18299-1-AP

antibody from Proteintech Group

Targeting: ERBB2 CD340, HER-2, HER2, NEU, NGL

Provider product page for 18299-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [98]
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Validations
Western blot [1]
Immunohistochemistry [2]
Flow cytometry [1]

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Product number: 18299-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#18299-1-AP, RRID:AB_2099264
Product name: HER2/ErbB2 antibody
Antibody type: Polyclonal
Description: HER2/ErbB2 antibody (Cat. #18299-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ERBB2 protein structure - 18299-1-AP shown in red.

Submitted references Copy Number Amplification and c-Myc Transcriptional Activation-Mediated RNA-Binding Protein MEX3A Promotes EGFR-TKI Resistance in Non-Small-Cell Lung Cancer.

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The Journal of biological chemistry 2026 Jan;302(1):110941

ERBB2 as a Prognostic Biomarker in Prostate Cancer: Integration of Single-Cell Transcriptomics, Deep Learning, and Immunohistochemical Validation.

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Mechanistic insights into modified Danggui Buxue Decoction for diabetic retinopathy via integrative analysis.

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Cigarette smoke extract promotes metastasis and oxaliplatin resistance in colon adenocarcinoma through GDF15/ERBB2/AKT pathway.

Jiang W, Wang Y, Wang WJ, Zhou BC, Hu XS, Xu AM
European journal of medical research 2025 Oct 10;30(1):958

Neburon induced cardiotoxicity in embryonic and adult male zebrafish via over-activation of the Ahr-Notch1 signaling pathway.

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XBP1s Mediates Cross-resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer.

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Scientific reports 2025 Jul 7;15(1):24303

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Zhou Y, Tang Y, Huang F, Wang Z, Wen Z, Fang Q, Wang C
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Comprehensive characterization of early-onset lung cancer, in Chinese young adults.

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Sorensen JR, Hoffman DB, Raymond-Pope CJ, Lillquist TJ, Russell AM, Corona BT, Greising SM
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Cai Y, Yu D, Meng J, Qiu Y, Liu J, Yao J
Annals of medicine 2025 Dec;57(1):2548045

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Wang NN, Luo R, Ji ZH, Chen YH, Su LJ, Xu MX, Yang C, Zhang JC, Gao Y, Xu S, Lin YX
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International immunopharmacology 2025 Apr 24;153:114451

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International journal of nanomedicine 2024;19:10941-10959

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Qi X, Wang F, Thomas L, Ma S, Palen K, Lu Y, Sheinin Y, Gershan J, Fu L, Chen G
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European journal of medicinal chemistry 2024 Sep 5;275:116572

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Cell reports 2024 Oct 22;43(10):114812

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Journal of nanobiotechnology 2024 Nov 29;22(1):743

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Sun N, Wang J, Qin J, Ma S, Luan J, Hou G, Zhang W, Gao M
Cell death & disease 2024 Nov 27;15(11):861

Targeting Erbin-mitochondria axis in platelets/megakaryocytes promotes B cell-mediated antitumor immunity.

Zhang Z, Xu X, Zhang D, Zhao S, Wang C, Zhang G, Chen W, Liu J, Gong H, Rixiati Y, Li S, Shen T, Li J
Cell metabolism 2024 Mar 5;36(3):541-556.e9

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Journal of translational medicine 2024 Jul 29;22(1):689

Neratinib enhances the efficacy of CDK4/6 inhibitor plus endocrine therapy in HR(+)/HER2-low breast cancer cell line ZR-75-1 via hsa-miR-23a-5p.

Chen L, Ye L, Liang Y, Luo W, Zuo Q, Huang P, Hu Y, Dai Y, Wu Y, Guo Q, Chen Q
Scientific reports 2024 Dec 28;14(1):31062

Metabolic shifts in lipid utilization and reciprocal interactions within the lung metastatic niche of triple-negative breast cancer revealed by spatial multi-omics.

Kan JY, Lee HC, Hou MF, Tsai HP, Jian SF, Chang CY, Tsai PH, Lin YS, Tsai YM, Wu KL, Huang YC, Hsu YL
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Amplified and Specific Staining of Protein Dimerization on Cell Membrane Catalyzed by Responsively Installed DNA Nanomachines for Cancer Diagnosis.

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Advanced healthcare materials 2024 Apr;13(10):e2303398

Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis.

Yang C, Wang X, To KKW, Cui C, Luo M, Wu S, Huang L, Fu K, Pan C, Liu Z, Fan T, Yang C, Wang F, Fu L
Signal transduction and targeted therapy 2024 Apr 5;9(1):84

A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice.

Ma X, Yin J, Qiao L, Wan H, Liu X, Zhou Y, Wu J, Niu L, Wu M, Wang X, Ye H
Molecular cell 2024 Apr 18;84(8):1585-1600.e7

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Li W, Zheng C, Xu X, Xia Y, Zhang K, Huang A, Zhang X, Zheng Y, Chen G, Zhang S
Cellular & molecular biology letters 2024 Apr 10;29(1):50

A prognostic biomarker NRG1 promotes U-87 MG glioblastoma cell malignancy by inhibiting autophagy via ERBB2/AKT/mTOR pathway.

Lin JZ, Lin N, Zhao WJ
Journal of cellular biochemistry 2023 Sep;124(9):1273-1288

Identification of a receptor tyrosine kinase inhibitor CP-724714 inhibits SADS-CoV related swine diarrhea coronaviruses infection in vitro.

Zhou L, Li C, Zhang R, Li Q, Sun Y, Feng Y, Lan T, Ma J
Virologica Sinica 2023 Oct;38(5):778-786

A HER2-targeted Antibody-Drug Conjugate, RC48-ADC, Exerted Promising Antitumor Efficacy and Safety with Intravesical Instillation in Preclinical Models of Bladder Cancer.

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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(32):e2302377

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Small (Weinheim an der Bergstrasse, Germany) 2023 May;19(20):e2204031

Structure optimization and discovery of novel compound for the treatment of insertion mutations within exon 20 of EGFR and HER2.

Cui Y, Wang R, Wei Y, Hou F, Li H, Jiang Y, Sun Y, Fu S, Zuo L, Wang X, Li M, Li J, Liu N, Zhang K, Wei M, Yang G
Bioorganic & medicinal chemistry 2023 Mar 1;81:117202

Efficacy, toxicity and prognostic factors of pyrotinib‑involved neoadjuvant therapy in HER2‑positive breast cancer: A retrospective study.

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Oncology letters 2023 Jul;26(1):314

Molecular characteristics and prognosis of breast cancer patients with different level of HER2 positivity after adjuvant and neoadjuvant chemotherapy.

Tuluhong D, Li X, Gao H, Zhu Y, Li Q, Wang S
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2023 Jul 1;32(4):377-387

Macrophage renewal modes affect acquired resistance to gefitinib in EGFR‑mutant lung cancer PC‑9 cells.

Zhao B, Zhang Y, Lu S, Li M
Oncology reports 2023 Feb;49(2)

Jatrorrhizine ameliorates Schwann cell myelination via inhibiting HDAC3 ability to recruit Atxn2l for regulating the NRG1-ErbB2-PI3K-AKT pathway in diabetic peripheral neuropathy mice.

Gong X, Gui Z, Ye X, Li X
Phytotherapy research : PTR 2023 Feb;37(2):645-657

Characterization of Expression and Function of the Formins FHOD1, INF2, and DAAM1 in HER2-Positive Breast Cancer.

Peippo M, Gardberg M, Kronqvist P, Carpén O, Heuser VD
Journal of breast cancer 2023 Dec;26(6):525-543

EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.

Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7

Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability.

Tuluhong D, Gao H, Li X, Wang L, Zhu Y, Xu C, Wang J, Li H, Li Q, Wang S
Experimental cell research 2023 Dec 1;433(1):113805

TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression.

Bi J, Wu Z, Zhang X, Zeng T, Dai W, Qiu N, Xu M, Qiao Y, Ke L, Zhao J, Cao X, Lin Q, Chen XL, Xie L, Ouyang Z, Guo J, Zheng L, Ma C, Guo S, Chen K, Mo W, Fu G, Zhao TJ, Wang HR
Nature communications 2023 Apr 24;14(1):2342

Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.

Adediran S, Wang L, Khan MA, Guang W, Fan X, Dan H, Qi J, Jay SM, Carrier F, Hussain A
Cancers 2022 Sep 23;14(19)

Label-Free Plasmon-Enhanced Spectroscopic HER2 Detection for Dynamic Therapeutic Surveillance of Breast Cancer.

Xie Y, Wen Y, Su X, Zheng C, Li M
Analytical chemistry 2022 Sep 20;94(37):12762-12771

Prognostic significance of HER2 status evaluation using immunohistochemistry in patients with urothelial carcinoma of the bladder: A retrospective single‑center experience.

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Experimental and therapeutic medicine 2022 Nov;24(5):704

Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch.

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Cell reports 2022 Mar 8;38(10):110468

Triple-Negative Apocrine Breast Carcinoma Has Better Prognosis despite Poor Response to Neoadjuvant Chemotherapy.

Hu T, Liu Y, Wu J, Hu XL, Zhao G, Liang B, Wang S, Long M
Journal of clinical medicine 2022 Mar 14;11(6)

Genome-scale CRISPR-Cas9 screen reveals novel regulators of B7-H3 in tumor cells.

Zhao S, Wang Y, Yang N, Mu M, Wu Z, Li H, Tang X, Zhong K, Zhang Z, Huang C, Cao T, Zheng M, Wang G, Nie C, Yang H, Guo G, Zhou L, Zheng X, Tong A
Journal for immunotherapy of cancer 2022 Jun;10(6)

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Wu Q, Yuan C, Liu N, Shu J, Wang J, Qian J, Zeng L, Zhang H, Wang X, Mei W
Journal of experimental & clinical cancer research : CR 2022 Jun 13;41(1):201

Upregulation of estrogen receptor alpha (ERα) expression in transgenic mice expressing human CYP4Z1.

Khayeka-Wandabwa C, Zhao J, Pathak JL, Wu H, Bureik M
Breast cancer research and treatment 2022 Jan;191(2):319-326

Ionic Liquid-Based Extraction System for In-Depth Analysis of Membrane Protein Complexes.

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Analytical chemistry 2022 Jan 18;94(2):758-767

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Chinese medicine 2022 Dec 17;17(1):140

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Clinical & experimental metastasis 2022 Aug;39(4):623-639

Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer.

Wang J, Huang Q, Hu X, Zhang S, Jiang Y, Yao G, Hu K, Xu X, Liang B, Wu Q, Ma Z, Wang Y, Wang C, Wu Z, Rong X, Liao W, Shi M
Cancer research 2022 Apr 15;82(8):1503-1517

Rolling Circle Amplification-Assisted Flow Cytometry Approach for Simultaneous Profiling of Exosomal Surface Proteins.

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ACS sensors 2021 Oct 22;6(10):3611-3620

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Scientific reports 2021 May 26;11(1):10973

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European journal of cancer (Oxford, England : 1990) 2021 Mar;145:92-108

MicroRNA-133a-3p suppresses malignant behavior of non-small cell lung cancer cells by negatively regulating ERBB2.

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Oncology letters 2021 Jun;21(6):457

Formin-like protein 2 promotes cell proliferation by a p27-related mechanism in human breast cancer cells.

Jiao X, Wang B, Feng C, Song S, Tian B, Zhou C, Gao X, Sun W, Liu P
BMC cancer 2021 Jun 30;21(1):760

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Cells 2021 Jun 30;10(7)

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Cancer medicine 2021 Dec;10(24):8808-8819

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Journal of Cancer 2020;11(5):1162-1169

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Pu X, Zhu L, Li F, Zheng J, Wu H, Fu Y, Chen J, Qi L
Pathology, research and practice 2020 Sep;216(9):153116

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Bioconjugate chemistry 2020 Jul 15;31(7):1766-1774

An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway.

Yang ZY, Yang L, Xu CW, Wang XJ, Lei L
Biology open 2020 Jan 24;9(1)

CMIP promotes Herceptin resistance of HER2 positive gastric cancer cells.

Xiang R, Han X, Ding K, Wu Z
Pathology, research and practice 2020 Feb;216(2):152776

BML-111 inhibits EMT, migration and metastasis of TAMs-stimulated triple-negative breast cancer cells via ILK pathway.

Lin L, Luo X, Wang L, Xu F, He Y, Wang Q, Yuan C, Xu J, Yan L, Hao H
International immunopharmacology 2020 Aug;85:106625

SEMA3C Promotes Cervical Cancer Growth and Is Associated With Poor Prognosis.

Liu R, Shuai Y, Luo J, Zhang Z
Frontiers in oncology 2019;9:1035

Efficient Acquisition of Fully Human Antibody Genes against Self-Proteins by Sorting Single B Cells Stimulated with Vaccines Based on Nitrated T Helper Cell Epitopes.

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Journal of immunology research 2019;2019:7914326

FOXA1 is Prognostic of Triple Negative Breast Cancers by Transcriptionally Suppressing SOD2 and IL6.

Dai X, Cheng H, Chen X, Li T, Zhang J, Jin G, Cai D, Huang Z
International journal of biological sciences 2019;15(5):1030-1041

ANLN and KDR Are Jointly Prognostic of Breast Cancer Survival and Can Be Modulated for Triple Negative Breast Cancer Control.

Dai X, Mei Y, Chen X, Cai D
Frontiers in genetics 2019;10:790

Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers.

Wang D, Hu X, Liu C, Jia Y, Bai Y, Cai C, Wang J, Bai L, Yang R, Lin C, Liu YR, Li S, Qiao F, Yao L, Chen L, Ge G, Jiang H, Li D, Li L, Chen J, Shao ZM, Zeng YA
Cell research 2019 Oct;29(10):832-845

Anti-KL-6/MUC1 monoclonal antibody reverses resistance to trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity by capping MUC1.

