AKT and blocking ROS-mediated p38MAPK signaling.
Hydroquinone inhibits PRV infection in neurons in vitro and in vivo.
The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model.
Establishment and characterization of a docetaxel-resistant human prostate cancer cell line.
SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway.
Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate-induced colitis.
Extracellular ubiquitin protects cardiomyocytes during ischemia/hypoxia by inhibiting mitochondrial apoptosis pathway through CXCR4.
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP-9/PI3K/AKT pathway.
Hypoxia-induced SPOP attenuates the mobility of trophoblast cells through inhibition of the PI3K/AKT/GSK3β pathway.
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Arsenic induces hepatic insulin resistance via mtROS-NLRP3 inflammasome pathway.
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Kp-10 promotes bovine mammary epithelial cell proliferation by activating GPR54 and its downstream signaling pathways.
MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
CRISPR/Cas9-Mediated miR-29b Editing as a Treatment of Different Types of Muscle Atrophy in Mice.
Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes.
Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury.
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Do You Know the Details of Your PAX8 Antibody? Monoclonal PAX8 (MRQ-50) Is Not Expressed in a Series of 45 Medullary Thyroid Carcinomas.
Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats.
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
Galectin-1 Overexpression Activates the FAK/PI3K/AKT/mTOR Pathway and Is Correlated with Upper Urinary Urothelial Carcinoma Progression and Survival.
LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway.
Tolfenamic acid inhibits GSK-3β and PP2A mediated tau hyperphosphorylation in Alzheimer's disease models.
lncRNA PVT1 Promotes Tumorigenesis of Colorectal Cancer by Stabilizing miR-16-5p and Interacting with the VEGFA/VEGFR1/AKT Axis.
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro.
TSPO ligand Ro5-4864 modulates microglia/macrophages polarization after subarachnoid hemorrhage in mice.
LAMC2 modulates the acidity of microenvironments to promote invasion and migration of pancreatic cancer cells via regulating AKT-dependent NHE1 activity.
Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway.
Prenatal High-Salt Diet-Induced Metabolic Disorders via Decreasing Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in Adult Male Rat Offspring.
Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.
TGF‑β1 induces CREB1‑mediated miR‑1290 upregulation to antagonize lung fibrosis via Napsin A.
Fluid shear stress induces Runx-2 expression via upregulation of PIEZO1 in MC3T3-E1 cells.
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway.
A novel antitumor dithiocarbamate compound inhibits the EGFR/AKT signaling pathway and induces apoptosis in esophageal cancer cells.
PRR11 and SKA2 promote the proliferation, migration and invasion of esophageal carcinoma cells.
MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.
Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma.
Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.
Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy.
Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway.
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.
Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway.
Alisol A-24-acetate promotes glucose uptake via activation of AMPK in C2C12 myotubes.
FAM60A, increased by Helicobacter pylori, promotes proliferation and suppresses apoptosis of gastric cancer cells by targeting the PI3K/AKT pathway.
MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury.
Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis.
Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.
Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis.
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
Involvement of neurotrophic signaling in doxorubicin-induced cardiotoxicity.
Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress.
The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice.
DHPAC, a novel microtubule depolymerizing agent, suppresses angiogenesis and vasculogenic mimicry formation of human non-small cell lung cancer.
Lycium barbarum polysaccharide protects against Homocysteine-induced Vascular smooth muscle cell proliferation and phenotypic transformation via PI3K/Akt pathway.
Heat stress activates YAP/TAZ to induce the heat shock transcriptome.
Zinc application alleviates the adverse renal effects of arsenic stress in a protein quality control way in common carp.
Ssc-miR-21-5p regulates endometrial epithelial cell proliferation, apoptosis and migration via the PDCD4/AKT pathway.
Exploration of the Effects of Substrate Stiffness on Biological Responses of Neural Cells and Their Mechanisms.
MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway.
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.
Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer.
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
NCOA5 is a master regulator of amino acid-induced mTOR activation and β-casein synthesis in bovine mammary epithelial cells.
Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway.
Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21Waf1 signalling pathway.
MicroRNA‑22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway.
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1.
Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease.
Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice.
Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs.
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
CAPE-pNO2 Inhibited the Growth and Metastasis of Triple-Negative Breast Cancer via the EGFR/STAT3/Akt/E-Cadherin Signaling Pathway.
Hsa_circ_001569 is an unfavorable prognostic factor and promotes cell proliferation and metastasis by modulating PI3K-AKT pathway in breast cancer.
A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation.
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway.
VEGF Induce Vasculogenic Mimicry of Choroidal Melanoma through the PI3k Signal Pathway.
Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB).
MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway.
CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression.
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways.
Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K/Akt pathway.
ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma.
Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin.
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
Rutin suppresses FNDC1 expression in bone marrow mesenchymal stem cells to inhibit postmenopausal osteoporosis.
HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells.
Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway.
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Hydroxytyrosol Improves Obesity and Insulin Resistance by Modulating Gut Microbiota in High-Fat Diet-Induced Obese Mice.
The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.
Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt.
RasGRP1 is a target for VEGF to induce angiogenesis and involved in the endothelial-protective effects of metformin under high glucose in HUVECs.
DEPDC1 drives hepatocellular carcinoma cell proliferation, invasion and angiogenesis by regulating the CCL20/CCR6 signaling pathway.
Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8+ T cell recruitment.
Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia.
Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma.
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
MiR-92a regulates endothelial progenitor cells (EPCs) by targeting GDF11 via activate SMAD2/3/FAK/Akt/eNOS pathway.
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells.
TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation.
Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration.
CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK½/mTOR signaling pathways in oral squamous cell carcinomas.
The clinical characteristics and molecular mechanism of pituitary adenoma associated with meningioma.
NT3P75-2 gene-modified bone mesenchymal stem cells improve neurological function recovery in mouse TBI model.
12N-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells.
MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis.
Brain-derived neurotrophic factor induces thioredoxin-1 expression through TrkB/Akt/CREB pathway in SH-SY5Y cells.
Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways.
Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.
Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells.
MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte.
Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN.
Knockdown of endothelin receptor B inhibits the progression of triple-negative breast cancer.
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Taurine protects against arsenic trioxide-induced insulin resistance via ROS-Autophagy pathway in skeletal muscle.
Thyroid hormone (T3) is involved in inhibiting the proliferation of newborn calf Sertoli cells via the PI3K/Akt signaling pathway in vitro.
Characterization, functional and signaling elucidation of pigeon (Columba livia) interferon-α: Knockdown p53 negatively modulates antiviral response.
Everolimus Reverses Palbociclib Resistance in ER+ Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase(PI3K)/Akt/Mammalian Target of Rapamycin (mTOR) Pathway.
Involvement of Hepatic SHIP2 and PI3K/Akt Signalling in the Regulation of Plasma Insulin by Xiaoyaosan in Chronic Immobilization-Stressed Rats.
Long noncoding FOXD2-AS1 is activated by CREB1 and promotes cell proliferation and metastasis in glioma by sponging miR-185 through targeting AKT1.
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Testosterone preserves endothelial function through regulation of S1P1/Akt/FOXO3a signalling pathway in the rat corpus cavernosum.
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Low density lipoprotein mimics insulin action on autophagy and glucose uptake in endothelial cells.
Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury.
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Indoxyl sulfate-induced calcification of vascular smooth muscle cells via the PI3K/Akt/NF-κB signaling pathway.
Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model.
PP2Ac upregulates PI3K-Akt signaling and induces hepatocyte apoptosis in liver donor after brain death.
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways.
Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling.
Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K /Akt/mTOR pathway.
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway.
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3β pathway in lung adenocarcinoma.
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Taurine improves low-level inorganic arsenic-induced insulin resistance by activating PPARγ-mTORC2 signalling and inhibiting hepatic autophagy.
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
TMEM30A deficiency in endothelial cells impairs cell proliferation and angiogenesis.
Immunomodulatory effects of an acidic polysaccharide fraction from herbal Gynostemma pentaphyllum tea in RAW264.7 cells.
Protective Effect of Extract of Bletilla Striata on Isoflurane Induced Neuronal Injury By Altering PI3K/Akt Pathway.
A somatic mutation of RasGRP3 decreases Na+/I- symporter expression in metastases of radioactive iodine-refractory thyroid cancer by stimulating the Akt signaling pathway.
Astragaloside IV Improves Vasodilatation Function by Regulating the PI3K/Akt/eNOS Signaling Pathway in Rat Aorta Endothelial Cells.
The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction.
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Epithelial Cells Attenuate Toll-Like Receptor-Mediated Inflammatory Responses in Monocyte-Derived Macrophage-Like Cells to Mycobacterium tuberculosis by Modulating the PI3K/Akt/mTOR Signaling Pathway.
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
GPX3 suppresses tumor migration and invasion via the FAK/AKT pathway in esophageal squamous cell carcinoma.
Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway.
Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart.
Triptolide protects podocytes via autophagy in immunoglobulin A nephropathy.
miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN.
LP1 from Lentinula edodes C91-3 Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway.
ZKSCAN3 promotes breast cancer cell proliferation, migration and invasion.
Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor κB-Matrix Metalloproteinase Signaling.
Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells.
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase(mTORC2/AKT) to Promote Ca2+Production.
PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells in vitro.
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
Saponins from Boussingaultia gracilis prevent obesity and related metabolic impairments in diet-induced obese mice.
SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
Patulin induced ROS-dependent autophagic cell death in Human Hepatoma G2 cells.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Knockdown of hnRNP A2/B1 inhibits cell proliferation, invasion and cell cycle triggering apoptosis in cervical cancer via PI3K/AKT signaling pathway.
Marine Bacterial Polysaccharide EPS11 Inhibits Cancer Cell Growth via Blocking Cell Adhesion and Stimulating Anoikis.
Increased ZNF84 expression in cervical cancer.
Small interfering RNA-mediated silencing of G-protein-coupled receptor 137 inhibits growth of osteosarcoma cells.
A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy.
Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic reticulum stress and prevents hepatic steatosis in diet-induced obesity mice.
Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression.
Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p.
Thioredoxin-interacting protein deficiency ameliorates diabetic retinal angiogenesis.
UNBS5162 inhibits the proliferation of human A549 non-small-cell lung cancer cells by promoting apoptosis.
Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation.
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus.
UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway.
Pramlintide regulation of extracellular matrix (ECM) and apoptosis through mitochondrial-dependent pathways in human nucleus pulposus cells.
Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy.
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout.
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
Interleukin‑10 promotes proliferation and migration, and inhibits tendon differentiation via the JAK/Stat3 pathway in tendon‑derived stem cells in vitro.
LASP1 promotes glioma cell proliferation and migration and is negatively regulated by miR-377-3p.
4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling.
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells.
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Lactobacillus rhamnosus GG Affects Microbiota and Suppresses Autophagy in the Intestines of Pigs Challenged with Salmonella Infantis.
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells.
Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1-42-Induced Rat Model of Alzheimer's Disease.
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells.
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Lithium alleviates neurotoxic prion peptide-induced synaptic damage and neuronal death partially by the upregulation of nuclear target REST and the restoration of Wnt signaling.
Mono-(2-ethylhexyl) phthalate induced ROS-dependent autophagic cell death in human vascular endothelial cells.
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
RasGRP3 controls cell proliferation and migration in papillary thyroid cancer by regulating the Akt-MDM2 pathway.
Maslinic acid inhibits impairment of endothelial functions induced by high glucose in HAEC cells through improving insulin signaling and oxidative stress.
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs.
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways.
miR-29b contributes to multiple types of muscle atrophy.
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis.
Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-κB signaling pathways in RAW264.7 cells.
PTEN/PI3k/AKT Regulates Macrophage Polarization in Emphysematous mice.
Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway.
Down-regulation of islet amyloid polypeptide expression induces death of human annulus fibrosus cells via mitochondrial and death receptor pathways.
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice.
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles.
Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.
MicroRNA-302a enhances 5-fluorouracil-induced cell death in human colon cancer cells.
PRL-3 Is Involved in Estrogen- and IL-6-Induced Migration of Endometrial Stromal Cells From Ectopic Endometrium.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.
TRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway.
miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway.
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.
Scutellaria barbata D. Don inhibits migration and invasion of colorectal cancer cells via suppression of PI3K/AKT and TGF-β/Smad signaling pathways.
CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice.
Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway.
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
siRNA knockdown validation 101: Incorporating negative controls in antibody research.
Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.
Dexmedetomidine Inhibits Maturation and Function of Human Cord Blood-Derived Dendritic Cells by Interfering with Synthesis and Secretion of IL-12 and IL-23.
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma.
Oral kanglaite injection (KLTI) attenuates the lung cancer-promoting effect of high-fat diet (HFD)-induced obesity.
Thioredoxin-interacting protein regulates lipid metabolism via Akt/mTOR pathway in diabetic kidney disease.
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis.
17β-Estradiol Inhibites Tumor Necrosis Factor-α Induced Apoptosis of Human Nucleus Pulposus Cells via the PI3K/Akt Pathway.
AKT/TSC2/p70S6K signaling pathway is involved in quinocetone-induced death-promoting autophagy in HepG2 cells.
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.
Apelin-13 Protects PC12 Cells from Corticosterone-Induced Apoptosis Through PI3K and ERKs Activation.
Preventive Effects of a Novel Polysaccharide from Sepia esculenta Ink on Ovarian Failure and Its Action Mechanisms in Cyclophosphamide-Treated Mice.
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Dysregulation of Neuregulin-1/ErbB signaling in the prefrontal cortex and hippocampus of rats exposed to chronic unpredictable mild stress.
bFGF Protects Against Blood-Brain Barrier Damage Through Junction Protein Regulation via PI3K-Akt-Rac1 Pathway Following Traumatic Brain Injury.
Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.
miR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis.
Paper-based microreactor array for rapid screening of cell signaling cascades.
CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.
Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice.
Down-regulation of ribosomal protein S15A inhibits proliferation of human glioblastoma cells in vivo and in vitro via AKT pathway.
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth.
TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Inhibitive effects of 15-deoxy-Δ(12),(14)-prostaglandin J2 on hepatoma-cell proliferation through reactive oxygen species-mediated apoptosis.
NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/mTOR phosphorylation.
Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis.
Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway.
Low dose photodynamic-therapy induce immune escape of tumor cells in a HIF-1α dependent manner through PI3K/Akt pathway.
Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas.
Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway.
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Activated estrogen receptor-mitogen-activated protein kinases cross talk confer acquired resistance to lapatinib.
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3.
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways.
Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells.
Quetiapine inhibits osteoclastogenesis and prevents human breast cancer-induced bone loss through suppression of the RANKL-mediated MAPK and NF-κB signaling pathways.
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.
Salidroside stimulates mitochondrial biogenesis and protects against H₂O₂-induced endothelial dysfunction.
