Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60842 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- EDN1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human EDN1.
- Description
- The human endothelins represent a gene family comprised of endothelin-1, endothelin-2, and endothelin-3, also known as ET-1, ET-2, and ET-3 . Endothelins can affect the central nervous system and neuronal excitability, and they elicit potent vasoconstrictor action . The two receptor subtypes responsible for inducing vasoconstriction and vasodilation, ETA and ETB, have different receptor affinities for ET-1, ET-2, and ET-3 . Of the three isopeptides, ET-2 has the most potent vasoconstrictor activity . Biologically active ETs are proteolytically generated from a larger precursor, the big-endothelin, by action of the endothelin-converting enzyme (ECE) family. ET-1 is a potent, 21-amino acid vasoconstrictor peptide produced by vascular endothelial cells. The ET-2 cDNA is 1.3 kb in length and encodes a proprotein consisting of 178 amino acid residues. ET3 mRNA encodes a 230-amino acid precursor that includes ET3 and a 15-amino acid homologous segment called the ET3-like sequence.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of EDN1 pAb at 1:500 dilutionLane1:MCF-7 whole cell lysateLane2:H9C2 whole cell lysate