Namba M, Hattori N, Hamada H, Yamaguchi K, Okamoto Y, Nakashima T, Masuda T, Sakamoto S, Horimasu Y, Miyamoto S, Iwamoto H, Fujitaka K, Kohno N
Cancer letters 2019 Feb 1;442:31-39

The antimetastatic effect and underlying mechanisms of thioredoxin reductase inhibitor ethaselen.

Zheng X, Chen Y, Bai M, Liu Y, Xu B, Sun R, Zeng H
Free radical biology & medicine 2019 Feb 1;131:7-17

RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression.

Chen P, Yue X, Xiong H, Lu X, Ji Z
International journal of oncology 2019 Apr;54(4):1387-1397

Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer.

Liu Y, Xu J, Choi HH, Han C, Fang Y, Li Y, Van der Jeught K, Xu H, Zhang L, Frieden M, Wang L, Eyvani H, Sun Y, Zhao G, Zhang Y, Liu S, Wan J, Huang C, Ji G, Lu X, He X, Zhang X
Nature communications 2018 Nov 9;9(1):4718

Protein C receptor stimulates multiple signaling pathways in breast cancer cells.

Wang D, Liu C, Wang J, Jia Y, Hu X, Jiang H, Shao ZM, Zeng YA
The Journal of biological chemistry 2018 Jan 26;293(4):1413-1424

Crucial microRNAs and genes in metformin's anti-pancreatic cancer effect explored by microRNA-mRNA integrated analysis.

Li Y, Li L, Zhang G, Wang Y, Chen H, Kong R, Pan S, Sun B
Investigational new drugs 2018 Feb;36(1):20-27

Simvastatin inhibits tumor angiogenesis in HER2-overexpressing human colorectal cancer.

Li G, Zheng J, Xu B, Ling J, Qiu W, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:418-424

Synergistic antitumor activity of regorafenib and lapatinib in preclinical models of human colorectal cancer.

Zhang WJ, Li Y, Wei MN, Chen Y, Qiu JG, Jiang QW, Yang Y, Zheng DW, Qin WM, Huang JR, Wang K, Zhang WJ, Wang YJ, Yang DH, Chen ZS, Shi Z
Cancer letters 2017 Feb 1;386:100-109

Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells.

Tan S, Ding K, Chong QY, Zhao J, Liu Y, Shao Y, Zhang Y, Yu Q, Xiong Z, Zhang W, Zhang M, Li G, Li X, Kong X, Ahmad A, Wu Z, Wu Q, Zhao X, Lobie PE, Zhu T
The Journal of biological chemistry 2017 Aug 18;292(33):13551-13564

Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.

Zhang Z, Li HM, Zhou C, Li Q, Ma L, Zhang Z, Sun Y, Wang L, Zhang X, Zhu B, Hong YS, Wu CZ, Liu H
Journal of experimental & clinical cancer research : CR 2016 Sep 22;35(1):149

Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome.

Sakata K, Araki K, Nakano H, Nishina T, Komazawa-Sakon S, Murai S, Lee GE, Hashimoto D, Suzuki C, Uchiyama Y, Notohara K, Gukovskaya AS, Gukovsky I, Yamamura KI, Baba H, Ohmuraya M
Scientific reports 2016 Nov 15;6:37200

HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth.

Lu Y, Wang Y, Zhang M, Liu L, Li F, Zhang J, Ye M, Zhao H, Zhao J, Yan B, Yang A, Zhang R, Li X, Ren X
Oncotarget 2016 Apr 26;7(17):23594-607

Cellular stress induces cap-independent alpha-enolase/MBP-1 translation.

Maranto C, Perconti G, Contino F, Rubino P, Feo S, Giallongo A
FEBS letters 2015 Jul 22;589(16):2110-6

Negative transcriptional control of ERBB2 gene by MBP-1 and HDAC1: diagnostic implications in breast cancer.

Contino F, Mazzarella C, Ferro A, Lo Presti M, Roz E, Lupo C, Perconti G, Giallongo A, Feo S
BMC cancer 2013 Feb 19;13:81

Effect of acute acid-base disturbances on ErbB1/2 tyrosine phosphorylation in rabbit renal proximal tubules.

Skelton LA, Boron WF
American journal of physiology. Renal physiology 2013 Dec 15;305(12):F1747-64

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 18299-1-AP(ERBB2,p185-Specific antibody) at dilution of 1:2000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 18299-1-AP(ERBB2,p185-Specific antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 18299-1-AP(ERBB2,p185-Specific antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The HER2/ErbB2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human HER2/ErbB2. This antibody recognizes human,mouse,rat antigen. The HER2/ErbB2 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
Appendix: 18299-1-AP.pdf

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