11-epi-Sinulariolide acetate reduces cell migration and invasion of human hepatocellular carcinoma by reducing the activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR signaling pathways.
The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF.
Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.
ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21((CIP1/WAF1)) in human cancer cells.
The mechanisms of EGFR in the regulation of axon regeneration.
Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia.
Ubiquitin‑specific protease 22‑induced autophagy is correlated with poor prognosis of pancreatic cancer.
Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition.
MiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGF-VEGFR2 pathway.
Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway.
Effects of PI3K inhibitor NVP-BKM120 on acquired resistance to gefitinib of human lung adenocarcinoma H1975 cells.
Facio-genital dysplasia-5 regulates matrix adhesion and survival of human endothelial cells.
Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma.
Chen YQ, Zhu WT, Lin CY, Yuan ZW, Li ZH, Yan PK
International journal of nanomedicine 2021;16:269-281
International journal of nanomedicine 2021;16:269-281
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Li J, Chen H, Lou J, Bao G, Wu C, Lou Z, Wang X, Ding J, Li Z, Xiao J, Xu H, Gao W, Zhou K
Journal of cellular physiology 2021 May;236(5):3641-3659
Journal of cellular physiology 2021 May;236(5):3641-3659
Postnatal overfeeding induces hepatic microRNA-221 expression and impairs the PI3K/AKT pathway in adult male rats.
Huang F, Zhu P, Wang J, Chen J, Lin W
Pediatric research 2021 Jan;89(1):143-149
Pediatric research 2021 Jan;89(1):143-149
Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.
Jiang F, Ren S, Chen Y, Zhang A, Zhu Y, Zhang Z, Li Z, Piao D
Oncology reports 2021 Jan;45(1):139-150
Oncology reports 2021 Jan;45(1):139-150
Blocking VRK2 suppresses pulmonary adenocarcinoma progression via ERK1/2/AKT signal pathway by targeting miR-145-5p.
Mu Y, Liu WJ, Bie LY, Mu XQ, Zhao YQ
European review for medical and pharmacological sciences 2021 Jan;25(1):145-153
European review for medical and pharmacological sciences 2021 Jan;25(1):145-153
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Qing Ju Han, Han G, Peng J, Tang Z
Free radical biology & medicine 2021 Jan;162:181-190
Free radical biology & medicine 2021 Jan;162:181-190
Characteristics of inflammation process in monocrotaline-induced pulmonary arterial hypertension in rats.
Tang C, Luo Y, Li S, Huang B, Xu S, Li L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111081
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111081
Peptide OM-LV20 exerts neuroprotective effects against cerebral ischemia/reperfusion injury in rats.
Yin S, Yang M, Li Y, Li S, Fu Z, Liu N, Wang Y, Hu Y, Xie C, Shu L, Pang A, Gu Y, Wang Y, Sun J, Yang X
Biochemical and biophysical research communications 2021 Jan 22;537:36-42
Biochemical and biophysical research communications 2021 Jan 22;537:36-42
Typical phthalic acid esters induce apoptosis by regulating the PI3K/Akt/Bcl-2 signaling pathway in rat insulinoma cells.
Li L, Wang F, Zhang J, Wang K, De X, Li L, Zhang Y
Ecotoxicology and environmental safety 2021 Jan 15;208:111461
Ecotoxicology and environmental safety 2021 Jan 15;208:111461
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Sun Z, Zhang L, Li L, Shao C, Liu J, Zhou M, Wang Z
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer.
Wang Z, Yang Y, Hu S, He J, Wu Z, Qi Z, Huang M, Liu R, Lin Y, Tan C, Xu M, Zhang Z
Cell biology and toxicology 2021 Feb;37(1):35-49
Cell biology and toxicology 2021 Feb;37(1):35-49
RAB31 marks and controls an ESCRT-independent exosome pathway.
Wei D, Zhan W, Gao Y, Huang L, Gong R, Wang W, Zhang R, Wu Y, Gao S, Kang T
Cell research 2021 Feb;31(2):157-177
Cell research 2021 Feb;31(2):157-177
MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
Liu Z, Ma T, Duan J, Liu X, Liu L
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
ACTL6A knockdown inhibits cell migration by suppressing the AKT signaling pathway and enhances the sensitivity of glioma cells to temozolomide.
Chen X, Xiang Z, Li D, Zhu X, Peng X
Experimental and therapeutic medicine 2021 Feb;21(2):175
Experimental and therapeutic medicine 2021 Feb;21(2):175
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes.
Li J, Du S, Shi Y, Han J, Niu Z, Wei L, Yang P, Chen L, Tian H, Gao L
Experimental eye research 2021 Feb;203:108399
Experimental eye research 2021 Feb;203:108399
Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer.
Jhou AJ, Chang HC, Hung CC, Lin HC, Lee YC, Liu WT, Han KF, Lai YW, Lin MY, Lee CH
Biochemical pharmacology 2021 Feb;184:114403
Biochemical pharmacology 2021 Feb;184:114403
G-Rh4 improves pancreatic β-cells dysfunction in vivo and in vitro by increased expression of Nrf2 and its target genes.
Liu Y, Deng J, Fan D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111925
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111925
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Wang Z, Li B, Jiang H, Ma Y, Bao Y, Zhu X, Xia H, Jin Y
Cytokine 2021 Feb;138:155402
Cytokine 2021 Feb;138:155402
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
Peng MF, Tian S, Song YG, Li CX, Miao MS, Zhen-Ren, Li M
Journal of ethnopharmacology 2021 Feb 19;:113947
Journal of ethnopharmacology 2021 Feb 19;:113947
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
Xiao Y, Liu Y, Lai Z, Huang J, Li C, Zhang Y, Gong X, Deng J, Ye X, Li X
Journal of ethnopharmacology 2021 Apr 24;270:113806
Journal of ethnopharmacology 2021 Apr 24;270:113806
SPANXN2 functions a cell migration inhibitor in testicular germ cell tumor cells.
Zhu F, Bo H, Liu G, Li R, Liu Z, Fan L
PeerJ 2020;8:e9358
PeerJ 2020;8:e9358
miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism.
Chen X, Deng S, Lei Q, He Q, Ren Y, Zhang Y, Nie J, Lu W
Frontiers in cell and developmental biology 2020;8:598020
Frontiers in cell and developmental biology 2020;8:598020
Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.
Ma D, Liu X, Zhang JJ, Zhao JJ, Xiong YJ, Chang Q, Wang HY, Su P, Meng J, Zhao YB
Frontiers in cardiovascular medicine 2020;7:592550
Frontiers in cardiovascular medicine 2020;7:592550
Bta-miR-223 Targeting CBLB Contributes to Resistance to Staphylococcus aureus Mastitis Through the PI3K/AKT/NF-κB Pathway.
Han S, Li X, Liu J, Zou Z, Luo L, Wu R, Zhao Z, Wang C, Shen B
Frontiers in veterinary science 2020;7:529
Frontiers in veterinary science 2020;7:529
PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1R/VEGFR2 Pathway in Papillary Thyroid Carcinoma.
Chen Q, Yu WY, Zhang HH, Zhang SZ, Fang J, Wu F, Ying HZ, Yu CH
BioMed research international 2020;2020:8954513
BioMed research international 2020;2020:8954513
Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling.
Xing J, Li P, Hong J, Wang M, Liu Y, Gao Y, Dong J, Gu H, Li L
Mediators of inflammation 2020;2020:4121750
Mediators of inflammation 2020;2020:4121750
Tianma Gouteng Decoction Exerts Cardiovascular Protection by Upregulating OPG and TRAIL in Spontaneously Hypertensive Rats.
Deng LH, Li L, Zhai Y, Michael S, Yang CY, Guo R, Chen SF, Fan GW, Zhao YQ, Liu W
Evidence-based complementary and alternative medicine : eCAM 2020;2020:3439191
Evidence-based complementary and alternative medicine : eCAM 2020;2020:3439191
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma.
Jiang H, Guo W, Yuan S, Song L
BioMed research international 2020;2020:3418398
BioMed research international 2020;2020:3418398
miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway.
Tian R, Jiang H, Shao L, Yu Y, Guo Q, Cao B, Guo S
BioMed research international 2020;2020:2863236
BioMed research international 2020;2020:2863236
Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40.
Song W, Lv Y, Tang Z, Nie F, Huang P, Pei Q, Guo R
Cardiovascular therapeutics 2020;2020:1795853
Cardiovascular therapeutics 2020;2020:1795853
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Jing X, Du L, Niu A, Wang Y, Wang Y, Wang C
BioMed research international 2020;2020:1276328
BioMed research international 2020;2020:1276328
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
An Y, Zhang J, Cheng X, Li B, Tian Y, Zhang X, Zhao F
Cancer cell international 2020;20:237
Cancer cell international 2020;20:237
Apatinib suppresses tumor progression and enhances cisplatin sensitivity in esophageal cancer via the Akt/β-catenin pathway.
Wei B, Wang Y, Wang J, Cai X, Xu L, Wu J, Wang Y, Liu W, Gu Y, Guo W, Xu Q
Cancer cell international 2020;20:198
Cancer cell international 2020;20:198
Effects of Kindlin-2 on proliferation and migration of VSMC and integrinβ1 andβ3 activity via FAK-PI3K signaling pathway.
Wu X, Bian F, Hu H, Zhu T, Li C, Zhou Q
PloS one 2020;15(6):e0225173
PloS one 2020;15(6):e0225173
TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.
Han B, Pei Z, Shi L, Wang Q, Li C, Zhang B, Su X, Zhang N, Zhou L, Zhao B, Niu Y, Zhang R
International journal of nanomedicine 2020;15:6279-6294
International journal of nanomedicine 2020;15:6279-6294
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
Lin HY, Han HW, Wang YS, He DL, Sun WX, Feng L, Wen ZL, Yang MK, Lu GH, Wang XM, Qi JL, Yang YH
Chinese medicine 2020;15:23
Chinese medicine 2020;15:23
Insulin-Like Growth Factor-1 Down-Regulates the Phosphorylation of FXYD1 and Rescues Behavioral Deficits in a Mouse Model of Rett Syndrome.
Yuan ZF, Mao SS, Shen J, Jiang LH, Xu L, Xu JL, Gao F
Frontiers in neuroscience 2020;14:20
Frontiers in neuroscience 2020;14:20
RPL38 Regulates the Proliferation and Apoptosis of Gastric Cancer via miR-374b-5p/VEGF Signal Pathway.
Ji H, Zhang X
OncoTargets and therapy 2020;13:6131-6141
OncoTargets and therapy 2020;13:6131-6141
Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-β/Smad3 signaling and promoting angiogenesis.
Zong J, Jiang J, Shi P, Liu J, Wang W, Li B, Zhao T, Pan T, Zhang Z, Bi L, Diao Y, Wang S
American journal of translational research 2020;12(2):478-492
American journal of translational research 2020;12(2):478-492
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446
American journal of translational research 2020;12(2):428-446
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Jing X, Chen Y, Chen Y, Shi G, Lv S, Cheng N, Feng C, Xin Z, Zhang L, Wu J
Cancer management and research 2020;12:2185-2194
Cancer management and research 2020;12:2185-2194
Rutaecarpine Ameliorates Ethanol-Induced Gastric Mucosal Injury in Mice by Modulating Genes Related to Inflammation, Oxidative Stress and Apoptosis.
Ren S, Wei Y, Wang R, Wei S, Wen J, Yang T, Chen X, Wu S, Jing M, Li H, Wang M, Zhao Y
Frontiers in pharmacology 2020;11:600295
Frontiers in pharmacology 2020;11:600295
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
Luo H, Peng F, Weng B, Tang X, Chen Y, Yang A, Chen B, Ran M
Frontiers in genetics 2020;11:581593
Frontiers in genetics 2020;11:581593
Facilitating Granule Cell Survival and Maturation in Dentate Gyrus With Baicalin for Antidepressant Therapeutics.
Zhao F, Tao W, Shang Z, Zhang W, Ruan J, Zhang C, Zhou L, Aiello H, Lai H, Qu R
Frontiers in pharmacology 2020;11:556845
Frontiers in pharmacology 2020;11:556845
Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling.
Liu C, Chen K, Wang H, Zhang Y, Duan X, Xue Y, He H, Huang Y, Chen Z, Ren H, Wang H, Zeng C
Frontiers in pharmacology 2020;11:540479
Frontiers in pharmacology 2020;11:540479
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
Xu HX, Lin SX, Gong Y, Huo ZX, Zhao CY, Zhu HM, Xi SY
Frontiers in pharmacology 2020;11:245
Frontiers in pharmacology 2020;11:245
HPV16 E6/E7 promote the translocation and glucose uptake of GLUT1 by PI3K/AKT pathway via relieving miR-451 inhibitory effect on CAB39 in lung cancer cells.
Wang HM, Lu YJ, He L, Gu NJ, Wang SY, Qiu XS, Wang EH, Wu GP
Therapeutic advances in chronic disease 2020;11:2040622320957143
Therapeutic advances in chronic disease 2020;11:2040622320957143
Metformin activates the STING/IRF3/IFN-β pathway by inhibiting AKT phosphorylation in pancreatic cancer.
Ren D, Qin G, Zhao J, Sun Y, Zhang B, Li D, Wang B, Jin X, Wu H
American journal of cancer research 2020;10(9):2851-2864
American journal of cancer research 2020;10(9):2851-2864
Precise and efficient silencing of mutant KrasG12D by CRISPR-CasRx controls pancreatic cancer progression.
Jiang W, Li H, Liu X, Zhang J, Zhang W, Li T, Liu L, Yu X
Theranostics 2020;10(25):11507-11519
Theranostics 2020;10(25):11507-11519
LRRC4 Suppresses E-Cadherin-Dependent Collective Cell Invasion and Metastasis in Epithelial Ovarian Cancer.
Zhao C, She X, Zhang Y, Liu C, Li P, Chen S, Sai B, Li Y, Feng J, Liu J, Sun Y, Xiao S, Li L, Wu M
Frontiers in oncology 2020;10:144
Frontiers in oncology 2020;10:144
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
Wu Y, Wang Z, Fu X, Lin Z, Yu K
International immunopharmacology 2020 Sep;86:106713
International immunopharmacology 2020 Sep;86:106713
Targeting CPT1B as a potential therapeutic strategy in castration-resistant and enzalutamide-resistant prostate cancer.
Abudurexiti M, Zhu W, Wang Y, Wang J, Xu W, Huang Y, Zhu Y, Shi G, Zhang H, Zhu Y, Shen Y, Dai B, Wan F, Lin G, Ye D
The Prostate 2020 Sep;80(12):950-961
The Prostate 2020 Sep;80(12):950-961
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway.
