12071-1-AP

antibody from Proteintech Group

Targeting: STAT5B

Provider product page for 12071-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [15]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

Submit

Product number: 12071-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12071-1-AP, RRID:AB_2196933
Product name: STAT5A/B antibody
Antibody type: Polyclonal
Description: STAT5A/B antibody (Cat. #12071-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

STAT5B protein structure - 12071-1-AP shown in red.

Submitted references CCL5 deficiency aggravates acute DSS-induced colitis by restricting IL-33-induced formation of Tregs in intestinal tract.

Luo Y, Gong TY, Zhao YH, Li H, Ye GY, Zhang ZZ, Yu MH, Zhang Y, Zhong M
Clinical science (London, England : 1979) 2026 Jan 7;140(1):27-46

MSCs-derived HGF alleviates senescence after AKI by modulating mitoSTAT3-controlled copper flux and respiration.

Zhuang K, Wang W, Xu C, Wang S, Chen Y, Zhang Y, Liang Y, Zheng X, Chen X, Feng Z, Cai G
Stem cell research & therapy 2025 Sep 29;16(1):526

Discovery of a Proteolysis-Targeting Chimera Degrader of JAK2 as a Potential Therapeutic Agent for JAK2-Mediated Myeloproliferative Neoplasms.

Wang C, Chen Z, Wang S, Wang J, Yu P, Huang C, Wu Y, Zhao Z, Mei W, Li H, Zhu L
Journal of medicinal chemistry 2025 Jun 12;68(11):12085-12099

Design, Synthesis, and Biological Evaluation of Macrocyclic 2-Amino-4-phenylaminopyrimidine Derivatives as Potent JAK2 Inhibitors.

Mei W, Jia X, Hu F, Liao W, Chen Z, Bi H, Zhao Z, Chen Z, Li H, Zhu L, Diao Y
Journal of medicinal chemistry 2025 Jul 10;68(13):13822-13835

Astragalus polysaccharide ameliorates diabetic retinopathy by inhibiting the SHH-Gli1-AQP1 signaling pathway in streptozotocin-induced type 2 diabetic rats.

Qu J, Wang B, Wang Y, Li H, An X
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 Jan 1;29(1):21-32

A CCL5(+)CD20(+)CD8(+) T cell subset drives pathogenic transformation of synoviocytes in rheumatoid arthritis via JAK-STAT signaling.

Jia H, Xue J, Jiang S, Li W, Wei X, Wang Y, Zhuang J, Zhu X, Li H, Liu X, Chu M, Zhang Z, Zhang J
Cell & bioscience 2025 Dec 6;16(1):2

Quercetin of huoxuehuayu tongluo decoction and azithromycin combination therapy effectively improves rat tubal factor infertility by inhibiting inflammation.

Shao L, Wang N, Yan Y, Tan Y, Wu Q, Lei L, Wang M, Liu L
Iranian journal of basic medical sciences 2024;27(6):685-694

HSP90β shapes the fate of Th17 cells with the help of glycolysis-controlled methylation modification.

Yang L, Zhu JC, Li SJ, Zeng X, Xue XR, Dai Y, Wei ZF
British journal of pharmacology 2024 Oct;181(20):3886-3907

Freeze-dried powder of daylily bud improves bromocriptine-induced lactation disorder in rats via JAK2/STAT5 pathway.

Guo S, Qin N, Wang X, Zuo Z, Li Q, Wang Y
Journal of ethnopharmacology 2023 Sep 15;313:116536

Macrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery.

Diao Y, Liu D, Ge H, Zhang R, Jiang K, Bao R, Zhu X, Bi H, Liao W, Chen Z, Zhang K, Wang R, Zhu L, Zhao Z, Hu Q, Li H
Nature communications 2023 Jul 28;14(1):4552

Efficacy of WWQ-131, a highly selective JAK2 inhibitor, in mouse models of myeloproliferative neoplasms.

Ge H, Wang C, Tian C, Diao Y, Wang W, Ma X, Zhang J, Li H, Zhao Z, Zhu L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113884

Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl(4)/2-AAF.

Xu Y, Xu W, Liu W, Chen G, Jiang S, Chen J, Jian X, Zhang H, Liu P, Mu Y
Pharmaceutical biology 2021 Dec;59(1):1150-1160

Kuijieling regulates the differentiation of Treg and Th17 cells to ameliorate experimental colitis in rats.

Long Y, Li S, Qin J, Xie L, Gan L, Jie F, Wu Y, Li Y, Du Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Sep;105:781-788

1, 25(OH)(2)D(3)-induced interaction of vitamin D receptor with p50 subunit of NF-κB suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation.

Ma D, Zhang RN, Wen Y, Yin WN, Bai D, Zheng GY, Li JS, Zheng B, Wen JK
Biochemical and biophysical research communications 2017 Jan 8;482(2):366-374

Effects of sexually dimorphic growth hormone secretory patterns on arachidonic acid metabolizing enzymes in rodent heart.

Zhang F, Yu X, He C, Ouyang X, Wu J, Li J, Zhang J, Duan X, Wan Y, Yue J
Toxicology and applied pharmacology 2015 Dec 15;289(3):495-506

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 12071-1-AP(STAT5B antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using STAT5B antibody 12071-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lung cancer using 12071-1-AP(STAT5B antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue