ERBB2

gene product
CD340, HER-2, HER2, NEU, NGL
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
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1791 antibodies from 32 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Thermo Fisher Scientific Pierce
44 antibodies
antibodies-online
593 antibodies
Bethyl Laboratories, Inc.
4 antibodies
Abnova Corporation
34 antibodies
Proteintech Group
3 antibodies
OriGene
8 antibodies
Novus Biologicals
172 antibodies
Cell Signaling Technology, Inc
12 antibodies
R&D Systems
9 antibodies
Aviva Systems Biology
40 antibodies
Acris Antibodies GmbH
104 antibodies