Zhang ZF, Huang TJ, Zhang XK, Xie YJ, Lin ST, Luo FF, Meng DF, Hu H, Wang J, Peng LX, Qian CN, Cheng C, Huang BJ
Journal of cellular and molecular medicine 2020 Sep;24(17):9999-10012
Journal of cellular and molecular medicine 2020 Sep;24(17):9999-10012
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
Liu Z, Ye S, Zhong X, Wang W, Lai CH, Yang W, Yue P, Luo J, Huang X, Zhong Z, Xiong Y, Fan X, Li L, Wang Y, Ye Q
Molecular medicine reports 2020 Sep;22(3):2373-2385
Molecular medicine reports 2020 Sep;22(3):2373-2385
FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.
Zhao L, Kong X, Zhong W, Wang Y, Li P
Pathology, research and practice 2020 Sep;216(9):153042
Pathology, research and practice 2020 Sep;216(9):153042
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
Yang F, Qu Q, Zhao C, Liu X, Yang P, Li Z, Han L, Shi X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Liu J, Shangguan Y, Sun J, Cong W, Xie Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
RNA-binding protein CUGBP1 controls the differential INSR splicing in molecular subtypes of breast cancer cells and affects cell aggressiveness.
Huang G, Song C, Wang N, Qin T, Sui S, Obr A, Zeng L, Wood TL, Leroith D, Li M, Wu Y
Carcinogenesis 2020 Sep 24;41(9):1294-1305
Carcinogenesis 2020 Sep 24;41(9):1294-1305
Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop.
Zhang X, Niu W, Mu M, Hu S, Niu C
Journal of experimental & clinical cancer research : CR 2020 Sep 22;39(1):196
Journal of experimental & clinical cancer research : CR 2020 Sep 22;39(1):196
FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis.
Gao W, Liang J, Ye Y, Lu J, Lin T, Wang N, Dong J, Pan J
BMC cancer 2020 Sep 18;20(1):895
BMC cancer 2020 Sep 18;20(1):895
Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.
Li P, Ding L, Cao S, Feng X, Zhang Q, Chen Y, Zhang N, Qiu F
Journal of ethnopharmacology 2020 Sep 15;259:113015
Journal of ethnopharmacology 2020 Sep 15;259:113015
Sphingomyelin Synthase 2 Participate in the Regulation of Sperm Motility and Apoptosis.
Li X, Luo T, Li H, Yan N
Molecules (Basel, Switzerland) 2020 Sep 15;25(18)
Molecules (Basel, Switzerland) 2020 Sep 15;25(18)
Neuronostatin Promotion Soluble Aβ1-42 Oligomers: Induced Dysfunctional Brain Glucose Metabolism in Mice.
Yang S, Zhou F, Ma M, Yuan Y, Zhao S, Yu P
Neurochemical research 2020 Oct;45(10):2474-2486
Neurochemical research 2020 Oct;45(10):2474-2486
Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.
Yang ZH, Li J, Chen WZ, Kong FS
Cell biochemistry and function 2020 Oct;38(7):943-954
Cell biochemistry and function 2020 Oct;38(7):943-954
LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.
Li Y, Zhang M, Li F
Histology and histopathology 2020 Oct;35(10):1171-1180
Histology and histopathology 2020 Oct;35(10):1171-1180
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Lv S, Yuan P, Dong J, Lu C, Li M, Qu F, Zhu Y, Yuan Z, Zhang J
Journal of cellular and molecular medicine 2020 Oct;24(19):11283-11293
Journal of cellular and molecular medicine 2020 Oct;24(19):11283-11293
Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene.
Wang X, Xu X, Jiang G, Zhang C, Liu L, Kang J, Wang J, Owusu L, Zhou L, Zhang L, Li W
Journal of cellular and molecular medicine 2020 Oct;24(19):11177-11187
Journal of cellular and molecular medicine 2020 Oct;24(19):11177-11187
Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway.
Gou Z, Su X, Hu X, Zhou Y, Huang L, Fan Y, Li J, Lu L
Brain research bulletin 2020 Oct;163:40-48
Brain research bulletin 2020 Oct;163:40-48
Protective effect of astaxanthin against La2O3 nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Yuan L, Qu Y, Li Q, An T, Chen Z, Chen Y, Deng X, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Paired like homeodomain 1 and SAM and SH3 domain-containing 1 in the progression and prognosis of head and neck squamous cell carcinoma.
Jin Y, Qin X
The international journal of biochemistry & cell biology 2020 Oct;127:105846
The international journal of biochemistry & cell biology 2020 Oct;127:105846
Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors.
Ma Z, Liu K, Li XR, Wang C, Liu C, Yan DY, Deng Y, Liu W, Xu B
Cell death & disease 2020 Oct 8;11(10):834
Cell death & disease 2020 Oct 8;11(10):834
Myostatin-1 Inhibits Cell Proliferation by Inhibiting the mTOR Signal Pathway and MRFs, and Activating the Ubiquitin-Proteasomal System in Skeletal Muscle Cells of Japanese Flounder Paralichthys olivaceus.
Liu J, Pan M, Huang D, Guo Y, Yang M, Zhang W, Mai K
Cells 2020 Oct 29;9(11)
Cells 2020 Oct 29;9(11)
Phosphatidylinositol 4-kinase β is required for the ciliogenesis of zebrafish otic vesicle.
Feng Y, Yu P, Li J, Cao Y, Zhang J
Journal of genetics and genomics = Yi chuan xue bao 2020 Oct 20;47(10):627-636
Journal of genetics and genomics = Yi chuan xue bao 2020 Oct 20;47(10):627-636
Bazedoxifene inhibits PDGF-BB induced VSMC phenotypic switch via regulating the autophagy level.
Song W, Gao K, Huang P, Tang Z, Nie F, Jia S, Guo R
Life sciences 2020 Oct 15;259:118397
Life sciences 2020 Oct 15;259:118397
Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway.
Chen Y, Niu J, Li L, Li Z, Jiang J, Zhu M, Dong T, Zhang J, Shi C, Xu P, Lu Y, Jiang Y, Liu P, Chen W
Life sciences 2020 Oct 1;258:118158
Life sciences 2020 Oct 1;258:118158
Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma.
Li L, Huang K, Lu Z, Zhao H, Li H, Ye Q, Peng G
Oncology reports 2020 Nov;44(5):2185-2197
Oncology reports 2020 Nov;44(5):2185-2197
Pea-derived peptides, VLP, LLP, VA, and LL, improve insulin resistance in HepG2 cells via activating IRS-1/PI3K/AKT and blocking ROS-mediated p38MAPK signaling.
Zhu Y, Zhang H, Wei Y, Cai M, Gu R, Wang Y, Ma Y, Chen L
Journal of food biochemistry 2020 Nov;44(11):e13454
Journal of food biochemistry 2020 Nov;44(11):e13454
Hydroquinone inhibits PRV infection in neurons in vitro and in vivo.
Fang L, Gao Y, Lan M, Jiang P, Bai J, Li Y, Wang X
Veterinary microbiology 2020 Nov;250:108864
Veterinary microbiology 2020 Nov;250:108864
The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model.
Cui H, Cheng Y, He Y, Cheng W, Zhao W, Zhao H, Zhou FH, Wang L, Dong J, Cai S
Molecular medicine reports 2020 Nov;22(5):3723-3734
Molecular medicine reports 2020 Nov;22(5):3723-3734
Establishment and characterization of a docetaxel-resistant human prostate cancer cell line.
Liu J, Huang Y, Zhu D, Dai Y, Liu D, Zhai Y, Liang X, Wu L, Zhao Q
Oncology letters 2020 Nov;20(5):230
Oncology letters 2020 Nov;20(5):230
SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway.
Du Q, Chen J
Experimental and therapeutic medicine 2020 Nov;20(5):110
Experimental and therapeutic medicine 2020 Nov;20(5):110
Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate-induced colitis.
Liu M, Xie W, Wan X, Deng T
Experimental and therapeutic medicine 2020 Nov;20(5):10
Experimental and therapeutic medicine 2020 Nov;20(5):10
Extracellular ubiquitin protects cardiomyocytes during ischemia/hypoxia by inhibiting mitochondrial apoptosis pathway through CXCR4.
Ji Y, Yao J, He Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110787
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110787
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
Li T, Zhang L, Jin C, Xiong Y, Cheng YY, Chen K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110769
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110769
CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP-9/PI3K/AKT pathway.
Chen H, Pan R, Li H, Zhang W, Ren C, Lu Q, Chen H, Zhang X, Nie Y
Cell biology international 2020 Nov 27;
Cell biology international 2020 Nov 27;
Hypoxia-induced SPOP attenuates the mobility of trophoblast cells through inhibition of the PI3K/AKT/GSK3β pathway.
Yuan D, Yang Z, Chen Y, Li S, Tan B, Yu Q
Cell biology international 2020 Nov 17;
Cell biology international 2020 Nov 17;
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Zhang H, Hui J, Yang J, Deng J, Fan D
European journal of pharmacology 2020 Nov 15;887:173557
European journal of pharmacology 2020 Nov 15;887:173557
Arsenic induces hepatic insulin resistance via mtROS-NLRP3 inflammasome pathway.
Jia X, Qiu T, Yao X, Jiang L, Wang N, Wei S, Tao Y, Pei P, Wang Z, Zhang J, Zhu Y, Yang G, Liu X, Liu S, Sun X
Journal of hazardous materials 2020 Nov 15;399:123034
Journal of hazardous materials 2020 Nov 15;399:123034
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
Zhang Y, Liu X, Yu M, Xu M, Xiao Y, Ma W, Huang L, Li X, Ye X
Life sciences 2020 Nov 1;260:118413
Life sciences 2020 Nov 1;260:118413
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Cai BB, Lu YN, Xu M
Acta pharmacologica Sinica 2020 May;41(5):650-660
Acta pharmacologica Sinica 2020 May;41(5):650-660
Kp-10 promotes bovine mammary epithelial cell proliferation by activating GPR54 and its downstream signaling pathways.
Li Y, Cao Y, Wang J, Fu S, Cheng J, Ma L, Zhang Q, Guo W, Kan X, Liu J
Journal of cellular physiology 2020 May;235(5):4481-4493
Journal of cellular physiology 2020 May;235(5):4481-4493
MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.
Zhang M, Li F, Wang X, Gong J, Xian Y, Wang G, Zheng Z, Shang C, Wang B, He Y, Wang W, Lin R
Histochemistry and cell biology 2020 May;153(5):357-366
Histochemistry and cell biology 2020 May;153(5):357-366
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
Yu YP, Cai LC, Wang XY, Cheng SY, Zhang DM, Jian WG, Wang TD, Yang JK, Yang KB, Zhang C
Cancer science 2020 May;111(5):1555-1566
Cancer science 2020 May;111(5):1555-1566
CRISPR/Cas9-Mediated miR-29b Editing as a Treatment of Different Types of Muscle Atrophy in Mice.
Li J, Wang L, Hua X, Tang H, Chen R, Yang T, Das S, Xiao J
Molecular therapy : the journal of the American Society of Gene Therapy 2020 May 6;28(5):1359-1372
Molecular therapy : the journal of the American Society of Gene Therapy 2020 May 6;28(5):1359-1372
Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes.
Han P, Hanlon D, Arshad N, Lee JS, Tatsuno K, Robinson E, Filler R, Sobolev O, Cote C, Rivera-Molina F, Toomre D, Fahmy T, Edelson R
Science advances 2020 Mar;6(11):eaaz1580
Science advances 2020 Mar;6(11):eaaz1580
Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury.
Wang X, Liu M, Zhu MJ, Shi L, Liu L, Zhao YL, Cheng L, Gu YJ, Zhou MY, Chen L, Kumar A, Wang Y
Cell proliferation 2020 Mar;53(3):e12773
Cell proliferation 2020 Mar;53(3):e12773
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Xiao T, Sun J, Xing Z, Xie F, Yang L, Ding W
Cell biology international 2020 Mar;44(3):821-829
Cell biology international 2020 Mar;44(3):821-829
Do You Know the Details of Your PAX8 Antibody? Monoclonal PAX8 (MRQ-50) Is Not Expressed in a Series of 45 Medullary Thyroid Carcinomas.
Gucer H, Caliskan S, Kefeli M, Mete O
Endocrine pathology 2020 Mar;31(1):33-38
Endocrine pathology 2020 Mar;31(1):33-38
Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats.
Tan XH, Zhang KK, Xu JT, Qu D, Chen LJ, Li JH, Wang Q, Wang HJ, Xie XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111179
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111179
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
Tang W, Wang D, Shao L, Liu X, Zheng J, Xue Y, Ruan X, Yang C, Liu L, Ma J, Li Z, Liu Y
Molecular therapy. Nucleic acids 2020 Mar 6;19:905-921
Molecular therapy. Nucleic acids 2020 Mar 6;19:905-921
Galectin-1 Overexpression Activates the FAK/PI3K/AKT/mTOR Pathway and Is Correlated with Upper Urinary Urothelial Carcinoma Progression and Survival.
Su YL, Luo HL, Huang CC, Liu TT, Huang EY, Sung MT, Lin JJ, Chiang PH, Chen YT, Kang CH, Cheng YT
Cells 2020 Mar 26;9(4)
Cells 2020 Mar 26;9(4)
LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway.
Zhang Y, Chen L, Cao Y, Chen S, Xu C, Xing J, Zhang K
Journal of gastric cancer 2020 Jun;20(2):139-151
Journal of gastric cancer 2020 Jun;20(2):139-151
Tolfenamic acid inhibits GSK-3β and PP2A mediated tau hyperphosphorylation in Alzheimer's disease models.
Zhang H, Wang X, Xu P, Ji X, Chi T, Liu P, Zou L
The journal of physiological sciences : JPS 2020 Jun 9;70(1):29
The journal of physiological sciences : JPS 2020 Jun 9;70(1):29
lncRNA PVT1 Promotes Tumorigenesis of Colorectal Cancer by Stabilizing miR-16-5p and Interacting with the VEGFA/VEGFR1/AKT Axis.
Wu H, Wei M, Jiang X, Tan J, Xu W, Fan X, Zhang R, Ding C, Zhao F, Shao X, Zhang Z, Shi R, Zhang W, Wu G
Molecular therapy. Nucleic acids 2020 Jun 5;20:438-450
Molecular therapy. Nucleic acids 2020 Jun 5;20:438-450
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Liu JZ, Hu YL, Feng Y, Jiang Y, Guo YB, Liu YF, Chen X, Yang JL, Chen YY, Mao QS, Xue WJ
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro.
Tan Y, Yin L, Sun Z, Shao S, Chen W, Man X, Du Y, Chen Y
International journal of biological macromolecules 2020 Jun 15;153:349-356
International journal of biological macromolecules 2020 Jun 15;153:349-356
TSPO ligand Ro5-4864 modulates microglia/macrophages polarization after subarachnoid hemorrhage in mice.
