Antibody data

Product number
BS60842 - Provider product page
Provider
Bioworld Technology, Inc
Product name
EDN1 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human EDN1.
Description
The human endothelins represent a gene family comprised of endothelin-1, endothelin-2, and endothelin-3, also known as ET-1, ET-2, and ET-3 . Endothelins can affect the central nervous system and neuronal excitability, and they elicit potent vasoconstrictor action . The two receptor subtypes responsible for inducing vasoconstriction and vasodilation, ETA and ETB, have different receptor affinities for ET-1, ET-2, and ET-3 . Of the three isopeptides, ET-2 has the most potent vasoconstrictor activity . Biologically active ETs are proteolytically generated from a larger precursor, the big-endothelin, by action of the endothelin-converting enzyme (ECE) family. ET-1 is a potent, 21-amino acid vasoconstrictor peptide produced by vascular endothelial cells. The ET-2 cDNA is 1.3 kb in length and encodes a proprotein consisting of 178 amino acid residues. ET3 mRNA encodes a 230-amino acid precursor that includes ET3 and a 15-amino acid homologous segment called the ET3-like sequence.
Reactivity
Human, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
EDN1 protein structure - BS60842 shown in red.