BS6860

antibody from Bioworld Technology, Inc
Targeting: AIRE APECED, APS1, PGA1
Provider product page for BS6860
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6860 - Provider product page
Provider
Bioworld Technology, Inc
Product name
AIRE polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human AIRE.
Description
The autoimmune regulator gene, which is defective in the hereditary autoimmune disease APECED, encodes the transcriptional activator AIRE. AIRE is expressed in the medullary epithelial cells and monocyte-dendritic cells of the thymus, with lower expression in the spleen, fetal liver and lymph nodes. In adult tissue, AIRE expression in the thymus is confined to the medulla and the cortico-medullary junction, where it is modulated by thymocytes undergoing negative selection. At the cellular level, AIRE is located in microtubular structures of the cytoskeleton and in discrete nuclear dots resembling ND10 nuclear bodies.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
AIRE protein structure - BS6860 shown in red.