Zhou J, Zhang X, Peng J, Xie Y, Du F, Guo K, Feng Y, Zhang L, Chen L, Jiang Y
Neuroscience letters 2020 Jun 11;729:134977
Neuroscience letters 2020 Jun 11;729:134977
LAMC2 modulates the acidity of microenvironments to promote invasion and migration of pancreatic cancer cells via regulating AKT-dependent NHE1 activity.
Wang H, Cai J, Du S, Wei W, Shen X
Experimental cell research 2020 Jun 1;391(1):111984
Experimental cell research 2020 Jun 1;391(1):111984
Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway.
Han B, Jiang L, Jiang P, Zhou D, Jia X, Li X, Ye X
Planta medica 2020 Jul;86(11):767-775
Planta medica 2020 Jul;86(11):767-775
Prenatal High-Salt Diet-Induced Metabolic Disorders via Decreasing Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in Adult Male Rat Offspring.
Liu Y, Yang C, Feng X, Qi L, Guo J, Zhu D, Thai PN, Zhang Y, Zhang P, Sun M, Lv J, Zhang L, Xu Z, Lu X
Molecular nutrition & food research 2020 Jul;64(14):e2000196
Molecular nutrition & food research 2020 Jul;64(14):e2000196
Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.
Jiang F, Chen Y, Ren S, Li Z, Sun K, Xing Y, Zhu Y, Piao D
International journal of oncology 2020 Jul;57(1):183-196
International journal of oncology 2020 Jul;57(1):183-196
TGF‑β1 induces CREB1‑mediated miR‑1290 upregulation to antagonize lung fibrosis via Napsin A.
Guan S, Wu Y, Zhang Q, Zhou J
International journal of molecular medicine 2020 Jul;46(1):141-148
International journal of molecular medicine 2020 Jul;46(1):141-148
Fluid shear stress induces Runx-2 expression via upregulation of PIEZO1 in MC3T3-E1 cells.
Song J, Liu L, Lv L, Hu S, Tariq A, Wang W, Dang X
Cell biology international 2020 Jul;44(7):1491-1502
Cell biology international 2020 Jul;44(7):1491-1502
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, Qiu B, Tang B
Oncology reports 2020 Jul;44(1):103-114
Oncology reports 2020 Jul;44(1):103-114
AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway.
Chen Y, Cao W, Wang L, Zhong T
Journal of cellular and molecular medicine 2020 Jul;24(13):7652-7659
Journal of cellular and molecular medicine 2020 Jul;24(13):7652-7659
A novel antitumor dithiocarbamate compound inhibits the EGFR/AKT signaling pathway and induces apoptosis in esophageal cancer cells.
Yang Y, Tian Z, Zhao X, Li Y, Duan S
Oncology letters 2020 Jul;20(1):877-883
Oncology letters 2020 Jul;20(1):877-883
PRR11 and SKA2 promote the proliferation, migration and invasion of esophageal carcinoma cells.
Chen J, Yang HM, Zhou HC, Peng RR, Niu ZX, Kang CY
Oncology letters 2020 Jul;20(1):639-646
Oncology letters 2020 Jul;20(1):639-646
MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.
Wen X, Li H, Sun H, Zeng A, Lin R, Zhao J, Zhang Z
Life sciences 2020 Jul 15;253:117718
Life sciences 2020 Jul 15;253:117718
Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma.
Li D, Tang Z, Gao Z, Shen P, Liu Z, Dang X
Molecular and cellular biology 2020 Jul 14;40(15)
Molecular and cellular biology 2020 Jul 14;40(15)
Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.
Li T, Liu T, Chen X, Li L, Feng M, Zhang Y, Wan L, Zhang C, Yao W
Journal of neuroinflammation 2020 Jul 14;17(1):211
Journal of neuroinflammation 2020 Jul 14;17(1):211
Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy.
Xu D, Liu J, Ma H, Guo W, Wang J, Kan X, Li Y, Gong Q, Cao Y, Cheng J, Fu S
International immunopharmacology 2020 Jan;78:105983
International immunopharmacology 2020 Jan;78:105983
Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway.
Wu P, Shi X, Luo M, Inam-U-Llah, Li K, Zhang M, Ma J, Li Y, Liu Y, Zhang C, Liu X, Li S, Li Q, Chen X, Che X, Piao F
Amino acids 2020 Jan;52(1):87-102
Amino acids 2020 Jan;52(1):87-102
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
Jiang ZH, Tang YZ, Song HN, Yang M, Li B, Ni CL
International journal of molecular medicine 2020 Jan;45(1):45-52
International journal of molecular medicine 2020 Jan;45(1):45-52
Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.
Li W, Jiang YH, Wang Y, Zhao M, Hou GJ, Hu HZ, Zhou L
Chinese journal of integrative medicine 2020 Jan;26(1):46-53
Chinese journal of integrative medicine 2020 Jan;26(1):46-53
Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
Zhu Y, Shi F, Wang M, Ding J
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820915958
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820915958
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway.
Meng Q, Xue H
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820905823
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820905823
Alisol A-24-acetate promotes glucose uptake via activation of AMPK in C2C12 myotubes.
Chen JX, Li HY, Li TT, Fu WC, Du X, Liu CH, Zhang W
BMC complementary medicine and therapies 2020 Jan 29;20(1):22
BMC complementary medicine and therapies 2020 Jan 29;20(1):22
FAM60A, increased by Helicobacter pylori, promotes proliferation and suppresses apoptosis of gastric cancer cells by targeting the PI3K/AKT pathway.
Yao X, Liu D, Zhou L, Xie Y, Li Y
Biochemical and biophysical research communications 2020 Jan 22;521(4):1003-1009
Biochemical and biophysical research communications 2020 Jan 22;521(4):1003-1009
MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury.
Yan Z, Zang B, Gong X, Ren J, Wang R
Life sciences 2020 Jan 15;241:117118
Life sciences 2020 Jan 15;241:117118
Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis.
Guo SS, Liu R, Wen YF, Liu LT, Yuan L, Li YX, Li Y, Hao WW, Peng JY, Chen DN, Tang QN, Sun XS, Guo L, Mo HY, Qian CN, Zeng MS, Bei JX, Sun SY, Chen QY, Tang LQ, Mai HQ
Cancer letters 2020 Jan 1;468:27-40
Cancer letters 2020 Jan 1;468:27-40
Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.
Hua W, Li S, Luo R, Wu X, Zhang Y, Liao Z, Song Y, Wang K, Zhao K, Yang S, Yang C
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165575
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165575
Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis.
Tseng SH, Park ST, Lam B, Tsai YC, Cheng MA, Farmer E, Xing D, Hung CF
Journal for immunotherapy of cancer 2020 Feb;8(1)
Journal for immunotherapy of cancer 2020 Feb;8(1)
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
Hou B, Li W, Li J, Ma J, Xia P, Liu Z, Zeng Q, Zhang X, Chang D
Oncology reports 2020 Feb;43(2):536-548
Oncology reports 2020 Feb;43(2):536-548
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
He H, Xu C, Zheng L, Wang K, Jin M, Sun Y, Yue Z
Molecular medicine reports 2020 Feb;21(2):597-606
Molecular medicine reports 2020 Feb;21(2):597-606
Involvement of neurotrophic signaling in doxorubicin-induced cardiotoxicity.
Liao D, Zhang C, Liu N, Cao L, Wang C, Feng Q, Yao D, Long M, Jiang P
Experimental and therapeutic medicine 2020 Feb;19(2):1129-1135
Experimental and therapeutic medicine 2020 Feb;19(2):1129-1135
Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress.
Wang Y, Zhao H, Guo M, Fei D, Zhang L, Xing M
Journal of hazardous materials 2020 Feb 5;383:121217
Journal of hazardous materials 2020 Feb 5;383:121217
The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice.
Liu Q, Zhang S, Zhu D, Tang X, Che Y, Feng X
Behavioural brain research 2020 Feb 3;379:112337
Behavioural brain research 2020 Feb 3;379:112337
DHPAC, a novel microtubule depolymerizing agent, suppresses angiogenesis and vasculogenic mimicry formation of human non-small cell lung cancer.
Gong FL, Wang L, Yu LG, Dang YF, Jiang XN, Zhao L, Guo XL
Journal of cellular biochemistry 2020 Feb 14;
Journal of cellular biochemistry 2020 Feb 14;
Lycium barbarum polysaccharide protects against Homocysteine-induced Vascular smooth muscle cell proliferation and phenotypic transformation via PI3K/Akt pathway.
Zhang M, Li F, Pokharel S, Ma T, Wang X, Wang Y, Wang W, Lin R
Journal of molecular histology 2020 Dec;51(6):629-637
Journal of molecular histology 2020 Dec;51(6):629-637
Heat stress activates YAP/TAZ to induce the heat shock transcriptome.
Luo M, Meng Z, Moroishi T, Lin KC, Shen G, Mo F, Shao B, Wei X, Zhang P, Wei Y, Guan KL
Nature cell biology 2020 Dec;22(12):1447-1459
Nature cell biology 2020 Dec;22(12):1447-1459
Zinc application alleviates the adverse renal effects of arsenic stress in a protein quality control way in common carp.
Wang Y, Zhao H, Nie X, Guo M, Jiang G, Xing M
Environmental research 2020 Dec;191:110063
Environmental research 2020 Dec;191:110063
Ssc-miR-21-5p regulates endometrial epithelial cell proliferation, apoptosis and migration via the PDCD4/AKT pathway.
Hua R, Zhang X, Li W, Lian W, Liu Q, Gao D, Wang Y, Lei M
Journal of cell science 2020 Dec 9;133(23)
Journal of cell science 2020 Dec 9;133(23)
Exploration of the Effects of Substrate Stiffness on Biological Responses of Neural Cells and Their Mechanisms.
Zhang C, Tan Y, Feng J, Huang C, Liu B, Fan Z, Xu B, Lu T
ACS omega 2020 Dec 8;5(48):31115-31125
ACS omega 2020 Dec 8;5(48):31115-31125
MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway.
Qiu C, Su W, Shen N, Qi X, Wu X, Wang K, Li L, Guo Z, Tao H, Wang G, Chen B, Xiang H
BMC cancer 2020 Dec 3;20(1):1187
BMC cancer 2020 Dec 3;20(1):1187
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Li Y, Liu M, Yi J, Song X, Zheng X, Liu D, Wang S, Chu C, Yang J
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Zhang Y, Sun J, Dong Y, Shen X, Zhang Z
Journal of biochemical and molecular toxicology 2020 Dec 16;:e22680
Journal of biochemical and molecular toxicology 2020 Dec 16;:e22680
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Xiao S, Li S, Yuan Z, Zhou L
Annals of translational medicine 2020 Aug;8(15):937
Annals of translational medicine 2020 Aug;8(15):937
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Zhou H, Yuan D, Gao W, Tian J, Sun H, Yu S, Wang J, Sun L
IUBMB life 2020 Aug;72(8):1659-1679
IUBMB life 2020 Aug;72(8):1659-1679
IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
Gao Y, Lu J, Zeng C, Yang J, Huang B, Zhang N, Li L, Fu X
Clinical and experimental medicine 2020 Aug;20(3):449-459
Clinical and experimental medicine 2020 Aug;20(3):449-459
Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.
Liu YC, Tsai JJ, Weng YS, Hsu FT
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110319
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110319
Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer.
Li JM, Yang F, Li J, Yuan WQ, Wang H, Luo YQ
Medical science monitor : international medical journal of experimental and clinical research 2020 Aug 7;26:e925298
Medical science monitor : international medical journal of experimental and clinical research 2020 Aug 7;26:e925298
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J
Nutrition and cancer 2020 Aug 7;:1-12
Nutrition and cancer 2020 Aug 7;:1-12
NCOA5 is a master regulator of amino acid-induced mTOR activation and β-casein synthesis in bovine mammary epithelial cells.
Yuan X, Zhang L, Cui Y, Yu Y, Gao X, Ao J
Biochemical and biophysical research communications 2020 Aug 27;529(3):569-574
Biochemical and biophysical research communications 2020 Aug 27;529(3):569-574
Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway.
Yu M, Liu W, Li J, Lu J, Lu H, Jia W, Liu F
Stem cell research & therapy 2020 Aug 12;11(1):350
Stem cell research & therapy 2020 Aug 12;11(1):350
Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21Waf1 signalling pathway.
Du S, Wang H, Cai J, Ren R, Zhang W, Wei W, Shen X
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):191-202
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):191-202
MicroRNA‑22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway.
Meng CY, Zhao ZQ, Bai R, Zhao W, Wang YX, Xue HQ, Sun L, Sun C, Feng W, Guo SB
Oncology reports 2020 Apr;43(4):1169-1186
Oncology reports 2020 Apr;43(4):1169-1186
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Zhan D, Zhang X, Li J, Ding X, Cui Y, Jia J
Cancer biotherapy & radiopharmaceuticals 2020 Apr;35(3):223-232
Cancer biotherapy & radiopharmaceuticals 2020 Apr;35(3):223-232
Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1.
Sun X, Yang S, Song W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109731
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109731
Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease.
Fang X, Zhou X, Miao Y, Han Y, Wei J, Chen T
AMB Express 2020 Apr 24;10(1):80
AMB Express 2020 Apr 24;10(1):80
Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice.
Wang C, Le Y, Lu D, Zhao M, Dou X, Zhang Q
Journal of hazardous materials 2020 Apr 15;388:121732
Journal of hazardous materials 2020 Apr 15;388:121732
Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs.
Li H, Liu S, Hu Y, Zhao B, Sun Y, Xu D
Ecotoxicology and environmental safety 2020 Apr 1;192:110267
Ecotoxicology and environmental safety 2020 Apr 1;192:110267
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
Chen Y, Liu P, Sun P, Jiang J, Zhu Y, Dong T, Cui Y, Tian Y, An T, Zhang J, Li Z, Yang X
Theranostics 2019;9(5):1453-1473
Theranostics 2019;9(5):1453-1473
CAPE-pNO2 Inhibited the Growth and Metastasis of Triple-Negative Breast Cancer via the EGFR/STAT3/Akt/E-Cadherin Signaling Pathway.
Huang Q, Li S, Zhang L, Qiao X, Zhang Y, Zhao X, Xiao G, Li Z
Frontiers in oncology 2019;9:461
Frontiers in oncology 2019;9:461
Hsa_circ_001569 is an unfavorable prognostic factor and promotes cell proliferation and metastasis by modulating PI3K-AKT pathway in breast cancer.
Xu JH, Wang Y, Xu D
Cancer biomarkers : section A of Disease markers 2019;25(2):193-201
Cancer biomarkers : section A of Disease markers 2019;25(2):193-201
A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation.
