FNab03833

antibody from FineTest Biotech
Targeting: ERBB2 CD340, HER-2, HER2, NEU, NGL
Provider product page for FNab03833
Western blot
ELISA
Immunoprecipitation
Immunohistochemistry
Flow cytometry

Antibody data

Product number
FNab03833 - Provider product page
Provider
FineTest Biotech
Product name
HER2/ErbB2 antibody
Antibody type
Polyclonal
Antigen
Recombinant protein fragment
Description
HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor(EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas. This antibody raised against a synthesized peptide corresponding to 1237-1255aa of human HER2 recognizes the 185-kDa full-length glycosylated form and other lower molecular-mass forms of HER2, including the truncated form.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
v-erb-b2 erythroblastic leukemia vi
ral oncogene homolog 2, neuro/gliob
lastoma derived oncogene homolog(av
ian)
Epitope
IgG
Isotype
IgG
Vial size
100¦Ìg
Concentration
Immunogen affinity purified
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
ERBB2 protein structure - FNab03833 shown in red.