Ye Z, Zhang S, Liu Y, Wang S, Zhang J, Huang R
Mediators of inflammation 2019;2019:8709583
Mediators of inflammation 2019;2019:8709583
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway.
Huang F, Chen J, Wang J, Zhu P, Lin W
BioMed research international 2019;2019:8171989
BioMed research international 2019;2019:8171989
VEGF Induce Vasculogenic Mimicry of Choroidal Melanoma through the PI3k Signal Pathway.
Xu X, Zong Y, Gao Y, Sun X, Zhao H, Luo W, Jia S
BioMed research international 2019;2019:3909102
BioMed research international 2019;2019:3909102
Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB).
Ma Q, Gao Y, Xu P, Li K, Xu X, Gao J, Qi Y, Xu J, Yang Y, Song W, He X, Liu S, Yuan X, Yin W, He Y, Pan W, Wei L, Zhang J
BioMed research international 2019;2019:3235021
BioMed research international 2019;2019:3235021
MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway.
Lin Z, Liu Z, Wang X, Qiu C, Zheng S
BioMed research international 2019;2019:2821731
BioMed research international 2019;2019:2821731
CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression.
Liu Y, Zhang S, Xue J, Wei Z, Ao P, Shen B, Ding L
Oxidative medicine and cellular longevity 2019;2019:2053149
Oxidative medicine and cellular longevity 2019;2019:2053149
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Zhang C, Wang B, Wang X, Sheng X, Cui Y
Cancer cell international 2019;19:339
Cancer cell international 2019;19:339
Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways.
Jin Y, Li Y, Wang X, Yang Y
Cancer cell international 2019;19:220
Cancer cell international 2019;19:220
Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K/Akt pathway.
Zeng J, Li X, Cheng Y, Ke B, Wang R
International journal of clinical and experimental pathology 2019;12(11):4096-4105
International journal of clinical and experimental pathology 2019;12(11):4096-4105
ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma.
Ye Z, Zeng Z, Shen Y, Yang Q, Chen D, Chen Z, Shen S
OncoTargets and therapy 2019;12:4081-4092
OncoTargets and therapy 2019;12:4081-4092
Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin.
Dong C, Liu X, Wang H, Li J, Dai L, Li J, Xu Z
OncoTargets and therapy 2019;12:1947-1956
OncoTargets and therapy 2019;12:1947-1956
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
Qu L, Chen C, He W, Chen Y, Li Y, Wen Y, Zhou S, Jiang Y, Yang X, Zhang R, Shen L
American journal of translational research 2019;11(4):2042-2055
American journal of translational research 2019;11(4):2042-2055
Rutin suppresses FNDC1 expression in bone marrow mesenchymal stem cells to inhibit postmenopausal osteoporosis.
Xiao Y, Wei R, Yuan Z, Lan X, Kuang J, Hu D, Song Y, Luo J
American journal of translational research 2019;11(10):6680-6690
American journal of translational research 2019;11(10):6680-6690
HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells.
Pan C, Liu Q, Wu X
Cancer management and research 2019;11:10145-10156
Cancer management and research 2019;11:10145-10156
Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway.
Lin J, Jiao A, Lv W, Zhang C, Shi Y, Yang Z, Sun N, Li X, Zhang J
Frontiers in pharmacology 2019;10:896
Frontiers in pharmacology 2019;10:896
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Qiao X, Zhou ZC, Niu R, Su YT, Sun Y, Liu HL, Teng JL, Ye JN, Shi H, Yang CD, Cheng XB
Frontiers in pharmacology 2019;10:855
Frontiers in pharmacology 2019;10:855
Hydroxytyrosol Improves Obesity and Insulin Resistance by Modulating Gut Microbiota in High-Fat Diet-Induced Obese Mice.
Liu Z, Wang N, Ma Y, Wen D
Frontiers in microbiology 2019;10:390
Frontiers in microbiology 2019;10:390
The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.
Suo L, Chang X, Xu N, Ji H
Frontiers in endocrinology 2019;10:370
Frontiers in endocrinology 2019;10:370
Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt.
Xu F, Xiao H, Liu R, Yang Y, Zhang M, Chen L, Chen Z, Liu P, Huang H
Frontiers in pharmacology 2019;10:261
Frontiers in pharmacology 2019;10:261
RasGRP1 is a target for VEGF to induce angiogenesis and involved in the endothelial-protective effects of metformin under high glucose in HUVECs.
Xu J, Liu M, Yu M, Shen J, Zhou J, Hu J, Zhou Y, Zhang W
IUBMB life 2019 Sep;71(9):1391-1400
IUBMB life 2019 Sep;71(9):1391-1400
DEPDC1 drives hepatocellular carcinoma cell proliferation, invasion and angiogenesis by regulating the CCL20/CCR6 signaling pathway.
Guo W, Li H, Liu H, Ma X, Yang S, Wang Z
Oncology reports 2019 Sep;42(3):1075-1089
Oncology reports 2019 Sep;42(3):1075-1089
Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8+ T cell recruitment.
Diao W, Chen W, Cao W, Yuan H, Ji H, Wang T, Chen W, Zhu X, Zhou H, Guo H, Zhao X
Biochimica et biophysica acta. General subjects 2019 Sep;1863(9):1360-1370
Biochimica et biophysica acta. General subjects 2019 Sep;1863(9):1360-1370
Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia.
Cui K, Luan Y, Tang Z, Li CC, Wang T, Wang SG, Chen Z, Liu JH
Asian journal of andrology 2019 Sep-Oct;21(5):508-515
Asian journal of andrology 2019 Sep-Oct;21(5):508-515
Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma.
Zhong B, Shi D, Wu F, Wang S, Hu H, Cheng C, Qing X, Huang X, Luo X, Zhang Z, Shao Z
Cell death & disease 2019 Sep 18;10(10):687
Cell death & disease 2019 Sep 18;10(10):687
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Jing L, Jiang JR, Liu DM, Sheng JW, Zhang WF, Li ZJ, Wei LY
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.
Guan P, Sun ZM, Wang N, Zhou J, Luo LF, Zhao YS, Ji ES
Life sciences 2019 Sep 15;233:116748
Life sciences 2019 Sep 15;233:116748
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
Wang X, Luo C, Mao XY, Li X, Yin JY, Zhang W, Zhou HH, Liu ZQ
Brain research 2019 Sep 15;1719:30-39
Brain research 2019 Sep 15;1719:30-39
MiR-92a regulates endothelial progenitor cells (EPCs) by targeting GDF11 via activate SMAD2/3/FAK/Akt/eNOS pathway.
Huang HT, Liu ZC, Wu KQ, Gu SR, Lu TC, Zhong CJ, Zhou YX
Annals of translational medicine 2019 Oct;7(20):563
Annals of translational medicine 2019 Oct;7(20):563
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
Wen N, Guo B, Zheng H, Xu L, Liang H, Wang Q, Wang D, Chen X, Zhang S, Li Y, Zhang L
International journal of oncology 2019 Oct;55(4):879-895
International journal of oncology 2019 Oct;55(4):879-895
Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells.
Chen L, Cheng X, Tu W, Qi Z, Li H, Liu F, Yang Y, Zhang Z, Wang Z
Cellular oncology (Dordrecht) 2019 Oct;42(5):679-690
Cellular oncology (Dordrecht) 2019 Oct;42(5):679-690
TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.
Wu X, Li S, Wang K, Hua W, Li S, Song Y, Zhang Y, Yang S, Yang C
Inflammation 2019 Oct;42(5):1575-1584
Inflammation 2019 Oct;42(5):1575-1584
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
Dai B, Yu R, Fan M, Yang T, Wang B, Zhang Y
Oncology reports 2019 Oct;42(4):1451-1458
Oncology reports 2019 Oct;42(4):1451-1458
The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation.
Zhao H, Wang Y, Liu J, Guo M, Fei D, Yu H, Xing M
Environmental pollution (Barking, Essex : 1987) 2019 Oct;253:741-748
Environmental pollution (Barking, Essex : 1987) 2019 Oct;253:741-748
Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration.
Wang K, Zhu TN, Zhao RJ
Molecular medicine reports 2019 Oct;20(4):3671-3678
Molecular medicine reports 2019 Oct;20(4):3671-3678
CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK½/mTOR signaling pathways in oral squamous cell carcinomas.
Gao L, Dou ZC, Ren WH, Li SM, Liang X, Zhi KQ
Cell death & disease 2019 Oct 3;10(10):745
Cell death & disease 2019 Oct 3;10(10):745
The clinical characteristics and molecular mechanism of pituitary adenoma associated with meningioma.
Zhu H, Miao Y, Shen Y, Guo J, Xie W, Zhao S, Dong W, Zhang Y, Li C
Journal of translational medicine 2019 Oct 29;17(1):354
Journal of translational medicine 2019 Oct 29;17(1):354
NT3P75-2 gene-modified bone mesenchymal stem cells improve neurological function recovery in mouse TBI model.
Wu K, Huang D, Zhu C, Kasanga EA, Zhang Y, Yu E, Zhang H, Ni Z, Ye S, Zhang C, Hu J, Zhuge Q, Yang J
Stem cell research & therapy 2019 Oct 24;10(1):311
Stem cell research & therapy 2019 Oct 24;10(1):311
12N-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells.
Bao Y, Pang Y, Tang S, Niu T, Guo Z, He H, Li Y, Song D
Molecules (Basel, Switzerland) 2019 Oct 17;24(20)
Molecules (Basel, Switzerland) 2019 Oct 17;24(20)
MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis.
Xu W, Li J, Tian H, Wang R, Feng Y, Tang J, Jia J
Molecular medicine reports 2019 Nov;20(5):4594-4602
Molecular medicine reports 2019 Nov;20(5):4594-4602
Brain-derived neurotrophic factor induces thioredoxin-1 expression through TrkB/Akt/CREB pathway in SH-SY5Y cells.
Bai L, Zhang S, Zhou X, Li Y, Bai J
Biochimie 2019 May;160:55-60
Biochimie 2019 May;160:55-60
Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.
Yang F, Lin ZW, Huang TY, Chen TT, Cui J, Li MY, Hua YQ
Scientific reports 2019 May 6;9(1):6991
Scientific reports 2019 May 6;9(1):6991
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Cao D, Qi Z, Pang Y, Li H, Xie H, Wu J, Huang Y, Zhu Y, Shen Y, Zhu Y, Dai B, Hu X, Ye D, Wang Z
Cancer research 2019 May 15;79(10):2604-2618
Cancer research 2019 May 15;79(10):2604-2618
Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways.
Yang H, Liu JX, Shang HX, Lin S, Zhao JY, Lin JM
World journal of gastrointestinal oncology 2019 May 15;11(5):377-392
World journal of gastrointestinal oncology 2019 May 15;11(5):377-392
Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.
Li Z, Chen Y, An T, Liu P, Zhu J, Yang H, Zhang W, Dong T, Jiang J, Zhang Y, Jiang M, Yang X
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139
Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells.
Zhou T, Sun Y, Wang Y, Chen X, Zhuo L, Bu L, Xu S, Han J, Li X, Shi J
Inflammation 2019 Jun;42(3):987-993
Inflammation 2019 Jun;42(3):987-993
MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte.
Wan GX, Cheng L, Qin HL, Zhang YZ, Wang LY, Zhang YG
Cardiovascular toxicology 2019 Jun;19(3):264-275
Cardiovascular toxicology 2019 Jun;19(3):264-275
Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN.
Lu Q, Liu T, Feng H, Yang R, Zhao X, Chen W, Jiang B, Qin H, Guo X, Liu M, Li L, Guo H
Molecular cancer 2019 Jun 22;18(1):111
Molecular cancer 2019 Jun 22;18(1):111
Knockdown of endothelin receptor B inhibits the progression of triple-negative breast cancer.
Gu X, Han S, Cui M, Xue J, Ai L, Sun L, Zhu X, Wang Y, Liu C
Annals of the New York Academy of Sciences 2019 Jul;1448(1):5-18
Annals of the New York Academy of Sciences 2019 Jul;1448(1):5-18
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Sun Z, Liu Y, Yu F, Xu Y, Yanli L, Liu N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Taurine protects against arsenic trioxide-induced insulin resistance via ROS-Autophagy pathway in skeletal muscle.
Yang L, Qiu T, Yao X, Jiang L, Wei S, Pei P, Wang Z, Bai J, Liu X, Yang G, Liu S, Sun X
The international journal of biochemistry & cell biology 2019 Jul;112:50-60
The international journal of biochemistry & cell biology 2019 Jul;112:50-60
Thyroid hormone (T3) is involved in inhibiting the proliferation of newborn calf Sertoli cells via the PI3K/Akt signaling pathway in vitro.
Wang C, Zheng P, Adeniran SO, Ma M, Huang F, Adegoke EO, Zhang G
Theriogenology 2019 Jul 15;133:1-9
Theriogenology 2019 Jul 15;133:1-9
Characterization, functional and signaling elucidation of pigeon (Columba livia) interferon-α: Knockdown p53 negatively modulates antiviral response.
Li S, Wang Y, Zhao H, Shao Y, Liu J, Xing M
Developmental and comparative immunology 2019 Jan;90:29-40
Developmental and comparative immunology 2019 Jan;90:29-40
Everolimus Reverses Palbociclib Resistance in ER+ Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase(PI3K)/Akt/Mammalian Target of Rapamycin (mTOR) Pathway.
Chen L, Yang G, Dong H
Medical science monitor : international medical journal of experimental and clinical research 2019 Jan 3;25:77-86
Medical science monitor : international medical journal of experimental and clinical research 2019 Jan 3;25:77-86
Involvement of Hepatic SHIP2 and PI3K/Akt Signalling in the Regulation of Plasma Insulin by Xiaoyaosan in Chronic Immobilization-Stressed Rats.
Pan Q, Wu J, Liu Y, Li X, Chen J
Molecules (Basel, Switzerland) 2019 Jan 29;24(3)
Molecules (Basel, Switzerland) 2019 Jan 29;24(3)
Long noncoding FOXD2-AS1 is activated by CREB1 and promotes cell proliferation and metastasis in glioma by sponging miR-185 through targeting AKT1.
Dong H, Cao W, Xue J
Biochemical and biophysical research communications 2019 Jan 22;508(4):1074-1081
Biochemical and biophysical research communications 2019 Jan 22;508(4):1074-1081
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Zhu BL, Long Y, Luo W, Yan Z, Lai YJ, Zhao LG, Zhou WH, Wang YJ, Shen LL, Liu L, Deng XJ, Wang XF, Sun F, Chen GJ
Brain : a journal of neurology 2019 Jan 1;142(1):176-192
Brain : a journal of neurology 2019 Jan 1;142(1):176-192
Testosterone preserves endothelial function through regulation of S1P1/Akt/FOXO3a signalling pathway in the rat corpus cavernosum.
Cui K, Li R, Liu K, Wang T, Liu J, Rao K
Andrologia 2019 Feb;51(1):e13173
Andrologia 2019 Feb;51(1):e13173
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Zhang X, Liu J, Gu Y, Sun C, Qu F
Cell biology international 2019 Feb;43(2):158-166
Cell biology international 2019 Feb;43(2):158-166
Low density lipoprotein mimics insulin action on autophagy and glucose uptake in endothelial cells.
Zhu L, Wu G, Yang X, Jia X, Li J, Bai X, Li W, Zhao Y, Li Y, Cheng W, Liu S, Jin S
Scientific reports 2019 Feb 28;9(1):3020
Scientific reports 2019 Feb 28;9(1):3020
Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury.
Bei Y, Pan LL, Zhou Q, Zhao C, Xie Y, Wu C, Meng X, Gu H, Xu J, Zhou L, Sluijter JPG, Das S, Agerberth B, Sun J, Xiao J
BMC medicine 2019 Feb 20;17(1):42
BMC medicine 2019 Feb 20;17(1):42
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Zhang Y, Li Q, Yu S, Zhu C, Zhang Z, Cao H, Xu J
Biochemical and biophysical research communications 2019 Feb 12;509(3):753-762
Biochemical and biophysical research communications 2019 Feb 12;509(3):753-762
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Zhang D, Zhang J, Zeng J, Li Z, Zuo H, Huang C, Zhao X
Journal of biomedical nanotechnology 2019 Feb 1;15(2):288-300
Journal of biomedical nanotechnology 2019 Feb 1;15(2):288-300
Indoxyl sulfate-induced calcification of vascular smooth muscle cells via the PI3K/Akt/NF-κB signaling pathway.
He X, Jiang H, Gao F, Liang S, Wei M, Chen L
Microscopy research and technique 2019 Dec;82(12):2000-2006
Microscopy research and technique 2019 Dec;82(12):2000-2006
Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model.
Wang J, Wan D, Wan G, Wang J, Zhang J, Zhu H
Annals of translational medicine 2019 Dec;7(23):756
Annals of translational medicine 2019 Dec;7(23):756
PP2Ac upregulates PI3K-Akt signaling and induces hepatocyte apoptosis in liver donor after brain death.
Xiong Y, Lan J, Huang K, Zhang Y, Zheng L, Wang Y, Ye Q
Apoptosis : an international journal on programmed cell death 2019 Dec;24(11-12):921-933
Apoptosis : an international journal on programmed cell death 2019 Dec;24(11-12):921-933
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin YE, Coppé JP, Lam EW, Campisi J, Sun Y
Aging cell 2019 Dec;18(6):e13027
Aging cell 2019 Dec;18(6):e13027
Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways.
Zhu B, Ren C, Du K, Zhu H, Ai Y, Kang F, Luo Y, Liu W, Wang L, Xu Y, Jiang X, Zhang Y
Biochemical pharmacology 2019 Dec;170:113642
Biochemical pharmacology 2019 Dec;170:113642
Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.
Tateyama H, Murase Y, Higuchi H, Inasaka Y, Kaneoka H, Iijima S, Nishijima KI
Immunology 2019 Dec;158(4):340-352
Immunology 2019 Dec;158(4):340-352
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
Wang J, Li L, Wang J, Song L, Tan N, Wang Z
Cells 2019 Dec 7;8(12)
Cells 2019 Dec 7;8(12)
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Wang Z, Liang M, Li H, Cai L, Yang L
International journal of molecular sciences 2019 Dec 6;20(24)
International journal of molecular sciences 2019 Dec 6;20(24)
PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling.
Gao H, Zhang J, Ren X
Bioscience reports 2019 Dec 20;39(12)
Bioscience reports 2019 Dec 20;39(12)
Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K /Akt/mTOR pathway.
Liu JZ, Hu YL, Feng Y, Guo YB, Liu YF, Yang JL, Mao QS, Xue WJ
Experimental cell research 2019 Dec 15;385(2):111691
Experimental cell research 2019 Dec 15;385(2):111691
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Wu XT, Ansari AR, Pang XX, Li HZ, Zhang ZW, Luo Y, Arshad M, Song H
Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261
Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261
Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway.
Ming-Yan Y, Jing Z, Shu-Qin G, Xiao-Liang B, Zhi-Hong L, Xue Z
Bioscience reports 2019 Aug 30;39(8)
Bioscience reports 2019 Aug 30;39(8)
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2019 Aug 1;424:152236
Toxicology 2019 Aug 1;424:152236
Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3β pathway in lung adenocarcinoma.
Wang Y, Piao J, Wang Q, Cui X, Meng Z, Jin T, Lin Z
Human pathology 2019 Apr;86:233-242
Human pathology 2019 Apr;86:233-242
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Liang H, Mokrani A, Chisomo-Kasiya H, Ji K, Ge X, Ren M, Liu B, Xi B, Sun A
Fish physiology and biochemistry 2019 Apr;45(2):719-732
Fish physiology and biochemistry 2019 Apr;45(2):719-732
Taurine improves low-level inorganic arsenic-induced insulin resistance by activating PPARγ-mTORC2 signalling and inhibiting hepatic autophagy.
Gao N, Yao X, Jiang L, Yang L, Qiu T, Wang Z, Pei P, Yang G, Liu X, Sun X
Journal of cellular physiology 2019 Apr;234(4):5143-5152
Journal of cellular physiology 2019 Apr;234(4):5143-5152
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, Sun H, Qi Y, Fang L, Liu K, Peng J
British journal of pharmacology 2019 Apr;176(7):919-937
British journal of pharmacology 2019 Apr;176(7):919-937
TMEM30A deficiency in endothelial cells impairs cell proliferation and angiogenesis.
Zhang S, Liu W, Yang Y, Sun K, Li S, Xu H, Yang M, Zhang L, Zhu X
Journal of cell science 2019 Apr 3;132(7)
Journal of cell science 2019 Apr 3;132(7)
Immunomodulatory effects of an acidic polysaccharide fraction from herbal Gynostemma pentaphyllum tea in RAW264.7 cells.
Ren D, Zhao Y, Zheng Q, Alim A, Yang X
Food & function 2019 Apr 1;10(4):2186-2197
Food & function 2019 Apr 1;10(4):2186-2197
Protective Effect of Extract of Bletilla Striata on Isoflurane Induced Neuronal Injury By Altering PI3K/Akt Pathway.
Zhao G, Li K, Chen J, Li L
Translational neuroscience 2018;9:183-189
Translational neuroscience 2018;9:183-189
A somatic mutation of RasGRP3 decreases Na+/I- symporter expression in metastases of radioactive iodine-refractory thyroid cancer by stimulating the Akt signaling pathway.
Song J, Qiu W, Deng X, Qiu Z, Fan Y, Yang Z
American journal of cancer research 2018;8(9):1847-1855
American journal of cancer research 2018;8(9):1847-1855
Astragaloside IV Improves Vasodilatation Function by Regulating the PI3K/Akt/eNOS Signaling Pathway in Rat Aorta Endothelial Cells.
Lin XP, Cui HJ, Yang AL, Luo JK, Tang T
Journal of vascular research 2018;55(3):169-176
Journal of vascular research 2018;55(3):169-176
The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction.
Ye C, Zhang C, Huang H, Yang B, Xiao G, Kong D, Tian Q, Song Q, Song Y, Tan H, Wang Y, Zhou T, Zi X, Sun Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1230-1244
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1230-1244
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Gao Y, Yu H, Liu Y, Liu X, Zheng J, Ma J, Gong W, Chen J, Zhao L, Tian Y, Xue Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(1):131-147
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(1):131-147
Epithelial Cells Attenuate Toll-Like Receptor-Mediated Inflammatory Responses in Monocyte-Derived Macrophage-Like Cells to Mycobacterium tuberculosis by Modulating the PI3K/Akt/mTOR Signaling Pathway.
Yang Y, Sun Y, Xu J, Bao K, Luo M, Liu X, Wang Y
Mediators of inflammation 2018;2018:3685948
Mediators of inflammation 2018;2018:3685948
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
Jiang T, Zhou ML, Fan J
OncoTargets and therapy 2018;11:7865-7872
OncoTargets and therapy 2018;11:7865-7872
GPX3 suppresses tumor migration and invasion via the FAK/AKT pathway in esophageal squamous cell carcinoma.
Zhu X, Wang J, Li L, Deng L, Wang J, Liu L, Zeng R, Wang Q, Zheng Y
American journal of translational research 2018;10(6):1908-1920
American journal of translational research 2018;10(6):1908-1920
Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway.
Zhou W, Wang J, Qi Q, Feng Z, Huang B, Chen A, Zhang D, Li W, Zhang Q, Bjerkvig R, Li X, Wang J
Cancer medicine 2018 Sep;7(9):4729-4743
Cancer medicine 2018 Sep;7(9):4729-4743
Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart.
Liu F, Wen Y, Kang J, Wei C, Wang M, Zheng Z, Peng J
International journal of molecular medicine 2018 Sep;42(3):1436-1444
International journal of molecular medicine 2018 Sep;42(3):1436-1444
Triptolide protects podocytes via autophagy in immunoglobulin A nephropathy.
Liang S, Jin J, Shen X, Jiang X, Li Y, He Q
Experimental and therapeutic medicine 2018 Sep;16(3):2275-2280
Experimental and therapeutic medicine 2018 Sep;16(3):2275-2280
miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN.
Nie X, Fan J, Li H, Yin Z, Zhao Y, Dai B, Dong N, Chen C, Wang DW
Molecular therapy. Nucleic acids 2018 Sep 7;12:254-266
Molecular therapy. Nucleic acids 2018 Sep 7;12:254-266
LP1 from Lentinula edodes C91-3 Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Batool S, Joseph TP, Hussain M, Vuai MS, Khinsar KH, Din SRU, Padhiar AA, Zhong M, Ning A, Zhang W, Cao J, Huang M
International journal of molecular sciences 2018 Sep 30;19(10)
International journal of molecular sciences 2018 Sep 30;19(10)
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
Zou W, Ding F, Niu C, Fu Z, Liu S
Biochemical and biophysical research communications 2018 Sep 18;503(4):3212-3218
Biochemical and biophysical research communications 2018 Sep 18;503(4):3212-3218
DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway.
Xue Y, Jia X, Li L, Dong X, Ling J, Yuan J, Li Q
Biochemical and biophysical research communications 2018 Sep 18;503(4):2885-2891
Biochemical and biophysical research communications 2018 Sep 18;503(4):2885-2891
ZKSCAN3 promotes breast cancer cell proliferation, migration and invasion.
Chi Y, Xu H, Wang F, Chen X, Shan Z, Sun Y, Fan Q
Biochemical and biophysical research communications 2018 Sep 18;503(4):2583-2589
Biochemical and biophysical research communications 2018 Sep 18;503(4):2583-2589
Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor κB-Matrix Metalloproteinase Signaling.
Wang Y, Wang Y, Liu Z, Dong W, Yang B, Xia X, Song E, Song Y
Chemical research in toxicology 2018 Sep 17;31(9):954-963
Chemical research in toxicology 2018 Sep 17;31(9):954-963
Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells.
Tan F, Huang Y, Pei Q, Liu H, Pei H, Zhu H
Journal of cellular biochemistry 2018 Sep 14;
Journal of cellular biochemistry 2018 Sep 14;
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
Xu N, Fan W, Zhou X, Liu Y, Ma P, Qi S, Gu B
Metabolic brain disease 2018 Oct;33(5):1625-1633
Metabolic brain disease 2018 Oct;33(5):1625-1633
T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase(mTORC2/AKT) to Promote Ca2+Production.
Wang J, Yang C, Yuan Z, Yi J, Wu J
International journal of molecular sciences 2018 Oct 27;19(11)
International journal of molecular sciences 2018 Oct 27;19(11)
PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Yang T, Ren C, Qiao P, Han X, Wang L, Lv S, Sun Y, Liu Z, Du Y, Yu Z
Oncogene 2018 Nov;37(45):5997-6009
Oncogene 2018 Nov;37(45):5997-6009
Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells in vitro.
Huang C, Ji X, Peng Y, Wu M, Wu W, Luo Y, Cheng G, Zhu Y
Iranian journal of basic medical sciences 2018 Nov;21(11):1161-1166
Iranian journal of basic medical sciences 2018 Nov;21(11):1161-1166
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
Mu Z, Sun Q
Molecular medicine reports 2018 Nov;18(5):4603-4610
Molecular medicine reports 2018 Nov;18(5):4603-4610
Saponins from Boussingaultia gracilis prevent obesity and related metabolic impairments in diet-induced obese mice.
Liu L, Wang N, Ma Y, Liu Y, Wen D
Food & function 2018 Nov 14;9(11):5660-5673
Food & function 2018 Nov 14;9(11):5660-5673
SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D
EMBO reports 2018 May;19(5)
EMBO reports 2018 May;19(5)
Patulin induced ROS-dependent autophagic cell death in Human Hepatoma G2 cells.
Yang G, Bai Y, Wu X, Sun X, Sun M, Liu X, Yao X, Zhang C, Chu Q, Jiang L, Wang S
Chemico-biological interactions 2018 May 25;288:24-31
Chemico-biological interactions 2018 May 25;288:24-31
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Knockdown of hnRNP A2/B1 inhibits cell proliferation, invasion and cell cycle triggering apoptosis in cervical cancer via PI3K/AKT signaling pathway.
Shi X, Ran L, Liu Y, Zhong SH, Zhou PP, Liao MX, Fang W
Oncology reports 2018 Mar;39(3):939-950
Oncology reports 2018 Mar;39(3):939-950
Marine Bacterial Polysaccharide EPS11 Inhibits Cancer Cell Growth via Blocking Cell Adhesion and Stimulating Anoikis.
Cao R, Jin W, Shan Y, Wang J, Liu G, Kuang S, Sun C
Marine drugs 2018 Mar 8;16(3)
Marine drugs 2018 Mar 8;16(3)
Increased ZNF84 expression in cervical cancer.
Li P, Guo H, Zhou G, Shi H, Li Z, Guan X, Deng Z, Li S, Zhou S, Wang Y, Wang S
Archives of gynecology and obstetrics 2018 Jun;297(6):1525-1532
Archives of gynecology and obstetrics 2018 Jun;297(6):1525-1532
Small interfering RNA-mediated silencing of G-protein-coupled receptor 137 inhibits growth of osteosarcoma cells.
Li H, Fu X, Gao Y, Li X, Shen Y, Wang W
Journal of bone oncology 2018 Jun;11:17-22
Journal of bone oncology 2018 Jun;11:17-22
A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy.
Liu C, Zhang Y, She X, Fan L, Li P, Feng J, Fu H, Liu Q, Liu Q, Zhao C, Sun Y, Wu M
Journal of hematology & oncology 2018 Jun 4;11(1):77
Journal of hematology & oncology 2018 Jun 4;11(1):77
Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic reticulum stress and prevents hepatic steatosis in diet-induced obesity mice.
Wang N, Liu Y, Ma Y, Wen D
The Journal of nutritional biochemistry 2018 Jul;57:180-188
The Journal of nutritional biochemistry 2018 Jul;57:180-188
Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression.
Li Y, Zeng C, Hu J, Pan Y, Shan Y, Liu B, Jia L
Journal of hematology & oncology 2018 Jul 3;11(1):89
Journal of hematology & oncology 2018 Jul 3;11(1):89
Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p.
Kong F, Ma J, Yang H, Yang D, Wang C, Ma X
Biochimica et biophysica acta. Molecular cell research 2018 Jul 19;
Biochimica et biophysica acta. Molecular cell research 2018 Jul 19;
Thioredoxin-interacting protein deficiency ameliorates diabetic retinal angiogenesis.
Duan J, Du C, Shi Y, Liu D, Ma J
The international journal of biochemistry & cell biology 2018 Jan;94:61-70
The international journal of biochemistry & cell biology 2018 Jan;94:61-70
UNBS5162 inhibits the proliferation of human A549 non-small-cell lung cancer cells by promoting apoptosis.
Liu C, Xing J, Gao Y
Thoracic cancer 2018 Jan;9(1):105-111
Thoracic cancer 2018 Jan;9(1):105-111
Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation.
Huang L, Chen C, Zhang X, Li X, Chen Z, Yang C, Liang X, Zhu G, Xu Z
Journal of molecular neuroscience : MN 2018 Jan;64(1):129-139
Journal of molecular neuroscience : MN 2018 Jan;64(1):129-139
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788
Journal of cellular physiology 2018 Jan;234(1):777-788
Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus.
Sun X, Li J, Zhao H, Wang Y, Liu J, Shao Y, Xue Y, Xing M
Journal of inorganic biochemistry 2018 Jan;178:54-62
Journal of inorganic biochemistry 2018 Jan;178:54-62
UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway.
He D, Zhang S
Molecular medicine reports 2018 Jan;17(1):549-555
Molecular medicine reports 2018 Jan;17(1):549-555
Pramlintide regulation of extracellular matrix (ECM) and apoptosis through mitochondrial-dependent pathways in human nucleus pulposus cells.
Wu X, Song Y, Li S, Liu X, Hua W, Wang K, Liu W, Li S, Zhang Y, Shao Z, Yang C
International journal of immunopathology and pharmacology 2018 Jan-Dec;31:394632017747500
International journal of immunopathology and pharmacology 2018 Jan-Dec;31:394632017747500
Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy.
Wei W, An XR, Jin SJ, Li XX, Xu M
Scientific reports 2018 Jan 8;8(1):9
Scientific reports 2018 Jan 8;8(1):9
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout.
Zhang J, Zhao J, Zheng X, Cai K, Mao Q, Xia H
Molecular medicine reports 2018 Feb;17(2):2169-2176
Molecular medicine reports 2018 Feb;17(2):2169-2176
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
Yin N, Wang Y, Lu X, Liu R, Zhang L, Zhao W, Yuan W, Luo Q, Wu H, Luan X, Zhang H
Stem cell research & therapy 2018 Feb 14;9(1):37
Stem cell research & therapy 2018 Feb 14;9(1):37
Interleukin‑10 promotes proliferation and migration, and inhibits tendon differentiation via the JAK/Stat3 pathway in tendon‑derived stem cells in vitro.
Deng G, Li K, Chen S, Chen P, Zheng H, Yu B, Zhang K
Molecular medicine reports 2018 Dec;18(6):5044-5052
Molecular medicine reports 2018 Dec;18(6):5044-5052
LASP1 promotes glioma cell proliferation and migration and is negatively regulated by miR-377-3p.
Liu Y, Gao Y, Li D, He L, Iw L, Hao B, Chen X, Cao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:845-851
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:845-851
4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling.
Sun D, Zhang F, Qian J, Shen W, Fan H, Tan J, Li L, Xu C, Yang Y, Cheng H
Chemico-biological interactions 2018 Dec 25;296:26-33
Chemico-biological interactions 2018 Dec 25;296:26-33
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells.
Ke M, Dong J, Wang Y, Zhang J, Zhang M, Wu Z, Lv Y, Wu R
The international journal of biochemistry & cell biology 2018 Aug;101:39-48
The international journal of biochemistry & cell biology 2018 Aug;101:39-48
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Sun H
Pharmacological research 2018 Apr;130:466-480
Pharmacological research 2018 Apr;130:466-480
Lactobacillus rhamnosus GG Affects Microbiota and Suppresses Autophagy in the Intestines of Pigs Challenged with Salmonella Infantis.
Zhang W, Zhu YH, Yang GY, Liu X, Xia B, Hu X, Su JH, Wang JF
Frontiers in microbiology 2017;8:2705
Frontiers in microbiology 2017;8:2705
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
Yao H, Sun Y, Song S, Qi Y, Tao X, Xu L, Yin L, Han X, Xu Y, Li H, Sun H, Peng J
Frontiers in pharmacology 2017;8:120
Frontiers in pharmacology 2017;8:120
IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells.
Wu X, Song Y, Liu W, Wang K, Gao Y, Li S, Duan Z, Shao Z, Yang S, Yang C
Cell death discovery 2017;3:16107
Cell death discovery 2017;3:16107
Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1-42-Induced Rat Model of Alzheimer's Disease.
Sheng C, Xu P, Zhou K, Deng D, Zhang C, Wang Z
BioMed research international 2017;2017:7464872
BioMed research international 2017;2017:7464872
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.
Zhou W, Liu L, Xue Y, Zheng J, Liu X, Ma J, Li Z, Liu Y
Frontiers in molecular neuroscience 2017;10:68
Frontiers in molecular neuroscience 2017;10:68
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Zhao J, Zhu J, Lv X, Xing J, Liu S, Chen C, Xu Y
OncoTargets and therapy 2017;10:5471-5482
OncoTargets and therapy 2017;10:5471-5482
Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells.
Liang JX, Gao W, Cai L
OncoTargets and therapy 2017;10:3971-3978
OncoTargets and therapy 2017;10:3971-3978
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
Song Z, Shah SZA, Yang W, Dong H, Yang L, Zhou X, Zhao D
Frontiers in molecular neuroscience 2017;10:128
Frontiers in molecular neuroscience 2017;10:128
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Xu L, Yin L, Tao X, Qi Y, Han X, Xu Y, Song S, Li L, Sun P, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Lithium alleviates neurotoxic prion peptide-induced synaptic damage and neuronal death partially by the upregulation of nuclear target REST and the restoration of Wnt signaling.
Song Z, Yang W, Zhou X, Yang L, Zhao D
Neuropharmacology 2017 Sep 1;123:332-348
Neuropharmacology 2017 Sep 1;123:332-348
Mono-(2-ethylhexyl) phthalate induced ROS-dependent autophagic cell death in human vascular endothelial cells.
Liu N, Jiang L, Sun X, Yao X, Zhai X, Liu X, Wu X, Bai Y, Wang S, Yang G
Toxicology in vitro : an international journal published in association with BIBRA 2017 Oct;44:49-56
Toxicology in vitro : an international journal published in association with BIBRA 2017 Oct;44:49-56
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Liu J, Wang L, Du Y, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
RasGRP3 controls cell proliferation and migration in papillary thyroid cancer by regulating the Akt-MDM2 pathway.
Qiu W, Xia X, Qiu Z, Guo M, Yang Z
Gene 2017 Oct 30;633:35-41
Gene 2017 Oct 30;633:35-41
Maslinic acid inhibits impairment of endothelial functions induced by high glucose in HAEC cells through improving insulin signaling and oxidative stress.
Li F, Li Q, Shi X, Guo Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:904-913
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:904-913
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Song L, Wang Z, Wang Y, Guo D, Yang J, Chen L, Tan N
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs.
Ren K, Lu YJ, Mo ZC, -Liu X, Tang ZL, Jiang Y, Peng XS, Li L, Zhang QH, Yi GH
Journal of physiology and biochemistry 2017 May;73(2):287-296
Journal of physiology and biochemistry 2017 May;73(2):287-296
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
Liu W, Zhang B, Hu Q, Qin Y, Xu W, Shi S, Liang C, Meng Q, Xiang J, Liang D, Ji S, Liu J, Hu P, Liu L, Liu C, Long J, Ni Q, Yu X, Xu J
International journal of oncology 2017 May;50(5):1792-1800
International journal of oncology 2017 May;50(5):1792-1800
EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways.
Liu S, Sun Z, Chu P, Li H, Ahsan A, Zhou Z, Zhang Z, Sun B, Wu J, Xi Y, Han G, Lin Y, Peng J, Tang Z
Apoptosis : an international journal on programmed cell death 2017 May;22(5):672-680
Apoptosis : an international journal on programmed cell death 2017 May;22(5):672-680
miR-29b contributes to multiple types of muscle atrophy.
Li J, Chan MC, Yu Y, Bei Y, Chen P, Zhou Q, Cheng L, Chen L, Ziegler O, Rowe GC, Das S, Xiao J
Nature communications 2017 May 25;8:15201
Nature communications 2017 May 25;8:15201
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
Yin K, Zhu R, Wang S, Zhao RC
Stem cells and development 2017 May 15;26(10):762-775
Stem cells and development 2017 May 15;26(10):762-775
FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis.
Cui K, Ruan Y, Wang T, Rao K, Chen Z, Wang S, Liu J
The journal of sexual medicine 2017 Mar;14(3):323-335
The journal of sexual medicine 2017 Mar;14(3):323-335
Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-κB signaling pathways in RAW264.7 cells.
Ren D, Lin D, Alim A, Zheng Q, Yang X
Food & function 2017 Mar 22;8(3):1299-1312
Food & function 2017 Mar 22;8(3):1299-1312
PTEN/PI3k/AKT Regulates Macrophage Polarization in Emphysematous mice.
Lu J, Xie L, Liu C, Zhang Q, Sun S
Scandinavian journal of immunology 2017 Jun;85(6):395-405
Scandinavian journal of immunology 2017 Jun;85(6):395-405
Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway.
Xie XC, Zhao N, Xu QH, Yang X, Xia WK, Chen Q, Wang M, Fei X
Apoptosis : an international journal on programmed cell death 2017 Jun;22(6):769-776
Apoptosis : an international journal on programmed cell death 2017 Jun;22(6):769-776
Down-regulation of islet amyloid polypeptide expression induces death of human annulus fibrosus cells via mitochondrial and death receptor pathways.
Wu X, Wang K, Hua W, Li S, Liu X, Liu W, Song Y, Zhang Y, Shao Z, Yang C
Biochimica et biophysica acta. Molecular basis of disease 2017 Jun;1863(6):1479-1491
Biochimica et biophysica acta. Molecular basis of disease 2017 Jun;1863(6):1479-1491
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Xu J, Zhang S, Wang R, Wu X, Zeng L, Fu Z
Bioscience reports 2017 Jun 30;37(3)
Bioscience reports 2017 Jun 30;37(3)
Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice.
Zhuang S, Jian YM, Sun YN
World journal of gastroenterology 2017 Jun 21;23(23):4233-4242
World journal of gastroenterology 2017 Jun 21;23(23):4233-4242
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
Lu SY, Wang CY, Jin Y, Meng Q, Liu Q, Liu ZH, Liu KX, Sun HJ, Liu MZ
Scientific reports 2017 Jun 13;7(1):3331
Scientific reports 2017 Jun 13;7(1):3331
MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles.
He W, Wang C, Mu R, Liang P, Huang Z, Zhang J, Dong L
Oncogene 2017 Jul 20;36(29):4212-4223
Oncogene 2017 Jul 20;36(29):4212-4223
Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.
Ke Z, Wang G, Yang L, Qiu H, Wu H, Du M, Chen J, Song J, Jia X, Feng L
Journal of ethnopharmacology 2017 Jul 12;206:160-169
Journal of ethnopharmacology 2017 Jul 12;206:160-169
MicroRNA-302a enhances 5-fluorouracil-induced cell death in human colon cancer cells.
Liu N, Li J, Zhao Z, Han J, Jiang T, Chen Y, Hou N, Huang C
Oncology reports 2017 Jan;37(1):631-639
Oncology reports 2017 Jan;37(1):631-639
PRL-3 Is Involved in Estrogen- and IL-6-Induced Migration of Endometrial Stromal Cells From Ectopic Endometrium.
Ren S, Zhou Y, Fang X, She X, Wu Y, Wu X
Reproductive sciences (Thousand Oaks, Calif.) 2017 Jan;24(1):124-132
Reproductive sciences (Thousand Oaks, Calif.) 2017 Jan;24(1):124-132
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.
Zhang C, Li C, Chen S, Li Z, Ma L, Jia X, Wang K, Bao J, Liang Y, Chen M, Li P, Su H, Lee SM, Liu K, Wan JB, He C
Scientific reports 2017 Jan 23;7:41082
Scientific reports 2017 Jan 23;7:41082
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Huang T, Xiao Y, Yi L, Li L, Wang M, Tian C, Ma H, He K, Wang Y, Han B, Ye X, Li X
Scientific reports 2017 Feb 6;7:38524
Scientific reports 2017 Feb 6;7:38524
Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.
Li R, Yuan F, Fu W, Zhang L, Zhang N, Wang Y, Ma K, Li X, Wang L, Zhu WG, Zhao Y
The Journal of biological chemistry 2017 Feb 17;292(7):2830-2841
The Journal of biological chemistry 2017 Feb 17;292(7):2830-2841
TRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway.
Xu G, Guo Y, Xu D, Wang Y, Shen Y, Wang F, Lv Y, Song F, Jiang D, Zhang Y, Lou Y, Meng Y, Yang Y, Kang Y
Scientific reports 2017 Feb 16;7:42411
Scientific reports 2017 Feb 16;7:42411
miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway.
Jia L, Luo S, Ren X, Li Y, Hu J, Liu B, Zhao L, Shan Y, Zhou H
Digestive diseases and sciences 2017 Dec;62(12):3447-3459
Digestive diseases and sciences 2017 Dec;62(12):3447-3459
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Song Y, Kong L, Sun B, Gao L, Chu P, Ahsan A, Qaed E, Lin Y, Peng J, Ma X, Zhang J, Wang S, Tang Z
Cell biology international 2017 Dec;41(12):1367-1378
Cell biology international 2017 Dec;41(12):1367-1378
Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.
Yan Z, Feng J, Peng J, Lai Z, Zhang L, Jin Y, Yang H, Chen W, Lin J
Oncology letters 2017 Dec;14(6):7923-7930
Oncology letters 2017 Dec;14(6):7923-7930
Scutellaria barbata D. Don inhibits migration and invasion of colorectal cancer cells via suppression of PI3K/AKT and TGF-β/Smad signaling pathways.
Jin Y, Chen W, Yang H, Yan Z, Lai Z, Feng J, Peng J, Lin J
Experimental and therapeutic medicine 2017 Dec;14(6):5527-5534
Experimental and therapeutic medicine 2017 Dec;14(6):5527-5534
CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525
Oncotarget 2017 Dec 29;8(70):114506-114525
High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice.
Wang N, Liu Y, Ma Y, Wen D
Life sciences 2017 Dec 15;191:122-131
Life sciences 2017 Dec 15;191:122-131
Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.
Wang H, Cai J, Du S, Guo Z, Xin B, Wang J, Wei W, Shen X
Cell biochemistry and function 2017 Aug;35(6):315-326
Cell biochemistry and function 2017 Aug;35(6):315-326
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Wu L, Zhang Q, Mo W, Feng J, Li S, Li J, Liu T, Xu S, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Xu L, Zhou Y, Fan X, Guo C
Scientific reports 2017 Aug 24;7(1):9289
Scientific reports 2017 Aug 24;7(1):9289
Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway.
Du C, Zhang T, Xiao X, Shi Y, Duan H, Ren Y
The Biochemical journal 2017 Aug 2;474(16):2733-2747
The Biochemical journal 2017 Aug 2;474(16):2733-2747
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Chu P, Han G, Ahsan A, Sun Z, Liu S, Zhang Z, Sun B, Song Y, Lin Y, Peng J, Tang Z
Vascular pharmacology 2017 Apr;91:26-35
Vascular pharmacology 2017 Apr;91:26-35
siRNA knockdown validation 101: Incorporating negative controls in antibody research.
Olds W, Li J
F1000Research 2016;5:308
F1000Research 2016;5:308
Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.
Sun B, Bai Y, Zhang L, Gong L, Qi X, Li H, Wang F, Chi X, Jiang Y, Shao S
PloS one 2016;11(9):e0163622
PloS one 2016;11(9):e0163622
Dexmedetomidine Inhibits Maturation and Function of Human Cord Blood-Derived Dendritic Cells by Interfering with Synthesis and Secretion of IL-12 and IL-23.
Chen G, Le Y, Zhou L, Gong L, Li X, Li Y, Liao Q, Duan K, Tong J, Ouyang W
PloS one 2016;11(4):e0153288
PloS one 2016;11(4):e0153288
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
Wei WJ, Shen CT, Song HJ, Qiu ZL, Luo QY
Oncology reports 2016 Sep;36(3):1576-84
Oncology reports 2016 Sep;36(3):1576-84
Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma.
Song Y, Sun B, Hao L, Hu J, Du S, Zhou X, Zhang L, Liu L, Gong L, Chi X, Liu Q, Shao S
Oncotarget 2016 Sep 6;7(36):58470-58482
Oncotarget 2016 Sep 6;7(36):58470-58482
Oral kanglaite injection (KLTI) attenuates the lung cancer-promoting effect of high-fat diet (HFD)-induced obesity.
Cao N, Ma X, Guo Z, Zheng Y, Geng S, Meng M, Du Z, Lin H, Duan Y, Du G
Oncotarget 2016 Sep 20;7(38):61093-61106
Oncotarget 2016 Sep 20;7(38):61093-61106
Thioredoxin-interacting protein regulates lipid metabolism via Akt/mTOR pathway in diabetic kidney disease.
Du C, Wu M, Liu H, Ren Y, Du Y, Wu H, Wei J, Liu C, Yao F, Wang H, Zhu Y, Duan H, Shi Y
The international journal of biochemistry & cell biology 2016 Oct;79:1-13
The international journal of biochemistry & cell biology 2016 Oct;79:1-13
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
Sun B, Gao L, Ahsan A, Chu P, Song Y, Li H, Zhang Z, Lin Y, Peng J, Song Z, Wang S, Tang Z
International immunopharmacology 2016 Nov;40:400-409
International immunopharmacology 2016 Nov;40:400-409
The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis.
Wang X, Yuan W, Wang X, Qi J, Qin Y, Shi Y, Zhang J, Gong J, Dong Z, Liu X, Sun C, Chai R, Le Noble F, Liu D
Oncotarget 2016 Nov 22;7(47):77749-77763
Oncotarget 2016 Nov 22;7(47):77749-77763
17β-Estradiol Inhibites Tumor Necrosis Factor-α Induced Apoptosis of Human Nucleus Pulposus Cells via the PI3K/Akt Pathway.
Wang T, Yang SD, Liu S, Wang H, Liu H, Ding WY
Medical science monitor : international medical journal of experimental and clinical research 2016 Nov 12;22:4312-4322
Medical science monitor : international medical journal of experimental and clinical research 2016 Nov 12;22:4312-4322
AKT/TSC2/p70S6K signaling pathway is involved in quinocetone-induced death-promoting autophagy in HepG2 cells.
Zhang S, Zhang C, Tang S, Deng S, Zhou Y, Dai C, Yang X, Xiao X
Toxicology mechanisms and methods 2016 May;26(4):301-10
Toxicology mechanisms and methods 2016 May;26(4):301-10
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
Wang D, Wang M, Jiang N, Zhang Y, Bian X, Wang X, Roberts TM, Zhao JJ, Liu P, Cheng H
Oncotarget 2016 Mar 15;7(11):13153-66
Oncotarget 2016 Mar 15;7(11):13153-66
The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.
Zhao S, Cao Y, Liu SB, Wang XA, Bao RF, Shu YJ, Hu YP, Zhang YJ, Jiang L, Zhang F, Liang HB, Li HF, Ma Q, Xu Y, Wang Z, Zhang YC, Chen L, Zhou J, Liu YB
Journal of experimental & clinical cancer research : CR 2016 Jun 18;35(1):97
Journal of experimental & clinical cancer research : CR 2016 Jun 18;35(1):97
Apelin-13 Protects PC12 Cells from Corticosterone-Induced Apoptosis Through PI3K and ERKs Activation.
Zou Y, Wang B, Fu W, Zhou S, Nie Y, Tian S
Neurochemical research 2016 Jul;41(7):1635-44
Neurochemical research 2016 Jul;41(7):1635-44
Preventive Effects of a Novel Polysaccharide from Sepia esculenta Ink on Ovarian Failure and Its Action Mechanisms in Cyclophosphamide-Treated Mice.
Liu HZ, Tao YX, Luo P, Deng CM, Gu YP, Yang L, Zhong JP
Journal of agricultural and food chemistry 2016 Jul 20;64(28):5759-66
Journal of agricultural and food chemistry 2016 Jul 20;64(28):5759-66
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Wu J, Yang C, Guo C, Li X, Yang N, Zhao L, Hang H, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Chemico-biological interactions 2016 Jan 25;244:94-104
Chemico-biological interactions 2016 Jan 25;244:94-104
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Gao L, Xu Z, Wang Y, Sun B, Song Z, Yang B, Liu X, Lin Y, Peng J, Han G, Wang S, Tang Z
Oncology reports 2016 Feb;35(2):1101-8
Oncology reports 2016 Feb;35(2):1101-8
Dysregulation of Neuregulin-1/ErbB signaling in the prefrontal cortex and hippocampus of rats exposed to chronic unpredictable mild stress.
Dang R, Cai H, Zhang L, Liang D, Lv C, Guo Y, Yang R, Zhu Y, Jiang P
Physiology & behavior 2016 Feb 1;154:145-50
Physiology & behavior 2016 Feb 1;154:145-50
bFGF Protects Against Blood-Brain Barrier Damage Through Junction Protein Regulation via PI3K-Akt-Rac1 Pathway Following Traumatic Brain Injury.
Wang ZG, Cheng Y, Yu XC, Ye LB, Xia QH, Johnson NR, Wei X, Chen DQ, Cao G, Fu XB, Li XK, Zhang HY, Xiao J
Molecular neurobiology 2016 Dec;53(10):7298-7311
Molecular neurobiology 2016 Dec;53(10):7298-7311
Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.
Wang W, McKinnie SM, Farhan M, Paul M, McDonald T, McLean B, Llorens-Cortes C, Hazra S, Murray AG, Vederas JC, Oudit GY
Hypertension (Dallas, Tex. : 1979) 2016 Aug;68(2):365-77
Hypertension (Dallas, Tex. : 1979) 2016 Aug;68(2):365-77
miR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis.
Niu X, Fu N, Du J, Wang R, Wang Y, Zhao S, Du H, Wang B, Zhang Y, Sun D, Nan Y
FEBS letters 2016 Aug;590(16):2709-24
FEBS letters 2016 Aug;590(16):2709-24
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20
Lab on a chip 2016 Aug 7;16(15):2911-20
CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.
Zhang L, Liu L, He X, Shen Y, Liu X, Wei J, Yu F, Tian J
Biochemical and biophysical research communications 2016 Aug 26;477(3):356-62
Biochemical and biophysical research communications 2016 Aug 26;477(3):356-62
Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice.
Lv Y, Meng B, Dong H, Jing T, Wu N, Yang Y, Huang L, Moses RE, O'Malley BW, Mei B, Li X
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2016 Apr;41(5):1340-9
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2016 Apr;41(5):1340-9
Down-regulation of ribosomal protein S15A inhibits proliferation of human glioblastoma cells in vivo and in vitro via AKT pathway.
Yao Y, Liu Y, Lv X, Dong B, Wang F, Li J, Zhang Q, Xu R, Xu Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Apr;37(4):4979-90
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Apr;37(4):4979-90
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
DU Q, Hao C, Gou J, Li X, Zou K, He X, Li Z
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth.
Lu Y, Wang Y, Zhang M, Liu L, Li F, Zhang J, Ye M, Zhao H, Zhao J, Yan B, Yang A, Zhang R, Li X, Ren X
Oncotarget 2016 Apr 26;7(17):23594-607
Oncotarget 2016 Apr 26;7(17):23594-607
TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis.
Dong F, Ling Q, Ye D, Zhang Z, Shu J, Chen G, Fei Y, Li C
Scientific reports 2016 Apr 25;6:24859
Scientific reports 2016 Apr 25;6:24859
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Yao Z, Sun B, Hong Q, Yan J, Mu D, Li J, Sheng H, Guo H
Drug design, development and therapy 2015;9:5911-23
Drug design, development and therapy 2015;9:5911-23
Inhibitive effects of 15-deoxy-Δ(12),(14)-prostaglandin J2 on hepatoma-cell proliferation through reactive oxygen species-mediated apoptosis.
Chen K, Dai W, Wang F, Xia Y, Li J, Li S, Liu T, Zhang R, Wang J, Lu W, Zhou Y, Yin Q, Zheng Y, Abudumijiti H, Chen R, Lu J, Zhou Y, Guo C
OncoTargets and therapy 2015;8:3585-93
OncoTargets and therapy 2015;8:3585-93
NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/mTOR phosphorylation.
Sun Z, Li Q, Zhang S, Chen J, Huang L, Ren J, Chang Y, Liang Y, Wu G
OncoTargets and therapy 2015;8:269-77
OncoTargets and therapy 2015;8:269-77
Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis.
Farhan MA, Carmine-Simmen K, Lewis JD, Moore RB, Murray AG
PloS one 2015;10(8):e0135245
PloS one 2015;10(8):e0135245
Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway.
Xing SS, Yang XY, Zheng T, Li WJ, Wu D, Chi JY, Bian F, Bai XL, Wu GJ, Zhang YZ, Zhang CT, Zhang YH, Li YS, Jin S
Vascular pharmacology 2015 Sep;72:141-52
Vascular pharmacology 2015 Sep;72:141-52
Low dose photodynamic-therapy induce immune escape of tumor cells in a HIF-1α dependent manner through PI3K/Akt pathway.
Wan J, Wu W, Che Y, Kang N, Zhang R
International immunopharmacology 2015 Sep;28(1):44-51
International immunopharmacology 2015 Sep;28(1):44-51
Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas.
Hao L, Zhou X, Liu S, Sun M, Song Y, Du S, Sun B, Guo C, Gong L, Hu J, Guan H, Shao S
Proteomics 2015 Sep;15(17):3087-100
Proteomics 2015 Sep;15(17):3087-100
Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway.
Xie HX, Xu ZY, Tang JN, DU YA, Huang L, Yu PF, Cheng XD
Experimental and therapeutic medicine 2015 Sep;10(3):1212-1218
Experimental and therapeutic medicine 2015 Sep;10(3):1212-1218
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Zhang Q, Zhuang J, Deng Y, Zhao X, Tang B, Yao D, Zhao W, Chang C, Lu Q, Chen W, Zhang S, Ji C, Cao L, Guo H
Oncotarget 2015 Oct 13;6(31):32177-92
Oncotarget 2015 Oct 13;6(31):32177-92
Activated estrogen receptor-mitogen-activated protein kinases cross talk confer acquired resistance to lapatinib.
Li Z, Yang SS, Yin PH, Chang T, Shi LX, Fang L, Fang GE
Thoracic cancer 2015 Nov;6(6):695-703
Thoracic cancer 2015 Nov;6(6):695-703
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Li X, Zou K, Gou J, Du Q, Li D, He X, Li Z
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L, Zhang X
Cancer research 2015 Mar 1;75(5):846-57
Cancer research 2015 Mar 1;75(5):846-57
MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3.
Cao G, Dong W, Meng X, Liu H, Liao H, Liu S
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jun;36(6):4453-9
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jun;36(6):4453-9
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Dong D, Yin L, Qi Y, Xu L, Peng J
Nutrients 2015 Jun 15;7(6):4829-50
Nutrients 2015 Jun 15;7(6):4829-50
Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways.
Wu YJ, Neoh CA, Tsao CY, Su JH, Li HH
International journal of molecular sciences 2015 Jul 20;16(7):16469-82
International journal of molecular sciences 2015 Jul 20;16(7):16469-82
Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells.
Deng S, Tang S, Zhang S, Zhang C, Wang C, Zhou Y, Dai C, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jan;75:173-86
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jan;75:173-86
Quetiapine inhibits osteoclastogenesis and prevents human breast cancer-induced bone loss through suppression of the RANKL-mediated MAPK and NF-κB signaling pathways.
Wang H, Shen W, Hu X, Zhang Y, Zhuo Y, Li T, Mei F, Li X, Xiao L, Chu T
Breast cancer research and treatment 2015 Feb;149(3):705-14
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10176-2-AP(AKT antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-AKT (IP:10176-2-AP, 3ug; Detection:10176-2-AP 1:500) with HeLa cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 10176-2-AP(AKT antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AKT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AKT1. This antibody recognizes human,mouse,rat,zebrafish antigen. The AKT1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
